Robust multishot diffusion-weighted imaging of the abdomen with region-based shot rejection.

PURPOSE: Diffusion-weighted (DW) imaging provides a useful clinical contrast, but is susceptible to motion-induced dephasing caused by the application of strong diffusion gradients. Phase navigators are commonly used to resolve shot-to-shot motion-induced phase in multishot reconstructions, but poor phase estimates result in signal dropout and Apparent Diffusion Coefficient (ADC) overestimation. These artifacts are prominent in the abdomen, a region prone to involuntary cardiac and respiratory motion. To improve the robustness of DW imaging in the abdomen, region-based shot rejection schemes that selectively weight regions where the shot-to-shot phase is poorly estimated were evaluated. METHODS: Spatially varying weights for each shot, reflecting both the accuracy of the estimated phase and the degree of subvoxel dephasing, were estimated from the phase navigator magnitude images. The weighting was integrated into a multishot reconstruction using different formulations and phase navigator resolutions and tested with different phase navigator resolutions in multishot DW-echo Planar Imaging acquisitions of the liver and pancreas, using conventional monopolar and velocity-compensated diffusion encoding. Reconstructed images and ADC estimates were compared qualitatively. RESULTS: The proposed region-based shot rejection reduces banding and signal dropout artifacts caused by physiological motion in the liver and pancreas. Shot rejection allows conventional monopolar diffusion encoding to achieve median ADCs in the pancreas comparable to motion-compensated diffusion encoding, albeit with a greater spread of ADCs. CONCLUSION: Region-based shot rejection is a linear reconstruction that improves the motion robustness of multi-shot DWI and requires no sequence modifications.

Distortionless, free-breathing, and respiratory resolved 3D diffusion weighted imaging of the abdomen.

PURPOSE: Abdominal imaging is frequently performed with breath holds or respiratory triggering to reduce the effects of respiratory motion. Diffusion weighted sequences provide a useful clinical contrast but have prolonged scan times due to low signal-to-noise ratio (SNR), and cannot be completed in a single breath hold. Echo-planar imaging (EPI) is the most commonly used trajectory for diffusion weighted imaging but it is susceptible to off-resonance artifacts. A respiratory resolved, three-dimensional (3D) diffusion prepared sequence that obtains distortionless diffusion weighted images during free-breathing is presented. Techniques to address the myriad of challenges including: 3D shot-to-shot phase correction, respiratory binning, diffusion encoding during free-breathing, and robustness to off-resonance are described. METHODS: A twice-refocused, M1-nulled diffusion preparation was combined with an RF-spoiled gradient echo readout and respiratory resolved reconstruction to obtain free-breathing diffusion weighted images in the abdomen. Cartesian sampling permits a sampling density that enables 3D shot-to-shot phase navigation and reduction of transient fat artifacts. Theoretical properties of a region-based shot rejection are described. The region-based shot rejection method was evaluated with free-breathing (normal and exaggerated breathing), and respiratory triggering. The proposed sequence was compared in vivo with multishot DW-EPI. RESULTS: The proposed sequence exhibits no evident distortion in vivo when compared to multishot DW-EPI, robustness to B0 and B1 field inhomogeneities, and robustness to motion from different respiratory patterns. CONCLUSION: Acquisition of distortionless, diffusion weighted images is feasible during free-breathing with a b-value of 500 s/mm2, scan time of 6 min, and a clinically viable reconstruction time.

Multichip multidimensional quantum networks with entanglement retrievability.

Quantum networks provide the framework for quantum communication, clock synchronization, distributed quantum computing, and sensing. Implementing large-scale and practical quantum networks relies on the development of scalable architecture and integrated hardware that can coherently interconnect many remote quantum nodes by sharing multidimensional entanglement through complex-medium quantum channels. We demonstrate a multichip multidimensional quantum entanglement network based on mass-manufacturable integrated-nanophotonic quantum node chips fabricated on a silicon wafer by means of complementary metal-oxide-semiconductor processes. Using hybrid multiplexing, we show that multiple multidimensional entangled states can be distributed across multiple chips connected by few-mode fibers. We developed a technique that can efficiently retrieve multidimensional entanglement in complex-medium quantum channels, which is important for practical uses. Our work demonstrates the enabling capabilities of realizing large-scale practical chip-based quantum entanglement networks.

Chylomicrons Regulate Lacteal Permeability and Intestinal Lipid Absorption.

BACKGROUND: Lymphatic vessels are responsible for tissue drainage, and their malfunction is associated with chronic diseases. Lymph uptake occurs via specialized open cell-cell junctions between capillary lymphatic endothelial cells (LECs), whereas closed junctions in collecting LECs prevent lymph leakage. LEC junctions are known to dynamically remodel in development and disease, but how lymphatic permeability is regulated remains poorly understood. METHODS: We used various genetically engineered mouse models in combination with cellular, biochemical, and molecular biology approaches to elucidate the signaling pathways regulating junction morphology and function in lymphatic capillaries. RESULTS: By studying the permeability of intestinal lacteal capillaries to lipoprotein particles known as chylomicrons, we show that ROCK (Rho-associated kinase)-dependent cytoskeletal contractility is a fundamental mechanism of LEC permeability regulation. We show that chylomicron-derived lipids trigger neonatal lacteal junction opening via ROCK-dependent contraction of junction-anchored stress fibers. LEC-specific ROCK deletion abolished junction opening and plasma lipid uptake. Chylomicrons additionally inhibited VEGF (vascular endothelial growth factor)-A signaling. We show that VEGF-A antagonizes LEC junction opening via VEGFR (VEGF receptor) 2 and VEGFR3-dependent PI3K (phosphatidylinositol 3-kinase)/AKT (protein kinase B) activation of the small GTPase RAC1 (Rac family small GTPase 1), thereby restricting RhoA (Ras homolog family member A)/ROCK-mediated cytoskeleton contraction. CONCLUSIONS: Our results reveal that antagonistic inputs into ROCK-dependent cytoskeleton contractions regulate the interconversion of lymphatic junctions in the intestine and in other tissues, providing a tunable mechanism to control the lymphatic barrier.

High coupling efficiency waveguide grating couplers on lithium niobate.

We propose and validate a new, to the best of our knowledge, approach for high coupling efficiency (CE) grating couplers (GCs) in the lithium niobate on insulator photonic integration platform. Enhanced CE is achieved by increasing the grating strength using a high refractive index polysilicon layer on the GC. Due to the high refractive index of the polysilicon layer, the light in the lithium niobate waveguide is pulled up to the grating region. The optical cavity formed in the vertical direction enhances the CE of the waveguide GC. With this novel structure, simulations predicted the CE to be -1.40 dB, while the experimentally measured CE was -2.20 dB with a 3-dB bandwidth of 81 nm from 1592 nm to 1673 nm. The high CE GC is achieved without using bottom metal reflectors or requiring the etching of the lithium niobate material.

Combined polysilicon and silicon gratings for dual-wavelength-band waveguide grating couplers.

We proposed a novel, to the best of our knowledge, design for a dual-wavelength-band waveguide grating coupler. The proposed structure works in both the C band and O band. The proposed device is optimized from an initial design of two independent gratings formed on the silicon and polysilicon overlay layers, respectively. We designed the up layer (polysilicon) for the C band and the down layer (silicon) for the O band as the initial optimization seed. After numerical optimization of this structure using a genetic algorithm, the grating coupler has a coupling efficiency of -3.86 dB at the C band and -4.46 dB at the O band. We validate the approach in a commercial foundry using 193-nm photolithography in a multi-project wafer, and the experimental result has coupling efficiencies of -4.37 dB in the C band and -5.8 dB in the O band.

Alleviating experimental allergic eye disease by inhibiting pro-lymphangiogenic VEGFR3 signal.

PURPOSE: Ocular allergy leads to acute and chronic inflammation that may deteriorate the conjunctiva and other ocular tissue. The conjunctiva is covered with abundant lymphatic vessels but how the conjunctival lymphatic system patriciates in the development of allergic eye disease (AED) remains to be elucidated. METHODS AND RESULTS: By using ovalbumin (OVA)+pertussis toxin (PTX) as a sensitizer followed by daily OVA challenges, we induced optimized AED manifestations in mice. We show that conjunctival lymphatics underwent significant expansion after 28 days of chronic OVA challenge, and this process can be prevented by inducible genetic ablation of lymphatic Vegfr3. Through transcriptomic profile analysis in combination with histopathological examinations, we found that pro-lymphangiogenic VEGFR3 signal promoted allergy-induced activation of T helper 2 (Th2) type immune responses, including antigen presentation, and Th2 cells, B cells and mast cell-related pathways in the conjunctiva, thereby critically contributing to the immunoglobulin E (IgE) production and AED manifestations. As a result, ocular allergy can be alleviated by genetic inhibition of lymphatic Vegfr3. Interestingly, pro-lymphangiogenic VEGFR3 signal did not appear to affect the obstruction of meibomian glands (MGs) or the activation of Th17 type and neutrophil pathways that are associated with AED. CONCLUSIONS: These data reveal the key role of pro-lymphangiogenic VEGFR3 signaling in the development of AED and provide experimental evidence that VEGFR3 inhibition may be useful in treating ocular allergy in patients.

Optimized shift-pattern overlay for high coupling efficiency waveguide grating couplers.

We propose and validate a new, to the best of our knowledge, approach for increasing the coupling efficiency of waveguide grating couplers by introducing an optimized shift-patterned polysilicon overlay above the silicon grating structure. After optimizing the shifts in position and duty cycles of each period in the polysilicon overlay and silicon grating, the silicon grating and polysilicon overlay can form composite subwavelength structures which improve both the mode matching and the directionality of the grating coupler, and enable the design of a high-efficiency perfectly vertical grating coupler (PVGC) with -0.91 dB simulated coupling efficiency. The devices are fabricated using photolithography in a standard commercial multi-project wafer fabrication service by IMEC and have a measured coupling loss of approximately 1.45 dB.

Broadband high-Q multimode silicon concentric racetrack resonators for widely tunable Raman lasers.

Multimode silicon resonators with ultralow propagation losses for ultrahigh quality (Q) factors have been attracting attention recently. However, conventional multimode silicon resonators only have high Q factors at certain wavelengths because the Q factors are reduced at wavelengths where fundamental modes and higher-order modes are both near resonances. Here, by implementing a broadband pulley directional coupler and concentric racetracks, we present a broadband high-Q multimode silicon resonator with average loaded Q factors of 1.4 × 106 over a wavelength range of 440 nm (1240-1680 nm). The mutual coupling between the two multimode racetracks can lead to two supermodes that mitigate the reduction in Q factors caused by the mode coupling of the higher-order modes. Based on the broadband high-Q multimode resonator, we experimentally demonstrated a broadly tunable Raman silicon laser with over 516 nm wavelength tuning range (1325-1841 nm), a threshold power of (0.4 ± 0.1) mW and a slope efficiency of (8.5 ± 1.5) % at 25 V reverse bias.

Polarization-independent waveguide grating coupler using an optimized polysilicon overlay.

We propose and validate a new, to the best of our knowledge, approach to designing a polarization-independent waveguide grating coupler, using an optimized polysilicon overlay on a silicon grating structure. Simulations predicted coupling efficiencies of about -3.6 dB and -3.5 dB for TE and TM polarizations, respectively. The devices were fabricated using photolithography in a multi-project wafer fabrication service by a commercial foundry and have measured coupling losses of -3.96 dB for TE polarization and -3.93 dB for TM polarization.

Preparation of reactive sintering Si3N4-Si2N2O composites ceramics with diamond-wire saw powder waste as raw material.

In this paper, the reactive sintering Si3N4-Si2N2O composites ceramics were fabricated from the diamond-wire saw powder through the reaction-sintering nitridation method. The effects of sintering temperatures, holding time and oxygen contents on the Si3N4-Si2N2O composites formation were investigated in detail. The results revealed that the phases of final products consisted of α/ß-Si3N4 and Si2N2O, and the proportion of three phases could be influenced by sintering temperatures and oxygen contents. In addition, rod-like particles and clastic granules were observed in final specimens, and rod-like particles mainly formed in low sintering temperatures and low oxygen contents, which could be attributed to the vapor-vapor-solid (VVS) growth mechanism. Furthermore, a lot of rod-like particles were distributed in cracks among the Si3N4-Si2N2O composites matrixes, which formed the bridge structures and enhanced the mechanical properties. The specimen obtained at 1500 ℃ with 5 wt.% SiO2 in raw materials had the highest compression strength of 150.6 MPa and the highest flexural strength of 46.1 MPa. Comparing with other typical composites, the Si3N4-Si2N2O composites in this work showed the desirable mechanical properties. Thus, this study provided an environment-friendly approach to recycle photovoltaic waste and reduce the cost of the reactive sintering Si3N4-Si2N2O composites ceramics.

Ultrabroad terahertz bandpass filter by hyperbolic metamaterial waveguide.

We propose and demonstrate an ultrabroad terahertz (THz) bandpass filter (BPF) by integrating two different-sized tapered hyperbolic metamaterial (HMM) waveguides, each of which has wide but different absorption and transmission bands, into a unit cell. With proper structural design of each HMM waveguide to control the absorption and transmission bands, we numerically demonstrate the designed BPF is capable of operating with a broad passband in the THz domain. A typical TM-polarized HMM BPF has a peak transmission of 37% at 3.3 THz with the passband bandwidth of 2.2 THz ranging from 2.97 to 5.17 THz. The co-designed three-dimensional HMM BPF also shows the capability of operating with independence to the polarization of incident light because of the structural symmetry and has sharp bandedge transitions of 22.6 and 17.6 dB/THz to the stop bands, respectively. The presented results here hold great promise for developing practical THz BPF with various applications in THz field.