1.
Org Lett
; 17(5): 1228-31, 2015 Mar 06.
Article
in English
| MEDLINE
| ID: mdl-25695876
ABSTRACT
A new Cu(II)-catalyzed oxidative coupling of arenes with malonates has been developed using an amide-oxazoline directing group. The reaction proceeds via C(sp(2))-H activation and malonate coupling, followed by intramolecular oxidative N-C bond formation. A variety of arenes bearing different substituents are shown to be compatible with this reaction.