Ti3AlC2 MXene nanosheets as a novel corrosion inhibitor for carbon steel in 0.5 M sulfuric acid solution.

Herein we report that Ti3AlC2 MXene nanosheets were identified as a highly effective cathodic protection corrosion inhibitor for carbon steel in hydrochloric acid solution. Ti3AlC2 Mxene nanosheets form a stable inhibition layer on metal surfaces due to their high adsorption capacity and act as a barrier or protective film to prevent attacks from corrosive substances and thus lead to an extended metal service life.

The Effect of Solvents on the Crystal Morphology of Isosorbide Mononitrate and Its Molecular Mechanisms.

In this work, the modified attachment energy model was used to predict the crystal morphology of isosorbide mononitrate (ISMN) in the dichloromethane (CH2Cl2) solvent system and dichloromethane-n-hexane (CH2Cl2-C6H14) mixed solvent system. The solvent effect can significantly affect the crystal morphology, which can profoundly impact both the drug's physicochemical properties and the subsequent technological treatment process. In addition, the interactions between solvent molecules and crystal faces were investigated using molecular dynamics simulation, and radial distribution function (RDF) analysis was performed to determine the types of interactions. The structural parameter S was introduced to characterize the roughness of each crystal surface; the change in the CH2Cl2 diffusion coefficient before and after the addition of C6H14 was analyzed using mean square displacement (MSD). The calculation results of the modified attachment energy from the two solvent systems revealed that C6H14 could accelerate crystal growth, while the crystal morphology was not greatly affected, which is of some significance as a guide for the industrial crystallization process.

Microstructures and Mechanical Properties of a Nanostructured Al-Zn-Mg-Cu-Zr-Sc Alloy under Natural Aging.

Nanocrystalline (NC) structure can lead to the considerable strengthening of metals and alloys. Obtaining appropriate comprehensive mechanical properties is always the goal of metallic materials. Here, a nanostructured Al-Zn-Mg-Cu-Zr-Sc alloy was successfully processed by high-pressure torsion (HPT) followed by natural aging. The microstructures and mechanical properties of the naturally aged HPT alloy were analyzed. The results show that the naturally aged HPT alloy primarily consists of nanoscale grains (~98.8 nm), nano-sized precipitates (20-28 nm in size), and dislocations (1.16 × 1015 m-2), and exhibits a high tensile strength of 851 ± 6 MPa and appropriate elongation of 6.8 ± 0.2%. In addition, the multiple strengthening modes that were activated and contributed to the yield strength of the alloy were evaluated according to grain refinement strengthening, precipitation strengthening, and dislocation strengthening, and it is shown that grain refinement strengthening and precipitation strengthening are the main strengthening mechanisms. The results of this study provide an effective pathway for achieving the optimal strength-ductility match of materials and guiding the subsequent annealing treatment.

Mass spectral and theoretical investigations of N-Cα bond cleavages in the disulfide-containing peptide TTCPYCKK and its analogues.

RATIONALE: For disulfide-containing peptides, mass spectrometric analyses are rarely comparably studied between their dithiol and disulfide forms. Persulfide ions afforded from peptides with a disulfide ring are from either an unusual N-Cα bond cleavage or a canonical peptide bond cleavage; their isomeric structures are, however, not identified just from peaks of mass spectra. METHODS: Isomeric structures of [C3 P4 X5 |C6 M ], [C3 MA P4 X5 |C6 MB ] and [P4 X5 C6 |C3 M ] were identified from a series of the X5 substituted dicysteine octapeptides using electrospray ionization tandem mass spectrometry for both their dithiol and disulfide forms. Formation mechanisms of different persulfide ions were investigated systematically by theoretical methods. Moreover, electrostatic potential-mapped molecular van der Waals surfaces were used to determine the stabilities of the intermediates, which gave a further evaluation of favored bond cleavage. RESULTS: Mass spectral analyses indicated that the fragmented ions changed largely when an intramolecular disulfide bond was formed. New types of disulfide-containing fragmented ions [C3 P4 X5 |C6 M ] or [C3 MA P4 X5 |C6 MB ] were thus proposed. Energy analysis showed that the N-Cα cleavage was not competitive energetically with that of the amide bond for Y5 and its phosphorylated analogue. However, the N-Cα cleavage products dominated for the S5 - and T5 -containing peptides. Stabilities of the intermediates were found to be related with the electrostatic potential-mapped molecular van der Waals surfaces. CONCLUSIONS: Persulfide ions containing more residues than previously found were proposed not only from b7 ions but also from y6 ions. In addition, a new kind of phosphorylated analogue, [C3 P4 p Y5 |C6 M ], is reported in this work. Our study provides convincing results for separating isomeric structures in the cases of N-Cα cleavages, which greatly assists in the structural identification of disulfide-containing peptides.