1.
J Org Chem
; 85(16): 11006-11013, 2020 08 21.
Article
in English
| MEDLINE
| ID: mdl-32672469
ABSTRACT
We herein establish a multicomponent annulation method for the synthesis of valuable iminocoumarins using aryl thiocarbamates, internal alkynes, and sulfonamides as starting materials, which are safe and readily available. The key step is a Rh-catalyzed and sulfur-directed C-H bond activation. Preliminary mechanistic investigations suggested that the nucleophilic attack of the sulfonamide on an active iminium cation finally completes the imine segment.