Subject(s)
Herpes Zoster/etiology , Sinus Thrombosis, Intracranial/complications , Aged , Anticoagulants/therapeutic use , Headache/etiology , Heparin, Low-Molecular-Weight/therapeutic use , Herpes Zoster/diagnostic imaging , Herpes Zoster/drug therapy , Herpesvirus 3, Human , Humans , Male , Sinus Thrombosis, Intracranial/diagnostic imaging , Sinus Thrombosis, Intracranial/drug therapy , Tomography, X-Ray Computed , Treatment OutcomeABSTRACT
BACKGROUND: To investigate the relationship between intracerebral hemorrhage hematoma expansion with low serum calcium level. METHODS: We will search the following electronic bibliographic databases: MEDLINE, Embase, PubMed, The Cochrane Library, and Web of Science. All sources have to be searched from the earliest date until May 1, 2019. The quality of the included studies will assess by 2 evaluation members according to the Cochrane Collaboration network standard or the Newcastle-Ottawa Scale. The included studies will analysis by using RevMan 5.3 software. RESULTS AND CONCLUSION: This will be the first systematic review and meta-analysis to evaluate the association of hematoma following intracerebral hemorrhage with hypocalcemia. The study will provide more reliable, evidence-based data for clinical decision making. PROSPERO REGISTRATION NUMBER: CRD42019135956.
Subject(s)
Cerebral Hemorrhage/blood , Hematoma/blood , Hypocalcemia/blood , Biomarkers/blood , Humans , Meta-Analysis as Topic , Research Design , Systematic Reviews as TopicABSTRACT
BACKGROUND: Hematoma expansion (HE) is related to clinical deterioration and unfavorable prognosis in intracerebral hemorrhage (ICH). Some studies have revealed that low serum magnesium level is associated with larger hematoma volume at admission, HE, and unfavorable outcomes. However, the conclusions remain unsettled. The purpose of this study is to evaluate the association between low serum magnesium level and HE by meta-analysis. METHODS: We will search the following electronic bibliographic databases: PubMed, Medline, Embase, Web of Science, and The Cochrane Library. Studies will be included if they reported a relationship of low serum magnesium level and HE, mortality or poor outcome. RESULTS: The results of this study will be submitted to a peer-reviewed journal for publication. CONCLUSION: This will be the first systematic review and meta-analysis to evaluate the association of HE following ICH with Hypomagnesemia. We look forward to the results will offer scientific proof to predict HE for ICH patients with low serum magnesium level. PROSPERO REGISTRATION NUMBER: This protocol has been registered in the PROSPERO network with number: CRD42019135995.