ABSTRACT
Currently, cisplatin resistance has been recognized as a multistep cascade process for its clinical chemotherapy failure. Hitherto, it remains challenging to develop a feasible and promising strategy to overcome the cascade drug resistance (CDR) issue for achieving fundamentally improved chemotherapeutic efficacy. Herein, a novel self-assembled nanoagent is proposed, which is constructed by Pt(IV) prodrug, cyanine dye (cypate), and gadolinium ion (Gd3+), for systematically conquering the cisplatin resistance by employing near-infrared (NIR) light activated mild-temperature hyperthermia in tumor targets. The proposed nanoagents exhibit high photostability, GSH/H+-responsive dissociation, preferable photothermal conversion, and enhanced cellular uptake performance. In particular, upon 785-nm NIR light irradiation, the generated mild temperature of ≈ 43 °C overtly improves the cell membrane permeability and drug uptake, accelerates the disruption of intracellular redox balance, and apparently enhances the formation of Pt-DNA adducts, thereby effectively overcoming the CDR issue and achieves highly improved therapeutic efficacy for cisplatin-resistant tumor ablation.
Subject(s)
Cisplatin , Drug Resistance, Neoplasm , Hyperthermia, Induced , Indoles , Propionates , Cisplatin/pharmacology , Cisplatin/chemistry , Drug Resistance, Neoplasm/drug effects , Humans , Animals , Hyperthermia, Induced/methods , Mice , Cell Line, Tumor , Infrared Rays , Gadolinium/chemistry , Gadolinium/pharmacology , Antineoplastic Agents/chemistry , Antineoplastic Agents/pharmacology , Prodrugs/chemistry , Prodrugs/pharmacology , Mice, Inbred BALB C , Neoplasms/therapy , Neoplasms/drug therapy , Neoplasms/pathology , Mice, Nude , Carbocyanines/chemistry , Carbocyanines/pharmacologyABSTRACT
Background: Prostate cancer is viewed as the second most common cancer in men worldwide. In our study, we used bibliometric analysis to construct a visual map of the relationship between prostate cancer and exosomes with the intent of uncovering research trends and current hotspots in this field. Method: We searched the Web of Science Core Collection for all publications in the prostate cancer associated with exosome field came out since 2010. With the assistance of bibliometric analysis software such as VOSviewer and CiteSpace, we conducted data extraction and analysis for countries/regions, institutions, authors, journals, references and keywords. Results: A bibliometric analysis of 990 publications was performed. Since 2010, the published quantity and cited frequency of the prostate cancer-associated exosome field have revealed an increasing tendency. In this field, we visualized the research trends by the means of analyzing the references and keywords. We obtained the statistical data: the total citations of publications have increased to 55,462, the average citation per article has reached 55.3 times, and the H-index has amounted to 110. Our findings supported that USA, China and Italy rank the top countries with both the maximum publications and strongest cooperations. Harvard Medical School, Cedars Sinai Med Ctr, Johns Hopkins University, are top institutions in the center of research as they are held to be. Thery C, Skog J and Taylor DD are the leading and outstanding professors and researchers. And top journals like Prostate, Plos One and Journal of Extracellular Vesicle expressed keen interests in this field. Based on our analysis and research, we believe that this field is attracting more and more attention and will focus on tumor bone metastasis, drug delivery, and tumor suppressor. Conclusion: In the past 12 years, researchers have dedicated their efforts to prostate cancer associated exosome. On the basis of previous studies, scientists are showing increasingly solicitude for the role of exosome in prostate cancer progression and potential therapy such as drug delivery.
ABSTRACT
Underwater optical wireless communication (UOWC) has received increasing attention due to its distinctive characteristics such as high bandwidth and low latency. However, the UOWC link is usually vulnerable to water flow, underwater turbulence and the terminals' own vibration. Thus, to maintain a stable transmission link, an accurate tracking method is essential for UOWC systems. In this paper, a monocular vision aided optical tracking method is proposed, where the deviation degree of the laser spot is employed to realize autonomous real-time alignment of the receiver with the transmitter. Experimental results verify that with the proposed tracking method, the bit error ratio can be ensured to be below the forward error correction (FEC) limit of 3.8×10-3 even under strong disturbance for the practical UOWC system.
