Orthobiologics: a review.

PURPOSE: The use of biologic materials in orthopaedics (orthobiologics) has gained significant attention over the past years. To enhance the body of the related literature, this review article is aimed at summarizing these novel biologic therapies in orthopaedics and at discussing their multiple clinical implementations and outcomes. METHODS: This review of the literature presents the methods, clinical applications, impact, cost-effectiveness, and outcomes, as well as the current indications and future perspectives of orthobiologics, namely, platelet-rich plasma, mesenchymal stem cells, bone marrow aspirate concentrate, growth factors, and tissue engineering. RESULTS: Currently available studies have used variable methods of research including biologic materials as well as patient populations and outcome measurements, therefore making comparison of studies difficult. Key features for the study and use of orthobiologics include minimal invasiveness, great healing potential, and reasonable cost as a nonoperative treatment option. Their clinical applications have been described for common orthopaedic pathologies such as osteoarthritis, articular cartilage defects, bone defects and fracture nonunions, ligament injuries, and tendinopathies. CONCLUSIONS: Orthobiologics-based therapies have shown noticeable clinical results at the short- and mid-term. It is crucial that these therapies remain effective and stable in the long term. The optimal design for a successful scaffold remains to be further determined.

Three-Dimensional Printed Calcaneus Implant for Open Calcaneal Fracture with Extensive Bone Loss: A Case Report and Literature Review.

Open calcaneal fractures with extensive bone loss and severe soft tissues injuries are very rare. There is no treatment protocol for these severe injuries. The incidence of infection, osteomyelitis, and amputation is high compared to closed calcaneal fractures. An independent prognostic factor for increased complications is the high type of fracture according to Gustillo and Anderson's classification. A one-stage or two-stage procedure with open reduction and internal fixation, external fixation, percutaneous pinning, minimally invasive procedures, and subtalar arthrodesis are treatment options. We present a case of open type IIIB fracture of the calcaneus with extensive bone loss managed with a two-stage procedure. First, a cement spacer was inserted to fill the void and then, after the soft tissue envelope had healed with no sign of infection, a three-dimensional (3D) printed custom-made calcaneus implant was inserted. This is the first report in the literature of using a 3D custom-made calcaneal implant for a severe open calcaneal fracture with extensive osseous defect. At one-year follow-up, plain radiographs of the foot showed the calcaneus implant in place. The American Orthopedic Foot and Ankle score (AOFAS) was 76, and the patient had mild restrictions to his daily activities due to mild heel pain.