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Connect Tissue Res ; 59(1): 55-65, 2018 01.
Article in English | MEDLINE | ID: mdl-28267379

ABSTRACT

Purpose/Aim of the study: To evaluate the biomechanical characteristics and biocompatibility of an injectable, biodegradable calcium phosphate cement (CPC) containing poly lactic-co-glycolic acid (PLGA). MATERIALS AND METHODS: A vertebral compression fracture model was established using 20 human cadaveric vertebrae (T11-L3) divided into CPC/PLGA composite versus PMMA groups for biomechanical testing. In addition, 35 New Zealand rabbits were used to evaluate biodegradability and osteoconductive properties of CPC/PLGA using a bone defect model. In vitro cytotoxicity was evaluated by culturing with L929 cells. RESULTS: The CPC/PLGA composite effectively restored vertebral biomechanical properties. Compared with controls, the maximum load and compression strength of the CPC/PLGA group were lower, and stiffness was lower after kyphoplasty (all p <.05). Degradation was much slower in the control CPC compared with CPC/PLGA group. The bone tissue percentage in the CPC/PLGA group (44.9 ± 23.7%) was significantly higher compared with control CPC group (25.7 ± 10.9%) (p <.05). The viability of cells cultured on CPC/PLGA was greater than 70% compared with the blanks. CONCLUSIONS: Our biodegradable CPC/PLGA composite showed good biomechanical properties, cytocompatibility, and osteoconductivity and may represent an ideal bone substitute for future applications.


Subject(s)
Bone Cements , Calcium Phosphates , Fractures, Compression/therapy , Materials Testing , Polylactic Acid-Polyglycolic Acid Copolymer , Spinal Fractures/therapy , Animals , Bone Cements/chemistry , Bone Cements/pharmacology , Calcium Phosphates/chemistry , Calcium Phosphates/pharmacology , Cell Line , Disease Models, Animal , Female , Fractures, Compression/metabolism , Fractures, Compression/pathology , Humans , Male , Mice , Middle Aged , Polylactic Acid-Polyglycolic Acid Copolymer/chemistry , Polylactic Acid-Polyglycolic Acid Copolymer/pharmacology , Rabbits , Spinal Fractures/metabolism , Spinal Fractures/pathology
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