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Gig Sanit ; (3): 71-2, 2012.
Article in Russian | MEDLINE | ID: mdl-23088137

ABSTRACT

The antibacterial activity of synthetic peptides of the active site of GM-CSF and supernatants of CD34+45- hematopoietic progenitor cells has been investigated GM-CSF peptides and cell supernatants were found to possess pronounced antibacterial activity, at that a combination of these substances has a more pronounced activity in comparison with the single substances. Possible mechanisms of the identified effects of synthetic peptides and substances from the supernatants of CD34+5- cells are discussed.


Subject(s)
Antigens, CD34/immunology , Bacteria/drug effects , Granulocyte-Macrophage Colony-Stimulating Factor/pharmacology , Hematopoietic Cell Growth Factors/pharmacology , Hematopoietic Stem Cells/immunology , Leukocyte Common Antigens/immunology , Bacteria/immunology , Catalytic Domain , Cell Division/drug effects , Colony-Forming Units Assay , Granulocyte-Macrophage Colony-Stimulating Factor/immunology , Hematopoietic Cell Growth Factors/immunology , Hematopoietic Stem Cells/cytology , Hematopoietic Stem Cells/drug effects , Humans
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