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1.
Sci Rep ; 14(1): 15978, 2024 07 10.
Article in English | MEDLINE | ID: mdl-38987416

ABSTRACT

Blood flow through the abdominal aorta and iliac arteries is a crucial area of research in hemodynamics and cardiovascular diseases. To get in to the problem, this study presents detailed analyses of blood flow through the abdominal aorta, together with left and right iliac arteries, under Earth gravity and weightless conditions, both at the rest stage, and during physical activity. The analysis were conducted using ANSYS Fluent software. The results indicate, that there is significantly less variation in blood flow velocity under weightless conditions, compared to measurement taken under Earth Gravity conditions. Study presents, that the maximum and minimum blood flow velocities decrease and increase, respectively, under weightless conditions. Our model for the left iliac artery revealed higher blood flow velocities during the peak of the systolic phase (systole) and lower velocities during the early diastolic phase (diastole). Furthermore, we analyzed the shear stress of the vessel wall and the mean shear stress over time. Additionally, the distribution of oscillatory shear rate, commonly used in hemodynamic analyses, was examined to assess the effects of blood flow on the blood vessels. Countermeasures to mitigate the negative effects of weightlessness on astronauts health are discussed, including exercises performed on the equipment aboard the space station. These exercises aim to maintain optimal blood flow, prevent the formation of atherosclerotic plaques, and reduce the risk of cardiovascular complications.


Subject(s)
Aorta, Abdominal , Weightlessness , Humans , Aorta, Abdominal/physiology , Blood Flow Velocity/physiology , Hemodynamics/physiology , Iliac Artery , Models, Cardiovascular , Earth, Planet , Weightlessness Simulation
2.
Sci Rep ; 13(1): 13384, 2023 08 17.
Article in English | MEDLINE | ID: mdl-37591932

ABSTRACT

The aim of this study was to present a methodology for predicting changes in uric acid concentrations in the blood of chronically hemodialyzed patients based on an optical measurement of the intensity of selected wavelengths in the dialysate. Blood samples were taken from the arterial line every 30 min throughout the hemodialysis period, to measure uric acid levels. Simultaneously, optical measurements were made on dialysate flowing from the dialyzer. Uric acid concentration can be measured either directly from the blood or from dialyzer outflow with acceptable error. In addition, both methods reveal any increased dynamics in uric acid concentration in the initial phase of hemodialysis. The wavelength of the light was adjusted for optimal uric acid particle detection. Comparing the uric acid concentration measured in the blood of patients with the intensity of wave absorption in the dialysate, the functional relationship between the uric acid concentration levels was determined. Using the optical method for measuring uric acid concentration in the dialysate, the concentration of uric acid in the blood during hemodialysis can be non-invasively and accurately estimated. This method can be used to assess the adequacy of hemodialysis by computer acquisition of uric acid concentrations determined in on-line dialysate.


Subject(s)
Dialysis Solutions , Vascular Access Devices , Humans , Uric Acid , Renal Dialysis
3.
Sci Rep ; 13(1): 2475, 2023 Feb 11.
Article in English | MEDLINE | ID: mdl-36774441

ABSTRACT

The article presents a numerical CFD simulation of a throttle-check valve used in an innovative control system for two pneumatic drives. This type of control is used in an innovative rehabilitation device for lower limbs. In order to determine the boundary conditions, experimental tests were carried out. The throttle valves on the test stand were scaled and the air flow rate values were read for different valve opening heights. The purpose of this article is to present a CFD simulation of a pre-adjusted check valve throttle. Numerical simulation (CFD) makes it possible to study the flow phenomena inside a pneumatic throttle-check valve, with different sizes of flow gaps. The obtained results made it possible to determine the distribution of physical quantities of static pressure, the velocity of the medium flowing through the valve, or the vector velocity distribution. The throttle valve assembly has been scaled for a suitable degree of synchronization of the movement of the piston actuators independently of the different external loads acting on each of them. The authors investigated airflow phenomena for different valve opening heights. The simulation provided information on the occurrence of supersonic and subsonic flow velocities at specific valve opening heights.

4.
Materials (Basel) ; 15(12)2022 Jun 07.
Article in English | MEDLINE | ID: mdl-35744107

ABSTRACT

The effect of a weak magnetic field (B = 0.17 T) and X-irradiation (D < 520 Gy) on the rearrangement of the defective structure of near-surface p-type silicon layers was studied. It was established that the effect of these external fields increases the positive accumulated charge in the region of spatial charge (RSC) and in the SiO2 dielectric layer. This can be caused by both defects in the near-surface layer of the semiconductor and impurities contained in the dielectric layer, which can generate charge carriers. It was found that the near-surface layers of the barrier structures contain only one deep level in the silicon band gap, with an activation energy of Ev + 0.38 eV. This energy level corresponds to a complex of silicon interstitial atoms SiI+SiI. When X-irradiated with a dose of 520 Gy, a new level with the energy of Ev + 0.45 eV was observed. This level corresponds to a point boron radiation defect in the interstitial site (BI). These two types of defect are effective in obtaining charge carriers, and cause deterioration of the rectifier properties of the silicon barrier structures. It was established that the silicon surface is quite active, and adsorbs organic atoms and molecules from the atmosphere, forming bonds. It was shown that the effect of a magnetic field causes the decay of adsorbed complexes at the Si−SiO2 interface. The released hydrogen is captured by acceptor levels and, as a result, the concentration of more complex Si−H3 complexes increases that of O3−Si−H.

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