ABSTRACT
BACKGROUND: Osteopenia in systemic sclerosis (scleroderma) patients was reported in X-ray studies of hands and by proximal and distal forearm bone mass measurement. It has been suggested that bone loss in these patients might be due to chronic ischemia, immobilization and early menopause. Nevertheless, it is not established if these patients present generalized osteopenia. To shed light into this point we studied bone mineral density in the spine, proximal femur and total body in patients with systemic sclerosis. PATIENTS AND METHOD: Twenty-five Caucasian women were evaluated. Mean age of patients was 48 +/- 12 years and mean time of disease was 7 +/- 7 years; 13 were postmenopausal (8 +/- 8 years). Bone mass was measured in the spine, proximal femur and total body by using a dual-photon absorptiometry with X rays source (Lunar-Model DPX). RESULTS: Bone mass in different sites was not statistically different from the age-matched control healthy women. Mean bone mass of patients with limited form was not different from patients with diffuse form of systemic sclerosis. Patients with calcinosis had lower bone mass at proximal femur than those without this alteration. CONCLUSIONS: Patients with systemic sclerosis do not present bone loss and this disease in not a risk factor for generalized osteoporosis.
Subject(s)
Bone Density , Bone Diseases, Metabolic/etiology , Scleroderma, Systemic/complications , Adult , Aged , Body Mass Index , Densitometry , Female , Humans , Middle AgedABSTRACT
Giant aneurysms have rarely been reported in association with intractable complex partial seizures (CPS). We report a 30-year-old man with intractable CPS since age 18 years. Seizure onset was electrically localized to right temporal lobe. Preoperative neuroimaging studies showed a partially thrombosed giant aneurysm of the right posterior cerebral artery. Selective amygdalohippocampectomy and occlusion of the posterior cerebral artery did not cause deficits. The patient has been seizure-free for 15 months after operation. We review the relevant literature on aneurysms as a cause of epilepsy.
Subject(s)
Cerebral Arterial Diseases/complications , Epilepsy, Complex Partial/etiology , Intracranial Aneurysm/complications , Adult , Cerebral Angiography , Cerebral Arterial Diseases/diagnosis , Humans , Intracranial Aneurysm/diagnosis , Magnetic Resonance Imaging , MaleABSTRACT
PURPOSE: A comparison between pathological features of chronic chagasic cardiomyopathy (CCC) in adolescents and adults. PATIENTS AND METHODS: Adolescents under the age of 15, with amastigote trypanosomal forms in the myocardium, a positive xenodiagnosis and/or serology for trypanosoma cruzi infection, were selected from 4.583 necropsies performed between 1958-86 at the Professor Edgard Santos Hospital in Bahia, Brazil. RESULTS: Nine CCC cases between the ages of 12 and 15 years were identified. Mean heart weight was under twice normal. Intracardiac thrombi were present in five (55.6%), apical left ventricle aneurysm in four (44.4%) and parasites in the myocardium in three (33.3%) cases. Systemic or pulmonary thromboembolism was found in six (66.7%) patients. Mitral regurgitation was present in six (66.7%) cases, two with valvar anatomic alterations. CONCLUSION: Pathological features of CCC in adolescents did not differ from those found in adult patients.
