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Protein Pept Lett ; 26(7): 523-531, 2019.
Article in English | MEDLINE | ID: mdl-30950337

ABSTRACT

BACKGROUND: Angiotensin Converting Enzyme (ACE) 2 is an important modulator of the Renin Angiotensin System (RAS) and the RAS plays a central role in renovascular hypertension. Very few studies investigated the role of components of the counterregulatory RAS axis (ACE2, Ang-(1-7) and Mas receptor) in renovascular hypertension and the results are controversial. OBJECTIVE: The aim of this study was to investigate the effects of Diminazene Aceturate (DIZE) administration on renal function and renal inflammation parameters in 2K1C hypertensive rats. METHODS: Male Wistar rats were divided into three experimental groups: sham-operated animals, 2K1C+saline and 2K1C+DIZE orally (1 mg/kg/day). At the end of the 30 days of treatment, renal function was analyzed and kidneys from all the groups were collected and processed separately for measurement of N-acetyl-beta-D-glucosaminidase (NAG) and Myeloperoxidase (MPO) activities, cytokines, chemokines and nitric oxide levels. RESULTS: Oral DIZE administration for 4 weeks in hypertensive rats attenuated renal dysfunction and reduced the levels of MPO and NAG, cytokines and chemokines (IL1ß, IL-6, TNF-α and MCP-1) and increased urinary nitrate/nitrite levels in 2K1C hypertensive rats. CONCLUSION: Our findings showed that ACE2 activation may effectively improve renal alterations and inflammation induced by renovascular hypertension.


Subject(s)
Diminazene/analogs & derivatives , Enzyme Activators/pharmacology , Hypertension, Renovascular/drug therapy , Peptidyl-Dipeptidase A/metabolism , Renin-Angiotensin System/drug effects , Acetylglucosaminidase/metabolism , Angiotensin I/metabolism , Angiotensin-Converting Enzyme 2 , Animals , Cytokines/metabolism , Diminazene/pharmacology , Diminazene/therapeutic use , Enzyme Activators/therapeutic use , Hypertension, Renovascular/metabolism , Hypertension, Renovascular/physiopathology , Inflammation/drug therapy , Inflammation/metabolism , Kidney/drug effects , Kidney/physiopathology , Male , Nitric Oxide/metabolism , Peptide Fragments/metabolism , Peroxidase/metabolism , Rats, Wistar
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