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Br J Radiol ; 58(687): 203-5, 1985 Mar.
Article in English | MEDLINE | ID: mdl-3904894

ABSTRACT

Forty-eight patients were examined by bilateral ascending phlebography in a crossover, prospective, randomised, double-blind study. A low-osmolar agent (Hexabrix) (ioxaglate, 200 mg iodine/ml) and a dilute conventional contrast medium (Angiografin) (meglumine diatrizoate) with the same iodine concentration were used for each limb alternately. The adverse reactions and the quality of diagnostic data were recorded: the Student paired-t-test showed statistically that ioxaglate containing 200 mg iodine per ml was better tolerated and that diagnostic information was equally good for the deep and ilio-caval systems, but seemed better with diatrizoate for superficial veins with extensive varicosity. The authors conclude that ioxaglate 200 is advantageous overall in lower-limb phlebography from the standpoints of tolerance, diagnostic data and cost.


Subject(s)
Contrast Media , Diatrizoate Meglumine , Diatrizoate/analogs & derivatives , Iodobenzoates , Leg/blood supply , Phlebography , Triiodobenzoic Acids , Adult , Aged , Clinical Trials as Topic , Contrast Media/adverse effects , Diatrizoate Meglumine/adverse effects , Double-Blind Method , Humans , Ioxaglic Acid , Middle Aged , Prospective Studies , Pulmonary Embolism/diagnostic imaging , Random Allocation , Triiodobenzoic Acids/adverse effects , Varicose Veins/diagnostic imaging
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