Natural logarithm particle swarm optimization for loss reduction in an island power system.

In an island power system, optimizing energy management is fundamental since there are renewable sources with their limitations. This management includes the allocation and capacity of energy sources to supply the loads. In this context, optimizing losses in the system contributes to improve the efficiency of this management. This paper proposes the losses optimization and energy management in the island power system. The authors propose the Natural Logarithm Particle Swarm Optimization to solve the problem and compare it with the Attractor Point Algorithm and Evolutionary Particle Swarm Optimization. And with that, we also propose a particle initialization for the studied particle-based algorithms to guarantee convergence in radial power systems. This is because the system configuration influences the response of the algorithm convergence. These techniques were applied to the IEEE-34 unbalanced radial island system.•Natural Logarithm Particle Swarm Optimization differs from classical PSO in that it does not calculate the velocity of the particles. Therefore, the method considers a cloud of particles with a natural logarithmic trajectory to solve the reduction of losses in a power system with a radial topology.•Natural Logarithmic Particle Swarm Optimization uses an initialization equation to minimize the initial estimation process, which is relevant to the convergence process.

Genomic study of Acinetobacter baumannii strains co-harboring bla OXA-58 and bla NDM-1 reveals a large multidrug-resistant plasmid encoding these carbapenemases in Brazil.

Introduction: Acinetobacter baumannii contributes significantly to the global issue of multidrug-resistant (MDR) nosocomial infections. Often, these strains demonstrate resistance to carbapenems (MDR-CRAB), the first-line treatment for infections instigated by MDR A. baumannii. Our study focused on the antimicrobial susceptibility and genomic sequences related to plasmids from 12 clinical isolates of A. baumannii that carry both the blaOXA-58 and bla NDM-1 carbapenemase genes. Methods: Whole-genome sequencing with long-read technology was employed for the characterization of an A. baumannii plasmid that harbors the bla OXA-58 and blaNDM-1 genes. The location of the bla OXA-58 and bla NDM-1 genes was confirmed through Southern blot hybridization assays. Antimicrobial susceptibility tests were conducted, and molecular characterization was performed using PCR and PFGE. Results: Multilocus Sequence Typing analysis revealed considerable genetic diversity among bla OXA-58 and bla NDM-1 positive strains in Brazil. It was confirmed that these genes were located on a plasmid larger than 300 kb in isolates from the same hospital, which also carry other antimicrobial resistance genes. Different genetic contexts were observed for the co-occurrence of these carbapenemase-encoding genes in Brazilian strains. Discussion: The propagation of bla OXA-58 and bla NDM-1 genes on the same plasmid, which also carries other resistance determinants, could potentially lead to the emergence of bacterial strains resistant to multiple classes of antimicrobials. Therefore, the characterization of these strains is of paramount importance for monitoring resistance evolution, curbing their rapid global dissemination, averting outbreaks, and optimizing therapy.

Tonabersat Significantly Reduces Disease Progression in an Experimental Mouse Model of Multiple Sclerosis.

Multiple sclerosis (MS) is a neurodegenerative disease marked by chronic neuroinflammation thought to be mediated by the inflammasome pathway. Connexin 43 (Cx43) hemichannels contribute to the activation of the inflammasome through the release of adenosine triphosphate (ATP) inflammasome activation signals. The objective of the study was to evaluate if the Cx43 hemichannel blocker, tonabersat, is effective in modulating the inflammatory response and reducing disability in the myelin oligodendrocyte glycoprotein 35-55-induced experimental autoimmune encephalomyelitis (MOG35-55 EAE) model of MS. Here, we show that the Cx43 hemichannel blocking drug, tonabersat, significantly reduced expression of neuroinflammatory markers for microglial activation (ionized calcium-binding adapter molecule 1 (Iba1)) and astrogliosis (glial fibrillary acidic protein (GFAP)) while preserving myelin basic protein (MBP) expression levels in the corpus callosum, motor cortex, and striatum regions of the brain in MOG35-55 EAE mice. Reduced NOD-like receptor protein 3 (NLRP3) inflammasome complex assembly and Caspase-1 activation confirmed the drug's mode of action. MOG35-55 EAE mice showed clinical signs of MS, but MOG35-55 EAE mice treated with tonabersat retained behavior closer to normal. These data suggest that clinical trial phase IIb-ready tonabersat may merit further investigation as a promising candidate for MS treatment.

Carbon gain is coordinated with enhanced stomatal conductance and hydraulic architecture in coffee plants acclimated to elevated [CO2]: The interplay with irradiance supply.

We recently demonstrated that, under elevated [CO2] (eCa), coffee (Coffea arabica L.) plants grown at high light (HL), but not at low light (LL), display higher stomatal conductance (gs) than at ambient [CO2] (aCa). We then hypothesized that the enhanced gs at eCa/HL, if sustained at the long-term, would lead to adjustments in hydraulic architecture. To test this hypothesis, potted plants of coffee were grown in open-top chambers for 12 months under HL or LL (ca. 9 or 1 mol photons m-2 day-1, respectively); these light treatments were combined with two [CO2] levels (ca. 437 or 705 µmol mol-1, respectively). Under eCa/HL, increased gs was closely accompanied by increases in branch and leaf hydraulic conductances, suggesting a coordinated response between liquid- and vapor-phase water flows throughout the plant. Still under HL, eCa also resulted in increased Huber value (sapwood area-to-total leaf area), sapwood area-to-stem diameter, and root mass-to-total leaf area, thus further improving the water supply to the leaves. Our results demonstrate that Ca is a central player in coffee physiology increasing carbon gain through a close association between stomatal function and an improved hydraulic architecture under HL conditions.

Antibacterial activity and anxiolytic-like effect of Ziziphus joazeiro Mart. leaves in adult zebrafish (Danio rerio).

Ziziphus joazeiro Mart. is an endemic plant of the Caatinga that presents a great socioeconomic importance for the Northeast and Semiarid Region of Brazil. In view of this, this study aimed to evaluate the antibacterial activity and anxiolytic-like effects of Ziziphus joazeiro Mart leaves in adult zebrafish (Danio rerio). The characterization of the main classes of metabolites was performed through chemical reactions. The antibacterial and antibiotic potentiating activity was evaluated by broth microdilution assays. The 96 h acute toxicity, open field test and anxiety models test was evaluated in vivo on adult zebrafish. The results obtained in the phytochemical prospection evidenced the presence of flobabenic tannins, leucoanthocyanidins, flavonois, flavonones, catechins, alkaloids, steroids, and triterpenoids. EEFZJ did not show antibacterial activity for all microorganism tested (MIC ≥ 1024 µg/mL), but reduced the concentration required for bacterial growth inhibition in combination with gentamicin and norfloxacin against multidrug-resistant strains of S. aureus (SA10) and E. coli (EC06), exhibiting synergistic effect with these antibiotics (p<0.0001). In the tests in vivo, EEFZJ was found to be nontoxic, performing reduced locomotor activity and demonstrated an anxiolytic-like effect in adult zebrafish via GABAergic and Serotoninergic systems (5-HT1, 5-HT2A/2C and 5-HT3A/3B).

Unlocking the effect of Li and Ce ions on the thermoluminescence and optically stimulated luminescence signals of the MgB4O7 compound.

Magnesium tetraborate (MgB4O7) is an example of a material that has attracted the attention of researchers in the field of ionising radiation dosimetry. Several challenges are present in order to achieve considerable advances in luminescence dosimetry. The incorporation of efficient dopants in the host matrix has been an experimentally useful but limited strategy. The lack of specific information about the introduced defects as well as their connection with the trapping and recombination processes associated with light emission may be quoted as challenging examples. Here, we demonstrate the influence of lithium incorporation on Optically Stimulated Luminescence (OSL)/Thermoluminescence (TL) signal modification/suppression of MgB4O7 by combining experimental and computational procedures. Li substitution into the Mg site leads to a signal suppression due to the probable quenching of the Fs and Fs+ centres in MgO and the formation of O''i, drastically reducing the possibility of MgO anti-Schottky defect formation in MgB4O7. When using Li-co-doped MgB4O7:Ce3+, the Li ions act as a charge balancer, facilitating the entry of Ce ions into the interstitial pores and making possible a positive synergistic effect on the luminescence and dosimetric properties. These findings provide new insights into designing more efficient dosimeters by tuning dopants.

Growth and Leaf Gas Exchange Upregulation by Elevated [CO2] Is Light Dependent in Coffee Plants.

Coffee (Coffea arabica L.) plants have been assorted as highly suitable to growth at elevated [CO2] (eCa), although such suitability is hypothesized to decrease under severe shade. We herein examined how the combination of eCa and contrasting irradiance affects growth and photosynthetic performance. Coffee plants were grown in open-top chambers under relatively high light (HL) or low light (LL) (9 or 1 mol photons m-2 day-1, respectively), and aCa or eCa (437 or 705 µmol mol-1, respectively). Most traits were affected by light and CO2, and by their interaction. Relative to aCa, our main findings were (i) a greater stomatal conductance (gs) (only at HL) with decreased diffusive limitations to photosynthesis, (ii) greater gs during HL-to-LL transitions, whereas gs was unresponsive to the LL-to-HL transitions irrespective of [CO2], (iii) greater leaf nitrogen pools (only at HL) and higher photosynthetic nitrogen-use efficiency irrespective of light, (iv) lack of photosynthetic acclimation, and (v) greater biomass partitioning to roots and earlier branching. In summary, eCa improved plant growth and photosynthetic performance. Our novel and timely findings suggest that coffee plants are highly suited for a changing climate characterized by a progressive elevation of [CO2], especially if the light is nonlimiting.

Environmentally Safe Photodynamic Control of Aedes aegypti Using Sunlight-Activated Synthetic Curcumin: Photodegradation, Aquatic Ecotoxicity, and Field Trial.

This study reports curcumin as an efficient photolarvicide against Aedes aegypti larvae under natural light illumination. Larval mortality and pupal formation were monitored daily for 21 days under simulated field conditions. In a sucrose-containing formulation, a lethal time 50 (LT50) of 3 days was found using curcumin at 4.6 mg L-1. This formulation promoted no larval toxicity in the absence of illumination, and sucrose alone did not induce larval phototoxicity. The photodegradation byproducts (intermediates) of curcumin were determined and the photodegradation mechanisms proposed. Intermediates with m/z 194, 278, and 370 were found and characterized using LC-MS. The ecotoxicity of the byproducts on non-target organisms (Daphnia, fish, and green algae) indicates that the intermediates do not exhibit any destructive potential for aquatic organisms. The results of photodegradation and ecotoxicity suggest that curcumin is environmentally safe for non-target organisms and, therefore, can be considered for population control of Ae. aegypti.

First Report of Meloidogyne Morocciensis Infecting Hops (Humulus Lupulus).

Humulus lupulus (Cannabaceae) is a climbing herbaceous plant with perennial production, intended mainly for the brewing industry. H. lupulus is widely cultivated in temperate regions; hop cultivars have shown good adaptation in regions of Brazil. In a hop-growing area in São Mateus, the state of Espírito Santo, leaf wilting and galling of the root system was observed. Soil and root samples were taken to the laboratory and processed, and the nematodes extracted from the Meloidogyne genus were identified by morphology, morphometry, and biochemical analysis. According to the results, the species identified in the hop roots was Meloidogyne morocciensis. This is the first report of H. lupulus as host of M. morocciensis.

Influence of Harvest Time on the Chemical Profile of Pereskia aculeate Mill. Using Paper Spray Mass Spectrometry.

This study evaluated the physicochemical characteristics and the production of bioactive compounds of Pereskia aculeata Mill. at different harvest times. Here, we performed a qualitative evaluation of the chemical profile by paper spray mass spectrometry (PSMS), the phenolic acid and flavonoid profile by high-performance liquid chromatography (HPLC), antioxidant activity, total carotenoids, total phenolic compounds, total flavonoids, total anthocyanins, color characteristics, total soluble solids (TSS), total solids (TS), pH, and total titratable acidity (TTA). The chemical profile was not affected, with the exception of 4,5-dimethyl-2,6-octadiene and azelaic acid, which was only identified in the leaves harvested during the winter. The content of four phenolic acids and three flavonoids were analyzed; out of these, no significant amounts of ellagic acid and quercetin were detected. There was no difference in production of bioactive compounds between seasons, reflecting the antioxidant activity, which also did not differ. Brightness, chroma, and leaf pH were the only physicochemical characteristics that did not vary between seasons.

Limb Salvage Surgery in Osteosarcoma of the Femur Using Liquid-Nitrogen-Frozen Free Femur Autograft in a Developing Country.

Introduction: Limb salvage is a technically demanding and capital intensive procedure. In low-income countries, amputation followed by prosthesis use is widely used for the treatment of limb malignancies. This is associated with considerable morbidity and frequent non-adherence to prosthetic use. Therefore, we are reporting a case of osteosarcoma of the femur treated by the use of pre-operative chemotherapy, followed by frozen free femur autograft and intramedullary nailing, with excellent radiologic and functional results at 1 year of follow-up, in a developing country. Case Report: A 16-year-old female presented with the left thigh swelling and pain for 3 months. X-ray of the left femur showed an osteosclerotic tumor in the medial aspect of the middle third of the left femur, diagnosed as osteogenic sarcoma on biopsy. Pre-operative chemotherapy was given. En bloc resection of the tumor was done. The cleaned femur shaft was frozen in liquid nitrogen, reimplanted, and stabilized with an intramedullary nail. One year after surgery, the femur osteotomy sites are fully united and the patient is fully ambulant, without evidence of metastasis or recurrence. Conclusion: This case describes the successful use of a free frozen autograft of the femur in a 16-year-old girl with osteosarcoma of the left femur, done in a developing country, Kenya. It demonstrates the feasibility of limb salvage using this technique in low-income countries.

A low-cost brewery waste as a carbon source in bio-surfactant production.

This work aims to produce bio-surfactant using a brewery waste (trub) as a strategy to reduce production costs related to the substrate, as well as to provide an eco-friendly destination for this residue. Trub is obtained during the boiling of the wort, being mainly composed of proteins and reducing sugars. To evaluate important process parameters on bio-surfactant production, a full factorial design (24) was elaborated, having agitation rate and concentrations of trub, yeast extract, and peptone as independent variables. The highest bio-surfactant concentration achieved was 100.76 mg L-1, where FTIR and Maldi-ToF-MS confirmed functional groups characteristic of peptides and isomers of surfactin in the bio-surfactant extract. Trub, agitation and yeast extract showed statistically significant effects on the response variable (surface tension), where an increase in the agitation rate and in the concentration of yeast extract demonstrated a positive impact on the production of bio-surfactant.

Functionalization of cellulosic fibers with a kaolinite-TiO2 nano-hybrid composite via a solvothermal process for flame retardant applications.

Eco-responsible flame retardant treatments with some resistance to washing are of considerable interest in the sale and applications of technical garments and home textiles. Thus, in the present study, a nano-hybrid composite based on kaolinite-TiO2 was prepared and incorporated into the fibers of cotton fabric through a more sustainable route compared to existing commercial processes. SEM analyses revealed a mineral covering of the treated cotton fibers, which do not propagate flames when exposed to fire and have a self-extinguishing behavior after the heat source removal. The method proved to be efficient in obtaining a cotton product with high fireproof performance. It was observed that after functionalization, the fabric showed a thermal degradation 41% less at 800 °C, an increase in the residue formation, and a reduction of about 85% in peak heat release measured by PCFC. Some resistance to washing was noticed, and the mechanical resistance of fibers was preserved.

Biodegradation of azo dye-containing wastewater by activated sludge: a critical review.

The effluent from the textile industry is a complex mixture of recalcitrant molecules that can harm the environment and human health. Biological treatments are usually applied for this wastewater, particularly activated sludge, due to its high efficiency, and low implementation and operation costs. However, the activated sludge microbiome is rarely well-known. In general, activated sludges are composed of Acidobacteria, Bacillus, Clostridium, Pseudomonas, Proteobacteria, and Streptococcus, in which Bacillus and Pseudomonas are highlighted for bacterial dye degradation. Consequently, the process is not carried out under optimum conditions (treatment yield). Therefore, this review aims to contextualize the potential environmental impacts of azo dye-containing wastewater from the textile industry, including toxicity, activated sludge microbiome identification, in particular using the matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) as a novel, rapid and accurate strategy for the identification of activated sludge microbiome (potential to enhance treatment yield).

Multivariate criteria applied in the performance of Tifton 85 grass in a constructed wetland: effects of organic, nutritional, and sodium loads from swine wastewater.

The purpose of this study was to analyze the effects of the application of multivariate criteria of principal components and hierarchical clustering as a mechanism for monitoring the performance of Tifton 85 grass (Cynodon spp.) planted in horizontal subsurface flow constructed wetland reactor (HSSF-CW) under different organic (OLR), nutritional and sodium loads of swine wastewater (SW). The HSSF-CW planted with Tifton 85 grass was used as a swine wastewater after treatment applying organic loading rates between 26.1 (1st cut) and 360.6 kg ha-1 day-1 COD (8th cut). The maximum performances of HSSF-CW consisted of 52.0 t ha-1 of productivity and 24.0% of crude protein, with the application of 59.7, 64.2, and 31.2 kg ha-1 day-1 of TKN, PT, and K+, respectively. The eleven original variables generated four new components, with PC4 accounting for 94.0% of total variance, a condition strengthened with four data groupings greater than 48% similarity and three data groupings greater than 95% similarity between the variables. There was a strong association between of nitrogen, phosphorus, and potassium concentration by the hierarchical grouping and the intermediate cuts and lower temperatures.

Does the ultrasonic activation of sealer hinder the root canal retreatment?

OBJECTIVES: To evaluate if the ultrasonic activation of sealer hinders the root canal retreatment. MATERIALS AND METHODS: Thirty mandibular premolars were prepared using the ProTaper Universal system (Dentsply) until the instrument F3 (0.30/0.09). The canals were distributed into 2 groups (n = 15), according to the filling technique: NUact group - sealer without ultrasonic activation + gutta-percha cones and Uact group - sealer with ultrasonic activation + gutta-percha cones. The canals were re-instrumented with Largo burs, followed by the instrument R50 (0.50/0.05) of the Reciproc system. The time required to perform re-instrumentation was recorded (s). The roots were longitudinally cleaved, and the total area of root canal and remaining filling material were quantified (%). The ANOVA test was applied to the data and complemented by Student's t test (P < 0.05). RESULTS: Uact group had higher percentage of remaining filling material than NUact group (P < 0.05). When the root thirds were considered, there was statistically significant difference only for Uact group at the apical third (P < 0.05). There was no difference between groups regarding the time required to perform re-instrumentation (P > 0.05). CONCLUSIONS: Ultrasonic activation of sealer leads to a higher percentage of remaining filling material attached to the root canal walls. However, it did not affect the retreatment time. CLINICAL SIGNIFICANCE: Ultrasonic activation increases sealer penetration into dentinal tubules, improving its resistance to dislodgement. However, there is no scientific evidence to prove if ultrasonic activation of sealer hinders its removal when root canal retreatment is necessary.

Application of graphene nanosheet oxide for atrazine adsorption in aqueous solution: synthesis, material characterization, and comprehension of the adsorption mechanism.

The present study aimed to investigate the application of graphene oxide (GO) as adsorbent material for the removal of atrazine (ATZ). The material produced was characterized to investigate the characteristics and applied as an adsorbent. The material obtained after the synthesis process presented oxygenated functional groups, which contributed to the development of a good adsorbent material. Studies were carried out to verify the influence of adsorbent material mass and initial pH of ATZ solution in adsorption capacity. Kinetic study determined that pseudo-second-order model best describes adsorbate-adsorbent interaction, with equilibrium time of 72 h. The effect of temperature on the material adsorption capacity was also studied. The Langmuir isotherm is the best fit to describe adsorption process GO-ATZ and maximum adsorption capacity obtained was 23.844 ± 0.694 mg g-1, at 318 K. Variations in process energies were determined, being a spontaneous adsorption, endothermic and characteristic of physical and chemical adsorption. Finally, influence of salts in solution on adsorption capacity was studied; the conclusion was that the presence of electrolytes affects the adsorption capacity of the material.

Facile fabrication of hybrid titanium(IV) isopropoxide/pozzolan nanosheets (TnS-Pz) of high photocatalytic activity: characterization and application for Cr(VI) reduction in an aqueous solution.

This paper presents the synthesis of a hybrid material through the use of natural pozzolan and titanium(IV) isopropoxide using the sol-gel method and its application in the photocatalytic hexavalent chromium reduction. The characterization data indicated a mesoporous material possessing a surface area of 271.7 m2 g-1. The morphology studies (SEM and TEM) showed nanosheet hybrid structures. The analysis of DRUV, FTIR, XRD, and Mössbauer spectroscopy provides a different electronic structure of the synthetized material when compared with the originals, proving the hybridization process between pozzolan and titanium(IV) isopropoxide. The photocatalytic reduction of Cr(VI) to Cr(III) using the hybrid material showed a better performance than conventional photocatalysts (precursor and TiO2-P25). Operational conditions such as chromium initial concentration (0.02-0.20 mM), solution pH (3-6), and type of scavenger (citric or tartaric acid) were evaluated in order to determine the best experimental conditions for the Cr(VI) photoreduction. At their optimum (catalyst load of 15 mg L-1, tartaric acid as scavenger, [scavenger]0/[Cr(VI)]0 M ratio = 3:1, pH 3, and 25 °C), the total photoreduction of 0.20 mM Cr(VI) was achieved in 180 min. The novel hybrid materials synthesized from pozzolan and titanium(IV) isopropoxide showed to be a potential catalyst for the Cr(VI) reduction in aqueous solution. Graphical abstract.

The use of low-cost brewery waste product for the production of surfactin as a natural microbial biocide.

Surfactin has potential as next generation antibiofilm agent to combat antimicrobial resistance against emerging pathogens. However, the widespread industrial applications of surfactin is hampered by its high production cost. In this work, surfactin was produced from Bacillus subtilis using a low-cost brewery waste as a carbon source. The strain produced 210.11 mg  L - 1 after 28 h. The antimicrobial activity was observed against all tested strains, achieving complete inhibition for Pseudomonas aeruginosa, at 500  µ g mL - 1 . A growth log reduction of 3.91 was achieved for P. aeruginosa while, Staphylococcus aureus and Staphylococcus epidermidis showed between 1 and 2 log reductions. In the anti-biofilm assays against P. aeruginosa, the co-incubation, anti-adhesive and disruption showed inhibition, where the greatest inhibition was observed in the co-incubation assay (79.80%). This study provides evidence that surfactin produced from a low-cost substrate can be a promising biocide due to its antimicrobial and anti-biofilm abilities against pathogens.