ABSTRACT
BACKGROUND: The aim of the present study was to report the clinicopathologic, radiographic and immunohistochemical features of five South American cases of intraosseous xanthomas of the mandible and to compare them to those detected in a literature review. METHODS: Clinical data were collected from the records of three Oral and Maxillofacial Pathology services in South America and compared with those compiled from a literature review based on a search of three electronic databases (PubMed, Web of Science and Scopus). All cases were evaluated by haematoxylin and eosin staining and immunohistochemistry for CD68 and S-100. RESULTS: The series comprised four females (80%) and one male (20%) with a mean age of 23.3 ± 10.9 years (range: 13-45 years). In four cases, there was involvement of the posterior region of the mandible (80%). The lesions presented radiographically as unilocular (60%) radiolucencies with punched-out margin (80%). All cases predominantly consisted of CD68-positive and S-100-negative xanthomatous cells. No recurrences were observed after curettage, with a median follow-up of 27 months. CONCLUSION: Intraosseous xanthoma of the jaws is a rare benign disorder. We report here five additional cases affecting the mandible, for a total of 36 cases of the jaws reported in the literature. Overall, this lesion has predilection for posterior sites of the mandible of asymptomatic young adults.
Subject(s)
Bone Neoplasms/diagnosis , Mandible/pathology , Xanthomatosis/diagnosis , Adolescent , Adult , Female , Humans , Immunohistochemistry , Male , Middle Aged , Young AdultABSTRACT
PURPOSE: To describe the effectiveness and safety of a sclerotherapy protocol with 5% ethanolamine oleate (EO) at 0.1 mL/3 mm for oral vascular anomalies (OVAs). Our hypothesis is that EO applied at a concentration of 5% may decrease the number of sessions necessary for clinical healing. MATERIALS AND METHODS: We describe a cohort of 15 consecutive patients. OVAs <20 mm were included. Clinical data of the OVAs were collected. Descriptive and bivariate statistical analyses were performed. RESULTS: Fifteen of the 19 OVAs were varicosities and the lower lip was the most affected site (n = 7). The median size was 6 mm, and one session was required in 89.5% of cases for clinical healing within 28 days. The pain/burning score was low (<2) for most lesions (63.1%) and the degree of satisfaction was high (>8) for all OVAs. The number of applications, final volume of drug and time to resolution differed significantly according to the size of the anomaly. CONCLUSION: The protocol with 5% EO was shown to be effective and safe to treat OVAs <20 mm, and with a decrease in the number of sessions, volume and time to resolution, without complications and with high patient satisfaction.
Subject(s)
Arteriovenous Malformations/therapy , Oleic Acids/administration & dosage , Oleic Acids/therapeutic use , Sclerotherapy/methods , Varicose Veins/therapy , Vascular Diseases/therapy , Aged , Aged, 80 and over , Cohort Studies , Female , Humans , Lip , Male , Middle Aged , Sclerosing Solutions/therapeutic use , Treatment OutcomeABSTRACT
Odontogenic myxomas are considered to be a benign odontogenic tumor with locally aggressive behavior, non-metastasizing neoplasm of the jaw bones. It derives from the dental mesenchyme or periodontal ligament. Despite the benign nature of these lesions, there is a high rate of local recurrence after curettage alone and in certain cases requires adequate resection. This paper describes a case of a large odontogenic myxoma in the maxilla, emphasizing a discussion on the differential diagnosis related to radiological findings and the surgical treatment.