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3.
Rev Assoc Med Bras (1992) ; 67(2): 173-177, 2021 Feb.
Article in English | MEDLINE | ID: mdl-34406239

ABSTRACT

The aging process occurs due to the decline of vital physiological functions and adaptability of the body, being influenced by genetics and lifestyle. With advances in genetics, biological aging can be calculated by telomere length. Telomeres are regions at the ends of chromosomes that play a role in the maintenance and integrity of DNA. With biological aging, telomere shortening occurs, causing cellular senescence. Several studies show that shorter telomeres are associated with acute and chronic diseases, stress, addictions, and intoxications. Even in the current COVID-19 pandemic, telomere shortening is proposed as a marker of severity in individuals infected by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). On the other hand, healthy lifestyle habits increase telomere length and balance of various cellular functions, preventing diseases.


Subject(s)
COVID-19 , Telomere , Aging/genetics , Biomarkers , Humans , Pandemics , SARS-CoV-2 , Telomere/genetics
4.
Homeopathy ; 110(4): 283-291, 2021 Nov.
Article in English | MEDLINE | ID: mdl-34000743

ABSTRACT

BACKGROUND: Philosophical-scientific correlations described in previous studies suggest that the genome can be the biological representation of the vital force, whilst the disease-promoting epigenetic alterations would be the biological representation of the chronic miasmas. In this study, we expand the functional correlation between vital force and chromosomes, describing the mechanism of action of the telomere-telomerase complex in the context of physiological balance. AIMS: The aim of the work is to study the role of the telomere-telomerase complex in cell vitality, biological aging, and the health-disease process, with the goal of proposing the use of telomere length as a biomarker of the vital force state and the effectiveness of homeopathic treatment. RESULTS: Similar to the vital force, telomere length and telomerase enzyme activity play an important role in maintaining cellular vitality, biological longevity, and physiological homeostasis. Telomere shortening functions as a biomarker of vital imbalance and is associated with numerous diseases and health disorders. On the other hand, health-promotion practices neutralize the pathological shortening of the telomeres, acting therapeutically in diseases or age-dependent health disorders. CONCLUSIONS: As a hypothetical biomarker of the vital force state, an intra-individual analysis of the mean leukocyte telomere length before, during, and after homeopathic treatment can be used as a biomarker of therapeutic effectiveness.


Subject(s)
Homeopathy , Telomerase , Biomarkers , Telomerase/genetics , Telomerase/metabolism , Telomere/metabolism , Treatment Outcome
5.
Rev. Assoc. Med. Bras. (1992) ; 67(2): 173-177, Feb. 2021.
Article in English | LILACS-Express | LILACS | ID: biblio-1287831

ABSTRACT

SUMMARY The aging process occurs due to the decline of vital physiological functions and adaptability of the body, being influenced by genetics and lifestyle. With advances in genetics, biological aging can be calculated by telomere length. Telomeres are regions at the ends of chromosomes that play a role in the maintenance and integrity of DNA. With biological aging, telomere shortening occurs, causing cellular senescence. Several studies show that shorter telomeres are associated with acute and chronic diseases, stress, addictions, and intoxications. Even in the current COVID-19 pandemic, telomere shortening is proposed as a marker of severity in individuals infected by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). On the other hand, healthy lifestyle habits increase telomere length and balance of various cellular functions, preventing diseases.

6.
São Paulo; Propria; 2; 2021. 140 p.
Monography in Portuguese | LILACS, HomeoIndex Homeopathy | ID: biblio-1178043

ABSTRACT

Estando a homeopatia fundamentada no modelo médico vitalista, conceitos como força vital, mente, alma, espírito, etc., referentes à natureza imaterial humana, são frequentemente citados, tornando-se indispensável sua compreensão. Fundamentado nas obras de Samuel Hahnemann, fundador da homeopatia, incluindo seus escritos menores e cartas, essa obra busca esclarecer essas concepções, no intuito de dissolver confusões doutrinárias. No referido estudo, fica claro o conceito de 'força vital instintiva e irracional', análoga à 'vis medicatrix naturae' hipocrática, formando um composto substancial com o corpo físico e de natureza distinta do espírito inteligente. Como outra entidade distinta das anteriores, Hahnemann também cita a mente, sede da alma, como 'órgãos físicos quase não-materiais, de mais alta hierarquia', atribuindo ao psiquismo humano a maior influência no binômio saúde-doença, referindo-se à moral e à ética como fatores preventivos e curativos das enfermidades que afetam a humanidade. Critica a escolástica e o excesso de especulações metafísicas, afastando-se de qualquer corrente filosófica ou religiosa, brindando-nos com conceitos espiritualistas universalistas dentro dos princípios morais e éticos, engrandecendo ainda mais sua obra e demonstrando ser um observador livre de preconceitos. Para Hahnemann, o corpo físico forma uma unidade substancial com o princípio vital, e não com a alma, sendo comandado pelo espírito inteligente que nele habita. A mente, como órgão psíquico, assume importante papel na relação entre essas entidades que compõe o ser humano. (AU)


Since homeopathy is based on the vitalist medical model, concepts such as vital force, mind, soul, spirit, etc., referring to the immaterial human nature, are frequently cited, making their understanding indispensable. Based on the works of Samuel Hahnemann, founder of homeopathy, including his minor writings and letters, this work seeks to clarify these conceptions, in order to dissolve doctrinal confusions. In this study, the concept of 'instinctive and irrational vital force', analogous to the Hippocratic 'vis medicatrix naturae', becomes clear, forming a substantial compound with the physical body and a nature distinct from the intelligent spirit. As another entity distinct from the previous ones, Hahnemann also mentions the mind, seat of the soul, as 'physical organs almost non-material, of higher hierarchy', attributing to the human psyche the greatest influence in the binomial health-disease, referring to the moral and ethics as preventive and curative factors for diseases that affect humanity. He criticizes scholasticism and the excess of metaphysical speculations, moving away from any philosophical or religious current, offering us universalistic spiritualist concepts within moral and ethical principles, further enhancing his work and demonstrating that he is a prejudice-free observer. For Hahnemann, the physical body forms a substantial unity with the vital principle, and not with the soul, being commanded by the intelligent spirit that in him dwells. The mind, as a psychic organ, assumes an important role in the relationship between these entities that make up the human being. (AU)


Subject(s)
Vitalism , Vital Force in Homeopathy , Homeopathic Philosophy , Health-Disease Process , Homeopathy
7.
São Paulo; Propria; 2; 2021. 387 p.
Monography in Portuguese | LILACS, HomeoIndex Homeopathy | ID: biblio-1148202

ABSTRACT

Realizando a ponte entre a farmacologia homeopática (princípio da similitude) e a farmacologia moderna, encontramos uma infinidade de relatos, tanto em compêndios farmacológicos como em experimentos e ensaios clínicos publicados em periódicos científicos, que descrevem uma reação do organismo oposta e secundária a uma ação primária da droga, confirmando a teoria hahnemanniana. Essa ação secundária do organismo, no sentido de manter a homeostase orgânica, é denominada de efeito rebote ou reação paradoxal segundo a racionalidade científica moderna, sendo usada pela homeopatia como resposta terapêutica. (AU)


Building a bridge between homeopathic pharmacology (principle of similitude) and modern pharmacology, one can find countless reports in pharmacological compendia and clinical and experimental trials published in the scientific media describing the secondary reaction of the organism opposed to the primary action of the drug, which confirm Hahnemann's theory. Such secondary action of the organism to preserve organic homeostasis is known in modern science as rebound effect or paradoxical reaction, being used by homeopathy as a therapeutic response.(AU)


Subject(s)
Pharmacology , Secondary Effect , Vital Force in Homeopathy , Law of Similars , Homeopathic Remedy, New , Rebound Effect , Homeopathy
8.
São Paulo; Propria; 2; 2021. 477 p.
Monography in English | LILACS, HomeoIndex Homeopathy | ID: biblio-1148205

ABSTRACT

Building a bridge between homeopathic pharmacology (principle of similitude) and modern pharmacology, one can find countless reports in pharmacological compendia and clinical and experimental trials published in the scientific media describing the secondary reaction of the organism opposed to the primary action of the drug, which confirm Hahnemann's theory. Such secondary action of the organism to preserve organic homeostasis is known in modern science as rebound effect or paradoxical reaction, being used by homeopathy as a therapeutic response. (AU)


Realizando a ponte entre a farmacologia homeopática (princípio da similitude) e a farmacologia moderna, encontramos uma infinidade de relatos, tanto em compêndios farmacológicos como em experimentos e ensaios clínicos publicados em periódicos científicos, que descrevem uma reação do organismo oposta e secundária a uma ação primária da droga, confirmando a teoria hahnemanniana. Essa ação secundária do organismo, no sentido de manter a homeostase orgânica, é denominada de efeito rebote ou reação paradoxal segundo a racionalidade científica moderna, sendo usada pela homeopatia como resposta terapêutica. (AU)


Subject(s)
Pharmacology , Secondary Effect , Vital Force in Homeopathy , Law of Similars , Rebound Effect , Homeopathy , Homeopathic Remedy, New
9.
São Paulo; Propio; 2; 2021. 1310 p.
Monography in Portuguese | LILACS, HomeoIndex Homeopathy | ID: biblio-1148215

ABSTRACT

Seguindo a mesma dinâmica da homeopatia clássica, essa obra sistematiza uma proposta para empregar os fármacos modernos segundo o princípio da similitude terapêutica, estimulando o efeito rebote (reação vital) curativo do organismo através da administração de substâncias (em doses dinamizadas) que despertaram sintomas semelhantes no estado de saúde humano. Vale ressaltar que os efeitos patogenéticos (ações primárias) dos medicamentos homeopáticos clássicos correspondem aos efeitos terapêuticos, adversos e colaterais dos fármacos modernos, os quais devem apresentar uma totalidade sintomática semelhante ao do paciente para estimular a reação vital curativa (efeito rebote curativo), de acordo ao princípio da similitude terapêutica. Para viabilizar essa proposta, foi necessário elaborar uma Matéria Médica Homeopática dos Fármacos Modernos, agrupando os efeitos terapêuticos, adversos e colaterais das drogas conforme a disposição anátomo-funcional dos capítulos das matérias médicas homeopáticas tradicionais, valorizando a frequência de manifestação dos sintomas observadas nas fases de estudo da droga. Como segundo passo, para facilitar a seleção do medicamento individualizado (semelhança com a totalidade de sintomas do paciente) e a aplicação clínica da proposta, foi elaborado um Repertório Homeopático dos Fármacos Modernos, dispondo os sintomas e seus respectivos medicamentos de forma análoga aos repertórios homeopáticos tradicionais, descrito em outra obra desta coleção. (AU)


Following the pattern of traditional homeopathy, this work proposes to employ modern drugs according to the principle of therapeutic similitude, stimulating the healing rebound effect (vital reaction) of the organism through the administration of substances (in infinitesimal doses) that caused similar symptoms in healthy human. Is worth emphasizing that the pathogenetic effects (primary actions) of classical homeopathic medicines correspond to the therapeutic, adverse and side effects of conventional drugs, which should be similar to totality of the symptoms of the patient to stimulate the curative vital reaction (curative rebound effect) according to the principle of therapeutic similitude. To make this proposal operative, a Homeopathic Materia Medica of Modern Drugs was elaborated, where the therapeutic, adverse and side effects of drugs were grouped following the structure of the traditional homeopathic materia medica, while giving particular value to the frequency of the symptoms observed during the phases of study of the drugs. In order to facilitate the selection of the individualized remedy (i.e., similar to the totality of symptoms of the patient), and thus the clinical application of the present proposal, at a later stage it was also elaborated a Homeopathic Repertory of Modern Drugs, where symptoms and remedies are arranged as in the traditional homeopathic repertories, described in another work of this collection. (AU)


Subject(s)
Pharmacology , Materia Medica , Secondary Effect , Law of Similars , Homeopathic Remedy, New , Rebound Effect , Homeopathy
10.
São Paulo; Propria; 2; 2021. 1336 p.
Monography in English | LILACS, HomeoIndex Homeopathy | ID: biblio-1148219

ABSTRACT

Following the pattern of traditional homeopathy, this work proposes to employ modern drugs according to the principle of therapeutic similitude, stimulating the healing rebound effect (vital reaction) of the organism through the administration of substances (in infinitesimal doses) that caused similar symptoms in healthy human. Is worth emphasizing that the pathogenetic effects (primary actions) of classical homeopathic medicines correspond to the therapeutic, adverse and side effects of conventional drugs, which should be similar to totality of the symptoms of the patient to stimulate the curative vital reaction (curative rebound effect) according to the principle of therapeutic similitude. To make this proposal operative, a Homeopathic Materia Medica of Modern Drugs was elaborated, where the therapeutic, adverse and side effects of drugs were grouped following the structure of the traditional homeopathic materia medica, while giving particular value to the frequency of the symptoms observed during the phases of study of the drugs. In order to facilitate the selection of the individualized remedy (i.e., similar to the totality of symptoms of the patient), and thus the clinical application of the present proposal, at a later stage it was also elaborated a Homeopathic Repertory of Modern Drugs, where symptoms and remedies are arranged as in the traditional homeopathic repertories, described in another work of this collection. (AU)


Seguindo a mesma dinâmica da homeopatia clássica, essa obra sistematiza uma proposta para empregar os fármacos modernos segundo o princípio da similitude terapêutica, estimulando o efeito rebote (reação vital) curativo do organismo através da administração de substâncias (em doses dinamizadas) que despertaram sintomas semelhantes no estado de saúde humano. Vale ressaltar que os efeitos patogenéticos (ações primárias) dos medicamentos homeopáticos clássicos correspondem aos efeitos terapêuticos, adversos e colaterais dos fármacos modernos, os quais devem apresentar uma totalidade sintomática semelhante ao do paciente para estimular a reação vital curativa (efeito rebote curativo), de acordo ao princípio da similitude terapêutica. Para viabilizar essa proposta, foi necessário elaborar uma Matéria Médica Homeopática dos Fármacos Modernos, agrupando os efeitos terapêuticos, adversos e colaterais das drogas conforme a disposição anátomo-funcional dos capítulos das matérias médicas homeopáticas tradicionais, valorizando a frequência de manifestação dos sintomas observadas nas fases de estudo da droga. Como segundo passo, para facilitar a seleção do medicamento individualizado (semelhança com a totalidade de sintomas do paciente) e a aplicação clínica da proposta, foi elaborado um Repertório Homeopático dos Fármacos Modernos, dispondo os sintomas e seus respectivos medicamentos de forma análoga aos repertórios homeopáticos tradicionais, descrito em outra obra desta coleção. (AU)


Subject(s)
Materia Medica , Secondary Effect , Vital Force in Homeopathy , Law of Similars , Homeopathic Remedy, New , Rebound Effect , Homeopathy
11.
São Paulo; Propria; 2; 2021. 781 p.
Monography in Portuguese | LILACS, HomeoIndex Homeopathy | ID: biblio-1148263

ABSTRACT

Seguindo a mesma dinâmica da homeopatia clássica, essa obra sistematiza uma proposta para empregar os fármacos modernos segundo o princípio da similitude terapêutica, estimulando o efeito rebote (reação vital) curativo do organismo através da administração de substâncias (em doses dinamizadas) que despertaram sintomas semelhantes no estado de saúde humano. Vale ressaltar que os efeitos patogenéticos (ações primárias) dos medicamentos homeopáticos clássicos correspondem aos efeitos terapêuticos, adversos e colaterais dos fármacos modernos, os quais devem apresentar uma totalidade sintomática semelhante ao do paciente para estimular a reação vital curativa (efeito rebote curativo), de acordo ao princípio da similitude terapêutica. Para viabilizar essa proposta, foi necessário elaborar uma Matéria Médica Homeopática dos Fármacos Modernos, agrupando os efeitos terapêuticos, adversos e colaterais das drogas conforme a disposição anátomo-funcional dos capítulos das matérias médicas homeopáticas tradicionais, valorizando a frequência de manifestação dos sintomas observadas nas fases de estudo da droga. Como segundo passo, para facilitar a seleção do medicamento individualizado (semelhança com a totalidade de sintomas do paciente) e a aplicação clínica da proposta, foi elaborado um Repertório Homeopático dos Fármacos Modernos, dispondo os sintomas e seus respectivos medicamentos de forma análoga aos repertórios homeopáticos tradicionais, descrito nessa obra. (AU)


Following the pattern of traditional homeopathy, this work proposes to employ modern drugs according to the principle of therapeutic similitude, stimulating the healing rebound effect (vital reaction) of the organism through the administration of substances (in infinitesimal doses) that caused similar symptoms in healthy human. Is worth emphasizing that the pathogenetic effects (primary actions) of classical homeopathic medicines correspond to the therapeutic, adverse and side effects of conventional drugs, which should be similar to totality of the symptoms of the patient to stimulate the curative vital reaction (curative rebound effect) according to the principle of therapeutic similitude. To make this proposal operative, a Homeopathic Materia Medica of Modern Drugs was elaborated, where the therapeutic, adverse and side effects of drugs were grouped following the structure of the traditional homeopathic materia medica, while giving particular value to the frequency of the symptoms observed during the phases of study of the drugs. In order to facilitate the selection of the individualized remedy (i.e., similar to the totality of symptoms of the patient), and thus the clinical application of the present proposal, at a later stage it was also elaborated a Homeopathic Repertory of Modern Drugs, where symptoms and remedies are arranged as in the traditional homeopathic repertories, described in this work. (AU)


Subject(s)
Pharmacology , Secondary Effect , Vital Force in Homeopathy , Law of Similars , Homeopathic Repertory , Homeopathic Remedy, New , Rebound Effect , Homeopathy
12.
São Paulo; Proprio; 2021. 808 p.
Monography in English | LILACS, HomeoIndex Homeopathy | ID: biblio-1148266

ABSTRACT

Following the pattern of traditional homeopathy, this work proposes to employ modern drugs according to the principle of therapeutic similitude, stimulating the healing rebound effect (vital reaction) of the organism through the administration of substances (in infinitesimal doses) that caused similar symptoms in healthy human. Is worth emphasizing that the pathogenetic effects (primary actions) of classical homeopathic medicines correspond to the therapeutic, adverse and side effects of conventional drugs, which should be similar to totality of the symptoms of the patient to stimulate the curative vital reaction (curative rebound effect) according to the principle of therapeutic similitude. To make this proposal operative, a Homeopathic Materia Medica of Modern Drugs was elaborated, where the therapeutic, adverse and side effects of drugs were grouped following the structure of the traditional homeopathic materia medica, while giving particular value to the frequency of the symptoms observed during the phases of study of the drugs. In order to facilitate the selection of the individualized remedy (i.e., similar to the totality of symptoms of the patient), and thus the clinical application of the present proposal, at a later stage it was also elaborated a Homeopathic Repertory of Modern Drugs, where symptoms and remedies are arranged as in the traditional homeopathic repertories, described in this work. (AU)


Subject(s)
Pharmacology , Secondary Effect , Vital Force in Homeopathy , Law of Similars , Homeopathic Repertory , Homeopathic Remedy, New , Rebound Effect , Homeopathy
17.
Homeopatia Méx ; 89(720): 12-17, ene.-mar. 2020.
Article in Spanish | LILACS, HomeoIndex Homeopathy | ID: biblio-1147377

ABSTRACT

El proceso de envejecimiento se produce por la disminución de las funciones fisiológicas y de la capacidad de adaptación del organismo, siendo influenciado por la genética y el estilo de vida. Actualmente, con los avances de la genética, el envejecimiento biológico se puede calcular por la longitud de los telómeros ('telomere lenght'). Los telómeros son regiones en los extremos de los cromosomas que juegan un papel en el mantenimiento y la integridad del ADN. Con el envejecimiento biológico, se produce el acortamiento de los telómeros, causando la senescencia celular. Numerosos estudios evidencian que telómeros más cortos están asociados a enfermedades crónicas, a vicios y a intoxicaciones. Por otro lado, hábitos de vida saludables propician el aumento de la longitud de los telómeros y el equilibrio de las diversas funciones celulares, previniendo enfermedades. Por lo tanto, los telómeros funcionan como un biomarcador de la vitalidad del organismo.(AU)


Subject(s)
Aging , Chronic Disease , Telomere , Telomerase , Homeopathy
18.
Sâo Paulo; Marcus Zulian Teixeira; mar. 2020. 60 p.
Monography in English | HomeoIndex Homeopathy, LILACS | ID: biblio-1088044

ABSTRACT

In addition to the recognized application in chronic diseases, individualized homeopathy can also act in a resolutive or complementary way in acute cases, including epidemic diseases. However, to achieve this intent, it presents a specific semiologic and therapeutic methodology that must be followed and respected, with the risk of not presenting the desired efficacy and safety. In the case of epidemic diseases, which due to the virulence of their agents causes a common symptomatological picture in most susceptible individuals, the individualized homeopathic medicine (homeopathic medicine of the epidemic genius) should present similarity with the set of characteristic symptoms and signs of the patients affected in the different stages of each epidemic outbreak. Studies show the efficacy and safety of this prophylactic and/or therapeutic practice in several epidemics of the past. Therefore, after the survey of possible homeopathic drugs individualized from the epidemic genius of each epidemic, its prophylactic and/or large-scale therapeutic application should be supported by previous clinical trials that demonstrate its efficacy and safety, in line with the ethical and bioethical aspects of research involving human beings. Fulfilling these premises of good clinical practice, we developed the current protocol with the objective of investigating, in a randomized, double-blind and placebo-controlled clinical trial, the effectiveness and safety of possible individualized homeopathic drugs of epidemic genius of COVID-19, in adjuvant and complementary treatment of patients affected by the disease. If effectiveness and safety are confirmed, and only in this condition, the medicine may be used in a generalized and collective manner in the treatment and prevention of the current epidemic. (AU)


Subject(s)
Epidemic Genius , Clinical Protocols , Coronavirus Infections/prevention & control , Coronavirus Infections/therapy , Ethics, Research , SARS Virus , Epidemics , Homeopathy , Brazil/epidemiology
19.
São Paulo; AMHB;APH; mar. 2020. 62 p.
Monography in Portuguese | MOSAICO - Integrative health, LILACS, HomeoIndex Homeopathy, MOSAICO - Integrative health | ID: biblio-1087238

ABSTRACT

Além da reconhecida aplicação nas doenças crônicas, a homeopatia individualizada também pode atuar de forma resolutiva ou complementar nos casos agudos, incluindo as doenças epidêmicas. No entanto, para atingir esse intento, apresenta uma metodologia semiológica e terapêutica específica que deve ser seguida e respeitada, com o risco de não apresentar a eficácia e a segurança desejada. No caso das doenças epidêmicas, que pela virulência dos seus agentes provoca um quadro sintomatológico comum na maioria dos indivíduos suscetíveis, o medicamento homeopático individualizado (medicamento homeopático do gênio epidêmico) deve apresentar semelhança com o conjunto de sinais e sintomas característicos dos pacientes acometidos nos diferentes estágios de cada surto epidêmico. Estudos evidenciam a eficácia e a segurança desta prática profilática e/ou terapêutica em diversas epidemias do passado. Assim sendo, após o levantamento dos possíveis medicamentos homeopáticos individualizados do gênio epidêmico de cada epidemia, sua aplicação profilática e/ou terapêutica em larga escala deve ser sustentada por ensaios clínicos prévios que demonstrem sua eficácia e segurança, em consonância com os aspectos éticos e bioéticos da pesquisa envolvendo seres humanos. Cumprindo essas premissas da boa prática clínica, elaboramos o atual protocolo com o objetivo de investigar, em ensaio clínico randomizado, duplo-cego e placebo-controlado, a eficácia e a segurança de possíveis medicamentos homeopáticos individualizados do gênio epidêmico da COVID-19, em tratamento adjuvante e complementar de pacientes acometidos pela doença. Caso a a eficácia e a segurança se confirme, e tão somente, o(s) medicamento(s) poderão ser utilizado de forma generalizada e coletiva no tratamento e na prevenção da atual epidemia. (AU)


In addition to the recognized application in chronic diseases, individualized homeopathy can also act in a resolutive or complementary way in acute cases, including epidemic diseases. However, to achieve this intent, it presents a specific semiological and therapeutic methodology that must be followed and respected, with the risk of not presenting the desired efficacy and safety. In the case of epidemic diseases, which due to the virulence of their agents causes a common symptomatological picture in most susceptible individuals, the individualized homeopathic medicine (homeopathic medicine of the epidemic genius) should present similarity with the set of characteristic symptoms and signs of the patients affected in the different stages of each epidemic outbreak. Studies show the efficacy and safety of this prophylactic and/or therapeutic practice in several epidemics of the past. Therefore, after the survey of possible homeopathic drugs individualized from the epidemic genius of each epidemic, its prophylactic and/or large-scale therapeutic application should be supported by previous clinical trials that demonstrate its efficacy and safety, in line with the ethical and bioethical aspects of research involving human beings. Fulfilling these premises of good clinical practice, we developed the current protocol with the objective of investigating, in a randomized, double-blind and placebo-controlled clinical trial, the efficacy and safety of possible individualized homeopathic drugs of epidemic genius of COVID-19, in adjuvant and complementary treatment of patients affected by the disease. If efficacy and safety are confirmed, and only in this condition, the medicine may be used in a generalized and collective manner in the treatment and prevention of the current epidemic. (AU)


Subject(s)
Humans , Epidemic Genius , Clinical Protocols , Coronavirus , Coronaviridae Infections/prevention & control , Coronaviridae Infections/therapy , Ethics, Research , SARS Virus , Epidemics , Homeopathy , Brazil/epidemiology
20.
Homeopathy ; 109(1): 30-36, 2020 02.
Article in English | MEDLINE | ID: mdl-31319421

ABSTRACT

BACKGROUND: In homeopathic philosophy, vital force is a non-material substrate that is responsible for maintaining the body's sensations and functions and where homeopathic medicines act. In genetics, the body's vital functions are controlled by biochemical information, which is contained in the cell genome and consists of a protein encoding portion (exome) and another that regulates this encoding scheme (epigenome). Both the philosophical vital force and the genome present properties of complex and dynamic self-organisation systems. AIMS: This study aimed to explore and develop a philosophical-scientific correlation between vitalism and genetics according to the complexity paradigm. RESULTS: Vital principle and genome present inseparable composition among distinct existing components that influence one another and form a network of connections that create complex and dynamic self-organisation behaviour. Described in both models, 'vortex' indicates the existence of a force coming from within the system that is externalised as an emergent, information-transmitting phenomenon. Supporting this correlation, some experimental studies show that homeopathic medicines act on the genome by modulating gene expression. CONCLUSIONS: In line with the similarity of existing characteristics and properties, the genome may be considered as hypothetical biological substrate of organic vital force.


Subject(s)
Epigenomics , Genome , Homeopathy , Vitalism , Humans
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