Dentifrícios branqueadores contendo Blue covarine: revisão de literatura / Bleaching dentifrices containing "Blue covarine" literature review

Introdução: O efeito branqueador dos dentifrícios contendo Blue covarine é fundamentado no seu mecanismo de ação, caracterizado pela sua deposição na superfície dentária, alterando a percepção da cor. Objetivo: Revisar a literatura e buscar evidência científica sobre o efeito branqueador do Blue Covarine em tecidos mineralizados e materiais restauradores estéticos. Materiais e métodos: Para a revisão da literatura foram feitas buscas nas bases de dados PubMed, LILACS, BBO, SciELO e MEDLINE para identificar estudos clínicos e laboratoriais que avaliassem a ação branqueadora do agente óptico Blue covarine. Como estratégia de busca foram utilizados os descritores "Blue covarine", "Blue covarine e pasta de dentes", "Blue covarine and toothpaste", "Blue covarine e dentifrícios", "Blue covarine and dentifrices", "Blue covarine e dentifrícios branqueadores", "Blue covarine and whitening dentifrices", "Blue covarine e dentifrícios clareadores", "Blue covarine and bleaching dentifrices", "Blue covarine e pasta de dentes branqueadoras", "Blue covarine and whitening toothpaste", "Blue covarine e pasta de dentes clareadoras", "Blue covarine and bleaching toothpaste". Resultados: Dois pesquisadores selecionaram e analisaram criticamente 31 artigos, sendo 2 revisões da literatura, 4 estudos clínicos e 25 estudos laboratoriais. Divergências quanto ao desenho de estudo, métodos, amostra, critérios clínicos e parâmetros laboratoriais foram observados, além de conflitos de interesse. Conclusão: O Blue Covarine presente nos dentifrícios branqueadores parece ser efetivo na promoção do branqueamento dentário apenas quando associado aos agentes abrasivos presentes nas formulações, evidenciando que ensaios clínicos e laboratoriais, com metodologias semelhantes, são necessários para se obter evidência científica conclusiva sobre o efeito deste agente branqueador.(AU)

Introduction: The whitening effect of dentifrices containing Blue Covarine is based on its mechanism of action, characterized by its deposition on the tooth surface, altering the perception of color. Objective: To review the literature and seek scientific evidence on the whitening effect of Blue Covarine on mineralized tissues and aesthetic restorative materials. Materials and methods: For the literature review, searches were carried out in the PubMed, LILACS, BBO, SciELO and MEDLINE databases, in order to identify clinical and laboratory studies that evaluated the whitening action of the optical agent Blue Covarine. As a search strategy, the descriptors "Blue Covarine", "Blue Covarine and toothpaste", "Blue Covarine and dentifrices", "Blue Covarine and whitening dentifrices", "Blue Covarine and bleaching dentifrices", "Blue Covarine and whitening toothpaste", "Blue Covarine and bleaching toothpaste". Results: Two researchers selected and critically analyzed 31 articles, including 2 literature reviews, 4 clinical studies and 25 laboratory studies. Differences in study design, methods, sample, clinical criteria and laboratory parameters were observed, in addition to conflicts of interest. Conclusion: Blue Covarine present in whitening dentifrices seems to be effective in promoting dental whitening only when associated with abrasive agents present in the formulations, showing that clinical and laboratory tests, with similar methodologies, are necessary to obtain conclusive scientific evidence on the effect of this bleaching agent.(AU)

Determination of the whitening effect of toothpastes on human teeth / Determinación del efecto blanqueador de los dentífricos en dientes humanos

Abstract The desire of individuals to have whiter teeth increases the interest in tooth whitening products. Our aim was to in vitro study the whitening effect of hydrogen peroxide, blue covarine and active charcoal containing whitening toothpastes on human teeth. A total of 40 extracted human incisor teeth were used in the study. To measure the whitening effect of toothpastes, the teeth were divided into four subgroups and placed in the phantom tooth jaw model. Then, daily brushing was done with an electric toothbrush. The colors of the teeth were measured initially using the spectrophotometer (single point and bleached shade mode) and at the end of 7th, 14th and 28th days. Whitening effectiveness of toothpastes were studied according to CIEDE2000 formula (ΔE00) and shade guide units (SGU). One- way analysis of variance (ANOVA) and Tukey test were used in the statistical analysis of the data. (p0.05). Blue covarine containing toothpaste had statistically the lowest whitening effect (p<0.05). All toothpastes showed a whitening effect on the teeth after 7 days of use. Activated charcoal containing toothpaste showed more whitening effect after 28 days of use than hydrogen peroxide, blue covarine and traditional toothpaste.

Resumen El deseo de los individuos de tener unos dientes más blancos aumenta el interés por los productos de blanqueamiento dental. Nuestro objetivo fue estudiar el efecto blanqueador de las pastas dentales blanqueadoras que contienen peróxido de hidrógeno, covarina azul y carbón activo en dientes humanos in vitro. En el estudio se utilizaron un total de 40 dientes incisivos humanos extraídos. Para medir el efecto blanqueador de los dentífricos, los dientes se dividieron en cuatro subgrupos y se colocaron en el modelo de diente fantasma en mandíbula. A continuación, se realizó un cepillado diario con un cepillo eléctrico. El color de los dientes se midió inicialmente con un espectrofotómetro (modo de punto único y tono blanqueado) y al final de los días 7, 14 y 28. Se estudió la eficacia blanqueadora de los dentífricos según la fórmula CIEDE2000 (ΔE00) y las unidades de guía de color (SGU). En el análisis estadístico de los datos se utilizó el análisis de varianza de una vía (ANOVA) y la prueba de Tukey. (p0,05). El dentífrico que contiene covarina azul tuvo estadísticamente el menor efecto blanqueador (p<0,05). Todos los dentífricos mostraron un efecto blanqueador en los dientes después de 7 días de uso. Los dentífricos con carbón activado mostraron un mayor efecto blanqueador tras 28 días de uso que el peróxido de hidrógeno, la covarina azul y el dentífrico tradicional.

The whitening effect of single brushing with blue-covarine containing toothpaste-A randomized controlled trial.

OBJECTIVE: To evaluate whether a blue covarine containing silica-based toothpaste promotes a whitening effect immediately after tooth brushing. METHODS: A triple-blind, parallel group, randomized design was used to compare the tooth color before and after brushing. Two silica-based toothpastes were chosen, one of them containing blue covarine (BCT) and the other one without pigment to serve as control (CT). Tooth color was measured using a spectrophotometer and expressed as CIEDE 2000 ΔE, CIELAB values, WIO index, WID index and VITA scale tooth shade. In addition, the participants' satisfaction with and perception of their own tooth color were registered using an aesthetic numeric analogue scale. RESULTS: No significant changes in color components or dimensions measured using CIEDE 2000 ΔE (CT: mean = 1.3, 95% CI 0.8, 1.7; BCT: mean = 1.6, 95% CI 1.2, 2.1), WIO, WID, VITA scale or CIELAB values were detected for the CT and BCT groups, comparing the results before and after brushing. Likewise, the participants' satisfaction with the treatment results (P = 0.31) and the participants' evaluation of tooth color (P = 0.71) did not differ significantly between groups. CONCLUSION: After a single application, no significant improvement in tooth whiteness by the presence of blue covarine in a silica-based toothpaste was detected in color dimensions or by assessing the participants' satisfaction and perception. CLINICAL SIGNIFICANCE: The present study does not show a clinically relevant increase in tooth whiteness after a single brushing with a blue covarine containing toothpaste, nor could the study participants observe a difference between treatment with blue covarine containing toothpaste and control treatment.

Effect of whitening dentifrices containing optical agent on the variation of color, roughness and mass of a nanoparticulate composite resin / Efeito de dentifrícios branqueadores contendo agente óptico na variação da cor, rugosidade e massa de uma resina composta nanoparticulada

Introduction: Blue covarine is a pigment that promotes optical changes in dental surfaces, providing whitening. Objective: To evaluate in vitro the effect of bleaching dentifrices containing Blue covarine in nanoparticulate composite resin subjected to artificial darkening. Material and method: One hundred sixty (160) specimens (PBs) of FILTEK Z350XT nanoparticulate composite resin were randomly divided into two experiments: Experiment I - 8 groups (n=10) submitted to brushing with an electric toothbrush for 1 month; Experiment II - 8 groups (n=10) submitted to simulated brushing for 6, 12 and 24 months. Groups were distributed according to the solution/dentifrice tested: CG (distilled water) and 7 test groups (GT1- Coltene Herjos, GT2- Colgate Total 12 Clean Mint, GT3- Colgate Luminous White Brilliant Mint, GT4- Oral B 3D White Perfection, GT5- Close Up White Now Glacier Fresh, GT6- Close Up White Attraction Diamond and GT7- Sorriso Xtreme White Evolution). Result In Experiment I, there was greater ∆E in GT6 in relation to CG, GT2, GT4 and GT5, with no differences among them. In Experiment II, after 24 months of brushing, there was greater ∆E in groups GT6 and GT7. After 24 months of simulated brushing, there was no change in roughness or loss of mass in any group. Conclusion: The whitening effect promoted by dentifrices containing the agent Blue covarine seems to be related to the association of this agent with the abrasives present in the formulations of whitening dentifrices.

Introdução: O Blue covarine é um pigmento que promove alterações ópticas nas superfícies dentárias proporcionando o seu branqueamento. Objetivo: Avaliar in vitro o efeito de dentifrícios branqueadores contendo Blue covarine em resina composta nanoparticulada submetida a escurecimento artificial. Material e método: 160 corpos de prova (CPs) de resina composta nanoparticulada FILTEK Z350XT foram divididos aleatoriamente em dois experimentos: Experimento I- 8 grupos (n=10) submetidos a escovação com escova elétrica por 1 mês; Experimento II- 8 grupos (n=10) submetidos a escovação simulada por 6, 12 e 24 meses. Os grupos foram distribuídos de acordo com a solução/dentifrício testado: GC (água destilada) e 7 grupos teste (GT1-Coltene Herjos, GT2- Colgate Total 12 Clean Mint, GT3- Colgate Luminous White Brilliant Mint, GT4- Oral B 3D White Perfection, GT5- Close Up White Now Glacier Fresh, GT6- Close Up White Attraction Diamond e GT7- Sorriso Xtreme White Evolution). Resultado: No experimento I, houve maior ∆E no GT6 com relação ao GC, GT2, GT4 e GT5, que não diferiram entre si. No experimento II, após 24 meses de escovação houve maior ∆E nos grupos GT6 e GT7. Após 24 meses de escovação simulada não houve alteração da rugosidade nem perda de massa em nenhum grupo. Conclusão: O efeito branqueador promovido pelos dentifrícios contendo o agente Blue covarine parece estar relacionado à associação deste agente com os abrasivos presentes nas formulações dos dentifrícios branqueadores.

Influence of different types of whitening tooth pastes on the tooth color, enamel surface roughness and enamel morphology of human teeth.

Background: Tooth whitening usually includes the direct use of gels containing carbamide or hydrogen peroxide on the tooth enamel surface through a wide variety of products formulas. A generally new advancement in whitening of teeth uses the significant importance of the tooth color shift from yellow to blue in delivering a general enhancement in the observation of tooth whiteness. The aim of the current work was to measure the tooth whitening effects, surface roughness and enamel morphology of six different types of blue covarine-containing and blue covarine-free toothpastes using in vitro models. Methods: A total of 70 sound extracted human premolars were randomly and equally divided into seven groups, and each subjected to tooth brushing using different toothpastes. Tooth color and enamel surface roughness were measured before and after the brushing procedure using a white light interferometer, and scanning electron microscopy (SEM) was used to assess tooth surface after the procedure. Results: Toothpaste containing blue covarine resulted in the greatest improvement in tooth color amongst all groups as well as a statistically significant color difference when compared to blue covarine-free toothpaste.  Furthermore, blue covarine-containing toothpaste resulted in fewer morphological changes to the enamel surface. This was confirmed with SEM images that showed smooth enamel surfaces with fine scratches.   Conclusions: The results from the present study show that blue covarine containing toothpastes are reliable, effective in tooth whitening and produce less surface abrasion when compared to blue covarine-free toothpastes.

Avaliação in vitro do efeito de dentifrícios branqueadores contendo blue covarine sobre o esmalte dentário bovino / In vitro evaluation of the effect of bleaching dentifrices containing blue covarine on bovine dental enamel

Introdução: O blue covarine é um agente branqueador que promove mudanças ópticas na superfície dos dentes, associado aos abrasivos dos dentifrícios, colaborando para o branqueamento dentário. Objetivo: Determinar as alterações de cor, rugosidade e massa do esmalte bovino, após escovação simulada com dentifrícios branqueadores contendo blue covarine nos tempos 6, 12 e 24 meses. Material e método: 80 corpos de prova (CP) foram divididos em 8 grupos (n = 10): grupo controle (GC-água) e 7 grupos teste (GT1-Colgate Total 12, GT2-Oral-B 3D White Perfection, GT3-Colgate Luminous Instant White, GT4-Close Up White Diamond Attraction, GT5-Close Up White-Glacier Fresh, GT6-Sorriso Xtreme White, GT7-Colgate Luminous White Advanced). Os CP foram escurecidos com café e submetidos à escovação simulada por 6, 12 e 24 meses. As avaliações de cor, rugosidade e massa foram realizadas após cada período de escovação. Resultado: Nenhum dentifrício teste promoveu alterações significativas na rugosidade e massa dos CP, contudo, quando comparados ao GC todos promoveram branqueamento significativo. A comparação dos grupos teste não demonstrou diferença significativa na variação de cor entre GT1, GT2, GT3, GT5, GT6 e GT7 nos tempos estudados. O GT4 apresentou comportamento variável de acordo com o tempo, não diferindo estatisticamente de GT3 aos 6, 12 e 24 meses, de GT6 aos 6 e 12 meses e de GT7 aos 12 meses. Conclusão: O efeito branqueador dos dentifrícios contendo blue covarine , após 2 anos de escovação, parece estar relacionado principalmente com a sua associação aos agentes branqueadores mecânicos, que promoveram o polimento das superfícies dentárias.

Introduction: Blue covarine is a bleaching agent that produces optical changes on the surface of the teeth, associated with the abrasives of the dentifrice leading to tooth whitening. Objective: To determine the changes in colour, roughness and mass of the bovine enamel, after simulated brushing with dentifrices - containing blue covariate bleaching - for 6, 12 and 24 months. Material and method: 80 specimens were divided into 8 groups (n = 10): Control group (CG-water) and 7 test groups (TG1-Colgate Total 12, TG2-Oral-B 3D White Perfection, TG3 -Colgate Luminous Instant White, TG4-Close Up White Diamond Attraction, TG5-Close Up White Now-Glacier Fresh, TG6-Sorriso Xtreme White, TG7-Colgate Luminous White Advanced). The specimens were stained with coffee and subjected to simulated brushing for 6, 12 and 24 months. The colour, roughness and mass evaluations were performed after each brushing period. Result: No dentifrice test produced significant alterations in the roughness and mass of the specimens, however, when compared to CG, all of themproduced significant whitening. The comparison of the test groups did not show a significant difference in the colour variation between TG1, TG2, TG3, TG5, TG6 and TG7 in the study. The TG4 presented a variable behavior according to time, not statistically differing from TG3 at 6, 12 and 24 months, neither from TG6 at 6 and 12 months nor from TG7 at 12 months. Conclusion: The whitening effect of dentifrices containing blue covarine, after long periods of brushing, seems to be related mainly to association with mechanical bleaching agents, which, despite abrasives, did not damage the dental structure.