Construction of Chinese Herbal Medicine Traceability System Based on Influencing Factors of Chinese Herbal Medicine Quality / 中国实验方剂学杂志

As a Chinese saying goes， "good Chinese medicinal material makes good medicine"， the quality of Chinese herbal medicines is related to the development prospect of Chinese medicine industry in China. With the rapid development of new technologies such as traceability methods and monitoring instruments， it is imperative to integrate and innovate traditional Chinese herbal medicines with new-generation information technology in view of the quality problems existing in the current production and circulation of Chinese herbal medicines， and it is of great significance for the construction of traceability system to ensure the quality and safety of Chinese herbal medicines and to promote the industry of Chinese herbal medicines to move towards high-quality development. This paper reviews the development history of the traceability system of Chinese herbal medicines in China， takes the influencing factors of the quality of Chinese herbal medicines as the entry point， and proposes that the construction of the traceability system should satisfy the traceability requirements of the characteristics of Chinese herbal medicines and their traditional medication experience. By analyzing the influencing factors of the quality of Chinese herbal medicines， it is pointed out that focusing on the influencing factors to build a traceability system is of great significance for targeting the problematic links at a later stage and exploring the interrelationship between environmental factors and the quality of Chinese herbal medicines. Based on the previous explorations， the author summarizes the system framework， functional modules and practical applications of the traceability system of Chinese herbal medicines， and looks forward to the development of a traceability system with risk early warning function and expert decision-making function in its functional development. Finally， based on the factors affecting the quality of Chinese herbal medicines， the author puts forward several thoughts on construction of the traceability system， and makes an in-depth analysis and puts forward a solution for the current situation that a unified， standardized and universal traceability system has not yet been built， with a view to providing ideas and references for the construction of traceability system of Chinese herbal medicines.

Logistics performance: critical factors in the implementation of end-of-life management practices in the pharmaceutical care process.

The management of healthcare waste and end-of-life medication coming from different sources are primary challenges faced by public health leaders. Several factors may be considered critical and inhibitive to reverse logistics within the context of waste management processes. If those factors are not addressed, they may become obstacles to reverse logistics implementation. The purpose of this study is to evaluate the effect that critical factors play in the adoption of end-of-life management practices for medication and its influence on logistics performance. Literature provided some critical factors: management factor, collaboration factor, information technology factor, infrastructure factor, politics factor, financial and economic factor, end-of-life management practices, and logistics performance factor. A sample of 67 professionals from the public pharmaceutical care process answered a structured questionnaire. The collected data was analyzed using partial least square-structural equation modeling. The theoretical structural test confirmed eleven out of the fifteen hypotheses considered. The results have indicated that end-of-life management practices exert a direct influence on logistics performance. The analysis confirmed a direct effect of the information technology factor on end-of-life management practices, but not a moderation effect. Findings have contributed to the literature by providing deeper insights into the relationship between end-of-life management practices for medicines and logistics performance. Moreover, it supports health managers' decision-making in the pharmaceutical care process improvement and engagement with solid waste management policies.

Critical events and pivotal factors as tools for analyzing the sustainability of online study programs.

A critical aspect of designing and running online study programs is the identification of factors and elements that could potentially threaten the continuation of studies. In this study, we first identified a set of critical events that occurred in the running of a Finnish online doctoral study program over 16 years. Next, we analyzed the events using a four-pillar sustainability model, which consisted of the economic, social, environmental, and ethical pillars. We detected several contextually relevant and dynamic pivotal factors related to each of the pillars, which had effects on the sustainability of the program at the time of the critical events. The analysis revealed that positive pivotal factors in one sustainability pillar can be used to compensate for negative pivotal factors in the other pillars. Two aspects that were crucial for the sustainability of the online doctoral study program were the resilience and shared commitment of the community involved in its activities, which helped in overcoming any challenges encountered. Based on this study, we recommended that future research should design novel solutions that help online study programs to proactively identify potential critical events and related pivotal factors. Furthermore, studies should find creative approaches for constructively coping with critical events that have been identified.

Impact of the critical factors of customer experience on well-being: Joy and customer satisfaction as mediators.

This study constructs a formation model of customer well-being (CWB) in customer experience with joy and customer satisfaction as mediating factors linking three critical factors-convenience, performance and relationship of customer experience with CWB. By collecting data from customers of retailing, the model was empirically tested. The results show that the three critical factors all have positive effects on CWB. Meanwhile, service performance has a direct effect on CWB. Joy plays a key role in the formation of CWB mediating the relationship between the three critical factors and CWB. This study is the first in the literature to explore CWB from the perspective of customer experience with joy as an antecedent of CWB. It provides important implications for managers to enhance customer experience and CWB in the service setting. It also helps managers to pay attention to the role of customer joy in customer experience and make full use of it.

Modeling Intention-Based Critical Determinants of E-Commerce Utilization: Emerging Business Models and Transformation in the Digital World.

Companies in the world today understand that keeping users in touch is essential to enhancing their trust. The primary objective of this study was to determine the intention-based critical determinants of E-commerce utilization in China from the end users' perspective. We developed a framework that identifies the factors that influence E-commerce utilization in China. Besides, we introduced observational research (data analysis) conducted in a real-world E-commerce sense. Results are based on a sample of 400 respondents by employing a comprehensive questionnaire survey. The structural equation modeling (SEM) and the partial least squares (PLS) regression approach was used to analyze the data. Study results show that perceived usefulness, perceived ease of use, reputation, trust in vendors, and purchase frequency significantly influence consumers' intention to use E-commerce systems. Research outcomes emphasize transforming social norms, raising consumers' awareness, redesigning policy frameworks, and highlighting the paybacks that E-commerce offers through integrative and consistent efforts.

Dynamic high pressure microfluidization-assisted extraction of plant active ingredients: a novel approach.

The extraction method has a great influence on the yield, quality, chemical structure, and biological activities of active ingredients. Safe and efficient extraction of active ingredients is one of the important problems facing the food and pharmaceutical industry. As a pretreatment approach for the extraction of active ingredients, dynamic high pressure microfluidization (DHPM) is a promising strategy that can not only effectively increase the yield of active ingredients but also strengthen the bioactivities of active ingredients, and take the advantages of mild operating temperature and environmental friendliness. In this review, the research progress of DHPM-assisted extraction of active ingredients from plant materials in recent ten years is overviewed. The DHPM equipment, strengthening mechanism, operating procedure, critical factors and application of DHPM-assisted extraction are introduced in detail, together with the advantages and disadvantages. Furthermore, its future development trend is discussed at the end. DHPM-assisted extraction is considered as the ideal technique of better homogenization effects, less solvent consumption, more reliable operation, and so on, making it a promising method to acquire active ingredients efficiently. Therefore, this technique is worthy of further theoretical research and experimental operation.

Experiencias sobre la implementación del Expediente Clínico Electrónico / Experiences on the implementation of the Electronic Medical Record

Resumen Introducción. Un elemento de la e-salud que ha cobrado gran relevancia es el Expediente Clínico Electrónico (ECE) ya que es un medio para lograr mejores resultados en la práctica médica. Al momento, han sido pocas las investigaciones que se han centrado en analizar e identificar la situación de esta estrategia en el mundo. Por ello, el objetivo de esta investigación es analizar el panorama actual del ECE en diversos países considerando las ventajas, desventajas, desafíos y factores de éxito en su implementación. Metodología: Se realizó una revisión de la literatura existente sobre el ECE en base de datos especializadas. Para obtener estos estudios se utilizó la base de datos de scopus y sciencedirect , utilizando palabras de búsqueda como como registro electrónico de salud, registro médico electrónico o expediente clínico electrónico; se seleccionaron solamente aquellos estudios con un alto factor de impacto, mismo que se refiere al número de veces que se hayan citado los artículos consultados. Se seleccionaron y analizaron 64 estudios académicos. Resultados. Se encontró que aún existen importantes desafíos y desventajas en la implementación del ECE como la interoperabilidad semántica y el estrés laboral que genera en los usuarios este sistema. Conclusiones. Existen cuestiones importantes que aún quedan por resolver para una implementación eficaz del ECE. Es necesario integrar a todos los involucrados en el proceso de cambio, así como establecer las medidas de seguridad necesarias para garantizar la privacidad de la información.

Abstract Introduction. An element of e-health that has gained great relevance is the Electronic Medical Record (ECE) since it is a means to achieve better results in medical practice. At the moment, few investigations have focused on analyzing and identifying the situation of this strategy in the world. Therefore, the objective of this research is to analyze the current panorama of ECE in various countries considering the advantages, disadvantages, challenges and success factors in its implementation. Methodology. A review of the existing literature on ECE was carried out in specialized databases. To obtain these studies, the scopus and sciencedirect databases were used, using search words such as "electronic health record", "electronic medical record" or "electronic medical record"; Only those studies with a high impact factor were selected, which refers to the number of times the articles consulted have been cited. 64 academic studies were selected and analyzed. Results. It was found that there are still important challenges and disadvantages in the implementation of ECE such as semantic interoperability and the work stress that this system generates in users. Conclusions. There are important issues that remain to be resolved in the effective implementation of the ECE. It is necessary to integrate all those involved in the change process as well as to establish the necessary security measures to guarantee the privacy of the information.

Pharmaceutical Development and Design of Thermosensitive Liposomes Based on the QbD Approach.

This study aimed to produce thermosensitive liposomes (TSL) by applying the quality by design (QbD) concept. In this paper, our research group collected and studied the parameters that significantly impact the quality of the liposomal product. Thermosensitive liposomes are vesicles used as drug delivery systems that release the active pharmaceutical ingredient in a targeted way at ~40-42 °C, i.e., in local hyperthermia. This study aimed to manufacture thermosensitive liposomes with a diameter of approximately 100 nm. The first TSLs were made from DPPC (1,2-dipalmitoyl-sn-glycerol-3-phosphocholine) and DSPC (1,2-dioctadecanoyl-sn-glycero-3-phosphocholine) phospholipids. Studies showed that the application of different types and ratios of lipids influences the thermal properties of liposomes. In this research, we made thermosensitive liposomes using a PEGylated lipid besides the previously mentioned phospholipids with the thin-film hydration method.

Critical Factors and Economic Methods for Regulatory Impact Assessment in the Medical Device Industry.

INTRODUCTION: The regulatory area is one that restricts human behaviour and opportunities, but it also allows the prevention of loss of property, health, or even life in various fields. Regulations provide the market with public confidence, which is extremely important in the field of innovative medical devices. The aim of this article is to analyse critical factors and economic methods for regulatory impact assessment in the medical device industry, to focus on the finances, processes, or innovation activity of organisations operating in the medical device sector. METHODS: The paper consists of a scoping review according to the PRISMA methodology of the available literature in Web of Science and Scopus database, whereby combing the keywords "regulation" AND "innovation" AND "medical device" AND "economic impact," we obtained a set of 156 results in the form of English-written articles. The output was then limited to the period between 2011 and 2020. Finally, 23 papers were used based on the exclusion and inclusion criteria. RESULTS: The resulting challenges of the identified problems in particular are the amount of high-quality data available at an appropriate cost and the availability of a flexible notified body. There are also challenges specific to the situation, such as demands on the safety of medical devices for children. From a public expectations point of view, there is a continuing need to maintain the urgency of the balance between available innovation and safety. DISCUSSION: As for the methods of economic assessment in general, or methods for assessing the economic impact of regulations in particular, cost-effectiveness analysis is the most commonly used method for research and development, while internal rate of return is frequently used for the producers, and budget impact analysis is typically used for healthcare service providers. A non-financial indicator that is often discussed is the time demands associated with meeting compliance requirements. The time-to-market indicator is also often mentioned. Economic and financial topics are not discussed in depth, as the reviewed articles simply mention the generally high costs attendant on complying with regulations and obtaining certificates.

The factors influencing the innovative performance of leaders in nurses' professional: a developing country perspective.

PURPOSE: The health-care services in Iraq currently face many challenges. The most noted is the lack of effective nursing leaders to meet the growing needs of the health-care services. Effective nursing leadership is critical to the health-care system, affecting work performance, quality of care and staff satisfaction. The literature suggests that nursing leaders in Iraq are not adequately trained to provide leadership to improve the nursing profession and have limited involvement in decision-making. The purpose of this study is to explore the views of nurses on what they believe constitutes effective leadership in Iraq. DESIGN/METHODOLOGY/APPROACH: A qualitative methods approach is used involving 20 semi-structured interviews of senior nurses. The sample of nurses came from two large general hospitals in Iraq. The qualitative data was thematically analyzed and interpreted. FINDINGS: The study results indicated that there were factors that influence the performance of nurse leader, namely, excessive workload, personal relationship with nursing staff, professional recognition of nursing and selection criteria of leaders. Test results show that there were significant differences in views of the nurses toward nurse leaders' performance. This research concludes that the nurse leader performance in developing countries is affected by excessive workload, personal relationship with nursing staff, professional recognition of nursing and selection criteria of leaders. ORIGINALITY/VALUE: The relevance of the study stems from the scarcity of research on the leader performance in developing countries, while studies on the factors influencing the innovative performance of leaders in nurses' professional are significantly limited. This study is one of the earliest studies that investigate these factors influencing the nurse leader's performance.

An Updated Risk Assessment as Part of the QbD-Based Liposome Design and Development.

Liposomal formulation development is a challenging process. Certain factors have a critical influence on the characteristics of the liposomes, and even the relevant properties can vary based on the predefined interests of the research. In this paper, a Quality by Design-guided and Risk Assessment (RA)-based study was performed to determine the Critical Material Attributes and the Critical Process Parameters of an "intermediate" active pharmaceutical ingredient-free liposome formulation prepared via the thin-film hydration method, collect the Critical Quality Attributes of the future carrier system and show the process of narrowing a general initial RA for a specific case. The theoretical liposome design was proved through experimental models. The investigated critical factors covered the working temperature, the ratio between the wall-forming agents (phosphatidylcholine and cholesterol), the PEGylated phospholipid content (DPPE-PEG2000), the type of the hydration media (saline or phosphate-buffered saline solutions) and the cryoprotectants (glucose, sorbitol or trehalose). The characterisation results (size, surface charge, thermodynamic behaviours, formed structure and bonds) of the prepared liposomes supported the outcomes of the updated RA. The findings can be used as a basis for a particular study with specified circumstances.

The Critical Factors Affecting the Deployment and Scaling of Healthcare AI: Viewpoint from an Experienced Medical Center.

Healthcare Artificial Intelligence (AI) has the greatest opportunity for development. Since healthcare and technology are two of Taiwan's most competitive industries, the development of healthcare AI is an excellent chance for Taiwan to improve its health-related services. From the perspective of economic development, promoting healthcare AI must be a top priority. However, despite having many breakthroughs in research and pilot projects, healthcare AI is still considered rare and is broadly used in the healthcare setting. Based on a medical center in Taiwan that has introduced a variety of healthcare AI into practice, this study discussed and analyzed the issues and concerns in the development and scaling of medical AIs from the perspective of various stakeholders in the healthcare setting, including the government, healthcare institutions, users (healthcare workers), and AI providers. The present study also identified critical influential factors for the deployment and scaling of healthcare AI. It is hoped that this paper can serve as an important reference for the advancement of healthcare AI not only in Taiwan but also in other countries.

Intention-Based Critical Factors Affecting Willingness to Adopt Novel Coronavirus Prevention in Pakistan: Implications for Future Pandemics.

Since human beings have a long tradition of coexistence with pandemics, which may profoundly impact them, adopting preventive measures is crucial for humankind's survival. This study explores the intention-based critical factors affecting the willingness of individuals to adopt pandemic prevention. To this end, a representative sample of 931 Pakistanis filled in an online questionnaire. However, only 828 questionnaires were found to be complete and valid for path modeling analysis. The core findings are as follows: Firstly, peer groups' beliefs, self-efficacy, perceived risk, pandemic knowledge, ease of pandemic prevention adoption, and risk-averse behavior are revealed as driving forces of the individuals' willingness to adopt pandemic prevention. Contrastingly, a lack of trust in political will and mythical attitude towards pandemics are uncovered as inhibitors. Nevertheless, moral values depict a neutral role. Secondly, the peer groups' beliefs are highest ranked, followed by the lack of trust in political will and a mythical attitude towards pandemic prevention. Finally, moral values are determined as the lowest-ranked critical factor. Based on these results, the government should promote awareness campaigns on lethality and fatality of the pandemic at both centralized and decentralized levels to win people's trust at the grass-roots level and overcome the mythical attitude of individuals at all societal levels. Besides, access to personal protective gears should be made feasible since an easier pandemic prevention adoption would increase the individuals' willingness to adopt such preventative measures.

Application of Green Nanoemulsion for Elimination of Rifampicin from a Bulk Aqueous Solution.

The study aimed to prepare green nanoemulsion (GNE) multi-components ((water/dimethyl sulfoxide-transcutol/isopropyl alcohol/capmul MCM C8 (CMC8)) to remove rifampicin (RIF) from a contaminated aqueous bulk solution. Pseudo ternary phase diagrams dictated several batches of GNE prepared following the reported method. Selected nanoemulsions (NF1-NF5) were characterized for morphology, globular size, size distribution (polydispersity index, PDI), viscosity, zeta potential, refractive index (RI), and free-thaw kinetic stability. They were investigated for percent removal efficiency (%RE) of RIF from the bulk aqueous solution for varied time intervals (10-60 min). Finally, scanning electron microscopy-energy dispersive x-ray (SEM-EDX) and inductive coupled plasma-optical emission system (ICP-OE) were used to confirm the extraction of trace content of dimethyl sulfoxide (DMSO) and others in the treated water. Considering the data obtained for globule size, PDI, viscosity, zeta potential, freeze-thaw stability, and refractive index, NF5 was the most suitable for RIF removal. The largest %RE value (91.7%) was related to NF5, which may be prudent to correlate with the lowest value (~39 nm) of size (maximum surface area available for contact adsorption), PDI (0.112), and viscosity (82 cP). Moreover, %RE was profoundly influenced by the content of CMC8 and the aqueous phase. These two phases had immense impact on the viscosity, size, and RI. The percent content of water, Smix, and CMC8 were 15% w/w), 60% w/w, and 25% w/w, respectively in NF5. SEM-EDX and ICP-OE confirmed the absence of DMSO and other hydrophilic components in the treated water. Thus, efficient NF5 could be a promising option to the conventional method to decontaminate the polluted aqueous system.

Investigating the Critical Factors of Professionals' BIM Adoption Behavior Based on the Theory of Planned Behavior.

In recent years, building information modeling (BIM) has been receiving growing interest from the construction industry of China. Nevertheless, although BIM has many foreseeable advantages, many studies claimed that these advantages have not been sufficiently achieved in practice at the current stage. In this circumstance, it is interesting to investigate what really drives the adoption of BIM. Based on Ajzen's theory of planned behavior (TPB), a hypothetical model which involves nine latent variables is initially established. Then, a questionnaire is designed and distributed to the construction professionals in the Chinese context. After reliability and validity analysis, the goodness-of-fit of the initial model and the related theoretical assumptions are tested through structural equation modeling (SEM). Based on the modification indicators, a modified model is finally derived. Results show that economic viability and governmental supervision are the most critical factors that influence construction professionals' BIM adoption behavior in China, sharing weights of 0.37 and 0.34, respectively, whereas other factors play limited roles in this regard. The research findings revealed from this study can provide insightful references for countries that intend to promote BIM adoption in a similar circumstance.

A Proposed Methodology for a Risk Assessment-Based Liposome Development Process.

The requirements of a liposomal formulation vary depending on the pharmaceutical indication, the target patient population, and the corresponding route of administration. Different preparation methods require various material attributes (MAs) (properties and characteristics of the components) and process parameters (PPs) (settings of the preparation method). The identification of the quality target product profile for a liposome-based formulation, the critical quality attributes of the liposomes, and the possible MAs and PPs that may influence the key characteristics of the vesicles facilitates pharmaceutical research. Researchers can systematise their knowledge by using the quality by design (QbD) approach. The potential factors that influence the quality of the product can be collected and studied through a risk assessment process. In this paper, the requirements of a liposome formulation prepared via the thin-film hydration preparation technique are presented; furthermore, the possible factors that have an impact on the quality of the final product and have to be considered and specified during the development of a liposomal formulation are herein identified and collected. The understanding and the application of these elements of QbD in the pharmaceutical developments help to influence the quality, the achievements, and the success of the formulated product.

Design and Fabrication of Silicon Nanowire-Based Biosensors with Integration of Critical Factors: Toward Ultrasensitive Specific Detection of Biomolecules.

As critical factors affecting the sensing performance of silicon nanowire (SiNW) biosensors, the structure, functional interface, and detection target were analyzed and designed to improve sensing performance. For an improved understanding of the dependence of sensor structure on sensitivity, a simple theoretical analysis was proposed to predict the sensitivity of biosensors with different SiNW types, widths, and doping concentrations. Based on the theoretical analysis, a biosensor integrating optimized critical factors was designed and fabricated. Optimizations focusing on the following aspects are considered: (1) employing n-type SiNW and controlling the impurity doping concentration of SiNW at approximately 2 × 1016-6 × 1016 atoms/cm3 to obtain a suitable charge density, (2) minimizing the SiNW width to 16.0 nm to increase the surface area-to-volume ratio, (3) using a native oxide layer on SiNW as a gate insulator to transport the captured charge molecules closer to the SiNW surface, (4) modifying the SiNW surface by 2-aminoethylphosphonic acid coupling to form a high-density self-assembled monolayer for enhancing the stability bound molecules, and (5) functionalizing the SiNW with ovalbumin molecules for specifically capturing the target immunoglobulin G (IgG) molecules. The sensing performance was evaluated by detecting IgG with concentrations ranging from 6 aM to 600 nM and control experiments. The SiNW biosensor revealed ultrahigh sensitivity and specific detection of target IgG with a measured limit of detection of 6 aM. The integration of the critical SiNW biosensor factors provides a significant possibility of a rapid and ultrasensitive diagnosis of diseases at their early stages.

Critical factors for lentivirus-mediated PRDX4 gene transfer in the HepG2 cell line.

Optimization of critical factors affects transduction efficiency and is able to reduce reagent consumption. The present study aimed to determine the optimum transduction conditions of small hairpin (sh)RNA against peroxiredoxin 4 (PRDX4) in the HepG2 cell line. Cell viability assays were conducted based on serum condition, incubation time, polybrene concentration and antibiotic dose selection. Non-targeting control shRNA was transduced into HepG2 cells in a 5-fold serial dilution, and colonies positive for green fluorescent protein were counted using ImageJ software. Reverse transcription-quantitative polymerase chain reaction and western blot analysis were performed to validate PRDX4 expression. The optimum cell density for transduction was 5.0×103 cells/well in 96-well plates to achieve 40 to 50% confluency the following day. The transduction media consisted of 10% fetal bovine serum (FBS) and 12 µg/ml polybrene, and was used to dilute lentiviral particles at a functional titer of 4.9×105 TU/ml for multiplicity of infection (MOI) of 20, 15 and 10, for 24 h of incubation. Selection with 7 µg/ml puromycin was performed in transduced cells. shRNA 3 was revealed to inhibit PRDX4 mRNA and protein expression. In conclusion, PRDX4 was successfully silenced in 5.0×103 HepG2 cells cultured with 10% FBS and 12 µg/ml polybrene, at a 4.9×105 TU/ml functional titer for MOI of 20, 15 and 10.

The Effects of Residual Air and Viscosity on the Rate of Heat Penetration of Retort Food Simulant in Pouch When Using Static and Oscillating Motions.

The objectives of this work were to determine the effect of 3 levels of residual air and 2 different retort motions on the value of the average heating slope of the rate of heat penetration of 3 different viscosities of a food simulant in flexible retort pouches. Pouches were thermally processed in a water spray automated batch retort system using 2 different methods of motion: static and oscillating continuously at a speed of 10.5 rotations per min (RPM) with an angle of 15°. Nine residual air and viscosity combinations were processed during each experimental run: low viscosity with no residual air (LV-NRA), medium viscosity with no residual air (MV-NRA), high viscosity with no residual air (HV-NRA), low viscosity with medium residual air (LV-MRA), medium viscosity with medium residual air (MV-MRA), high viscosity with medium residual air (HV-MRA), low viscosity with high residual air (LV-HRA), medium viscosity with high residual air (MV-HRA), and high viscosity with high residual air (HV-HRA). As the amount of residual air in the pouches increased, the average heating slope value decreased in both static and oscillating motions. As the viscosity of the product increased the amount of residual air affected the average heating slope less in static and oscillating motions. Overall, the oscillating motion resulted in faster rates of heat penetration in all viscosities compared to static mode. The oscillating motion reduced processing times up to 27% compared to static mode. PRACTICAL APPLICATION: This research can be applied to food manufacturers that are retorting foods in pouches. Residual air in pouches has been studied previously; however, with the development of new retort motions, more research needs to be conducted about the effect of residual air in a pouch using the different motions. Food manufacturers can use this information to optimize their amount of residual air based on their product viscosity and retort motion. This could dramatically lower processing time which would save money and increase output as well as potentially increases product quality. This research is aimed at influencing food manufacturers, process authorities, and product developers.

Carbon exchanges and their responses to temperature and precipitation in forest ecosystems in Yunnan, Southwest China.

Forest ecosystems play an increasingly important role in the global carbon cycle. However, knowledge on carbon exchanges, their spatio-temporal patterns, and the extent of the key controls that affect carbon fluxes is lacking. In this study, we employed 29-site-years of eddy covariance data to observe the state, spatio-temporal variations and climate sensitivity of carbon fluxes (gross primary productivity (GPP), ecosystem respiration (Reco), and net ecosystem carbon exchange (NEE)) in four representative forest ecosystems in Yunnan. We found that 1) all four forest ecosystems were carbon sinks (the average NEE was -3.40tCha-1yr-1); 2) contrasting seasonality of the NEE among the ecosystems with a carbon sink mainly during the wet season in the Yuanjiang savanna ecosystem (YJ) but during the dry season in the Xishuangbanna tropical rainforest ecosystem (XSBN), besides an equivalent NEE uptake was observed during the wet/dry season in the Ailaoshan subtropical evergreen broad-leaved forest ecosystem (ALS) and Lijiang subalpine coniferous forest ecosystem (LJ); 3) as the GPP increased, the net ecosystem production (NEP) first increased and then decreased when the GPP>17.5tCha-1yr-1; 4) the precipitation determines the carbon sinks in the savanna ecosystem (e.g., YJ), while temperature did so in the tropical forest ecosystem (e.g., XSBN); 5) overall, under the circumstances of warming and decreased precipitation, the carbon sink might decrease in the YJ but maybe increase in the ALS and LJ, while future strength of the sink in the XSBN is somewhat uncertain. However, based on the redundancy analysis, the temperature and precipitation combined together explained 39.7%, 32.2%, 25.3%, and 29.6% of the variations in the NEE in the YJ, XSBN, ALS and LJ, respectively, which indicates that considerable changes in the NEE could not be explained by variations in the temperature and precipitation. Therefore, the effects of other factors (e.g., CO2 concentration, N/P deposition, aerosol and other variables) on the NEE still require extensive research and need to be considered seriously in carbon-cycle-models.