Decreased Arsenic Disposition and Alteration of its Metabolic Profile in mice Coexposed to Fluoride.

Inorganic arsenic (iAs) and fluoride (iF) are ubiquitous elements whose coexistence is frequent in several regions of the world due to the natural contamination of water sources destined for human consumption. It has been reported that coexposure to these two elements in water can cause toxic effects on health, which are controversial since antagonistic and synergistic effects have been reported. However, there is little information on the possible toxicological interaction between concurrent exposure to iAs and iF on the iAs metabolism profile.The goal of this study was to determine the effect of iF exposure on iAs methylation patterns in the urine and the tissues of female mice of the C57BL/6 strain, which were divided into four groups and exposed daily for 10 days through drinking water as follows: purified water (control); arsenite 1 mg/L, fluoride 50 mg/L and arsenite & fluoride 1:50 mg/L.To characterize the iAs methylation pattern in concomitant iF exposure, iAs and its methylated metabolites (MAs and DMAs) were quantified in the tissues and the urine of mice was exposed to iAs alone or in combination. Our results showed a statistically significant decrease in the arsenic species concentrations and altered relative proportions of arsenic species in tissues and urine in the As-iF coexposure group compared to the iAs-exposed group. These findings show that iF exposure decreases arsenic disposition and alters methylation capacity.Nevertheless, additional studies are required to elucidate the mechanisms involved in the iAs-iF interaction through iF exposure affecting iAs disposition and metabolism.

Fatores que aumentam o tempo do processo judicial no Brasil / Factores que aumentan el tiempo del proceso judicial en Brasil / Factors increasing case disposition time in Brazil

Resumo A morosidade judicial no Brasil é um problema grave e persistente. Este trabalho ajuda a compreender as causas desse problema, na medida em que identifica e discute 12 fatores que aumentam o tempo do processo judicial no país, os quais foram identificados com base na análise de conteúdo de entrevistas com 15 atores-chave do sistema brasileiro de Justiça, entre juízes, promotores e advogados. Cada um dos fatores foi discutido segundo a literatura acadêmica, relatórios oficiais e indicadores de desempenho. Os achados da pesquisa mostram que fatores como o baixo custo do ajuizamento, a ausência de punição a litigantes repetitivos e o ajuizamento de execuções fiscais promovem uma sobrecarga de processos nos tribunais. O Judiciário também parece sobrecarregado por atribuições que extrapolam a função jurisdicional, como coletar evidências e localizar devedores e bens. O excesso de disputas e atribuições teria tornado a máquina judiciária brasileira grande e lenta, além de cara. Políticas públicas de redução da morosidade judicial no país são sugeridas.

Resumen Las demoras judiciales en Brasil son un problema grave y persistente. Este trabajo ayuda a comprender las causas de este problema, ya que identifica y discute 12 factores que aumentan la duración del proceso judicial en el país. Los factores fueron identificados a partir del análisis de contenido de entrevistas con 15 actores clave del sistema de justicia brasileño, entre jueces, fiscales y abogados. Cada factor fue discutido con base en la literatura académica, informes oficiales e indicadores de desempeño. Los hallazgos de la investigación muestran que factores como el bajo costo de presentación, la ausencia de sanción para los litigantes reincidentes y la presentación de ejecuciones fiscales promueven una sobrecarga de procesos en los tribunales. El Poder Judicial también parece estar cargado de atribuciones que van más allá de la función jurisdiccional, como reunir pruebas y localizar deudores y bienes. El exceso de disputas y asignaciones habría hecho grande y lenta la máquina judicial brasileña, además de costosa. Se sugieren políticas públicas para reducir las demoras judiciales en el país.

Abstract Judicial delay in Brazil is a severe and persistent problem. This work helps to understand the causes of this issue, by identifying and discussing 12 factors that increase the length of the judicial process in the country. These factors were identified through content analysis of interviews with 15 key players in the Brazilian justice system, including judges, prosecutors, and lawyers. Each factor was discussed based on academic literature, official reports, and performance indicators. The research findings show that factors such as the low cost of filling, the absence of punishment for repetitive litigants, and tax foreclosures promote an overload of processes in the courts. The Judiciary also seems to be burdened with attributions beyond the jurisdictional function, such as collecting evidence and locating debtors and assets. The excess of disputes and assignments has made the Brazilian judicial machine large, slow, and expensive. Public policies to reduce judicial delays in the country are suggested.

Maternal and Fetal Expression of ATP-Binding Cassette and Solute Carrier Transporters Involved in the Brain Disposition of Drugs.

Evidence from preclinical and clinical studies demonstrate that pregnancy is a physiological state capable of modifying drug disposition. Factors including increased hepatic metabolism and renal excretion are responsible for impacting disposition, and the role of membrane transporters expressed in biological barriers, including the placental- and blood-brain barriers, has received considerable attention. In this regard, the brain disposition of drugs in the mother and fetus has been the subject of studies attempting to characterize the mechanisms by which pregnancy could alter the expression of ATP-binding cassette (ABC) and solute carrier (SLC) transporters. This chapter will summarize findings of the influence of pregnancy on the maternal and fetal expression of ABC and SLC transporters in the brain and the consequences of such changes on the disposition of therapeutic drugs.

Cumplimiento de objetivos en pacientes adultos con diabetes mellitus tipo 1: tasa estimada de disposición de glucosa como marcador clínico / Achievement of objectives in adult patients with type 1 diabetes mellitus: estimated glucose disposition rate as a clinical marker

Resumen Introducción: las guías de práctica clínica en diabetes mellitus (DM) establecen objetivos clínicos precisos sobre el buen manejo de la enfermedad, pero poco se sabe sobre el adecuado cumplimiento en nuestro medio. El sobrepeso y el sedentarismo han generado estigmas de síndrome metabólico en la población con DM1. Objetivos: evaluar el cumplimiento en cinco de dichos criterios: HbA1c <7%, c-LDL ≤100 mg/dl, actividad física ≥3 veces/ semana, tensión arterial sistólica (TAS) <140 mm Hg y no tabaquismo, y su asociación con insulinorresistencia determinada por la tasa estimada de disposición de glucosa (TeDG). Materiales y métodos: en 415 DM1 ≥18 años, 52% mujer y una edad de 34,8±13,9 años, se evaluó HbA1c, c-LDL, frecuencia semanal de actividad física (AF) estructurada, TAS y tabaquismo actual. Se determinó el grado de asociación a género, edad, antigüedad de la DM, nivel de educación, cobertura médica, índice de masa corporal (IMC) y sensibilidad a la insulina medida a través de la TeDG. Las variables cualitativas se analizaron por test de chi. y las cuantitativas por test de ANOVA I con post hoc por test de Tukey. Un valor de p<0,05 se consideró estadísticamente significativo. En todos los casos se utilizó un intervalo de confianza del 95%. Resultados: el 94,8% presentó TAS <140 mm Hg, el 82,2% no tabaquismo actual, el 56,5% c-LDL ≤100 mg/dL, el 39% AF ≥3 veces/semana y el 20,3% HbA1c <7%. Solo 26 pacientes (6,2%) alcanzaron en forma combinada los cinco objetivos analizados. El cumplimiento de dichos objetivos se asoció a nivel de educación secundaria o mayor (p=0,002) y cobertura de salud con obra social o prepaga (p=0,002). Hubo asociación significativa entre la TeDG en quienes cumplieron los cinco objetivos (p=0,02) y en forma individual en cuatro de ellos (TAS, c-LDL, HbA1c y AF). Conclusiones: de los 415 pacientes evaluados, el 6,2% cumplió los cinco objetivos. Solo el control de la TAS, no fumar y un c-LDL <100 mg/dL lo cumplió la mayoría de los pacientes. Una HbA1c <7% fue el objetivo individual que presentó menor grado de cumplimiento.

Abstract Introduction: the clinical practice guidelines in diabetes mellitus (DM) establish precise clinical objectives for the good management of the disease, but little is known about adequate compliance in our environment. Being overweight and sedentary have generated stigmas of metabolic syndrome in the population with DM1. Objectives: to evaluate the compliance with 5 of these criteria: HbA1c <7%, c-LDL ≤100 mg/dL, physical activity (PA) ≥3 times/week, systolic blood preasure (SBP) <140 mm Hg, and no smoking and its association with insulin resistance determined by the estimated glucose disposition rate (eGDR). Materials and methods: in 415 DM1 ≥18 years, 52% women, age 34.8±13.9 years, HbA1c, c-LDL, weekly frequency of structured PA, SBP, and current smoking were evaluated. The degree of association with gender, age, age of DM, level of education, medical coverage, BMI, and insulin sensitivity measured through eGDR was determined. Qualitative variables were analyzed by chi-square test and quantitative variables by ANOVA I test and analysis post hoc by Tukey's test for multiple comparisons. A value of p<0.05 was considered statistically significant. A 95% confidence interval was used in all cases. Results: systolic BP <140 mm Hg presented 94.8%, current non-smoking 82.2%, c-LDL ≤ 100 mg/dL 56.5%, physical activity (PA) ≥3 times a week 39% and HbA1c <7% 20.3%. Only 26 patients (6.2%) achieved the 5 objectives analyzed in combination. The fulfillment of the 5 objectives was associated at the level of ≥ secondary education (p=0.002) and health coverage with social welfare or prepaid (p=0.002). There was a significant association between TeDG in those who fulfilled the 5 objectives (p=0.02) and individually in 4 of them (SPB, c-LDL, HbA1c, and PA). Conclusions: of the 415 patients evaluated in our study, only 6.2% met the 5 criteria under consideration. Only control of SBP, non-smoking and c-LDL <100 were complied with by the majority of the patients. HbA1c <7% was the individual objective with the lowest degree of compliance.

Descriptive Analysis of Casualties Rapidly Returned to the Fight after Injury: Reverse Triage Implications for Large Scale Combat Operations.

BACKGROUND: During large scale combat operations, rising numbers of casualties will likely outstrip in-theater US military medical hospitalization assets. This highlights the importance of identifying those casualties who can return to the fight in order to minimize further medical resource depletion. We describe specific characteristics of casualties returned to duty without requiring evacuation from theater during recent major combat operations. MATERIALS AND METHODS: We conducted a secondary analysis of previously published data from the Department of Defense Trauma Registry during 01 January 2007 through 17 March 2020. We included all adult US military casualties. We categorized casualties according to documented disposition, namely, return to duty within 72 hours without evacuation from theater, return to duty greater than 72 hours without evacuation from theater, and all other casualties. RESULTS: Of 10,182 adult US military casualties, 3,856 (37.9%) returned to duty within 72 hours without evacuation from theater and 220 (2.2%) returned to duty in greater than 72 hours without evacuation from theater. The cohort that rapidly returned to duty had a lower median injury severity score (2) than casualties returning to duty in greater than 72 hours (4) and those evacuated from theater (11). Notably higher proportions of casualties evacuated from theater sustained injuries to the face, thorax, abdomen, and extremities. Modes of transportation were similar across all three groups, though casualties undergoing evacuation from theater were more likely to undergo air transportation during the spectrum of their medical care. CONCLUSIONS: Most combat casualties returning to duty without evacuation from theater did so within 72 hours of hospitalization. Casualties not requiring evacuation from theater were less likely to sustain injuries to the face, thorax, abdomen, and extremities.

Pre-Operative Predictors for Discharge to Post-Acute Care Facilities After Total Knee Arthroplasty.

BACKGROUND: Joint replacement surgery is in increasing demand and is the most common inpatient surgery for Medicare beneficiaries. The venue for post-operative rehabilitation, including early outpatient therapy after surgery, influences recovery and quality of life. As part of a comprehensive total joint program at Kaiser Permanente Colorado, we developed and validated a predictive model to anticipate and plan the disposition for rehabilitation of our patients after total knee arthroplasty (TKA). METHODS: We analyzed data for TKA patients who completed a pre-operative Total Knee Risk Assessment in 2017 (the model development cohort) or during the first 6 months of 2018 (the model validation cohort). The Total Knee Risk Assessment, which is used to guide disposition for rehabilitation, included questions in mobility, social, and environment domains. Multivariable logistic regression was used to predict discharge to post-acute care facilities (PACFs) (ie, skilled nursing facilities or acute rehabilitation centers). RESULTS: Data for a total of 1481 and 631 patients who underwent TKA were analyzed in the development and validation cohorts, respectively. Ninety-three patients (6.3%) in the development cohort and 22 patients (3.5%) in the validation cohort were discharged to PACFs. Eight risk factors for discharge to PACFs were included in the final multivariable model. Patients with a diagnosis of neurological disorder and with a mobility/balance issue had the greatest chance of discharge to PACFs. CONCLUSION: This validated predictive model for discharge disposition following TKA may be used as a tool in shared decision-making and discharge planning for patients undergoing TKA.

Correlates between sexual desire and disposition to sexual fantasies with inhibitory control and cognitive planning in young Colombians / Correlación del deseo sexual y disposición a fantasías sexuales con control inhibitorio y planificación cognitiva en jóvenes colombianos

Abstract Objective: the research was oriented to investigate the correlation between some executive functions (inhibitory control, risk-benefit calculation, cognitive flexibility, the planning ability, and decision making) and the general, dyadic and solitary sexual desire, sexual desire inhibition and disposition to sexual fantasies in a 17-to-30-year-old people sample. Method: An observational cross-sectional study in a purposive sample of 64 young college students, aged between17 and -30, who were in a couple relationship at the time of the study and gave their consent for their participation in the research. The participants completed the Neuropsychological Battery of Executive Functions and Frontal Lobes tasks (BANFE for its abbreviation in Spanish): Stroop, card games, card classification and Hanoi Tower, and it was administered the Inhibited Sexual Desire Test, the Sexual Desire Inventory (SDI-2) and the Scale of Attitude Towards Sexual Fantasies. Results: The results indicate a correlation between the executive functions and sexual desire; it was found a correlation between total and dyadic sexual desire and disposition towards sexual fantasies with inhibitory control; and the inhibited sexual desire was correlated to planning ability and inhibitory control. Discussion: Although the study presents some methodological limitations (size of the sample and need of a more rigorous validation of instruments in the Colombian population), the results confirm previous research findings, allowing to formulate new hypotheses in the field of sexuality and neurosciences. The study findings draw attention to the educational implications aimed to develop the executive functions in adolescents and young people to prevent risky sexual behavior.

Resumen Objetivo: El estudio se orientó a indagar la relación entre algunas funciones ejecutivas (FE) (control inhibitorio, cálculo de riesgo-beneficio, flexibilidad cognitiva, habilidad de planeación y toma de decisiones) con el deseo sexual general, diádico y solitario, inhibición del deseo sexual y disposición hacia las fantasías sexuales en una muestra de jóvenes entre 17 y 30 años. Método: Estudio de enfoque cuantitativo de corte transversal. Mediante un muestreo intencional por conveniencia se seleccionaron 64 jóvenes entre 17 y 30 años, estudiantes universitarios que se encontraban en una relación de pareja. Para evaluar las variables de las FE se utilizaron tareas de la Batería Neuropsicológica de Funciones Ejecutivas y Lóbulos Frontales (BANFE): Stroop, juego de cartas, clasificación de cartas y Torre de Hanoi, y las variables relacionadas con el deseo sexual fueron valoradas mediante el Test del Deseo Sexual Inhibido, el Inventario del Deseo Sexual (SDI-2, sigla de Sexual Desire Inventory) y la Escala de la Actitud hacia las Fantasías Sexuales. Resultados: Se encontraron correlaciones entre las variables del deseo sexual, disposición hacia las fantasías sexuales y el deseo sexual inhibido; deseo sexual total y diádico y disposición hacia las fantasías sexuales correlacionó con el control inhibitorio; y el deseo sexual inhibido correlacionó con la planificación y el control de impulsos. Discusión: Los hallazgos del estudio llaman la atención sobre las implicaciones educativas encaminadas a desarrollar las funciones ejecutivas en adolescentes y jóvenes con el fin prevenir conductas sexuales de riesgo.

Perspectivas filosóficas a partir del problema del suicidio / Philosophical perspectives from the problem of suicide / Perspectivas filosóficas a partir do problema do suicídio

Resumen Varias de las actuales discusiones bioéticas parten del supuesto de que tenemos absoluto dominio/disposición sobre nuestro cuerpo. Bajo la tesis de la autonomía, del dominio de la vida propia y de la libertad para hacer cualquier cosa, al menos con nuestro cuerpo, se suele justificar la bondad o legitimidad de actos como el suicidio y la eutanasia. Supuesto lo anterior, el trabajo aborda la cuestión de la naturaleza de la disposición -principal atributo del dominio o propiedad- sobre el cuerpo. Se argumentará sobre la base de la teoría de Tomás de Aquino y de la exposición de Immanuel Kant, muchas veces consideradas, erróneamente a mi juicio, como doctrinas rivales. El escrito estará orientado a revisar las relaciones del moderno principio de autonomía con la problemática de la moralidad del suicidio.

Abstract Many of the actual bioethical discussions start from the assumption that we have absolute dominance/disposition over our body. Based on the thesis of autonomy, control over one's own life and the freedom to do anything, at least with one's body, the goodness or legitimacy of acts such as suicide and euthanasia are often justified. Considering the last statements, this paper seeks to approach the question of the nature of the disposition -main attribute of dominion or property- over the body. It will be argued on the basis of Thomas Aquinas' theory and Immanuel Kant's exposition, often wrongly considered, in my opinion, as rival doctrines. The whole writing will be oriented to review the relations of the modern principle of autonomy with the problem of the morality of suicide.

Resumo Várias das atuais discussões bioéticas partem do pressuposto de que temos absoluto domínio/disposição sobre nosso corpo. Sob a tese da autonomia, do domínio da vida própria e da liberdade para fazer qualquer coisa, ao menos com nosso corpo, costuma-se justificar a bondade ou legitimidade de atos como o suicídio e a eutanásia. Levando em consideração o anterior, este trabalho pretende abordar a questão da natureza da disposição -principal atributo do domínio ou da propriedade- sobre o corpo. Argumenta-se com base na teoria de Tomás de Aquino e na exposição de Immanuel Kant, muitas vezes conceituadas, erroneamente, em minha opinião, como doutrinas rivais. Este texto estará orientado a revisar as relações do moderno princípio de autonomia com a problemática da moralidade do suicídio.

La relación entre la edad, el engagement y la disposición al cambio organizacional / The relationship between age, engagement and disposition to organizational change

Resumen La gestión de recursos humanos como función estratégica en las organizaciones de trabajo constituye en la actualidad una actividad de alta complejidad que implica importantes retos para los líderes de gestión humana a nivel global, debido a los procesos de cambio constante que viven las organizaciones de todo tipo. Estos procesos están dados tanto por exigencias provenientes de las transformaciones del entorno como por los requerimientos internos de ajuste en las organizaciones para mantener su productividad y competitividad en la dinámica de los mercados actuales, condiciones que imprimen serias implicaciones en la gestión del cambio y su relación con el comportamiento, desempeño y compromiso de los trabajadores. El objetivo de esta investigación fue identificar la posible relación entre la edad, el engagement, y la disposición al cambio organizacional, ya que estas variables resultan tener un papel clave en la gestión de recursos humanos en el contexto actual del mundo del trabajo, según se concluye de estudios previos que muestran relaciones entre diferentes tipos de compromiso y procesos de cambio organizacional. La presente investigación se enmarca en la perspectiva de la psicología positiva, un enfoque reciente que busca alejarse del énfasis en lo patológico del comportamiento para centrarse en los aspectos positivos y el potencial del ser humano. Esta perspectiva de la psicología en el campo del estudio del comportamiento organizacional se ha denominado "psicología organizacional positiva". Para lograr los objetivos de identificar la relación entre las variables, se realizó un estudio predictivo, que se orienta fundamentalmente a indagar la relación funcional entre dos o más variables, con un diseño correlacional simple en el que no se utilizan formas de control de variables extrañas que puedan tener influencia en la relación funcional investigada. La muestra estuvo compuesta por 808 personas divididas en dos submuestras (35.5 % colombianos y 65.5 % ecuatorianos), seleccionadas de manera no probabilística accidental. Para la evaluación de las variables se utilizó el autorreporte en la edad, el cuestionario Utrecht Work Engagement Scale (UWES) y el instrumento Disposición al Cambio Organizacional. Los resultados mostraron relaciones significativas entre las variables disposición al cambio organizacional y engagement, tanto a nivel general como en las submuestras. Sin embargo, al indagar sobre el posible papel moderador de la edad entre las otras dos variables, no se encontraron evidencias al respecto. Otros análisis sugieren la posibilidad de un efecto mediado por aspectos culturales que puede incidir en la disposición al cambio. El presente estudio constituye un importante aporte en la comprensión del comportamiento humano en el trabajo en relación con procesos de cambio organizacional, específicamente la asociación de este con variables como el engagement y la edad. Sin embargo, sucesos recientes como la situación mundial derivada de la pandemia por el virus SARSCOV2 y su impacto en las dinámicas de trabajo sugieren la necesidad de avanzar en estudios complementarios al realizado por los autores y que se presenta en este artículo, puesto que las actividades laborales han migrado para muchas personas del contexto de la empresa al contexto del hogar, lo que pone en escena otras variables que podrían incidir en la relación aquí indagada.

Abstract Human resource management as a strategic function in work organizations is currently a highly complex activity that implies significant challenges for human management leaders at a global level, due to the processes of constant change that all kind of organizations must experience, due to demands arising from the transformations of the environment and the internal requirements of adjustment in organizations to maintain their productivity and competitiveness in the dynamics of current markets, conditions that have serious implications in the management of change and its relationship with behavior , performance and commitment of the workers.. In this context, the human resources area has the important task of contributing to the management of human talent to achieve high levels of commitment from people in organizations and facilitate change processes, if organizational leaders want to achieve strategic objectives in a much more effective way. To achieve this, it is necessary to identify key variables that affect human behavior in work contexts and understand the possible relationships between these variables. The main objective of this research was to identify the relationship between age, engagement, and disposition to organizational change since these variables turn out to have a key role in human resource management in the current context of the world of work. The present investigation is framed in the perspective of positive psychology, a recent approach that seeks to move away from the emphasis on the pathological behavior to focus on the positive aspects and potential of the human being. This is the perspective of psychology in the field of the study of organizational behavior has been called positive organizational psychology. To achieve the objectives of identifying the relationship between the variables, a predictive study with a simple correlational design was performed. This kind of study is mainly oriented to investigate the functional relationship between two or more variables in which no forms of control of strange variables are used. The sample was made up of 808 people divided into two sub-samples (35.5 % Colombian and 65.5 % Ecuadorian), selected in an accidental non-probabilistic way; The self-report on age, the Utrecht Work Engagement Scale (UWES) questionnaire and the instrument Disposition to organizational change were used to evaluate the variables. The results showed significant relationships between the variables disposition to organizational change and engagement, both in general and in the subsamples; however, when investigating the possible role of age in moderating the other two variables, no evidence was found in this regard. Other analyzes suggest the possibility of an effect mediated by cultural aspects that may affect the readiness to change. However, recent events such as the world situation derived from the SARSCOV2 virus pandemic and its impact on work dynamics, suggest the need to advance in complementary studies to the one carried out by the authors and presented in this article, since the Work activities have migrated for many people from the context of the company to the context of the home, which highlights other variables that could affect the relationship investigated here.

Readmission, Complication, and Disposition Calculators in Total Joint Arthroplasty: A Systemic Review.

BACKGROUND: Predictive tools are useful adjuncts in surgical planning. They help guide patient selection, candidacy for inpatient vs outpatient surgery, and discharge disposition as well as predict the probability of readmissions and complications after total joint arthroplasty (TJA). Surgeons may find it difficult due to significant variation among risk calculators to decide which tool is best suited for a specific patient for optimal decision-based care. Our aim is to perform a systematic review of the literature to determine the existing post-TJA readmission calculators and compare the specific elements that comprise their formula. Second, we intend to evaluate the pros and cons of each calculator. METHODS: Using a Preferred Reporting Items for Systematic Reviews and Meta-Analysis Protocols protocol, we conducted a systematic search through 3 major databases for publications addressing TJA risk stratification tools for readmission, discharge disposition, and early complications. We excluded those manuscripts that were not comprehensive for hips and knees, did not list discharge, readmission or complication as the primary outcome, or were published outside the North America. RESULTS: Ten publications met our criteria and were compared on their sourced data, variable types, and overall algorithm quality. Seven of these were generated with single institution data and 3 from large administrative datasets. Three tools determined readmission risk, 5 calculated discharge disposition, and 2 predicted early complications. Only 4 prediction tools were validated by external studies. Seven studies utilized preoperative data points in their risk equations while 3 utilized intraoperative or postsurgical data to delineate risk. CONCLUSION: The extensive variation among TJA risk calculators underscores the need for tools with more individualized stratification capabilities and verification. The transition to outpatient and same-day discharge TJA may preclude or change the need for many of these calculators. Further studies are needed to develop more streamlined risk calculator tools that predict readmission and surgical complications.

Tres versiones del "Ogtt Squeezer", un programa para evaluar de un vistazo la información metabólica de la curva de tolerancia a la glucosa / Three versions of the "Ogtt Squeezer", a program to evaluate ataglance the metabolic information of the oral glucose tolerance test

El diagnóstico clínico de resistencia insulínica (RI) es difícil, ya que el Clamp no es aplicable a la clínica. El así llamado "síndrome metabólico", un predictor clínico de la RI, no identifica alrededor de la mitad de los sujetos afectados. Previamente, definimos adecuadamente (Análisis ROC) los niveles de corte diagnóstico de los siguientes predictores bioquímicos: HOMA1, HOMA2, QUICKI e ISI-Composite, a través de analizar datos de 90 sujetos (53 no resistentes y 37 resistentes) que tenían una medición directa de su resistencia insulínica (Test de supresión pancreática, TSP, Test de Reaven) y también, una curva de tolerancia a la glucosa oral (CTG). Los puntos de corte obtenidos exhibieron un mucho mejor desempeño diagnóstico comparados con los puntos de corte convencionales. También encontramos un predictor nuevo, simple, económico y eficiente, el I0*G60. Definimos la "normalidad metabólica" de la CTG usando las medianas de los valores de varios parámetros en 312 sujetos con un G120 dentro de los 2 primeros terciles del grupo de normo-tolerantes a la glucosa (NGT, n=468; G120: 51-110 mg/dL, los con mejor función beta insular). A las medianas de la función beta insular y de la sensibilidad insulínica se les asignó un valor de un 100%. Se calculó el % relativo de función beta insular (%RFBI) y el % relativo de sensibilidad insulínica (%RSI) del resto de la cohorte (n=573) contra estos valores de referencia. El "OGTT Squeezer" se escribió en Excel. Las glicemias y las insulinemias de la CTG fueron las entradas del programa. Las salidas fueron: I0*G60, ISI-OL, QUICKI, and HOMA1 (predictores) y el índice insulinogénico, el índice de disposición, %RFBI y %RSI (parámetros). El programa también caracterizó la tolerancia glucídica de acuerdo a los criterios de la ADA 2003. El formato final del programa, HTML 5, facilita su uso. Desarrollamos tres versiones del programa: completa, abreviada y mínima.

Clinically, diagnosing insulin resistance (IR) is difficult since the Clamp is not applicable to clinical work. The so-called "Metabolic Syndrome", a clinical surrogate of IR, fails to identify around 50% of affected subjects. Previously, we properly defined (ROC Analysis) the diagnostic cut-offs of the following biochemical predictors: HOMA1, HOMA2, QUICKI, and ISI-Composite by analyzing data from 90 subjects (53 non-insulin-resistant and 37 insulin-resistant subjects) who had a direct measurement of insulin resistance (Pancreatic Suppression Test, PST, Reaven's Test), and also, an Oral Glucose Tolerance Test (OGTT). The resulting cut-offs exhibited much better performances compared with the conventional cut-offs. We also found a new, simple, inexpensive and efficient predictor, the I0*G60. We chose to define the "metabolic normalcy" of the OGTT by using the median values of several parameters in 312 NGT subjects with a G120 in the first 2 tertiles of the NGT group (n=468; G120: 51-110 mg/dL, those with the best beta-cell function). The median values of both Beta-Cell Function and Insulin Sensitivity of these subjects were assigned a 100% value. Both % Relative Beta-Cell Function (%RBCF) and % Relative Insulin Sensitivity (%RIS) of everyone else in the cohort (n=573) was calculated against these reference values. The "OGTT Squeezer" was written in Excel. The OGTT's glucose and insulin values served as the inputs of the program. The outputs were: I0*G60, ISI-OL, QUICKI, and HOMA1 (predictors), and Insulinogenic Index, Disposition Index, %RBCF, and %RIS (parameters). Moreover, the program characterized the OGTT according to the ADA 2003 criteria. The HTML 5 format of the program facilitates its use. We developed 3 versions of the program: complete, abbreviated, and minimal versions.

Aspectos de la cultura organizacional y su relación con la disposición al cambio organizacional / Aspects of organizational culture and its relation to the organizational change disposition

Resumen El objetivo de esta investigación fue determinar la relación entre la cultura organizacional y la disposición al cambio organizacional. Se trata de una investigación empírica que, de acuerdo con el objetivo de investigación, responde a una estrategia asociativa, en un estudio predictivo desarrollado bajo un diseño correlacional simple. La muestra estuvo compuesta por 558 participantes de cuatro entidades de educación superior. Para la evaluación de las variables se emplearon la adaptación para Colombia del OCAI (Organizational Culture Assessment Instrument) y la prueba Disposición al Cambio Organizacional. Los resultados mostraron relaciones significativas entre los factores y los tipos de cultura organizacional con las macro y microdimensiones de la disposición al cambio organizacional. También se encontraron diferencias significativas entre las instituciones en las dimensiones grupal y organizacional de la disposición al cambio, en el factor organizacional y en el tipo de cultura jerárquica. Se evidencia cómo la cultura organizacional se relaciona particularmente con aspectos organizacionales y la comunicación empresarial.

Abstract The objective of this research was to determine the relationship between aspects of organizational culture and the disposition to organizational change. A quantitative, nonexperimental study was carried out under a comparative design; with a sample of 558 participants from four higher education institutions. The instruments used allowed the evaluation of the organizational culture -OCAI- and the willingness to change. The results showed significant relationships between the factors and the types of organizational culture with the macro and micro dimensions of the disposition to organizational change. Significant differences were also found between the institutions in the group and organizational dimensions of the disposition to change; in the organizational factor and the type of hierarchical culture. It is evident how the organizational culture is particularly related to organizational aspects and business communication.

Pharmacokinetics and tissue disposition of enrofloxacin in rainbow trout after different routes of administration.

Plasma pharmacokinetics (PK) and tissue disposition of enrofloxacin (EFX) was studied in rainbow trout (Oncorhynchus mykiss) after a single oral administration of 10 mg/kg, and by immersion baths of 20 ppm during 2.5 h and 100 ppm during 0.5 h, at water temperature of 16.3 ± 0.3 °C.Concentrations of EFX in plasma and tissues (skin, muscle, liver, kidney and gut) were determined using high performance liquid chromatography (HPLC) with fluorescence detection.Pharmacokinetic parameters were analyzed with a non-compartmental model. After oral administration, t½ß, AUC and AUCtissues/AUCplasma ratio were 42.98 h, 21.80µg-h/ml and ≤ 18.63, respectively.After immersion baths of 20 ppm during 2.5 h and 100 ppm during 0.5 h, the t½ß, AUC and AUCtissues/AUCplasma were 42.77 and 44.67, 9.83 and 12.83 µg-h/ml and ≤ 9.81 and ≤ 7.13, respectively.Therefore, oral (10 mg/kg) and bath administration in rainbow trout can provide AUC/MIC of ≥125 and Cmax/MIC of ≥10 to treat diseases caused by susceptible bacteria with MIC ≤ 0.04 µg/ml. This information can be helpful for the right use of EFX in rainbow trout. Also, this is the first study that determines the antibiotic tissue disposition in rainbow trout by using different administration routes.

Development and Validation of a Model for Predicting Rehabilitation Care Location Among Patients Discharged Home After Total Knee Arthroplasty.

BACKGROUND: Demand for joint replacement is increasing, with many patients receiving postsurgical physical therapy (PT) in non-inpatient settings. Clinicians need a reliable tool to guide decisions about the appropriate PT setting for patients discharged home after surgery. We developed and validated a model to predict PT location for patients in our health system discharged home after total knee arthroplasty. METHODS: We analyzed data for patients who completed a preoperative total knee risk assessment in 2017 (model development cohort) or during the first 6 months of 2018 (model validation cohort). The initial total knee risk assessment, to guide rehabilitation disposition, included 28 variables in mobility, social, and environment domains, and on patient demographics and comorbidities. Multivariable logistic regression was used to identify factors that best predict discharge to home health service (HHS) vs home with outpatient PT. Model performance was assessed by standard criteria. RESULTS: The development cohort included 259 patients (19%) discharged to HHS and 1129 patients (81%) discharged to home with outpatient PT. The validation cohort included 609 patients, with 91 (15%) discharged to HHS. The final model included age, gender, motivation for outpatient PT, and reliable transportation. Patients without motivation for outpatient PT had the highest probability of discharge to HHS, followed by those without reliable transportation. Model performance was excellent in the development and validation cohort, with c-statistics of 0.91 and 0.86, respectively. CONCLUSION: We developed and validated a predictive model for total knee arthroplasty PT discharge location. This model includes 4 variables with accurate prediction to guide patient-clinician preoperative decision making.

Los actos de libre disposición del cuerpo humano / Atos de livre disposição do corpo humano / The acts of free disposal of the human body

Resumen: El cuerpo es la estructura biológica del ser humano. Determina al hombre en su existencia físico material. Los sujetos de derechos individuales tienen un cuerpo sobre el cual pueden decidir qué hacer, de forma directa o consentida, incluso cabe la posibilidad de actos de injerencia corporal indirectos o impuestos. La persona puede aspirar a un cuerpo mejor o utilizarlo en beneficio de los demás. El cuerpo humano, como base fisiológica de la personalidad, está protegido en el marco del núcleo duro de dignidad que le es atribuida per se. El derecho a los actos de libre disposición del cuerpo humano es la facultad de hacer con nuestro cuerpo lo que mejor creamos conveniente, siempre que no vaya contra las normas de orden público, las buenas costumbres o implique una disminución de la integridad y salud.

Resumo: O corpo é a estrutura biológica do ser humano e determina o homem em sua existência física material. Os sujeitos de direitos individuais têm um corpo sobre o qual podem decidir o que fazer, de forma direta ou consentida, incluso cabe a possibilidade de atos de ingerência corporal indireta ou imposta. A pessoa pode aspirar a um corpo melhor, ou usá-lo em benefício de demais. O corpo humano, como base fisiológica da personalidade, está protegido no marco do núcleo rígido da dignidade que a ele é atribuído per se. O direito aos atos de livre disposição do corpo humano é a faculdade de fazer com nossos corpos o que melhor entendemos que seja conveniente, sempre que isso não seja contra as normas de ordem pública, os bons costumes ou implique uma diminuição na integridade e saúde.

Abstract: The body is the biological structure of the human being. It determines man in his natural physical existence. Individual law subjects have a body over which they can decide what to do, directly or consensually, including the possibility of acts of indirect or imposed corporal interference. The person can aspire to a better body or use it for the benefit of others. The human body, as the physiological basis of personality, is protected within the framework of the hard core of dignity attributed to it per se. The right to acts of free disposal of the human body is the ability to do with our bodies what we believe best, provided that it does not go against the rules of public order, good manners or implies a decrease in integrity and health.

Effects of temperament on growth, plasma cortisol concentrations and puberty attainment in Nelore beef heifers.

Excitable temperament disrupts physiological events required for reproductive development in cattle, but no research has investigated the impacts of temperament on growth and puberty attainment in Bos indicus females. Hence, this experiment evaluated the effects of temperament on growth, plasma cortisol concentrations and puberty attainment in B. indicus heifers. A total of 170 Nelore heifers, weaned 4 months before the beginning of this experiment (days 0 to 91), were managed in two groups of 82 and 88 heifers each (mean ± SE; initial BW=238±2 kg, initial age=369±1 days across groups). Heifer temperament was evaluated via exit velocity on day 0. Individual exit score was calculated within each group by dividing exit velocity into quintiles and assigning heifers with a score from 1 to 5 (1=slowest; 5=fastest heifer). Heifers were classified according to exit score as adequate (ADQ, n=96; exit score⩽3) or excitable temperament (EXC, n=74; exit score>3). Heifer BW, body condition score (BCS) and blood samples were obtained on days 0, 31, 60 and 91. Heifer exit velocity and score were recorded again on days 31, 60 and 91. Ovarian transrectal ultrasonography was performed on days 0 and 10, 31 and 41, 60 and 70, 81 and 91 for puberty evaluation. Heifer was declared pubertal at the first 10-day interval in which a corpus luteum was detected. Exit velocity and exit score obtained on day 0 were correlated (r⩾0.64, P<0.01) with evaluations on days 31, 60 and 91. During the experiment, ADQ had greater (P<0.01) mean BCS and BW gain, and less (P<0.01) mean plasma cortisol concentration compared with EXC heifers. Temperament × time interactions were detected (P<0.01) for exit velocity and exit score, which were always greater (P<0.01) in EXC v. ADQ heifers. A temperament × time interaction was also detected (P=0.03) for puberty attainment, which was delayed in EXC v. ADQ heifers. At the end of the experiment, a greater (P<0.01) proportion of ADQ were pubertal compared with EXC heifers. In summary, B. indicus heifers classified as EXC had reduced growth, increased plasma cortisol concentrations and hindered puberty attainment compared to ADQ heifers. Moreover, exit velocity may serve as temperament selection criteria to optimize development of B. indicus replacement heifers.

Diagnóstico de áreas contaminadas pela disposição final de resíduos sólidos no município de Paço do Lumiar (MA) / Diagnosis of contaminated areas by final disposal of solid waste in the municipality of Paço do Lumiar (MA), Brazil

RESUMO A disposição final de resíduos sólidos é considerada uma fonte potencial de contaminação e tem merecido destaque em função dos problemas ambientais e socioeconômicos que pode gerar. O município de Paço do Lumiar, no Maranhão, utiliza um lixão como forma de disposição de resíduos sólidos urbanos mesmo após ter cessado o prazo para o fim dos lixões no Brasil conforme a Política Nacional de Resíduos Sólidos, Lei Federal nº 12.305, de 2 de agosto de 2010. Em virtude disso, este estudo teve como objetivo detectar áreas contaminadas pela disposição de resíduos sólidos em Paço do Lumiar com base na metodologia do Manual de Gerenciamento de Áreas Contaminadas do projeto CETESB/GTZ (1999), utilizando os compartimentos ambientais solo e água superficial como objetos de análise. Assim, verificou-se que o lixão tem contribuído para a contaminação do solo com metais pesados no local de disposição e a 200 m a sua jusante, o que pode significar contaminação potencial da água subterrânea em virtude de a geologia local e o solo arenoso serem facilitadores no processo de transporte de contaminantes. Já a análise da água superficial revelou que a disposição de resíduos sólidos pode estar contribuindo menos que outras fontes de contaminação, destacando-se, nesse contexto, os efluentes gerados pelas comunidades que ocupam a bacia. Portanto, como a contaminação verificada compromete alguns usos da terra (residencial e agrícola), estudos posteriores poderão contemplar o processo de remediação de áreas contaminadas conforme material da CETESB/GTZ (1999) para que medidas corretivas minimizem os impactos ambientais na região.

ABSTRACT The final disposal of solid waste is considered a potential source of contamination and has been highlighted due to the environmental problems and socioeconomic factors that it can generate. The municipality of Paço do Lumiar, Maranhão, uses a garbage dump as a way of disposing urban solid waste, even after the deadline for the end of dumps in Brazil, as established by the National Solid Waste Policy, Federal Law No. 12,305, dated August 2, 2010. As a result, the objective of this study was to detect areas contaminated by disposal of solid waste in Paço do Lumiar, based on the Workshop Management of Contaminated Areas' methodology, a part of the project CETESB/GTZ (1999), using the environmental compartments soil and surface water as objects of analysis. Thus, it was found that the garbage dump has contributed to the contamination of soil with heavy metals in the place of provision and 200m to its downstream, which can mean potential contamination of ground water due to the local geology and the fact that sandy soil facilitates the process of transporting contaminants. The analysis of the surface water revealed that the disposal of solid waste can contribute less than other sources of contamination, highlighting in this context those generated by the communities that occupy the basin. Therefore, as the verified contamination compromises some land uses (residential and agricultural), further studies may contemplate the remediation process of these contaminated areas according to the CTESB/GTZ (1999) material for stablishing measures to minimize this region's environmental impacts.

Relación entre apoyo social percibido y disposición resiliente en adolescentes paraguayos / Relation between perceived social support and resilient disposition in paraguayan adolescents

Resumen El estudio de la adolescencia ha destacado la vulnerabilidad del proceso asociado con variables como la disposición resiliente, presente en aquellos recursos que pueden hacer la diferencia para el sustento del bienestar o su ausencia. De estos recursos se destaca el apoyo social que el adolescente percibe de su entorno. El objetivo de la investigación se centró en establecer la relación entre el apoyo social percibido y la disposición resiliente, y compararlas conforme el sexo y la edad de una muestra de adolescentes paraguayos escolarizados. Se llevó a cabo un diseño comparativo y correlacional, con 1334 adolescentes escolarizados de 12 a 18 años (ME= 14.99; DE= 1.66), 725 mujeres y 609 varones. Se empleó la Escala de Apreciación de Apoyo Social -EAAS y el Inventario de Resiliencia IRES. Los datos evidenciaron que no existe correlación entre apoyo social y disposición resiliente en esta muestra específica de adolescentes paraguayos, por factores que habrá que seguir investigando. Se observan diferencias en el apoyo social de amigos y de otros, mayormente en los varones. En las mujeres, se observan diferencias significativas en las escalas de resiliencia, en el sentido del humor, autoeficiencia y empatía. En cuanto a edad, los adolescentes de 16 a 18 años puntúan más en religiosidad y en el apoyo social, familiar, de amigos y de otros. Se sugiere estudiar otras variables relacionadas con el apoyo social y la disposición resiliente, en tanto muchas de las políticas públicas preventivas de atención a la salud positiva refuerzan su importancia en la adolescencia.

Abstract The study of adolescence has highlighted the vulnerability of the process associated with variables such as the resilient disposition, present in those resources that can make a difference for the sustenance of well-being or its absence. Of these resources, the social support that adolescents perceive of their environment stands out. The objective of the research is to establish the relationship between perceived social support and resilient disposition, and compare them according to the sex and age of a sample of Paraguayan adolescents attending school. A comparative and correlational design is carried out, with 1334 school-age adolescents aged 12 to 18 (ME = 14.99, SD = 1.66), 725 women and 609 men. The instruments used were the Sociodemographic Certificate for Adolescents and their Families, the Scale of Appreciation of Social Support -EAAS de Martínez (2004) and the Inventory of Resilience IRES (Gaxiola Romero, Frias Armenta, Hurtado Abril, Salcido Noriega, Figueroa Franco, 2011). The results indicate that there is no correlation between social support and resilience, probably due to individual characteristics that generate resilient dispositions in adolescents. Regarding the scales of social support, there are differences in the social support of friends and others, mainly in males. In women, significant differences are observed in the scales of resilience, in the sense of humor, self-efficacy and empathy. Differences were found in the ages of the adolescents, the age group of 16 to 18 years obtained a higher score in religiosity and in social, family, friends and other support. It is suggested to study simultaneously more variables related to social support and the resilient disposition, since many of the preventive public policies of attention to positive health reinforces its importance in adolescence.

Comparative Oral Drug Classification Systems: Acetazolamide, Azithromycin, Clopidogrel, and Efavirenz Case Studies.

Biopharmaceutics classification systems based on the properties of solubility and permeability or the extension of metabolism are very important tools in the early stages of the development and regulatory stages of new products. However, until now, there was no clear understanding between the interplay among these classification systems. Therefore, the main objective of this work was to make a comparison of concepts of BCS and BDDCS to understand what are the key factors that allow for the integration of these biopharmaceutics classification systems. Also, the suitability of an in situ single-pass intestinal perfusion assay in rats (SPIP) development was assessed by us to determine the limit between high and low permeability following what the FDA BCS guidance suggests. An excellent correlation was found between the values of permeability obtained by applying SPIP assays and the extensions of the metabolism of the set of compounds studied in this work, with the exception of three compounds that showed disparity between their permeability coefficients ( Peff), obtained herein by SPIP, and their metabolism (acetazolamide, azithromycin, and efavirenz). Discrepancies allowed us to elucidate the interrelationship between BCS and BDDCS.

Numerical study of the influence of electrode arrangements in electrokinetic remediation technique.

The effectiveness of electrokinetic remediation for soils depends on several factors such as the arrangement and shape of electrodes. This paper presents a numerical study on external electrostatic field generated by seven different electrode configurations in any unbounded two-dimensional domain. The boundary condition at infinity for the voltage is approximated by the iterative algorithm that expands the domain till the limit of the specified tolerance (threshold value). The numerical results indicate that there is no unique configuration with larger effective area for all spacings between the oppositely charged electrodes. In addition, the configuration with the smallest inactive electric field strength spots for all spacings between the electrodes is not unique. Moreover, the voltage profile for all electrode configurations is nonlinear, and the external electric field strength varies widely near the electrodes. Only in the intermediate region between the electrodes the external electric field strength approaches a constant value.