MMP-1, MMP-8, and MMP-13 Gene Polymorphisms and Haplotype Is a Risk Factor for Dupuytren Contracture: A Case-Control Study.

BACKGROUND: There is an increased tissue expression of matrix metalloproteinases (MMPs) on Dupuytren contracture (DC). Genetic polymorphisms (single nucleotide polymorphism [SNPs]) in genes of these enzymes may individually influence these transcriptions. Haplotype analysis, which is the observation of a group of alleles, could be more useful to identify the association between SNPs and DC. The purpose of this study was to evaluate the influence of MMP-1 g.-1607 G>GG (rs1799750), MMP-8 g.-799 C>T (rs11225395), and MMP-13 g.-77 A>G (rs2252070) SNPs individually and in haplotype on DC. METHODS: A total of 60 patients with a clinical diagnosis of DC were evaluated and matched, according to age and gender, with the control group of 100 patients without this clinical diagnosis. Genomic DNA was extracted from saliva samples, and genotypes were obtained by polymerase chain reaction-restriction fragment length polymorphism. Statistical analysis of the results included Mann-Whitney U test, Chi-squared test, and PHASE and R software, with a significance level of 5%. RESULTS: The 3 SNPs studied showed significant differences in allele and genotype frequencies between the groups: 2G in MMP-1 (P = .018; odds ratio [OR] 1.80 (95% confidence interval [CI], 1.13-2.88)), T in MMP-8 (P = .015; OR 0.53 (95% CI, 0.33-0.88)), and A in MMP-13 (rs2252070) SNPs (P = .040, OR 0.54 (95% CI, 0.33-0.90)) are risk alleles. The global haplotype analysis indicated a significant difference between both groups. CONCLUSIONS: In conclusion, MMP-1 g.-1607 G>GG (rs1799750), MMP-8 g.-799 C>T (rs11225395), and MMP-13 g.-77 A>G (rs2252070) SNPs, individually and in haplotype, are a risk factor for DC, indicating that these SNPs may be a potential diagnostic and prognostic factor for DC.

Dupuytren Disease Surgical Treatment: A Randomized Clinical Trial Comparing Partial Fasciectomy by Bruner Approach Versus Zetaplasty.

BACKGROUND: Dupuytren is a fibroproliferative pathology leading to contracture of the palmar fascia. Several approaches have been described for the surgical treatment with partial fasciectomy with few comparisons in literature. Our purpose is to compare the functional outcomes between the partial fasciectomy performed by Bruner type incision and zetaplasty incision. METHODS: The method used was a randomized clinical trial including adult patients of both sexes with surgical indication for Dupuytren disease presented to a reference center. Patients were randomly and consecutively allocated in the groups 1:1. We recorded the Disabilities of the Arm, Shoulder, and Hand (DASH) score; range of motion for active and passive extension of the metacarpophalangeal (MP) and proximal interphalangeal (PIP) joints; visual analog scale for pain; and complications. RESULTS: In all, 62 patients were included, with 48 patients reaching the minimum follow-up of 6 months with 63 operated fingers. In the Bruner approach group, we obtained a correction of the active and passive extension of the MP of 28° and of the PIP of 23°. In the zetaplasty group, correction of MP was 30° for active and passive, and 18° for active extension and 16° for passive extension of the PIP. The reduction in the DASH score was 10 points in the Bruner group and 22 points in the zetaplasty group. There was no statistically significant effect of the type of treatment on preoperative and postoperative differences in any of the parameters evaluated. CONCLUSIONS: There were no statistically significant differences between the 2 techniques for self-reported functional outcomes or objective measures of physical examination.

CLINICAL RESULTS OF COLLAGENASE TREATMENT FOR DUPUYTREN'S DISEASE: A CASE SERIES STUDY WITH 2-YEARS FOLLOW-UP.

Objectives: This study aims to report our experience with Clostridium Histolyticum collagenase (CCH) to support the importance of its clinical use and assess its clinical efficacy, complications, and recurrences. Methods: This prospective observational study of 66 patients with a 2-year follow-up. Patients with an extension lag major of 20° at the metacarpophalangeal joint (MPJ) and/or proximal interphalangeal joint (PIPJ) were included. We collected data on demographic and anamnestic details, MPJ and PIPJ contracture degrees, DASH score, complications, and recurrences. Results: The mean pre-injection contracture was 34° for MPJ and 31° for PIPJ. At the 2-year follow-up, the mean contracture for the MPJ and PIPJ were respectively 3° and 14.5°. The mean DASH score decreased from 21.8 before injection to 10,4 after 2 years. The disease recurrence occurred in 34.8% of the patients, all with PIPJ contracture. The main complication was skin breakage (25.7%). Conclusion: The CCH injections remain a consistent option in treating DD; withdrawal from the European market deprives surgeons and patients of low invasiveness and safe tool for treating DD. Level of evidence IV, Therapeutic study investigating treatment results, Case series .

Objetivos: O objetivo deste estudo é relatar nossa experiência com Clostridium Histolyticum colagenase (CCH) para apoiar a importância de seu uso clínico e para avaliar sua eficácia clínica, complicações e recidivas. Métodos: Estudo observacional prospectivo de acompanhamento por 2 anos em 66 pacientes com um atraso de extensão maior de 20° na articulação metacarpofalângica (MPJ) e/ou articulação interfalângica proximal (PIPJ). Foram coletados dados sobre detalhes demográficos e anamnésicos, graus de contração da MPJ e PIPJ, escore de DASH, complicações e recidivas. Resultados: A média da contração pré-injeção foi de 34° para a MPJ e 31° para a PIPJ. Com 2 anos de acompanhamento, a contração média para a MPJ e PIPJ foi de 3° e 14,5° respectivamente. A pontuação média do DASH diminuiu de 21,8 antes da injeção para 10,4 após 2 anos. A recorrência da doença ocorreu em 34,8% dos pacientes, todos com contração de PIPJ. A principal complicação foi a quebra da pele (25,7%). Conclusão: As injeções de CCH continuam sendo uma opção consistente no tratamento do DD; a retirada do medicamento do mercado europeu priva os cirurgiões e pacientes de uma ferramenta pouco invasiva e segura para o tratamento do DD. Nível de evidência IV, Estudo terapêutico que investiga os resultados do tratamento, série de casos .

Clinical results of collagenase treatment for dupuytren's disease: a case series study with 2-years follow-up / Resultados clínicos do tratamento com colagenase para a doença de dupuytren: um estudo de série de casos com 2 anos de acompanhamento

ABSTRACT Objectives: This study aims to report our experience with Clostridium Histolyticum collagenase (CCH) to support the importance of its clinical use and assess its clinical efficacy, complications, and recurrences. Methods: This prospective observational study of 66 patients with a 2-year follow-up. Patients with an extension lag major of 20° at the metacarpophalangeal joint (MPJ) and/or proximal interphalangeal joint (PIPJ) were included. We collected data on demographic and anamnestic details, MPJ and PIPJ contracture degrees, DASH score, complications, and recurrences. Results: The mean pre-injection contracture was 34° for MPJ and 31° for PIPJ. At the 2-year follow-up, the mean contracture for the MPJ and PIPJ were respectively 3° and 14.5°. The mean DASH score decreased from 21.8 before injection to 10,4 after 2 years. The disease recurrence occurred in 34.8% of the patients, all with PIPJ contracture. The main complication was skin breakage (25.7%). Conclusion: The CCH injections remain a consistent option in treating DD; withdrawal from the European market deprives surgeons and patients of low invasiveness and safe tool for treating DD. Level of evidence IV, Therapeutic study investigating treatment results, Case series.

RESUMO Objetivos: O objetivo deste estudo é relatar nossa experiência com Clostridium Histolyticum colagenase (CCH) para apoiar a importância de seu uso clínico e para avaliar sua eficácia clínica, complicações e recidivas. Métodos: Estudo observacional prospectivo de acompanhamento por 2 anos em 66 pacientes com um atraso de extensão maior de 20° na articulação metacarpofalângica (MPJ) e/ou articulação interfalângica proximal (PIPJ). Foram coletados dados sobre detalhes demográficos e anamnésicos, graus de contração da MPJ e PIPJ, escore de DASH, complicações e recidivas. Resultados: A média da contração pré-injeção foi de 34° para a MPJ e 31° para a PIPJ. Com 2 anos de acompanhamento, a contração média para a MPJ e PIPJ foi de 3° e 14,5° respectivamente. A pontuação média do DASH diminuiu de 21,8 antes da injeção para 10,4 após 2 anos. A recorrência da doença ocorreu em 34,8% dos pacientes, todos com contração de PIPJ. A principal complicação foi a quebra da pele (25,7%). Conclusão: As injeções de CCH continuam sendo uma opção consistente no tratamento do DD; a retirada do medicamento do mercado europeu priva os cirurgiões e pacientes de uma ferramenta pouco invasiva e segura para o tratamento do DD. Nível de evidência IV, Estudo terapêutico que investiga os resultados do tratamento, série de casos.

EPIDEMIOLOGICAL ASPECTS OF DUPUYTREN'S DISEASE IN BRAZIL.

Objectives: The purpose of this study is to describe associated factors and epidemiological aspects of Dupuytren's Disease in patients followed up in a Brazilian tertiary public hospital, at the Hand Surgery service. Methods: A cross-sectional study was performed from 2014 to 2019. Data collected included: age, gender, ancestry, associated comorbidity presence, phenobarbital, tobacco, and alcohol use, family history of Dupuytren's Disease and associated fibrotic diseases. Then, the patients underwent a clinical examination to identify and characterize the involvement of the fingers. The patients were also assessed in regard to whether they presented Dupuytren's Disease severity factors. Results: 140 patients were included, 70.7% men and 29.3% women. Only 42.3% reported being of European ancestry; 20% had first-degree relatives with the disease; 59.3% presented comorbidities, including hypertension, diabetes, chronic heart disease, dyslipidemia, epilepsy, and HIV infection; 15.8% had Ledderhose disease, 7.1% had Peyronie's disease. 31% were smokers, 16.6% were alcoholic, and 37.1% were phenobarbital users; 40% presented with a severe form of DD. Conclusion: The population studied was composed of Brazilians, most of whom did not report European ancestry; still, they presented several characteristics similar to those described in literature worldwide. Level of Evidence II; Prognostic Studies; Investigating the effect of a patient characteristic on the outcome of a disease .

Obejtivo: Descrever fatores associados e aspectos epidemiológicos da Doença de Dupuytren em uma população de pacientes acompanhados em serviço de Cirurgia de Mão de hospital público terciário brasileiro. Métodos: Realizou-se um estudo transversal entre os anos de 2014 e 2019. Coletamos dados como idade, gênero, ascendência, comorbidades associadas, doenças fibróticas associadas, uso de fenobarbital, uso de tabaco e álcool e histórico familiar de Doença de Dupuytren. Em seguida, realizamos exame clínico, caracterizando o acometimento dos dedos da mão. Também foi avaliado se os pacientes da amostra apresentavam fatores de gravidade da Doença de Dupuytren. Resultados: 140 pacientes foram incluídos, 70,7% eram homens e 29,3% mulheres. Apenas 42,3% dos pacientes relataram ascendência europeia; 20% apresentaram parentes de primeiro grau com a doença; 59,3% apresentaram comorbidades, incluindo hipertensão, diabetes, cardiopatia crônica, dislipidemia e infecção por HIV; 15,8% tinham doença de Ledderhose e 7,1% tinham doença de Peyronie. 31% eram fumantes, 16,6% declararam alcoolismo, 37,1% faziam uso de fenobarbital e 40% apresentaram a forma grave da DD. Conclusão: A população estudada foi composta por brasileiros que apesar de, em sua maioria, não relatarem ascendência europeia, apresentaram diversas características semelhantes às descritas na literatura mundial. Nível de Evidência II; Estudos Prognósticos; Investigação do efeito de característica de um paciente sobre o desfecho da doença.

Epidemiological aspects of dupuytren's disease in brazil / Aspectos epidemiológicos da doença de dupuytren no brasil

ABSTRACT Objectives: The purpose of this study is to describe associated factors and epidemiological aspects of Dupuytren's Disease in patients followed up in a Brazilian tertiary public hospital, at the Hand Surgery service. Methods: A cross-sectional study was performed from 2014 to 2019. Data collected included: age, gender, ancestry, associated comorbidity presence, phenobarbital, tobacco, and alcohol use, family history of Dupuytren's Disease and associated fibrotic diseases. Then, the patients underwent a clinical examination to identify and characterize the involvement of the fingers. The patients were also assessed in regard to whether they presented Dupuytren's Disease severity factors. Results: 140 patients were included, 70.7% men and 29.3% women. Only 42.3% reported being of European ancestry; 20% had first-degree relatives with the disease; 59.3% presented comorbidities, including hypertension, diabetes, chronic heart disease, dyslipidemia, epilepsy, and HIV infection; 15.8% had Ledderhose disease, 7.1% had Peyronie's disease. 31% were smokers, 16.6% were alcoholic, and 37.1% were phenobarbital users; 40% presented with a severe form of DD. Conclusion: The population studied was composed of Brazilians, most of whom did not report European ancestry; still, they presented several characteristics similar to those described in literature worldwide. Level of Evidence II; Prognostic Studies; Investigating the effect of a patient characteristic on the outcome of a disease .

RESUMO Obejtivo: Descrever fatores associados e aspectos epidemiológicos da Doença de Dupuytren em uma população de pacientes acompanhados em serviço de Cirurgia de Mão de hospital público terciário brasileiro. Métodos: Realizou-se um estudo transversal entre os anos de 2014 e 2019. Coletamos dados como idade, gênero, ascendência, comorbidades associadas, doenças fibróticas associadas, uso de fenobarbital, uso de tabaco e álcool e histórico familiar de Doença de Dupuytren. Em seguida, realizamos exame clínico, caracterizando o acometimento dos dedos da mão. Também foi avaliado se os pacientes da amostra apresentavam fatores de gravidade da Doença de Dupuytren. Resultados: 140 pacientes foram incluídos, 70,7% eram homens e 29,3% mulheres. Apenas 42,3% dos pacientes relataram ascendência europeia; 20% apresentaram parentes de primeiro grau com a doença; 59,3% apresentaram comorbidades, incluindo hipertensão, diabetes, cardiopatia crônica, dislipidemia e infecção por HIV; 15,8% tinham doença de Ledderhose e 7,1% tinham doença de Peyronie. 31% eram fumantes, 16,6% declararam alcoolismo, 37,1% faziam uso de fenobarbital e 40% apresentaram a forma grave da DD. Conclusão: A população estudada foi composta por brasileiros que apesar de, em sua maioria, não relatarem ascendência europeia, apresentaram diversas características semelhantes às descritas na literatura mundial. Nível de Evidência II; Estudos Prognósticos; Investigação do efeito de característica de um paciente sobre o desfecho da doença.

Epidemiology of Dupuytren disease and Patients Undergoing Selective Fasciectomy.

Objective To describe the epidemiological and clinical profile of patients with Dupuytren disease treated by selective fasciectomy and the factors associated with the severity of the disease. Methods Retrospective descriptive observational study involving 247 patients with Dupuytren disease, from 2013 to 2019. Multivariate logistic regression was performed for data analysis. Results Most patients were male (83.8%), self-declared white (65.2%), alcoholics (59.6%) and 49% were smokers, with a mean age of 66 ± 9 years old, with 77.2% presenting symptoms of the disease after the age of 51 years old. Approximately 51.9, 29.6 and 17.3%, respectively, had arterial hypertension, diabetes mellitus and dyslipidemia comorbidities. Bilateral involvement of the hands was observed in 73.3% of the patients. The rate of intra- and post-selective fasciectomy complications was of 0.6 and 24.3%, respectively, with 5.2% of the patients needing reintervention after 1 year of follow-up. After multivariate analysis, males were associated with bilateral involvement of the hands (odds ratio [OR] = 2.10; 95% confidence interval [CI]: 1.03-4.31) and with a greater number of affected rays (OR = 3.41; 95% CI: 1.66-7.03). Dyslipidemia was associated with reintervention (OR = 5.7; 95% CI = 1.03-31.4) and bilaterality with a higher number of complications (35.7 versus 19.7%). Conclusion A low rate of reintervention and operative complications was observed in patients with Dupuytren disease treated by selective fasciectomy. Male gender was associated with severe disease (bilaterality and more than two affected rays), and dyslipidemia with reintervention.

Epidemiology of Dupuytren disease and Patients Undergoing Selective Fasciectomy / Epidemiologia da doença de Dupuytren e de pacientes submetidos a fasciectomia seletiva

Abstract Objective To describe the epidemiological and clinical profile of patients with Dupuytren disease treated by selective fasciectomy and the factors associated with the severity of the disease. Methods Retrospective descriptive observational study involving 247 patients with Dupuytren disease, from 2013 to 2019. Multivariate logistic regression was performed for data analysis. Results Most patients were male (83.8%), self-declared white (65.2%), alcoholics (59.6%) and 49% were smokers, with a mean age of 66 ± 9 years old, with 77.2% presenting symptoms of the disease after the age of 51 years old. Approximately 51.9, 29.6 and 17.3%, respectively, had arterial hypertension, diabetes mellitus and dyslipidemia comorbidities. Bilateral involvement of the hands was observed in 73.3% of the patients. The rate of intra- and post-selective fasciectomy complications was of 0.6 and 24.3%, respectively, with 5.2% of the patients needing reintervention after 1 year of follow-up. After multivariate analysis, males were associated with bilateral involvement of the hands (odds ratio [OR] = 2.10; 95% confidence interval [CI]: 1.03-4.31) and with a greater number of affected rays (OR = 3.41; 95% CI: 1.66-7.03). Dyslipidemia was associated with reintervention (OR = 5.7; 95% CI = 1.03-31.4) and bilaterality with a higher number of complications (35.7 versus 19.7%). Conclusion A low rate of reintervention and operative complications was observed in patients with Dupuytren disease treated by selective fasciectomy. Male gender was associated with severe disease (bilaterality and more than two affected rays), and dyslipidemia with reintervention.

Resumo Objetivo Descrever o perfil epidemiológico e clínico dos pacientes com doença de Dupuytren tratados por fasciectomia seletiva e os fatores associados com a gravidade da doença. Metodologia Estudo observacional descritivo retrospectivo envolvendo 247 pacientes com doença de Dupuytren, no período de 2013 a 2019. Foi realizada regressão logística multivariada para análise dos dados. Resultados A maioria dos pacientes era do sexo masculino (83,8%), autodeclarados brancos (65,2%), etilistas (59,6%), e 49% eram tabagistas. A média de idade foi de 66 ± 9 anos, sendo que 77,2% apresentaram os sintomas da doença após os 51 anos. Aproximadamente 51,9, 29,6, e 17,3%, respectivamente, apresentaram hipertensão arterial, diabetes mellitus e dislipidemia. O acometimento bilateral das mãos foi observado em 73,3% dos pacientes. A taxa de complicações intra- e pós-fasciectomia seletiva foi de 0,6 e 24,3%, respectivamente, sendo que 5,2% dos pacientes necessitaram de reintervenção após 1 ano de acompanhamento. Após análise multivariada, o sexo masculino foi associado com acometimento bilateral das mãos (odds ratio [OR] = 2,10; intervalo de confiança [IC] 95%: 1,03-4,31) e com maior número de raios acometidos (OR = 3,41; IC 95%: 1,66-7,03). A dislipidemia foi associada com a reintervenção (OR = 5,7; CI 95%: 1,03-31,4) e a bilateralidade com maior número de complicações (35,7% versus 19,7%). Conclusão Foi observada uma baixa taxa de reintervenção e complicações operatórias nos pacientes com doença de Dupuytren tratados por fasciectomia seletiva. O sexo masculino foi associado com o quadro grave da doença (bilateralidade e mais de dois raios acometidos), e a dislipidemia com a reintervenção.

Resultado de tratamiento de la enfermedad de Dupuytren / Treatment Outcome of Dupuytren's Disease

RESUMEN Introducción: La enfermedad de Dupuytren es una contractura de la fascia palmar debida a proliferación fibrosa, que provoca deformidades en flexión y pérdida de la función de los dedos de la mano. Puede también localizarse en las plantas de los pies, el pene y otras partes del cuerpo; un gran por ciento de los casos son de causa desconocida. Objetivos: Describir las variables sexo, enfermedades acompañantes, hábitos tóxicos y edad de los pacientes estudiados con la afección, e identificar las complicaciones relacionadas con la técnica quirúrgica aplicada. Métodos: Se realizó un estudio observacional descriptivo longitudinal en pacientes con enfermedad de Dupuytren, atendidos en el Hospital Carlos Manuel de Céspedes de Bayamo, en el período comprendido entre enero de 2018 y diciembre de 2019. La recolección de datos se realizó a través de las historias clínicas. La muestra fue de 67 pacientes atendidos en este periodo. Para la evaluación se utilizó el sistema de evaluación propuesto por Leuking Hung. Resultados: La enfermedad fue más frecuente en el sexo masculino y en el grupo de 51 a 60 años; se diagnostica más en fumadores, diabéticos y alcohólicos; los síntomas que más se presentaron fueron la presencia de cuerdas y nódulos; el tratamiento más utilizado fue la cirugía mediante zetaplastia; las infecciones en el sitio quirúrgico constituyeron la principal complicación. Conclusiones: En más del 73 por ciento de los pacientes tratados se obtuvieron resultados aceptables(AU)

ABSTRACT Introduction: Dupuytren's disease is a contracture of the palmar fascia due to fibrous proliferation, which causes flexion deformities and loss of function of the fingers of the hand. It can also be located on the soles of the feet, the penis and other parts of the body; a large percent of cases are of unknown cause. Objectives: To describe the variables sex, accompanying diseases, toxic habits and age of the patients studied with the condition, and to identify the complications related to the applied surgical technique. Methods: A longitudinal descriptive observational study was carried out in patients with Dupuytren's disease, treated at Carlos Manuel de Céspedes Hospital in Bayamo, from January 2018 to December 2019. Data collection was performed through the medical records. The sample consisted of 67 patients seen in this period. For the assessment, Leuking Hung´s evaluation system was used. Results: The disease was more frequent in males and in the group of 51 to 60 years. It is more diagnosed in smokers, diabetics and alcoholics; the most common symptoms were the presence of cords and nodules; zetaplasty surgery was the most used treatment. Surgical site infections were the main complication. Conclusions: In more than 73 percent of the treated patients, acceptable results were obtained(AU)

RANDOMIZED CONTROLLED TRIAL OF LIMITED FASCIOTOMY WITH INJECTION OF ADIPOSE GRAFT FOR DUPUYTREN'S DISEASE.

OBJECTIVE: Dupuytren's disease is a genetic disorder related to the proliferation of myofibroblasts. The pluripotent property of stem cells present in adipose tissue inhibits myofibroblast proliferation. Our study sought to evaluate the effect of stem cell-rich fat grafts in patients that underwent limited fasciotomy. METHODS: We studied 45 patients, in a single-blind, prospective, randomized clinical trial. All patients underwent limited fasciotomy. In one group, fat graft was injected. RESULTS: The total passive extension deficit results did not exhibit a significant difference. Fat group exhibited worse functional score at 6 months and 1 year postoperatively, such as higher complication rates (43%), when compared with control group (8%), and more pain at 6 weeks follow-up. CONCLUSION: Fat grafting associated with limited fasciotomy promotes worse functional results compared to conventional limited fasciotomy in the short term. However, long-term results and recurrence rates should be further assessed. Level of Evidence II, Prospective comparative study.

OBJETIVO: A moléstia de Dupuytren (MD) está associada a um distúrbio genético relacionado à proliferação de miofibroblastos. Acredita-se que a propriedade totipotente das células-tronco, presentes no tecido adiposo, seria capaz de inibir a formação dos miofibroblastos. O objetivo deste estudo foi avaliar o efeito do enxerto de gordura, rico em células-tronco, nos pacientes com MD, submetidos à fasciectomia parcial. MÉTODOS: Estudamos 45 pacientes, em um ensaio clínico prospectivo, randomizado e cego. No grupo-controle, era realizada apenas a fasciectomia parcial. No grupo com gordura, era realizada a fasciectomia parcial e injetado o enxerto de gordura. Os desfechos foram avaliados pelo Déficit de Extensão Passiva Total (DEPT) e escore funcional Brief Michigan Hand Questionnaire (BMHQ). RESULTADOS: Os resultados do déficit de extensão passiva total não apresentaram diferença significativa. O grupo com gordura apresentou pior escore funcional após 6 meses e 1 ano, como maiores taxas de complicações (43%) em comparação ao grupo controle (8%) e mais dor com 6 semanas de seguimento. CONCLUSÃO: O uso de enxerto de gordura associado à fasciectomia parcial promove piores resultados funcionais em comparação com a fasciectomia parcial convencional, a curto prazo. No entanto, a recidiva e os resultados a longo prazo devem ser avaliados. Nível de Evidência II, Estudo prospectivo comparativo.

Randomized controlled trial of limited fasciectomy with injection of adipose graft for dupuytrens disease / Estudo comparativo randomizado de enxerto de gordura para a doença de dupuytren

ABSTRACT Objective: Dupuytren's disease is a genetic disorder related to the proliferation of myofibroblasts. The pluripotent property of stem cells present in adipose tissue inhibits myofibroblast proliferation. Our study sought to evaluate the effect of stem cell-rich fat grafts in patients that underwent limited fasciectomy. Methods: We studied 45 patients, in a single-blind, prospective, randomized clinical trial. All patients underwent limited fasciectomy. In one group, fat graft was injected. Results: The total passive extension deficit results did not exhibit a significant difference. Fat group exhibited worse functional score at 6 months and 1 year postoperatively, such as higher complication rates (43%), when compared with control group (8%), and more pain at 6 weeks follow-up. Conclusion: Fat grafting associated with limited fasciectomy promotes worse functional results compared to conventional limited fasciectomy in the short term. However, long-term results and recurrence rates should be further assessed. Level of Evidence II, Prospective comparative study.

RESUMO Objetivo: A moléstia de Dupuytren (MD) está associada a um distúrbio genético relacionado à proliferação de miofibroblastos. Acredita-se que a propriedade totipotente das células-tronco, presentes no tecido adiposo, seria capaz de inibir a formação dos miofibroblastos. O objetivo deste estudo foi avaliar o efeito do enxerto de gordura, rico em células-tronco, nos pacientes com MD, submetidos à fasciectomia parcial. Métodos: Estudamos 45 pacientes, em um ensaio clínico prospectivo, randomizado e cego. No grupo-controle, era realizada apenas a fasciectomia parcial. No grupo com gordura, era realizada a fasciectomia parcial e injetado o enxerto de gordura. Os desfechos foram avaliados pelo Déficit de Extensão Passiva Total (DEPT) e escore funcional Brief Michigan Hand Questionnaire (BMHQ). Resultados: Os resultados do déficit de extensão passiva total não apresentaram diferença significativa. O grupo com gordura apresentou pior escore funcional após 6 meses e 1 ano, como maiores taxas de complicações (43%) em comparação ao grupo controle (8%) e mais dor com 6 semanas de seguimento. Conclusão: O uso de enxerto de gordura associado à fasciectomia parcial promove piores resultados funcionais em comparação com a fasciectomia parcial convencional, a curto prazo. No entanto, a recidiva e os resultados a longo prazo devem ser avaliados. Nível de Evidência II, Estudo prospectivo comparativo.

Enfermedad de Dupuytren en múltiples sitios / Multiple Site Dupuytren Disease

RESUMEN Introducción: La enfermedad de Dupuytren es una contractura de la fascia palmar debido a una proliferación fibrosa que provoca deformidades en flexión y pérdida de la función de los dedos de la mano. Puede también localizarse en las plantas de los pies, en el pene y otras localizaciones. La causa es desconocida. Objetivo: Describir la enfermedad en dos pacientes con características peculiares en múltiples sitios. Conclusiones: La enfermedad es más frecuente en el sexo masculino y en el grupo de edad de mayores de 40 años. El tratamiento utilizado fue la cirugía mediante fasciectomia más zetaplastia y la amputación(AU)

ABSTRACT Introduction: Dupuytren's disease is a contracture of the palmar fascia due to a fibrous proliferation that causes flexion deformities and loss of function of fingers. It can also be located on the soles of the feet, on the penis or other locations. The cause is unknown. Objectives: To describe the disease in two patients with peculiar characteristics at multiple sites. Conclusions: The disease is more frequent in males and older than 40 years. The treatment used was fasciectomy surgery plus zetaplasty and amputation(AU)

The Effects of Collagenase Clostridium histolyticum on Plantar Fibromatosis: A Case Study.

Plantar fibromatosis, also known as Ledderhose's disease, is a rare disorder of benign fibroblast proliferation involving the plantar aponeurosis (i.e., plantar fascia). Traditionally, surgical intervention has been the most common treatment for plantar fibromatosis. However, numerous studies have reported high recurrence rates of plantar fibromatosis after surgical intervention, as well as wound healing difficulties and nerve injury. Plantar fibromatosis often coexists with other superficial fibrous diseases such as Dupuytren's contracture and Peyronie's disease; immunohistochemical and ultrastructural analyses suggest a relationship between Ledderhose's disease and Dupuytren's contracture. The US Food and Drug Administration approved collagenase Clostridium histolyticum for the treatment of Dupuytren's contracture in 2010 and Peyronie's disease in 2013. This case study presents the successful treatment of Ledderhose's disease almost 4 years (45.5 months) after off-label use of collagenase C. histolyticum injection in a 22-year-old white female who had recurrent plantar fibromatosis after surgical intervention.

Contractura de Dupuytren. Estudio de 33 casos en Colombia / Dupuytren's contracture. Study of SS cases in Colombia

RESUMEN Objetivo: Describir el comportamiento clínico y epidemiológico de la contractura de Dupuytren (CD) en la población colombiana y comparar nuestros resultados con otras series publicadas en la literatura. Materiales y métodos: Estudio descriptivo observacional de 33 casos de CD presentados en el hospital San Pedro y San Pablo de la Virginia, Risaralda, durante los últimos 6 arios. Los pacientes cumplieron con el diagnóstico de CD de acuerdo con el parámetro establecido. Se compararon los resultados con diferentes series de casos de CD publicadas en la literatura. Resultados: La edad promedio al momento del diagnóstico fue de 61,3 años con mayor prevalencia en hombres (64% de los casos). La forma de presentación más frecuente fue unilateral en mano derecha (73%), a diferencia de lo reportado en otras series, donde el compromiso usualmente fue bilateral. La diabetes mellitus fue la comorbilidad con mayor asociación a la CD (24,24%), hallazgo similar a lo publicado previamente. La mayoría de los pacientes requirió tratamiento quirúrgico. Conclusiones: La CD es una entidad de mayor ocurrencia en hombres de la sexta a la séptima década de la vida. La diabetes mellitus es la enfermedad que más se asocia a su aparición, sin encontrase diferencias entre los estudios realizados. En población colombiana no hay relación aparente con epilepsia. La presentación de la CD es variable, encontrándose en nuestra serie un mayor compromiso unilateral a diferencia de otras poblaciones donde la presentación usualmente es bilateral.

ABSTRACT Objective: To describe the clinical and epidemiological behavior of Dupuytren's contracture (DC) in the Colombian population, and to compare the results of this study with other series published in the literature. Materials and methods: A descriptive, observational study of 33 cases of DC presented at the Hospital San Pedro y San Pablo, La Virginia Risaralda, over the last 6 years. The patients were diagnosed with DC according to the established parameter. The results were compared against different series of DC cases published in the literature. Results: The mean age at diagnosis was 61.3 years, with a higher prevalence of men (64% of cases). The most frequent form of presentation was unilateral in the right hand (73%), unlike the reports from other series with usually bilateral involvement. Diabetes mellitus was the comorbidity most often associated with DC (24.24%), a finding similar to those of previous publications. Most patients required surgical treatment. Conclusions: DC is a condition that occurs more often in men in the sixth or seventh decade of life. Diabetes mellitus is the most frequently associated disease, with no differences being found among the various studies. In the Colombian population there is no apparent association with epilepsy. The presentation of DC is variable, but our series showed more unilateral involvement as compared to other populations where the presentation is usually bilateral.

Resultados a tres años de seguimiento de Fasciotomía percutánea con aguja en enfermedad de Dupuytren / Results after three years of follow-up of percutaneous fasciotomy with needle in Dupuytren's disease

Dupuytren's disease is the abnormal and progressive proliferation of the palmar fascia, its etiology remains unknown. Percutaneous needle fasciotomy is a minimally invasive procedure, where hypodermic needles are used as a scalpel blade to break the pathological cord in Dupuytren's disease. OBJECTIVE: To evaluate the results of percutaneous needle fasciotomy in patients with 3-year follow-up METHODS: Percutaneous needle fasciotomy was performed in patients from the regional hospital of Talca from January 2014 to January 2017, pre and post-procedure contracture measurement was performed, followed up at 6 weeks, 3 months and annually up to three years. there was a registry of complications, recurrence and functional results with the QuickDASH scale. RESULTS: Of the 17 patients chosen, 13 completed the follow-up. 15 fingers (5 little fingers, 9 ring fingers, 1 middle) and 23 joints. The metacarpophalangeal joints achieved an immediate correction of 89%, maintaining a correction of 48% at three years. The proximal interphalangeal joint achieved a correction of 62%, maintaining 32% at the end of the follow-up. The QuickDash managed to descend from 39.4 to 21.5 points. There was recurrence of 35.7% in the metacarpophalangeal joints and 42.8% in proximal interphalangeal joints. We found that percutaneous fasciotomy is a treatment option.

Epidemiological analysis of patients with Dupuytren's disease / Análise epidemiológica dos pacientes com doença de Dupuytren

ABSTRACT Objective: To evaluate the risk factors and analyze the characteristics of patients and lesions in Dupuytren's disease. Methods: Retrospective analysis of patients diagnosed with Dupuytren's disease in a hand surgery clinic in 2013. The authors evaluated parameters associated with the patient profiles and risk factors, the form and severity of involvement, and characteristics of the lesions. Results: 58 patients were evaluated, totaling 79 hands, with bilateral involvement in 46% of cases. The involvement of the ulnar fingers of the hand represented 78%, 44% being the ring finger. In 55% of cases, the patients had cords, while 45% showed only nodules. As for related factors, they were found most commonly in men (55%), whites (93%), and the elderly. Of coexisting diseases, the following were present: diabetes mellitus (49%), especially in the insulin-dependent (62%), hypertension (55.2%), and dyslipidemia (19%). With regard to lifestyle, 22% were smokers and 9% were alcohol consumers. Conclusion: It was observed a higher incidence of Dupuytren's disease was observed among men, whites, and the ulnar fingers of the hand, especially the ring finger. The most common associated diseases were diabetes mellitus and hypertension.

RESUMO Objetivo: Avaliar os fatores de risco e analisar as características dos pacientes e das lesões encontradas em portadores da doença de Dupuytren. Métodos: Análise retrospectiva dos pacientes diagnosticados com a doença de Dupuytren no ambulatório de cirurgia da mão em 2013. Foram avaliados parâmetros associados ao perfil dos pacientes e fatores de risco, a forma e gravidade do acometimento e as características das lesões. Resultados: Foram avaliados 58 pacientes, 79 mãos, com acometimento bilateral em 46% dos casos. O envolvimento dos dedos do lado ulnar da mão representou 78%, 44% dos casos no dedo anular. Em 55% dos casos os pacientes apresentavam cordas, enquanto 45% mostravam apenas nódulos. Quanto aos fatores relacionados, encontramos predomínio em homens (55%), brancos (93%) e idosos. Das doenças coexistentes, estavam presentes a diabetes mellitus (49%), especialmente nos insulinodependentes (62%), hipertensos (55,2%) e dislipidêmicos (19%). Com relação aos hábitos de vida, 22% eram fumantes e 9% etilistas. Conclusão: Foi observada uma maior incidência da doença de Dupuytren entre homens, brancos, nos dedos do lado ulnar da mão, principalmente no dedo anular. As doenças mais comumente associadas foram o diabetes mellitus e hipertensão arterial sistêmica.

Epidemiological analysis of patients with Dupuytren's disease.

OBJECTIVE: To evaluate the risk factors and analyze the characteristics of patients and lesions in Dupuytren's disease. METHODS: Retrospective analysis of patients diagnosed with Dupuytren's disease in a hand surgery clinic in 2013. The authors evaluated parameters associated with the patient profiles and risk factors, the form and severity of involvement, and characteristics of the lesions. RESULTS: 58 patients were evaluated, totaling 79 hands, with bilateral involvement in 46% of cases. The involvement of the ulnar fingers of the hand represented 78%, 44% being the ring finger. In 55% of cases, the patients had cords, while 45% showed only nodules. As for related factors, they were found most commonly in men (55%), whites (93%), and the elderly. Of coexisting diseases, the following were present: diabetes mellitus (49%), especially in the insulin-dependent (62%), hypertension (55.2%), and dyslipidemia (19%). With regard to lifestyle, 22% were smokers and 9% were alcohol consumers. CONCLUSION: It was observed a higher incidence of Dupuytren's disease was observed among men, whites, and the ulnar fingers of the hand, especially the ring finger. The most common associated diseases were diabetes mellitus and hypertension.

OBJETIVO: Avaliar os fatores de risco e analisar as características dos pacientes e das lesões encontradas em portadores da doença de Dupuytren. MÉTODOS: Análise retrospectiva dos pacientes diagnosticados com a doença de Dupuytren no ambulatório de cirurgia da mão em 2013. Foram avaliados parâmetros associados ao perfil dos pacientes e fatores de risco, a forma e gravidade do acometimento e as características das lesões. RESULTADOS: Foram avaliados 58 pacientes, 79 mãos, com acometimento bilateral em 46% dos casos. O envolvimento dos dedos do lado ulnar da mão representou 78%, 44% dos casos no dedo anular. Em 55% dos casos os pacientes apresentavam cordas, enquanto 45% mostravam apenas nódulos. Quanto aos fatores relacionados, encontramos predomínio em homens (55%), brancos (93%) e idosos. Das doenças coexistentes, estavam presentes a diabetes mellitus (49%), especialmente nos insulinodependentes (62%), hipertensos (55,2%) e dislipidêmicos (19%). Com relação aos hábitos de vida, 22% eram fumantes e 9% etilistas. CONCLUSÃO: Foi observada uma maior incidência da doença de Dupuytren entre homens, brancos, nos dedos do lado ulnar da mão, principalmente no dedo anular. As doenças mais comumente associadas foram o diabetes mellitus e hipertensão arterial sistêmica.

Surgical treatment results for dupuytren's disease.

OBJECTIVE: To present the results of our cases of Dupuytren's disease treated with regional selective fasciectomy in light of the literature. METHODS: Patients diagnosed with Dupuytren's contracture and surgically treated with regional selective fasciectomy at our institution with adequate follow-up data were included in the study. All patients were routinely followed after surgery to assess results and complications. QuickDASH scoring was used to evaluate the patients and recurrences and complications were recorded. RESULTS: Twenty-one hands of 19 patients (13 males, 6 females) who underwent surgery and received adequate follow-up were retrospectively evaluated. Mean patient age was 65.8 (range: 41 to 86) and the mean follow-up period was 48.2 months (range: 24 to 86). Fourteen (66.6%) hands had excellent results, five (23%) hands had good results and two (9.4%) had fair results. The mean QuickDASH score for the patients at the final follow-up was 6.58 (range: 0 to 20.4). CONCLUSION: Our study results demonstrated that regional selective fasciectomy is a reliable and efficient method to treat Dupuytren's disease with low rates of complications and recurrence and the technique can be considered the gold standard. Level of Evidence IV, Case Series.

OBJETIVO: Apresentar os resultados de nossos casos de doença de Dupuytren tratados com fasciotomia seletiva regional, à luz da literatura. MÉTODOS: Os pacientes diagnosticados com contratura de Dupuytren e tratados cirurgicamente com fasciotomia seletiva regional em nossa instituição que tinham dados de acompanhamento adequados foram incluídos no estudo. Todos os pacientes foram rotineiramente acompanhados após a cirurgia para avaliação dos resultados e das complicações. Foi utilizada a pontuação QuickDASH na avaliação dos pacientes e as recorrências e complicações foram registradas. RESULTADOS: Foram avaliadas retrospectivamente vinte e uma mãos de 19 pacientes (13 homens, 6 mulheres) submetidos à cirurgia e acompanhados adequadamente. A média de idade dos pacientes foi de 65,8 (intervalo: 41 a 86) e o período médio de seguimento foi 48,2 meses (intervalo: 24 a 86). Quatorze (66,6%) mãos tiveram excelentes resultados, enquanto cinco (23%) mãos tiveram bons e duas (9,4%) tiveram resultados moderados. A pontuação média no QuickDASH dos pacientes no seguimento final foi de 6,58 (intervalo: 0 a 20,4). CONCLUSÃO: Os resultados do nosso estudo demonstraram que a fasciotomia seletiva regional é um método confiável e eficiente, com baixas taxas de complicação e recorrência no tratamento da doença de Dupuytren e a técnica pode ser considerada o padrão-ouro. Nível de Evidência IV, Série de Casos.

Surgical treatment results for dupuytren's disease / Resultados do tratamento cirúrgico na doença de dupuytren

ABSTRACT OBJECTIVE: To present the results of our cases of Dupuytren's disease treated with regional selective fasciectomy in light of the literature. METHODS: Patients diagnosed with Dupuytren's contracture and surgically treated with regional selective fasciectomy at our institution with adequate follow-up data were included in the study. All patients were routinely followed after surgery to assess results and complications. QuickDASH scoring was used to evaluate the patients and recurrences and complications were recorded. RESULTS: Twenty-one hands of 19 patients (13 males, 6 females) who underwent surgery and received adequate follow-up were retrospectively evaluated. Mean patient age was 65.8 (range: 41 to 86) and the mean follow-up period was 48.2 months (range: 24 to 86). Fourteen (66.6%) hands had excellent results, five (23%) hands had good results and two (9.4%) had fair results. The mean QuickDASH score for the patients at the final follow-up was 6.58 (range: 0 to 20.4). CONCLUSION: Our study results demonstrated that regional selective fasciectomy is a reliable and efficient method to treat Dupuytren's disease with low rates of complications and recurrence and the technique can be considered the gold standard. Level of Evidence IV, Case Series.

RESUMO OBJETIVO: Apresentar os resultados de nossos casos de doença de Dupuytren tratados com fasciotomia seletiva regional, à luz da literatura. MÉTODOS: Os pacientes diagnosticados com contratura de Dupuytren e tratados cirurgicamente com fasciotomia seletiva regional em nossa instituição que tinham dados de acompanhamento adequados foram incluídos no estudo. Todos os pacientes foram rotineiramente acompanhados após a cirurgia para avaliação dos resultados e das complicações. Foi utilizada a pontuação QuickDASH na avaliação dos pacientes e as recorrências e complicações foram registradas. RESULTADOS: Foram avaliadas retrospectivamente vinte e uma mãos de 19 pacientes (13 homens, 6 mulheres) submetidos à cirurgia e acompanhados adequadamente. A média de idade dos pacientes foi de 65,8 (intervalo: 41 a 86) e o período médio de seguimento foi 48,2 meses (intervalo: 24 a 86). Quatorze (66,6%) mãos tiveram excelentes resultados, enquanto cinco (23%) mãos tiveram bons e duas (9,4%) tiveram resultados moderados. A pontuação média no QuickDASH dos pacientes no seguimento final foi de 6,58 (intervalo: 0 a 20,4). CONCLUSÃO: Os resultados do nosso estudo demonstraram que a fasciotomia seletiva regional é um método confiável e eficiente, com baixas taxas de complicação e recorrência no tratamento da doença de Dupuytren e a técnica pode ser considerada o padrão-ouro. Nível de Evidência IV, Série de Casos.