Spanish Society of Medical Oncology recommendations for comprehensive assessment and care of cancer survivors' needs.

This article reviews the contemporary and inclusive definition of cancer survivorship, including patients with and without disease who have completed or continue to undergo treatment. The Spanish Society of Medical Oncology (SEOM) describes in this article the needs of these patients and outlines a care model based on an estimation of cancer incidence and identification of patient needs, to enable the provision of practical actions to achieve effective care. The objectives of this review are to identify the main effects of cancer on survivors and to establish appropriate ways of measuring these effects, as well as discussing the management of physical, psychological and social, occupational, financial, and other health-related needs. We suggest a multidisciplinary care model and training programs for the different professionals involved in care, and highlight challenges and the future role of the SEOM and health-care policy in ensuring optimum care of cancer survivors.

¿Está la cirugía académica en jaque? Visión acerca de los cirujanos/as del futuro

La cirugía académica requiere de un compromiso mayor comparado a la práctica quirúrgica fuera de centros académicos. Es mucho mas demandante por la carga docente y de investigación que involucra aparte de la labor asistencial, lo cual provoca conflictos en la relación laboral, familiar y desarrollo profesional integral. Las futuras generaciones tienen aspiraciones y visiones diferentes de cómo enfrentar el trabajo diario sin descuidar la calidad de vida. En este articulo se analizan los diferentes factores que afectan este equilibrio y como se espera que se manejará el escenario laboral en los próximos años.

Academic surgery requires a greater commitment compared to surgical practice outside academic centers. It is much more demanding due to the teaching and research load that it involves apart from the care work, which causes conflicts in the work, family relationship and comprehensive professional development. Future generations have different aspirations and visions of how to face daily work without neglecting quality of life. This article analyzes the different factors that affect this balance and how the labor scenario is expected to be managed in the coming years.

Urban air pollution evaluation in downtown streets of a medium-sized Latin American city using AERMOD dispersion model.

The transport sector is considered the largest contributor of air pollutants in urban areas, mainly on-road vehicles, affecting the environment and human health. Bahía Blanca is a medium-sized Latin American city, with high levels of traffic in the downtown area during peak hours. In this regard, it is necessary to analyze air pollution using an air quality model considering that there are no air pollutant measurements in the central area. Furthermore, this type of study has not been carried out in the region and since the city is expected to grow, it is necessary to evaluate the current situation in order to make effective future decisions. In this sense, the AERMOD model (US-EPA version) and the RLINE source type were used in this work. This study analyzes the variations of pollutant concentrations coming from mobile sources in Bahía Blanca's downtown area, particularly carbon monoxide (CO) and nitrogen oxides (NOx) during the period Jul-2020 to Jun-2022. It is interesting to note the results show the maximum concentration values detected are not directly associated with maximum levels of vehicle flow or emission rates, which highlights the importance of meteorological parameters in the modeling. In addition, alternative scenarios are proposed and analyzed from a sustainable approach. Regarding the scenario analysis, it can be concluded that diesel vehicles have a large influence on NOx emissions. Moreover, restrictions as strict as those proposed for a Low Emission Zone would be less applicable in the city than alternative temporary measures that modify traffic at peak hours.

La cirugía de corazón: pasado, presente y futuro

Toda especialidad médica, y en especial las quirúrgicas, necesitan, de alguna manera, vislumbrar el futuro que puedan ofrecer a los miembros más jóvenes de la especialidad y eventuales interesados en esta, de manera de asegurarles las mejores posibilidades de desarrollo profesional y personal, para, a su vez, poder reclutar a los mejores. Empero, para imaginar y forjar el futuro, es necesario vivir y enfrentar el presente. Pero, todo presente se asienta en un pasado, que es necesario conocer y meditar. Y de esto trata este artículo especial: pasado, presente y futuro de la cirugía de corazón, desde la particular visión de su autor.

Every medical specialty, mainly surgical specialties, needs to envision the future they can offer to the specialty's younger members and those eventually interested in it to assure them of the best possibilities for professional and personal development and, in turn, to be able to recruit the best one. However, it is necessary to live and face the present to imagine and forge the future. But every present is based on a past, which must be known and meditated upon. This article is about the past, present, and future of heart surgery, according to the particular vision of its author.

An overview of air pollution research in Chile: Bibliometric analysis and scoping review, challenger and future directions.

This study provides a comprehensive overview and bibliometric analysis of air pollution research in Chile from 1980 to 2022. The analysis reveals a significant increase in scientific production, a 9.2 annual growth rate, and an H-index of 60. The research spans 33 countries and is influenced by environmental sciences, meteorology, and atmospheric sciences journals. The top ten authors account for 33.49 % of all publications, with local institutions contributing more than 35 %. The University of Chile and the Pontifical Catholic University of Chile are significant contributors. The most cited articles focus on health impacts and various pollutant sources, emphasizing air pollution as a critical public health concern. The study also emphasizes environmental science, meteorology, and atmospheric science, focusing on topics such as air pollution and health, pollutants, models, sources and chemistry, and social sciences. The findings are affirmed through rigorous discussion and review, providing a roadmap for future research, guiding decision-making processes, and expanding the knowledge frontier in the field.

Environmental remediation of the norfloxacin in water by adsorption: Advances, current status and prospects.

Antibiotics are considered as the new generation water pollutants as these disturb endocrine systems if water contaminated with antibiotics is consumed. Among many antibiotics norfloxacin is present in various natural water bodies globally. This antibiotic is considered an emerging pollutant due to its low degradation in aquatic animals. Besides, it has many side effects on human vital organs. Therefore, the present article discusses the recent advances in the removal of norfloxacin by adsorption. This article describes the presence of norfloxacin in natural water, consumption, toxicity, various adsorbents for norfloxacin removal, optimization factors for norfloxacin removal, kinetics, thermodynamics, modeling, adsorption mechanism and regeneration of the adsorbents. Adsorption takes place in a monolayer following the Langmuir model. The Pseudo-second order model represents the kinetic data. The adsorption capacity ranged from 0.924 to 1282 mg g-1. In this sense, the parameters such as the NFX concentration added to the adsorbent textural properties exerted a great influence. Besides, the fixed bed-based removal at a large scale is also included. In addition to this, the simulation studies were also discussed to describe the adsorption mechanism. Finally, the research challenges and future perspectives have also been highlighted. This article will be highly useful for academicians, researchers, industry persons, and government authorities for designing future advanced experiments.

Light-Responsive and Dual-Targeting Liposomes: From Mechanisms to Targeting Strategies.

In recent years, nanocarriers have played an ever-increasing role in clinical and biomedical applications owing to their unique physicochemical properties and surface functionalities. Lately, much effort has been directed towards the development of smart, stimuli-responsive nanocarriers that are capable of releasing their cargos in response to specific stimuli. These intelligent-responsive nanocarriers can be further surface-functionalized so as to achieve active tumor targeting in a sequential manner, which can be simply modulated by the stimuli. By applying this methodological approach, these intelligent-responsive nanocarriers can be directed to different target-specific organs, tissues, or cells and exhibit on-demand controlled drug release that may enhance therapeutic effectiveness and reduce systemic toxicity. Light, an external stimulus, is one of the most promising triggers for use in nanomedicine to stimulate on-demand drug release from nanocarriers. Light-triggered drug release can be achieved through light irradiation at different wavelengths, either in the UV, visible, or even NIR region, depending on the photophysical properties of the photo-responsive molecule embedded in the nanocarrier system, the structural characteristics, and the material composition of the nanocarrier system. In this review, we highlighted the emerging functional role of light in nanocarriers, with an emphasis on light-responsive liposomes and dual-targeted stimuli-responsive liposomes. Moreover, we provided the most up-to-date photo-triggered targeting strategies and mechanisms of light-triggered drug release from liposomes and NIR-responsive nanocarriers. Lastly, we addressed the current challenges, advances, and future perspectives for the deployment of light-responsive liposomes in targeted drug delivery and therapy.

Prospective Teachers' Knowledge of Physical Activity in Children and Adolescents.

Over the past few years, organizations around the world have tried to reach different populations with recommendations about physical activity (PA), due to this subject playing an important role in the phases of intention development and in preparation for it. Thus, the knowledge of future educators in the fields of health and PA is of vital importance when improving the levels of the latter in students. The objective of this research is to determine what knowledge future teachers have about health and PA, examining possible disparities according to the gender, age, and level of physical exercise of the participants. In addition, the psychometric properties of the instrument used were explored. A total of 321 Colombian university students from the Faculty of Education between the ages of sixteen and thirty-five participated in this study, providing sociodemographic information by filling out the CUAFYS-A questionnaire. Significant differences were found in the scale items according to sex and self-perception of being physically active. Also, the findings revealed a single-factor structure with nine items that had satisfactory reliability (α = 0.71; CR = 0.72) and excellent goodness-of-fit indices (RMSEA = 0.055 (90% CI (0.3, 0.8), RMSR = 0.02, CFI = 0.935, NNFI = 0.912, CMIN/DF = 1.97). Therefore, strategies and campaigns to promote PA knowledge in prospective teachers should be tailored according to gender and PA levels. Similarly, the CUAFYS-A questionnaire can be considered a valid and reliable instrument to identify the PA knowledge of future educators.

Potential application of bee products in food industry: An exploratory review.

Over the past eight years, bee products such as wax, honey, propolis, and pollen have generated intense curiosity about their potential food uses; to explore these possibilities, this review examines the nutritional benefits and notable characteristics of each product related to the food industry. While all offer distinct advantages, there are challenges to overcome, including the risk of honey contamination. Indeed, honey has excellent potential as a healthier alternative to sugar, while propolis's remarkable antibacterial and antioxidant properties can be enhanced through microencapsulation. Pollen is a versatile food with multiple applications in various products. In addition, the addition of beeswax to oleogels and its use as a coating demonstrate significant improvements in the quality and preservation of environmentally sustainable foods over time. This study demonstrates that bee products and apitherapy are essential for sustainable future food and innovative medical treatments.

Low-Cost Biosensor Technologies for Rapid Detection of COVID-19 and Future Pandemics.

Many systems have been designed for the detection of SARS-CoV-2, which is the virus that causes COVID-19. SARS-CoV-2 is readily transmitted, resulting in the rapid spread of disease in human populations. Frequent testing at the point of care (POC) is a key aspect for controlling outbreaks caused by SARS-CoV-2 and other emerging pathogens, as the early identification of infected individuals can then be followed by appropriate measures of isolation or treatment, maximizing the chances of recovery and preventing infectious spread. Diagnostic tools used for high-frequency testing should be inexpensive, provide a rapid diagnostic response without sophisticated equipment, and be amenable to manufacturing on a large scale. The application of these devices should enable large-scale data collection, help control viral transmission, and prevent disease propagation. Here we review functional nanomaterial-based optical and electrochemical biosensors for accessible POC testing for COVID-19. These biosensors incorporate nanomaterials coupled with paper-based analytical devices and other inexpensive substrates, traditional lateral flow technology (antigen and antibody immunoassays), and innovative biosensing methods. We critically discuss the advantages and disadvantages of nanobiosensor-based approaches compared to widely used technologies such as PCR, ELISA, and LAMP. Moreover, we delineate the main technological, (bio)chemical, translational, and regulatory challenges associated with developing functional and reliable biosensors, which have prevented their translation into the clinic. Finally, we highlight how nanobiosensors, given their unique advantages over existing diagnostic tests, may help in future pandemics.

Detection of atmospheric aerosols and terrestrial nanoparticles collected in a populous city in southern Brazil.

The main objective of this study is to analyze hazardous elements in nanoparticles (NPs) (smaller than 100 nm) and ultrafine particles (smaller than 1 µm) in Porto Alegre City, southern Brazil using a self-made passive sampler and Sentinel-3B SYN satellite images in 32 collection points. The Aerosol Optical Thickness proportion (T550) identification was conducted using images of the Sentinel-3B SYN satellite at 634 points sampled in 2019, 2020, 2021, and 2022. Focused ion beam scanning electron microscopy analyses were performed to identify chemical elements present in NPs and ultrafine particles, followed by single-stage cascade impactor to be processed by high-resolution transmission electron microscopy. This process was coupled with energy-dispersive X-ray spectroscopy and later analysis via secondary ion mass spectrometry. Data was acquired from Sentinel-3B SYN images, normalized to a standard mean of 0.83 µg/mg, at moderate spatial resolution (260 m), and modeled in the Sentinel Application Platform (SNAP) software v.8.0. Statistical matrix data was generated in the JASP software (Jeffreys's Amazing Statistics Program) v.0.14.1.0 followed by a K-means cluster analysis. The results demonstrate the presence of between 1 and 100 nm particles of the following chemical elements: Si, Al, K, Mg, P, and Ti. Many people go through these areas daily and may inhale or absorb these elements that can harm human health. In the Sentinel-3B SYN satellite images, the sum of squares in cluster 6 is 168,265 and in cluster 7 a total of 21,583. The use of images from the Sentinel-3B SYN satellite to obtain T550 levels is of great importance as it reveals that atmospheric pollution can move through air currents contaminating large areas on a global scale.

Towards the Future of Public Health: Roadmapping Trends and Scenarios in the Post-COVID Healthcare Era.

The COVID-19 pandemic, a transformative event in modern society, has disrupted routine, work, behavior, and human relationships. Organizations, amidst the chaos, have innovatively adapted to the evolving situation. However, many countries were unprepared for the magnitude of the challenge, revealing the fragility of health responses due to inadequate leadership, insufficient resources, and poor information system integration. Structural changes in health systems are imperative, particularly in leadership, governance, human resources, financing, information systems, technology, and health service provision. This research utilizes the Technological Roadmapping method to analyze the health sector, focusing on public health, drawing on articles from SCOPUS and PubMed databases, and creating a roadmap extending to 2050. The research presents three long-term scenarios based on the literature-derived roadmap and explores various alternatives, including integrated care, telemedicine, Big Data utilization, nanotechnology, and Big Tech's AI services. The results underscore the anticipation of post-pandemic public health with high expectations, emphasizing the importance of integrating health history access, encouraging self-care, and leveraging technology for streamlined treatment. Practical implications include insights for decision makers and stakeholders to inform strategic planning and adapt to evolving industry demands, recognizing the significance of preventive services and the humanizing potential of technology.

Fluctuation of ecological niches and geographic range shifts along chile pepper's domestication gradient.

Domestication is an ongoing well-described process. However, while many have studied the changes domestication causes in plant genetics, few have explored its impact on the portion of the geographic landscape in which the plants exist. Therefore, the goal of this study was to understand how the process of domestication changed the geographic space suitable for chile pepper (Capsicum annuum) in its center of origin (domestication). C. annuum is a major crop species globally whose center of domestication, Mexico, has been well-studied. It provides a unique opportunity to explore the degree to which ranges of different domestication classes diverged and how these ranges might be altered by climate change. To this end, we created ecological niche models for four domestication classes (wild, semiwild, landrace, modern cultivar) based on present climate and future climate scenarios for 2050, 2070, and 2090. Considering present environment, we found substantial overlap in the geographic niches of all the domestication classes. Yet, environmental and geographic aspects of the current ranges did vary among classes. Wild and commercial varieties could grow in desert conditions, while landraces could not. With projections into the future, habitat was lost asymmetrically, with wild, semiwild, and landraces at greater risk of territorial declines than modern cultivars. Further, we identified areas where future suitability overlap between landraces and wilds is expected to be lost. While range expansion is widely associated with domestication, we found little support of a constant niche expansion (either in environmental or geographical space) throughout the domestication gradient in chile peppers in Mexico. Instead, particular domestication transitions resulted in loss, followed by capturing or recapturing environmental or geographic space. The differences in environmental characterization among domestication gradient classes and their future potential range shifts increase the need for conservation efforts to preserve landraces and semiwild genotypes.

Perception of the Level of Competency of Candidates for Graduation: A Multidisciplinary Approach to Complex Thinking.

Complex thinking is a cognitive skill that focuses on the integrated analysis and synthesis of information with a systemic and critical perspective that enables creative decision-making in the face of complex realities or challenges. At the educational level, it is valued as a transdisciplinary competency, meaning it is relevant for individuals regardless of their profession or field of study. This article presents the results of measuring the perceived achievement of complex thinking among 830 graduating students from a technological university in Mexico, aiming to identify possible significant differences based on their discipline or major. Methodologically, a multivariate descriptive statistical analysis was performed using R and RStudio software, including calculation of means and standard deviations, violin plots, boxplot and ANOVA significance analysis, and t-test. The results show that the differences were not statistically significant in all the disciplines, although it is possible to note significant differences, which reveals a differentiated behavior in the process of formation and development of complex thinking according to the discipline of study. In conclusion, the present study shows that the students' areas of training are associated with differences in perception of complex thinking and its associated sub-competencies, thus differentiating this ability in their graduation profile. This article contributes to the existing literature on the formation and development of complex thinking and its sub-competencies as relevant professional skills for lifelong learning.

Lying about the future: Shuar-Achuar epistemic norms, predictions, and commitments.

Is there variation across cultures in what counts as a lie? Here we present evidence for a potentially unique conceptualization of lying in Shuar-Achuar communities in Ecuador, contrasting this conceptualization with people in twelve other countries and non-Shuar-Achuar Ecuadorians. In Shuar-Achuar communities, but not others, predictions of the future that turn out to be false are considered lies, even when the events that render them false are unforeseen. Failed commitments, on the other hand, are not seen as lies when unforeseen events prevent them from being kept. To explain this phenomenon, we suggest that there is an epistemic norm that regulates predictive speech acts in Shuar-Achuar communities, linked to the view that the future can be known under certain special circumstances. This norm holds that claiming knowledge of the future is a form of lying when events prove the prediction false. Commitments, on the other hand, do not imply certainty about the future and so are not considered lies when circumstances prevent them from being fulfilled. In addition, we found several other factors that influence whether speech acts are categorized as lies, including the speaker's expertise, group membership, and the nature of the outcome.

La percepción de un futuro significativo y su relación con el autoconcepto y las experiencias positivas durante pandemia de covid-19 en estudiantes de nivel superior

Objetivo: Analizar la relación entre las experiencias en las actividades de disfrute, la claridad en el autoconcepto y la percepción de un futuro significativo en jóvenes que cursan estudios superiores durante la pandemia de covid-19. Método: Participantes: estudiantes (n = 228), de ambos sexos de distintas carreras de nivel superior de Buenos Aires. Instrumentos: Cuestionario sociodemográfico. Cuestionario de los posibles sí mismos. Escala de propósito vital para estudiantes universitarios. Escala de claridad en el autoconcepto. Escala de Disfrute en la Actividad. Escala de Autorrealización en la Actividad. Escala de Indicadores Físicos y Psicoemocionales de Estrés. Resultados: más de la mitad de los estudiantes (65,8 %) percibe grandes cambios en su actividad de disfrute durante la cuarentena, pero estos no se relacionan con la percepción de un futuro significativo. La claridad en el autoconcepto predice la probabilidad de alcanzar los posibles sí mismos deseados y la búsqueda de propósito vital. La claridad, el afecto positivo y la autorrealización predicen la identificación de propósito vital. Las variables estudiadas se asocian a menores síntomas de estrés. Conclusión: los resultados muestran la necesidad de favorecer estas experiencias, así como la exploración del autoconocimiento, valores e intereses, que promuevan la identificación de metas, como factor de protección frente a los efectos y consecuencias del contexto actual.

Objective: Analyze the relationship between experiences in enjoyment activities, self-concept clarity and the perception of a significant future in young people who are pursuing higher education during the covid-19 pandemic. Method: Participants: students (n = 228), of both sexes who were studying different higher-level careers in Buenos Aires. Instruments: Sociodemographic questionnaire. Possible Selves Questionnaire. Purpose in Life Scale for College Students. Self-concept clarity Scale. Scale of Enjoyment in Activity, Scale of Personal Achievement. Scale of Physical and Psychoemotional Indicators of Stress. Results: More than a half of the students (65,8 %) perceive great changes in their enjoyment activity during the quarantine, but these are not related to the perception of a significant future. Self-concept clarity predicts the probability of attaining possible desired selves and the pursuit of purpose in life Clarity, positive affect, and self-actualization predict purpose in life identification. The variables studied are associated with fewer stress symptoms. Conclusion: The results show the need to favor these experiences, as well as the exploration of self-knowledge, values and interests, which promote the identification of goals, as a protective factor against the effects and consequences of the current context.

Nanoparticles containing hazardous elements and the spatial optics of the Sentinel-3B OLCI satellite in Amazonian rivers: a potential tool to understand environmental impacts.

The Amazon River is the longest river in the world. The Tapajós River is a tributary to the Amazon. At their junction, a marked decrease in water quality is evident from negative impacts from the constant activity of clandestine gold mining in the Tapajós River watershed. The accumulation of hazardous elements (HEs), capable of compromising environmental quality across large regions is evident in the waters of the Tapajós. Sentinel-3B OLCI (Ocean Land Color Instrument) Level-2 satellite imagery with Water Full Resolution (WFR) of 300 m was utilized to detect the highest potential for the absorption coefficient of detritus and gelbstoff in 443 m-1 (ADG443_NN), chlorophyll-a (CHL_NN) and total suspended matter concentration (TSM_NN), at 25 points in the Amazon and Tapajós rivers (in 2019 and 2021). Physical samples of riverbed sediment collected in the field at the same locations were analyzed for NPs and ultra-fine particles to verify the geospatial findings. The riverbed sediment samples collected in the field were studied by Transmission electron microscopy (TEM) and scanning transmission electron microscopy (STEM), with selected area electron diffraction (SAED), following laboratory analytical procedures. The Sentinel-3B OLCI images, based on the Neural Network (NN) were calibrated by the European Space Agency (ESA), with a standard average normalization of 0.83 µg/mg, containing a maximum error of 6.62% applied to the sampled points. The analysis of the riverbed sediment samples revealed the presence of the following hazardous elements: As, Hg, La, Ce, Th, Pb, Pd, among several others. The Amazon River has significant potential to transport ADG443_NN (55.475 m-1) and TSM_NN (70.787 gm-3) in sediments, with the possibility of negatively impacting marine biodiversity, in addition to being harmful to human health over very large regions.

Responses of population structure and genomic diversity to climate change and fishing pressure in a pelagic fish.

The responses of marine species to environmental changes and anthropogenic pressures (e.g., fishing) interact with ecological and evolutionary processes that are not well understood. Knowledge of changes in the distribution range and genetic diversity of species and their populations into the future is essential for the conservation and sustainable management of resources. Almaco jack (Seriola rivoliana) is a pelagic fish with high importance to fisheries and aquaculture in the Pacific Ocean. In this study, we assessed contemporary genomic diversity and structure in loci that are putatively under selection (outlier loci) and determined their potential functions. Using a combination of genotype-environment association, spatial distribution models, and demogenetic simulations, we modeled the effects of climate change (under three different RCP scenarios) and fishing pressure on the species' geographic distribution and genomic diversity and structure to 2050 and 2100. Our results show that most of the outlier loci identified were related to biological and metabolic processes that may be associated with temperature and salinity. The contemporary genomic structure showed three populations-two in the Eastern Pacific (Cabo San Lucas and Eastern Pacific) and one in the Central Pacific (Hawaii). Future projections suggest a loss of suitable habitat and potential range contractions for most scenarios, while fishing pressure decreased population connectivity. Our results suggest that future climate change scenarios and fishing pressure will affect the genomic structure and genotypic composition of S. rivoliana and lead to loss of genomic diversity in populations distributed in the eastern-central Pacific Ocean, which could have profound effects on fisheries that depend on this resource.

Las respuestas de las especies marinas ante los cambios ambientales y presiones antropogénicas (por ejemplo, la sobrepesca) interactúan con procesos ecológicos y evolutivos que no se comprenden bien. El conocimiento del cambio en el rango de distribución y la diversidad genética de las especies y sus poblaciones en el futuro es fundamental para la conservación y gestión sostenible de los recursos. El jurel (Seriola rivoliana) es un pez pelágico de gran importancia para la pesca y la acuicultura en el Océano Pacífico. En este estudio, evaluamos la diversidad y estructura genómica contemporánea en loci que supuestamente están bajo selección (loci atípicos) y determinamos sus funciones potenciales. Se utilizó la combinación de métodos de asociación genotipo-ambiente, modelos de distribución espacial y simulaciones demogenéticas, para modelar los efectos del cambio climático (bajo tres escenarios RCP diferentes) y presión de pesca sobre la distribución geográfica de la especie, la diversidad y estructura genómica para los años 2050 y 2100. Nuestros resultados mostraron que la mayoría de los loci atípicos están relacionados con procesos biológicos y metabólicos que pueden estar asociados con la temperatura y la salinidad. La estructura genómica contemporánea mostró tres poblaciones: dos en el Pacífico oriental (Cabo San Lucas y el Pacífico oriental) y una en el Pacífico central (Hawai). Las proyecciones futuras sugieren una pérdida de hábitat idóneo y posibles contracciones del área de distribución para la mayoría de los escenarios, mientras que la presión de la pesca redujo la conectividad de las poblaciones. Nuestros resultados sugieren que los escenarios de cambio climático y la presión pesquera afectarán la estructura genómica y la composición genotípica de S. rivoliana y conducirán a la pérdida de diversidad genómica en las poblaciones distribuidas en el Océano Pacífico centro-oriental, lo que podría tener efectos en las pesquerías que dependen de este recurso.

Three years of COVID-19 pandemic: comparative analysis of incidence, lethality and mortality among the States of the south region of Brazil / Três anos de pandemia da COVID-19: análise comparativa da incidência, letalidade e mortalidade entre os Estados da região sul do Brasi

Introduction: the first COVID-19 case in Brazil was confirmed on February 26, 2020. As of March 17, 2023, the Ministry of Health reported 699,634 deaths from COVID-19, with a case fatality rate of 1.9%. The impact of the COVID-19 pandemic in Brazil extends to socioeconomic and healthcare systems, reflecting significant regional disparities. Objective: To analyze mortality, incidence, and case fatality rates for COVID-19 in the states of Paraná and Santa Catarina, in the southern region of Brazil. Methods: This is an ecological time-series study using official Brazilian secondary data for COVID-19 cases and deaths. Data were extracted from the dashboard of the State Health Department of Santa Catarina and Paraná. Temporal series were developed for trend analysis using the Prais-Winsten regression model. Statistical analyses were performed using STATA 14.0 software (College Station, TX, USA, 2013). Results: In the analysis of rates over the entire period, trends for mortality, case fatality, and incidence in the state of Santa Catarina are decreasing, decreasing, and stationary, respectively. In Paraná, rates over the entire period showed a stationary trend for mortality, decreasing for case fatality, and increasing for incidence. Conclusion: COVID-19 had a devastating effect on the states of Santa Catarina and Paraná. Both states experienced the progression of the COVID-19 pandemic, with higher case fatality and mortality rates observed in Paraná, while Santa Catarina had a higher incidence rate over the three years of the COVID-19 pandemic.