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1.
J Psychiatr Res ; 178: 147-155, 2024 Oct.
Article in English | MEDLINE | ID: mdl-39141994

ABSTRACT

Disturbed sleep is a common feature after exposure to a traumatic event, especially when PTSD develops. However, although there is evidence suggesting a potential role of sleep disturbance in the progression of PTSD symptoms, the interrelationship between sleep and PTSD symptoms has yet to be determined. In order to address this knowledge gap, we have investigated the influence of initial sleep characteristics on the evolution of post-traumatic stress disorder (PTSD) symptoms over 4 years of follow-up among individuals exposed to the Brazilian Kiss nightclub fire. Participants were individuals exposed to the 2013 Kiss nightclub fire in Brazil. Sleep characteristics and PTSD symptoms were measured within the 4 years following the fire by self-report questionnaires, such as The Pittsburgh Sleep Quality Index (PSQI), and PTSD Checklist - Civilian version (PCL-C). Generalized estimating equations (GEE) models were used to examine the longitudinal associations (by estimating the relative effects of initial sleep problems on PTSD symptoms after adjusting for covariates). Comprehensive information concerning socio-demographic factors, health status, and sleep complaints were obtained. A total of 232 individuals were included. In GEE models, no significant interactions were observed between sociodemographic variables and PTSD symptoms in the follow-up period, however, associations were found between PTSD at baseline and the following factors: the female gender, the victim individuals and the existence of prior psychiatric disease. Initial subjective sleep parameters were strongly associated with PTSD symptoms over 4 years, mainly the presence of disturbed dreams (p = 0.012), increased sleep latency (p = 0.029), and reduced sleep duration (p = 0.012). Sleep complaints and PTSD symptoms were common among individuals after the disaster. The current study has found that the presence of sleep complaints, especially increased sleep latency, presence of disturbed dreams and short sleep duration, in the initial presentation after the fire was consistently associated with the perpetration of PTSD symptoms in the next 4 years of follow-up. These findings suggest that interventions addressing these sleep complaints have the potential to reduce the persistence and/or severity of PTSD symptoms.


Subject(s)
Sleep Wake Disorders , Stress Disorders, Post-Traumatic , Humans , Stress Disorders, Post-Traumatic/physiopathology , Stress Disorders, Post-Traumatic/epidemiology , Male , Female , Adult , Longitudinal Studies , Sleep Wake Disorders/epidemiology , Sleep Wake Disorders/physiopathology , Sleep Wake Disorders/etiology , Middle Aged , Brazil/epidemiology , Young Adult , Disease Progression , Follow-Up Studies
2.
Hemoglobin ; 48(2): 87-93, 2024 Mar.
Article in English | MEDLINE | ID: mdl-38616298

ABSTRACT

Poor sleep and chronic illnesses have a bidirectional relationship where presence of one can worsen the other. Sickle cell disease (SCD) is associated with significant morbidity and early mortality. In this study, we examine sleep quality, its predictors, and its association with quality of life in Jamaican adults with SCD. This cross-sectional study evaluated 177 well adult SCD patients for sleep quality using The Pittsburgh Sleep Quality Index (PSQI) and quality of life using the Adult Sickle Cell Quality of Life Measurement Information System (ASCQ-Me). Multiple linear regression models examined the predictors of poor sleep quality. The mean global PSQI score was 6.9 (SD 4.2) with 56.5% having poor sleep quality. Women had significantly worse scores for sleep efficiency (p 0.005), sleep latency (p 0.03) and higher use of sleeping medications (p 0.02). Those overweight/obese had significantly worse subjective sleep quality (p 0.001) and sleep efficiency (p 0.05). In multivariate regression analysis, overweight individuals had poorer sleep quality (OR: 2.9; 95% C.I.: 1.07, 7.88) than those with normal weight whereas those unemployed and looking for a job had lower prevalence of poor sleep quality (OR 0.2; 95% C.I.: 0.05, 0.77) compared to employed individuals. Participants with good sleep quality had significantly better functioning in all 5 domains of the ASCQ-Me. In conclusion, persons with SCD who are overweight or obese are at increased risk of poor sleep which can negatively affect quality of life. Patient populations and healthcare providers will need to manage the emerging burden of overweight/obesity.


Subject(s)
Anemia, Sickle Cell , Quality of Life , Sleep Quality , Humans , Anemia, Sickle Cell/complications , Anemia, Sickle Cell/epidemiology , Female , Male , Adult , Jamaica/epidemiology , Risk Factors , Prevalence , Cross-Sectional Studies , Sleep Wake Disorders/epidemiology , Sleep Wake Disorders/etiology , Middle Aged , Young Adult , Surveys and Questionnaires
3.
Article in Spanish | LILACS, UY-BNMED, BNUY | ID: biblio-1447208

ABSTRACT

El año 2020 será recordado por el comienzo de la pandemia de COVID-19, la que ha generado trágicas consecuencias para la salud personal y social. Además de los fallecimientos, contagios y el temor a estos, se redujo considerablemente la interacción social debido al confinamiento. Trabajos realizados en distintos países demostraron que la pandemia ha generado importantes trastornos del sueño. Con el objetivo de explorar si la pandemia afectó el sueño de los uruguayos, del 16 al 20 mayo del 2020 se realizó una encuesta anónima vía Web, a mayores de 18 años residentes en Uruguay (n =1137). Esta consistió en el Índice de Calidad de Sueño de Pittsburgh (ICSP), que es el cuestionario auto administrado más utilizado para este fin. El ICSP explora 7 dimensiones de sueño (calidad subjetiva, latencia, duración, eficiencia, perturbaciones, medicación y disfunción diurna), con un rango de puntaje de 0 a 21 (mayor puntuación, menor calidad de sueño), donde un ICSP mayor a 5 se considera una mala calidad de sueño. Los resultados mostraron que el ICSP promedio fue de 7,4 ± 4,0, presentando 63% de los encuestados un ICSP > 5. El ICSP fue mayor en mujeres (8,2 ± 4,0) que en hombres (6,4 ± 3,8; P < 0.001). El ICSP junto con otros parámetros relevados, sugieren que los residentes en Uruguay presentaron una mala calidad de sueño al comienzo de la pandemia.


The year 2020 will be remembered for the beginning of the COVID-19 pandemic, which has generated tragic consequences for personal and social health. In addition to deaths, infections and the fear of these, social interaction was considerably reduced due to confinement. Studies carried out in different countries showed that the pandemic has generated significant sleep disorders. With the aim of exploring whether the pandemic affected the sleep of Uruguayans, from May 16 to 20, 2020, an anonymous survey was carried out via the Web, to residents over 18 years of age in Uruguay (n = 1137). This consisted of the Pittsburgh Sleep Quality Index (PSQI), which is the most widely used self-administered questionnaire for this purpose. The PSQI explores 7 dimensions of sleep (subjective quality, latency, duration, efficiency, disturbances, medication, and daytime dysfunction), with a score range from 0 to 21 (higher score, lower sleep quality), where an ICSP greater than 5 it is considered a poor quality of sleep. The results showed that the average ICSP was 7.4 ± 4.0, with 63% of the respondents presenting an ICSP > 5. The ICSP was higher in women (8.2 ± 4.0) than in men (6.4 ± 3.8, P < 0.001). The ICSP, together with other parameters collected, suggest that residents of Uruguay had poor sleep quality at the beginning of the pandemic.


O ano de 2020 será lembrado pelo início da pandemia do COVID-19, que gerou consequências trágicas para a saúde pessoal e social. Além das mortes, das infecções e do medo destas, o convívio social foi consideravelmente reduzido devido ao confinamento. Trabalhos realizados em diferentes países mostraram que a pandemia gerou distúrbios significativos do sono. Com o objetivo de explorar se a pandemia afetou o sono dos uruguaios, de 16 a 20 de maio de 2020, foi realizada uma pesquisa anônima via Web, para maiores de 18 anos residentes no Uruguai (n = 1137). Este consistiu no Índice de Qualidade do Sono de Pittsburgh (ICSP), que é o questionário autoaplicável mais utilizado para esse fim. O ICSP explora 7 dimensões do sono (qualidade subjetiva, latência, duração, eficiência, distúrbios, medicação e disfunção diurna), com uma escala de pontuação de 0 a 21 (maior pontuação, menor qualidade do sono), onde um ICSP maior que 5 é considerado uma má qualidade de sono. Os resultados mostraram que o ICSP médio foi de 7,4 ± 4,0, com 63% dos entrevistados apresentando ICSP > 5. O ICSP foi maior nas mulheres (8,2 ± 4,0) do que nos homens (6,4 ± 3,8, P < 0,001). O ICSP, juntamente com outros parâmetros coletados, sugere que os residentes do Uruguai tinham má qualidade de sono no início da pandemia.


Subject(s)
Humans , Male , Female , Sleep Wake Disorders/epidemiology , Sleep Quality , Uruguay/epidemiology , Health Surveys , Sex Distribution , Pandemics , COVID-19/epidemiology , Sociodemographic Factors
4.
Mol Genet Metab Rep ; 31: 100870, 2022 Jun.
Article in English | MEDLINE | ID: mdl-35782624

ABSTRACT

Introduction: Although the diurnal fluctuation of motor dysfunction, reversible with small doses of dopamine, is a cornerstone for the phenotype of the autosomal dominant Segawa syndrome, the non-motor symptoms of this neurotransmitter deficiency have still received limited attention. Objective: This study aims to evaluate non-motor symptoms of this dopa-responsive dystonia through an intrafamilial comparative cross-sectional study. Methods: Seventeen individuals with a c.IVS5 + 3insT (c.626 + 3insT) variation in the GTP cyclohydrolase-1 gene (GCH1, HGNC: 4193) and 34 intrafamilial controls were studied using the Beck Depression Inventory-II, the Wiener Matrizen Test 2, the Epworth Sleepiness Scale, the Pittsburgh Sleep Quality Index, the MINI/MINI PLUS Questionnaires, the World Health Organization Quality of Life - BREF Instrument and a drug use assessment questionnaire. Results: No significant difference was found between the groups in the prevalence of sleep disorders and in cognitive function. Nevertheless, generalized anxiety disorder (p = 0.050) and attention-deficit/hyperactivity disorder in childhood (p = 0.011) were observed only in individuals without the molecular variation. The group with the GCH1 variation presented a worse perception about how safe they feel in their daily lives (p = 0.034), less satisfaction with themselves (p = 0.049) and with their relationships (p = 0.029), and a higher prevalence of past major depressive episodes before use of L-Dopa (p = 0.046). Conclusion: Low dopamine could have been protective against generalized anxiety disorder and attention-deficit/hyperactivity disorder in childhood in Segawa group individuals. The prevalence of depression was higher in individuals with the molecular variant prior to the L-Dopa treatment. Considering it, the penetrance estimates for the variant carriers increased from 58.8% to up to 88% in this large studied family. Additionally, neuropsychiatric tests of all individuals with a molecular diagnosis in an affected family are a valuable instrument for its clinical management.

5.
Article in English | MEDLINE | ID: mdl-34206786

ABSTRACT

This study aimed to examine the prevalence rates of poor quality sleep and daytime sleepiness in health professionals and their association with socioeconomic, lifestyle, and anthropometric factors and psychosocial work conditions. This cross-sectional study was performed with health professionals from various public and private hospitals in Rio Verde, Goiás, Brazil. Daytime sleepiness and sleep quality were assessed using the Epworth Sleepiness Scale and the Pittsburgh Sleep Quality Index, respectively. The variables were analyzed using multiple hierarchical Poisson regression in the statistical package Stata version 13.0. A total of 244 health professionals participated in this study (women, 78.28%). The rates of abnormal daytime sleepiness and poor sleep quality were 50.41% (n = 123) and 55.74% (n = 136), respectively. Reduced physical activity was associated with poor sleep quality (prevalence ratio (PR) = 1.32; 95% confidence interval (CI) 1.02-1.70, p = 0.035). Age between 20 and 29 years (PR = 2.59; 95% CI 1.37-4.91, p = 0.021) and 30 and 49 years (PR = 2.09; 95% CI 1.12-3.91, p = 0.021), as well as excessive alcohol consumption (PR = 1.29; 95% CI 1.01-1.66, p = 0.048), were risk factors for daytime sleepiness. Conversely, adequate bodyweight (PR = 0.52; 95% CI 0.33-0.82, p = 0.005) was considered a protective factor. The present findings suggest high rates of abnormal daytime sleepiness and poor sleep quality among healthcare professionals. We emphasize the importance of physical activity, adequate weight, and healthy habits for better quality sleep and reduced daytime sleepiness.


Subject(s)
Disorders of Excessive Somnolence , Sleep Wake Disorders , Adult , Brazil/epidemiology , Cross-Sectional Studies , Disorders of Excessive Somnolence/epidemiology , Female , Humans , Prevalence , Sleep , Sleep Wake Disorders/epidemiology , Surveys and Questionnaires , Young Adult
6.
Eur J Psychotraumatol ; 12(1): 1934788, 2021 06 24.
Article in English | MEDLINE | ID: mdl-34221253

ABSTRACT

Background: Most posttraumatic stress disorder (PTSD) sleep disturbances reports have been conducted in male combat veteran populations, usually decades after the disorder's onset. Given the increase in the prevalence of violence against women and the fact that women are at greater risk for developing PTSD, it is critical to examine sleep abnormalities in this population. Objectives: To examine subjective and objective sleep quality in young women with PTSD following sexual assault compared with a control group at baseline and after one year of treatment. Methods: Seventy-four women with PTSD following sexual assault and 64 healthy controls with no history of sexual assault were assessed using the Clinician-Administered PTSD Scale (CAPS-5), the Beck Depression Inventory, the Beck Anxiety Inventory, the Pittsburgh Sleep Quality Index (PSQI), the Modified Fatigue Impact Scale, and the Insomnia Severity Index. Subjects also underwent full in-lab polysomnography. PTSD participants received pharmacological and/or psychological therapy between baseline and one-year follow-up. Results: The PTSD group had significantly higher scores in the clinical and sleep measurements than the control group. Although the PTSD group reported poorer subjective sleep quality than healthy controls, there were few between-group differences in objective sleep. Analysis of the PTSD group at baseline and one-year follow-up showed that the PSQI global score was a significant predictor of PTSD improvement. Conclusions: Sleep quality is impaired in young women with PTSD and may impact long-term treatment responses. Better sleep quality is significantly associated with PTSD improvement, independent of depression and anxiety.


Antecedentes: la mayoría de los reportes de trastornos del sueño en el trastorno por estrés postraumático (TEPT) se han realizado en poblaciones de hombres veteranos de guerra, generalmente décadas después del inicio del trastorno. Dado el aumento en la prevalencia de la violencia contra las mujeres y el hecho de que las mujeres tienen un mayor riesgo de desarrollar TEPT, es fundamental examinar las anomalías del sueño en esta población.Objetivos: Examinar la calidad del sueño subjetiva y objetiva en mujeres jóvenes con trastorno de estrés postraumático después de una agresión sexual en comparación con un grupo control al inicio y después de un año de tratamiento.Métodos: Se evaluaron 74 mujeres con TEPT después de agresión sexual y 64 controles sanos sin antecedentes de agresión sexual utilizando la Escala de TEPT administrada por un médico (CAPS-5, en su sigla en inglés), el Inventario de Depresión de Beck, el Inventario de Ansiedad de Beck, la Calidad del Sueño de Pittsburgh. (PSQI, en su sigla en inglés), la escala de impacto de fatiga modificada y el índice de gravedad del insomnio. Los sujetos también se sometieron a una polisomnografía completa en el laboratorio. Los participantes con TEPT recibieron terapia farmacológica y/o psicológica entre el inicio y el seguimiento al año.Resultados: El grupo de TEPT tuvo puntuaciones significativamente más altas en las mediciones clínicas y del sueño que el grupo de control. Aunque el grupo de TEPT reportó una peor calidad del sueño subjetivo que los controles sanos, hubo pocas diferencias entre grupos en el sueño objetivo. El análisis del grupo de TEPT al inicio y al año de seguimiento mostró que la puntuación global del PSQI fue un predictor significativo de la mejoría del TEPT.Conclusiones: La calidad del sueño se ve afectada en mujeres jóvenes con TEPT y puede afectar las respuestas al tratamiento a largo plazo. Una mejor calidad del sueño se asocia significativamente con la mejora del TEPT, independientemente de la depresión y la ansiedad.


Subject(s)
Antidepressive Agents/therapeutic use , Psychotherapy , Sertraline/therapeutic use , Sleep Initiation and Maintenance Disorders/therapy , Sleep Quality , Stress Disorders, Post-Traumatic/complications , Adult , Anxiety/psychology , Depression/psychology , Female , Humans , Polysomnography , Prospective Studies , Sex Offenses/psychology , Sleep Initiation and Maintenance Disorders/complications , Sleep Initiation and Maintenance Disorders/etiology , Surveys and Questionnaires/statistics & numerical data
7.
Hosp Pract (1995) ; 49(3): 194-202, 2021 Aug.
Article in English | MEDLINE | ID: mdl-33682592

ABSTRACT

Objective: Unprecedented work pressures and social isolation during the COVID-19 pandemic may worsen loneliness and sleep problems in health-care professionals. Heartfulness meditation has been shown to improve burnout and sleep. In the current study, the effects of remote Heartfulness meditation in improving loneliness and sleep quality were measured. Methods: Physicians and advance practice providers were randomly assigned to receive either daily Heartfulness Meditation program or no intervention (control group) in a prospective four-week randomized control study design. UCLA loneliness and PSQI scores were collected at baseline and after the program duration of 4 weeks. The study was retrospectively registered with trial Number, ISRCTN85787008 (8 January 2021). Results: Of the 155 subjects enrolled in the study, 50% were lonely and 97% had sleep problems. Attrition rate was 36%. Among those who completed the study, the mean UCLA loneliness scores decreased from 42.1 to 39.4 in the Heartfulness group (N = 40, p = 0.009) and 42.2 to 41.15 in the control group (N = 57, p = 0.254). The mean PSQI scores decreased from 10.75 to 9.14 in the Heartfulness group (N = 41, p = 0.001) and 9.41 to 8.87 in the control group (N = 58, p = 0.122). Younger participants aged 30 and under had higher loneliness and sleep problems. Conclusions: The current study is one of the first attempts to assess loneliness and sleep problems among physicians and advance practice providers during COVID-19 pandemic in the US. A significant burden of loneliness and sleep problems was identified. An improvement of sleep and loneliness was noted with the practice of Heartfulness meditation. This remote intervention might be a useful tool to be explored in larger studies.


Subject(s)
COVID-19/psychology , Health Personnel/psychology , Loneliness/psychology , Meditation/methods , Occupational Stress/prevention & control , Adult , Anxiety/prevention & control , Humans , Male , Meditation/psychology , Middle Aged , Mindfulness/methods , Occupational Stress/psychology , Prospective Studies
8.
Cranio ; 39(4): 335-343, 2021 Jul.
Article in English | MEDLINE | ID: mdl-31204605

ABSTRACT

Objective: To evaluate, in the short term, the effectiveness of conservative therapies in pain, quality of life, and sleep in TMD patients.Methods: Eighty-nine TMD patients diagnosed by RDC-TMD were distributed in occlusal splints (OS; n= 24), manual therapy (MT; n= 21), counseling (C; n= 19), and OS associated with C (OSC; n= 25) therapy groups. Data collection was performed at baseline and within one month by VAS (pain), PSQI (sleep quality -SQ), WHOQOL-BREF (Quality of life - QL) and OHIP-14 (quality of life related to oral health -QLOH). The Split Plot ANOVA test was used to observe the difference between groups and over time.Results: All therapies were effective over time, improving pain (p< .001), SQ (p=.001), QLOH (p< .001), and QL (p= .006), but not between them.Discussion: The therapies were effective in improving pain, SQ, and quality of life; however, no therapeutic group was superior to the other.


Subject(s)
Quality of Life , Temporomandibular Joint Disorders , Conservative Treatment , Humans , Pain , Sleep , Temporomandibular Joint Disorders/complications , Temporomandibular Joint Disorders/therapy
9.
Mol Genet Metab Rep ; 22: 100547, 2020 Mar.
Article in English | MEDLINE | ID: mdl-31871893

ABSTRACT

BACKGROUND: Fabry disease (FD) is a lysosomal disease in which mutations affect the GLA gene located on the X chromosome. The defective product, the enzyme alpha-galactosidase A, causes accumulation of substrate and contributes to the disruption of cell function in several organs, with variable severity and consequent damage of tissue or organ function. Patient reported outcomes (PROs) enable patients to provide information regarding the consequences of their disease and its treatment and are often recognized as the most important outcomes for them. OBJECTIVES: To evaluate pain, depression, sleep disturbances, disability and disease impact on quality of life in a cohort of Brazilian FD patients and compare between groups stratified by the Mainz Symptom Severity Index (MSSI) Methods: Thirty-seven genotype confirmed classic FD patients - 16 male and 21 female - (mutations: C142R, A156D, L180F, R227X, W262X, G271A, P293S, Y264SX) were evaluated and answered the following questionnaires: Brief Pain Inventory (BPI), Hamilton Depression Rating Scale (HAM-D), Pittsburgh Sleep Quality Index (PSQI), Health Assessment Questionnaire Disability Index (HAQ-DI), Short-Form Health Survey 36 (SF-36). RESULTS: In FD patients, mean ± SD BPI severity result was 2.78 ± 2.66 for severe; 2.80 ± 2.55 for moderate and 1.55 ± 2.38 for mild severity patients. Mean ± SD BPI interference result was 2.55 ± 2.44 for severe; 2.80 ± 3.18 for moderate and 1.36 ± 2.83 for mild patients. BPI severity and interference values correlated with MSSI scores (r = 0.24; p < .001 / r = 0.25; p < .001). Application of HAM-D indicated depression in 21 patients (56.8%). HAM-D results had positive correlation with MSSI values (r = 0.21; p < .001), with BPI severity (r = 0.54; p < .001) and interference (r = 0.65; p < .001). PSQI depicted sleep disturbances in 22 patients (59.5%). PSQI values correlated with MSSI values (r = 0.25; p < .001), with HAM-D results (r = 0.65; p < .001) and BPI severity (r = 0.47; p < .001) and interference (r = 0.66; p < .001). Mean HAQ-DI result was 0.490 for severe; 0.274 for moderate and 0.157 for mild severity patients. CONCLUSIONS: Depression, sleep disturbances and disability were under-recognized in FD patients. HAQ-DI revealed worse disability according to MSSI severity status. The lowest raw scores from the SF-36 questionnaire were for the domains general health perception and physical role functioning. Standardized assessments should be routine care and started as early as diagnosis of Fabry disease is made.

10.
Sleep Med ; 57: 30-35, 2019 05.
Article in English | MEDLINE | ID: mdl-30897453

ABSTRACT

AIM: To test the association between cardiometabolic risk factors and subjective sleep quality assessed by the Pittsburgh sleep quality index (PSQI), independent of obstructive sleep apnea (OSA) and sleep duration. METHODS: A total of 573 participants from the Baependi Heart Study, a rural cohort from Brazil, completed sleep questionnaires and underwent polygraphy for OSA evaluation. Multivariable linear regression analysis tested the association between cardiovascular risk factors (outcome variables) and sleep quality measured by PSQI, adjusting for OSA and other potential confounders (age, sex, race, salary/wage, education, marital status, alcohol intake, obesity, smoking, hypertension, and sleep duration). RESULTS: The sample mean age was 43 ± 16 years, 66% were female, and mean body mass index (BMI) was 26 ± 5 kg/m2. Only 20% were classified as obese (BMI ≥30). Overall, 50% of participants reported poor sleep quality as defined by a PSQI score ≥5. A high PSQI score was significantly associated with higher very-low-density lipoprotein (VLDL) cholesterol levels (beta = 0.392, p = 0.012) and higher triglyceride levels (beta = 0.017, p = 0.006), even after adjustments, including the apnea-hypopnea index. Further adjustments accounting for marital status, alcohol intake, and medication use did not change these findings. No significant association was observed between PSQI scores and glucose or blood pressure. According to PSQI components, sleep disturbances (beta = 1.976, p = 0.027), sleep medication use (beta = 1.121, p = 0.019), and daytime dysfunction (beta = 1.290, p = 0.024) were significantly associated with higher VLDL serum levels. Only the daytime dysfunction domain of the PSQI components was significantly associated with higher triglyceride levels (beta = 0.066, p = 0.004). CONCLUSION: Poorer lipid profile was independently associated with poor sleep quality, assessed by the PSQI questionnaire, regardless of a normal sleep duration and accounting for OSA and socio-economic status.


Subject(s)
Lipids/blood , Rural Population , Sleep Apnea, Obstructive/diagnosis , Sleep Apnea, Obstructive/physiopathology , Sleep/physiology , Adult , Brazil , Cohort Studies , Cross-Sectional Studies , Female , Humans , Male , Obesity , Polysomnography , Risk Factors , Surveys and Questionnaires
11.
Clin Rheumatol ; 37(12): 3345-3349, 2018 Dec.
Article in English | MEDLINE | ID: mdl-30341701

ABSTRACT

The objective of this study was to evaluate the sleep quality, the presence of sleep disorders in patients with primary antiphospholipid syndrome (pAPS), and their possible clinical and laboratory associations. This was a cross-sectional study of 40 consecutive pAPS patients and 211 healthy age- and sex-matched controls. Demographic and clinical data, drug use, and antiphospholipid antibodies were evaluated. Sleep was evaluated using the Pittsburgh Sleep Quality Index (PSQI). pAPS patients had significantly worse sleep quality than healthy controls. Analyzing the individual components, pAPS had worse scores in five of seven components: sleep duration (p = 0.002), habitual sleep efficiency (p = 0.003), sleep disturbance (p < 0.001), use of sleep medication (p < 0.001), and daytime somnolence (p = 0.03). No association of sleep disturbance and demographic, clinical, and laboratory features of the disease was observed. This is the first study to analyze sleep quality in pAPS. We observed that pAPS had significant worse sleep quality; however, no demographic, clinical, or laboratory feature was associated with sleep disturbance.


Subject(s)
Antibodies, Antiphospholipid/blood , Antiphospholipid Syndrome/complications , Sleep Wake Disorders/complications , Adolescent , Adult , Brazil/epidemiology , Case-Control Studies , Cross-Sectional Studies , Female , Humans , Language , Male , Middle Aged , Retrospective Studies , Sleep , Surveys and Questionnaires , Young Adult
12.
Psychopharmacology (Berl) ; 235(6): 1775-1782, 2018 06.
Article in English | MEDLINE | ID: mdl-29589068

ABSTRACT

RATIONALE: Binge drinking during adolescence is common, and adolescents and young adults with alcohol problems may also have sleep difficulties. However, few studies have documented the effects of a history of adolescent binge drinking on sleep in young adulthood in high-risk minority populations. OBJECTIVES: To quantify sleep disturbance, as indexed by the Pittsburgh Sleep Quality Index (PSQI), in a sample of young adult Mexican American and American Indian men and women (18-30 years, n = 800) with and without a history of alcohol binge drinking during adolescence, controlling for age, gender, and race. RESULTS: Gender was found to affect PSQI responses with females reporting waking up at night, having more bad dreams, and later habitual bedtimes than males, and males reporting more problems with breathing and snoring. Increasing age was associated with snoring or coughing, less hours spent in bed, and later evening bedtimes. Race also influenced the PSQI with American Indians reporting longer sleep latencies and sleep durations, more hours spent in bed, and more trouble with coughing and snoring than Mexican Americans, and Mexican Americans reporting later bedtimes. A history of adolescent regular binge drinking was associated with longer sleep latencies, more problems with breathing, bad dreams, and an overall higher PSQI total score, when controlling for age, race, and gender. CONCLUSIONS: This report suggests, like what has been found in young adults in general population samples, that binge drinking during adolescence is associated with deleterious consequences on sleep quality in young adulthood in these high-risk and understudied ethnic groups.


Subject(s)
Binge Drinking/ethnology , Binge Drinking/psychology , Indians, North American/psychology , Mexican Americans/psychology , Sleep Wake Disorders/ethnology , Sleep Wake Disorders/psychology , Adolescent , Adult , Binge Drinking/physiopathology , Female , Humans , Indians, North American/ethnology , Male , Retrospective Studies , Risk Factors , Sleep/physiology , Sleep Wake Disorders/complications , Sleep Wake Disorders/physiopathology , Young Adult
13.
Rev. méd. hered ; 21(2): 65-69, abr.-jun. 2010. tab, graf
Article in Spanish | LILACS, LIPECS | ID: lil-568267

ABSTRACT

Objetivo: Describir la calidad de sueño en los pobladores andinos de Huaripampa-Ancash (3 200 msnm). Material y métodos: Se utilizó el Índice de Calidad de Sueño de Pittsburgh (ICSP). Se calculó el tamaño de la muestra (n=92) mediante el método de proporciones, y se realizó una aleatorización sistemática de casas, encuestando a los pobladores presentes que cumplieron con los criterios de inclusión. Resultados: Se encuestaron a 83 pobladores, 46% fueron hombres, la edad media fue de 40,59 +/- 17,5 (18-65 años) y la mediana del puntaje del PSQI fue de 6 más menos 4,5 (RIC) [2-18]. Se encontró que 53 (63,8%) fueron malos durmientes. La alteración de sueño más frecuente fue el insomnio, presente en 47% de la población. Conclusiones: La alteración del sueño es un problema frecuente en esta población. Una herramienta como la del Índice de calidad de sueño de Pittsburgh, con algunas modificaciones, puede ser implementada en poblaciones rurales-andinas.


Objective: To describe the sleep quality in the inhabitants of Huaripampa-Ancash. Material and methods: We usedthe Pittsburgh Sleep Quality Index (PSQI). Using the method of proportions was calculated the sample size (n = 92), and there was a systematic randomization of houses, surveying the present inhabitants that meet the inclusion criteria. Results: There were surveying a total of 83 inhabitants, 38 (46%) were men, mean age was 40.59 +/- 17.5 (18-65 years old) and the average score of PSQI was 6 +/- 4.5 [2 -18], 53 (63.8%) of the population were poor sleepers. The most frequent disruption of sleep was insomnia, which was present in 39 (47%) inhabitants. Conclusions: Symptoms associated with various sleep disorders are common in rural Andean population. A tool such as the sleep quality index in Pittsburgh, with some modifications, can be implemented in rural Andean populations.


Subject(s)
Humans , Male , Adolescent , Adult , Female , Middle Aged , Aged, 80 and over , Rural Population , Sleep , Sleep Initiation and Maintenance Disorders , Sleep Wake Disorders , Epidemiology, Descriptive , Cross-Sectional Studies , Peru
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