Human health risks associated to trace elements and metals in commercial fish from the Brazilian Amazon.

Fish constitutes the main protein source for the Amazonian population. However, the impact of different anthropogenic activities on trace element and metal accumulation in fish and their risks for human health at a regional scale remain largely unexplored. Here we assessed exposure levels of 10 trace elements and metals (Cr, Mn, Fe, Ni, Cu, Zn, As, Cd, Pb, and Hg) in 56 samples belonging to 11 different species of fish from the Brazilian Amazon. We studied the relationship between exposure levels, fish origin, and fish feeding habits, and assessed toxicological and carcinogenic risks for the Amazonian population. No significant correlation was found between sampling site and exposure levels to the studied elements, but a significant difference was found between the accumulation of some metals and the position of the fish species in the food chain. The concentrations of Cr and Hg in fish flesh were found to exceed the Brazilian limits for human consumption. This study shows that current fish consumption patterns can lead to estimated daily intakes of Hg, As and Cr that exceed the oral reference dose, thus posing a toxicological concern. Furthermore, carcinogenic risks may be expected due to the continued exposure to Cr and As. The results of this study show that the consumption of wild caught fish in the Amazon region should be controlled. Moreover, continued monitoring of trace element and metal contamination in fish and on the health of the Amazonian population is recommended, particularly for riverine and indigenous communities.

The burden of type 2 diabetes attributable to dietary risks in China: Insights from the global burden of disease study 2021.

OBJECTIVES: This study aims to comprehensively assess how dietary risk factors have influenced the prevalence of Type 2 Diabetes Mellitus (T2DM) in China from 1990 to 2021. The study seeks to provide robust data and scientific evidence essential for formulating effective preventive and control strategies to combat T2DM in China. STUDY DESIGN: This cross-sectional study conducted secondary analyses using data from the Global Burden of Disease 2021 (GBD 2021) to assess the burden of T2DM in China attributable to dietary risks. METHODS: The study analyzed age-adjusted metrics related to T2DM, including death counts, Disability-Adjusted Life Years (DALYs), and Age-Standardized Rates (ASRs), using GBD 2021 data, stratified by age and sex. Additionally, Estimated Annual Percentage Changes (EAPCs) were employed to track trends over time. RESULTS: In 2021, the results show that 21.43 % of T2DM-related deaths and 23.51 % of DALYs were attributable to dietary risk factors, notably a diet low in whole grains and high in red and processed meats. Over the period from 1990 to 2021, there has been an increasing trend in the EAPCs of death rates and DALYs associated with dietary risks in China, suggesting a substantial impact of dietary factors on the burden of T2DM in the country. CONCLUSION: This study highlights the urgent need for targeted public health interventions to promote dietary changes and reduce the burden of T2DM in China.

Risk Assessment Suicidality Scale (RASS)-Based On-Line Calculator Targeting Early Prevention of Suicides in General Population: from COMET-G Study Results Towards Integration of the Screening Tool into Routine Clinical Practice.

BACKGROUND: Suicide is a major global health concern, particularly among young people. This study evaluates an online suicide risk calculator based on the Risk Assessment of Suicidality Scale (RASS), which is designed to enhance accessibility and early detection of suicide risk. METHODS: The study involved 444 participants who completed the RASS via an online calculator. Results were compared with data from the COMET-G study's Russian sample (n=7572). Descriptive statistics, correlation analysis, and two-way ANOVA were used to analyze the data. RESULTS: The mean age of participants was 22.71 years (SD=7.94). The mean total RASS standardized score was 837.7 (SD=297.8). There was a significant negative correlation between age and RASS scores (r=-0.463, p<0.0001). The online calculator sample showed significantly higher RASS scores compared to the COMET-G sample, with 71% of online users scoring above the 90th percentile of the COMET-G sample. CONCLUSION: Our study demonstrated the advantage of the on-line suicidality risk calculator based on the RASS scale as a sensitive tool in detecting suicidal behaviours and measuring the severity of suicidality risks, offering a capability for broad reach and immediate assessment during clinical conversation between doctor and patient. Moreover, the RASS on-line psychometric instrument, when being freely distributed among the general population over internet sources, enabled to attract vulnerable groups of respondents with significantly higher suicidality risks. Future research should focus on integrating such tools into comprehensive suicide prevention programs and developing appropriate follow-up monitoring strategies for high risk-cases.

Invisible hazards: Exploring neonicotinoid contamination and its environmental risks in urban parks across China.

Neonicotinoids (NEOs) are commonly used pesticides in agriculture. Urban parks containing numerous green plants and flowers also require NEOs for pest control. However, information on the distribution patterns and environmental risks of NEOs and their metabolites in urban park soils has yet to be discovered, which seriously limits the comprehensive evaluation of the potential hazards of NEOs. Our study explored the occurrence and distribution patterns of ten NEOs and five major metabolites in park soils from Guangzhou, Shijiazhuang, and Urumqi of China. At least three NEOs were detected in 95 % of soil samples, with the sum of all NEOs (∑10NEOs) ranging from 2.21 to 204 ng/g. Guangzhou has the highest levels of ∑10NEOs (median: 52.1 ng/g), followed by Urumqi (49.3 ng/g) and Shijiazhuang (21.7 ng/g). The top three most common NEOs in all three cities are imidacloprid, acetamiprid, and thiacloprid, which together account for 67 % to 70 % of ∑10NEOs. The levels of the metabolites of NEOs show a significant positive correlation with their corresponding parent NEOs. These NEOs pose detrimental effects to non-targeted invertebrates in the soil. Our findings raise concern about the environmental risks posed by NEO exposure to humans and other organisms in urban parks.

Composite endpoints in COVID-19 randomized controlled trials: a systematic review.

BACKGROUND/AIMS: This study aimed to determine the prevalence of ordinal, binary, and numerical composite endpoints among coronavirus disease 2019 trials and the potential bias attributable to their use. METHODS: We systematically reviewed the Cochrane COVID-19 Study Register to assess the prevalence, characteristics, and bias associated with using composite endpoints in coronavirus disease 2019 randomized clinical trials. We compared the effect measure (relative risk) of composite outcomes and that of its most critical component (i.e. death) by estimating the Bias Attributable to Composite Outcomes index [ln(relative risk for the composite outcome)/ln(relative risk for death)]. RESULTS: Composite endpoints accounted for 152 out of 417 primary endpoints in coronavirus disease 2019 randomized trials, being more frequent among studies published in high-impact journals. Ordinal endpoints were the most common (54% of all composites), followed by binary or time-to-event (34%), numerical (11%), and hierarchical (1%). Composites predominated among trials enrolling patients with severe disease when compared to trials with a mild or moderate case mix (odds ratio = 1.72). Adaptations of the seven-point World Health Organization scale occurred in 40% of the ordinal primary endpoints, which frequently underwent dichotomization for the statistical analyses. Mortality accounted for a median of 24% (interquartile range: 6%-48%) of all events when included in the composite. The median point estimate of the Bias Attributable to Composite Outcomes index was 0.3 (interquartile range: -0.1 to 0.7), being significantly lower than 1 in 5 of 24 comparisons. DISCUSSION: Composite endpoints were used in a significant proportion of coronavirus disease 2019 trials, especially those involving severely ill patients. This is likely due to the higher anticipated rates of competing events, such as death, in such studies. Ordinal composites were common but often not fully appreciated, reducing the potential gains in information and statistical efficiency. For studies with binary composites, death was the most frequent component, and, unexpectedly, composite outcome estimates were often closer to the null when compared to those for mortality death. Numerical composites were less common, and only two trials used hierarchical endpoints. These newer approaches may offer advantages over traditional binary and ordinal composites; however, their potential benefits warrant further scrutiny. CONCLUSION: Composite endpoints accounted for more than a third of coronavirus disease 2019 trials' primary endpoints; their use was more common among studies that included patients with severe disease and their point effect estimates tended to underestimate those for mortality.

Lower Incidence of Dementia Following Cancer Diagnoses: Evidence from a Large Cohort and Mendelian Randomization Study.

BACKGROUND: The reported inverse association between cancer and subsequent Alzheimer's disease and related dementias (ADRD) remains uncertain. OBJECTIVES: To investigate the association between these common conditions of old age and explore possible causal factors. DESIGN, SETTING, PARTICIPANTS AND MEASUREMENTS: We conducted a large population-based cohort analysis using data from 3,021,508 individuals aged 60 and over in the UK Clinical Practice Research Datalink (CPRD), over a period up to 30 years (1988-2018). Cox proportional hazards models were fitted to estimate hazard ratios (HR) for risk of dementia associated with previous cancer diagnosis. Competing risk models were employed to account for competing risk of death. Two-sample Mendelian Randomization analysis based on meta-analysis data from large-scale GWAS studies was also conducted. RESULTS: In the CPRD cohort, 412,903 participants had cancer diagnosis and 230,558 were subsequently diagnosed with dementia over a median follow-up period of 7.9 years. Cancer survivors had a 25% lower risk of developing dementia (HR=0.75, 95% CI:0.74-0.76) after adjustment for potential confounders. Accounting for competing risk of death provided a sub-distribution HR of 0.56 (95% CI:0.55-0.56). Results were consistent for prevalent and incident cancer and different common cancer types. Two-sample Mendelian Randomization analysis, using 357 cancer-related instrumental single-nucleotide polymorphisms (SNPs) revealed evidence of vertical pleiotropy between genetically predicted cancer and reduced risk of Alzheimer's disease (OR=0.97,95% CI:0.95-0.99). CONCLUSION: Our results provide strong epidemiological evidence of the inverse association between cancer and risk of ADRD and support the potential causal nature of this association via genetic instruments. Further investigations into the precise underlying biological mechanisms may reveal valuable information for new therapeutic approaches.

Assessing the asymmetric interrelationships between sovereign bond yields and selected potential determinants: The case of frontier WAMZ economies.

The spot of frontier market economies in the global financial arena continues to be significant for many market participants because of their size, diversification advantage, and interconnectedness. Financial market innovations, globalization and pandemics have made it even more urgent to explore their dynamics. This paper focuses on analysing the risks associated with investing in frontier West African monetary zone bonds by appropriately modelling them in relation to cultural, administrative/political, geographic, economic and financial indicators that are specific to these countries, primarily due to their locations and interlinkages. This study employed the nonlinear autoregressive distributed lag model to investigate the asymmetric effects of different economic factors on sovereign bond yields in Ghana and Nigeria from July 2014 to September 2022 with 99 observations. Period selection allows researchers to unravel the complexities of market behaviour, investor sentiment, and policy effectiveness in the face of economic turmoil and uncertainty. The results provide valuable insights into how these factors affect bond yields differently in the two countries.

Parabens as the double-edged sword: Understanding the benefits and potential health risks.

Parabens are globally employed as important preservatives in pharmaceutical, food, and personal care products. Nonetheless, improper disposal of commercial products comprising parabens can potentially contaminate various environmental components, including the soil and water. Residues of parabens have been detected in surface water, ground water, packaged food materials, and other consumer items. Long-term exposure to parabens through numerous consumer products and contaminated water can harm human health. Paraben can modulate the hormonal and immune orchestra of the body. Recent findings have correlated paraben use with hypersensitivity, obesity, and infertility. Notably, parabens have also been detected in the samples of breast cancer patients, suggesting a potential cross-talk between parabens and carcinogenesis. Therefore, the present article aims to dissect the significance of parabens as a preservative in several consumer products and their impact of chronic exposure to human health. This review encompasses various facets of paraben, including its sources, mechanism of action at the molecular level, and sheds light on its toxicological implications on human health.

Evaluation of the geochemical background of soil in a hyper-arid zone using a multivariate statistical methodology: The case of the city of Antofagasta in the Atacama Desert.

This study investigates the geochemical background and factors influencing the variability of 19 environmentally relevant elements in the soils of Antofagasta, Chile, a region known for its extensive mining activities. Employing robust multivariate statistical techniques on a dataset of 94 soil samples, we identified four main factors explaining 70% of the total variance in elemental concentrations. These four factors reflect the influence of Jurassic volcanic rocks, intrusive rocks, marine sediments, and mafic to intermediate intrusive rocks. Cluster analysis revealed three distinct geochemical populations, each reflecting a unique combination of natural and anthropogenic influences. We established background concentrations for each element within these clusters using robust statistical methods. Geostatistical analysis, employing inverse distance weighted interpolation, produced factor distribution maps that, when integrated with geological data, provided insights into lithological and anthropogenic influences on soil geochemistry. Our findings highlight the complex interplay between natural geological processes, the region's unique arid climate, and anthropogenic activities in shaping the geochemical landscape of Antofagasta. This study contributes to the understanding of geochemical backgrounds in mining-intensive, arid regions and provides a methodological framework applicable to similar environments worldwide.

Shift in potential pathogenic bacteria during permafrost degradation on the Qinghai-Tibet Plateau.

Permafrost acts as a potential pathogen reservoir. With accelerating climate change and intensifying permafrost degradation, the release of these pathogens poses significant threats to ecosystems and public health. However, the changes in pathogenic communities during permafrost degradation remain unclear. This study utilized quantitative PCR and Illumina high-throughput sequencing to analyze the composition and quantities of potential pathogenic bacteria in four types of permafrost soil on the northeast edge of the Qinghai-Tibet Plateau (QTP): sub-stable permafrost (SSP), transition permafrost (TP), unstable permafrost (UP), and extremely unstable permafrost (EUP). The results showed that during permafrost degradation, the quantity of potential pathogenic bacteria decreased from 7.8 × 106 to 3.1 × 106 copies/g. Both the Richness and Shannon indices initially declined from SSP, to TP, UP, and then began to rise when permafrost degraded to EUP. A total of 216 potential pathogenic bacterial species were identified, including 166 animal pathogens, 28 zoonotic pathogens, and 22 plant pathogens. The pathogenic community intergroup differences (ANOSIM), unique taxa, and dominant pathogen analysis indicated the significant changes in pathogenic communities during permafrost degradation. The potential pathogenic community was significantly influenced by non-pathogenic bacterial communities (Procrustes analysis), with soil moisture being the primary environmental factor, followed by TDS, soil organic carbon, and total nitrogen. SourceTracker2 analysis indicated that the majority of potential pathogenic bacteria in the soil originated from external sources, only a small portion coming from the permafrost itself. These findings suggest that a large number of pathogens were released into the environment while also preserving amount from external sources. It elucidates that each stage of permafrost degradation presents unique biosecurity risks. This study highlights the release and redistribution of pathogenic bacteria associated with the potential public health risks. It provides the crucial insights into the ecological dynamics of permafrost degradation, emphasizing the need for ongoing monitoring and proactive management strategies.

Soil benzene emissions and inhalation health risks affected by various land covers.

Accurate quantification of soil volatile organic compounds (VOCs) flux is crucial for assessing inhalation environmental health risks and developing region-specific remediation strategies. However, land cover significantly influences VOCs emissions from soil. This study investigated benzene, a representative VOCs, using a laboratory flux chamber and numerical simulations to evaluate its release patterns under different surface covers, including bare soil (no cover), clay brick, cement, and grass. In the experiment, gaseous benzene was collected using an adsorption tube filled with Tenax-TA adsorbent. The collected samples were subsequently analyzed using thermal desorption coupled with gas chromatography-mass spectrometry. By integrating these findings with environmental health risk assessment methodologies, we developed a tailored approach for assessing inhalation health risks at benzene-contaminated sites with varying land covers. Additionally, we conducted application studies of this method across various scenarios. The results indicate that soil benzene emissions could be reduced by using low-permeability coverings such as clay brick and cement, as well as by planting vegetation. The average fluxes of benzene through covering materials were of the order of 1.22×10-2, 4.37×10-3, 2.47×10-3, and 9.88×10-4 mg·m-2·s-1 for bare soil, clay brick, grass, and cement, respectively. The application of clay brick and cement coverings on the soil surface results in more pollutants remaining in the soil in liquid and adsorbed states, making them less likely to volatilize. The inhalation carcinogenic risk (CR) values for soil benzene at an abandoned oil refinery site in Northwestern China under bare soil, brick, and cement cover are 1.3×10-6, 1.22×10-6, and 9.73×10-7, respectively. Low-permeability covers such as clay brick and cement reduces the inhalation CR of gaseous benzene from the surface soil, and delays the growth trend of cumulative inhalation CR.

Diagnosis of the risk of occupational disease among outsourced workers.

Introduction: The outsourcing of work activities has caused new and precarious working conditions, impacting the health and safety of workers, resulting in an increase in disease and accidents given the vulnerability established in the contemporary labor market. Objectives: To identify the occurrence of risk of disease resulting from work, among outsourced workers. Methods: Quantitative, observational, analytical and cross-sectional study, with application of the Inventário de Trabalho e Riscos de Adoecimento in 187 workers of a company that supplies and manages human resources for third parties, under contract with a Federal University, located in the state of Minas Gerais. Results: The Inventário de Trabalho e Riscos de Adoecimento obtained the following averages for the following factors: work organization, 2.9 (standard deviation = 0.6) (critical); working conditions, 2.4 (standard deviation = 0.7) (critical); physical cost, 3.9 (standard deviation = 0.6) (severe); physical damage, 2.1 (standard deviation = 1.3) (critical). Conclusions: The participating workers showed a good perception associated with the Inventory of Inventário de Trabalho e Riscos de Adoecimento factors, resulting in diagnoses with the presence of risks of disease and accidents resulting from work.

Introdução: A terceirização das atividades laborais tem provocado novas e precárias condições de trabalho, impactando na saúde e segurança dos trabalhadores e acarretando o aumento de adoecimentos e de acidentes, dada a vulnerabilidade estabelecida no mercado de trabalho contemporâneo. Objetivos: Identificar risco de adoecimento decorrente do trabalho entre trabalhadores terceirizados. Métodos: Estudo quantitativo, observacional, analítico, transversal com aplicação do Inventário de Trabalho e Riscos de Adoecimento a 187 trabalhadores de uma empresa de fornecimento e gestão de recursos humanos para terceiros sob contrato com uma universidade federal localizada no estado de Minas Gerais. Resultados: O Inventário de Trabalho e Riscos de Adoecimento obteve as seguintes médias para os fatores a seguir: organização do trabalho, 2,9 (desvio-padrão = 0,6) (crítico); condições de trabalho, 2,4 (desvio-padrão = 0,7) (crítico); custo físico, 3,9 (desvio-padrão = 0,6) (grave); danos físicos, 2,1 (desvio-padrão = 1,3) (crítico). Conclusões: Os participantes apresentaram boa percepção associada aos fatores do Inventário de Trabalho e Riscos de Adoecimento, resultando em diagnósticos que apresentaram risco de adoecimentos e de acidentes decorrentes do trabalho.

Evaluation of the Smokeless Tobacco Awareness, Attitude, and Response Knowledge (STAARK) Scale With Integrated Risk Assessment for Tailored Intervention.

Background Smokeless tobacco (SLT) use, particularly gutkha, is prevalent in India, with cultural acceptance contributing to widespread use, especially among tribal populations. Despite awareness programs, there is limited assessment of their effectiveness, leading to continued vulnerability, even among educated groups. This study aims to evaluate public health strategies by developing and validating the SLT Awareness, Attitude, and Response Knowledge (STAARK) scale, which assesses knowledge and attitudes post-awareness programs on SLT usage through questionnaires, identifying vulnerable individuals, and enabling targeted interventions to reduce SLT use and associated health risks, particularly through integrated risk assessment (IRA). Methods This study was performed during an SLT awareness program in Nagaland, utilizing a comprehensive survey to assess participants' demographics, knowledge, and attitudes. The STAARK score was calculated by combining normalized attitude and knowledge scores, ranging from 0 to 10, categorizing participants' comprehension and attitudes toward SLT usage awareness. The obtained scores were assessed twice for consistency evaluation of the scale, and vulnerable individuals were subjected to IRA for targeted intervention recommendations. Reliability and correlation analyses were performed, with Cronbach's alpha validating the scale's internal consistency. Results About 182 participants took up the assessment, with only 180 completing the survey among the population attending the awareness program. Demographic data revealed a diverse participant group, with ages ranging from 13 to 42 years. The survey assessed participants' knowledge and attitudes toward SLT, scoring them on a 0-10 scale for knowledge and a 10-60 scale for attitude. The STAARK scale was developed to combine these scores, providing a comprehensive measure of participants' understanding and attitudes toward SLT. The mean STAARK score was 5.27 with an observed lower limit of 2.40 and an upper limit of 6.50 in the responded population. Reliability testing using Cronbach's alpha showed acceptable internal consistency, though attitude had a weaker correlation with the overall STAARK score compared to knowledge. In a follow-up assessment with 88 participants, the STAARK score averaged 5.10, reinforcing the initial findings. The risk assessment of 17 participants with STAARK scores above six identified varying levels of risk, with most falling into the low- or moderate-risk categories. The study highlights the importance of targeted interventions to address SLT usage, particularly in populations with lenient attitudes toward its consumption. Conclusions The STAARK scale can serve as a key tool for evaluating SLT awareness programs by assessing participants' knowledge and attitudes and identifying high-risk individuals requiring personalized interventions for SLT usage cessation. It standardizes the assessment, enabling comparison across groups and times, and helps identify individuals with lenient attitudes toward SLT for targeted interventions. Its reliability ensures consistency, and by tracking changes in scores before and after programs, it assesses impact and guides future improvements. The STAARK scale is crucial for personalized, evidence-based public health efforts to reduce SLT use. However, eradicating SLT requires ongoing commitment, adaptability, and a focus on long-term outcomes to translate knowledge into lasting change.

Mobilization mechanisms and spatial distribution of arsenic in groundwater of western Bangladesh: Evaluating water quality and health risk using EWQI and Monte Carlo simulation.

Arsenic (As) contamination in groundwater is emerging as a significant global concern, posing serious risks to the safety of drinking water and public health. To understand the release mechanisms, mobilization processes, spatial distribution, and probabilistic health risks of As in western Bangladesh, forty-seven samples were collected and analyzed using an atomic absorption spectrometer (AAS). The As concentrations in groundwater ranged from 1.97 to 697.4 µg L⁻1 (mean: 229.9), significantly exceeding recommended levels. The dominant hydrochemistry of As-enriched groundwater was Ca-Mg-HCO3, with the primary sources of arsenic in groundwater being the dissolution of arsenic-bearing minerals in sediment and the recharge of aquifers from the Ganges River Basin. The assessment using the Entropy Water Quality Index revealed that the groundwater is unsuitable for drinking, with 89.36% (n = 42) of the samples surpassing the WHO's limit for arsenic. Rock-water interactions, including calcite dissolution and silicate weathering within the confined aquifer, predominantly influenced hydrochemical properties. The significant relationships among Fe, Mn, and As indicate that the reductive dissolution of FeOOH and/or MnOOH considerably contributes to the release of As from sediment into groundwater. Geochemical modeling analysis revealed that siderite and rhodochrosite precipitate into aquifer solids, suggesting a weak to moderate relationship among As, Fe, and Mn. The long residence time of groundwater, combined with the presence of a clayey aquitard, likely controls the mobilization of arsenic in the aquifer. For the first time, Monte Carlo simulations have been used in arsenic-prone areas to assess the severity of arsenic contamination in western Bangladesh. The analysis indicates that out of 100,000 people, 10 may develop cancer as a result of drinking arsenic-contaminated water, with children being more susceptible than adults.

Higher hair cortisol levels associated with previous cardiovascular events and cardiovascular risks in a large cross-sectional population study.

BACKGROUND: Stress is today a common feature of patients seeking medical care and a growing public health issue in society. A method has been developed to measure biological chronic stress by Hair Cortisol Concentrations (HCC). This biomarker, for chronic stress, captures information about cumulative cortisol levels over the course of several months. Long-term stress might be one of the factors contributing to the onset of cardiovascular conditions and also affecting different risk factors. The aim of this study was to analyse the association between Hair Cortisol Concentrations and previous cardiovascular diseases and cardiovascular risk factors. METHODS: The method of measuring chronic stress by Hair Cortisol Concentration was applied in a large Swedish national observational cross-sectional study. A population-based random sample of N = 4,821 Swedish middle-aged men and women was analysed for hair cortisol levels in relation to diagnosed previous cardiovascular diseases and biologically measured cardiovascular risk factors. RESULTS: Long-term stress, measured by hair cortisol, was significantly associated with the classical cardiovascular risk factors hypertension and high cholesterol, but not smoking. Those with elevated HCC levels also had a significantly increased pre-history of myocardial infarction, type 2 diabetes, atrial fibrillation and by-pass surgery, but not regarding stroke, angina pectoris or sleep apnoea. Higher HCC was significantly associated (p < 0.001) with Body mass index and waist circumference, but only for females. HCC was also associated with the risk markers leukocytes, and high-sensitivity CRP, indicating a possible linkage between HCC and inflammation and hypothetically also the bodily immune defense. No association was found between perceived stress and HCC. CONCLUSIONS: An overall conclusion of our results is that health care should put more emphasis on patients reporting that they have been exposed to long term stress. Altogether, these analyses of Hair cortisol levels in a large middle-aged population show that chronically elevated cortisol levels represent a relevant and significant factor associated with cardiovascular diseases and classical cardiovascular risk factors.

Adoption of mobile dementia prevention services for middle-aged and older adults: applying the theory of coping strategies for dementia risks.

The prevalence of dementia is increasing due to the aging population, leading to significant investments in information technology-based dementia care solutions such as mobile dementia prevention services (MDPS). These services aim to facilitate early diagnosis and prevent cognitive decline, with the ultimate goal of reducing medical costs. This study examines how aging individuals perceive and evaluate MDPS and how these perceptions influence their adoption intentions. Drawing from a coping perspective, we analyze the impact of susceptibility and severity dimensions in dementia risk perception on the perceived usefulness and self-incongruence in MDPS adoption. Focusing on middle-aged and older adults aged 55 and above, the study reveals significant but contrasting effects of susceptibility and severity. Perceived susceptibility of dementia is associated with emotion-focused coping, positively influencing self-incongruence with MDPS. Perceived severity of dementia is linked to problem-focused coping, negatively impacting self-incongruence but positively influencing the perceived usefulness of MDPS, promoting adoption. These findings provide insights into promoting MDPS by considering dementia risk perceptions and contribute to the development of effective dementia-related strategies for aging individuals.

Assessment of environmental and health risks of potentially toxic elements associated with desert dust particles affected by industrial activities in Isfahan metropolitan.

Dust particles and their associated compounds can adversely affect human health and ecosystems. The aim of this study was to investigate the concentration, health, and ecological risks of selected potentially toxic elements (e.g. Pb, Cd, Cr, Co, Cu, Zn, V, Ni, and As) bound to air particles generated by dust storms in the Sejzi plain desert area within the industrial district of Isfahan metropolitan, Iran. The enrichment factor revealed the highest values for Zn, Pb, and Cd which among them Zn showed the highest value (8.1) with the potential source of industrial activities confirmed by the integrated pollution index, accumulation coefficient, and ecological risk index. Regarding health risk analysis (non-cancer and cancer risks) the elements including Co, As, and Cr showed a significant risk for adults and children across all seasons. It's concluded that mitigation of air particles originated from both natural and industrial activities is necessary to reduce their relevant risks to human being and ecosystems in the region.

Edible vegetables grown in the vicinity of electronic wastes: A study of potential health risks and DNA damage in consumers.

There has been a growing concern on the health effect of edible plants growing near/on/within the vicinity of dumpsites. This study investigated two edible vegetables: Amarathus hybridus and Talinum triangulare (Jacq) grown in the vicinity of a major informal dumpsite of electronic waste in Nigeria. The levels of polyaromatic hydrocarbons (PAHs), polychlorinated biphenyls (PCBs), polybrominated diphenyl ethers (PBDEs), and heavy metal concentrations in the vegetables were measured. The health risks of consuming the vegetables were assessed using the hazard index (HI), lifetime cancer risk (LCR), estimated daily intake (EDI), and hazard quotient (HQ). Using the Ames Salmonella fluctuation test on Salmonella typhimurium (TA100 and TA98) and the SOS chromo test on Escherichia coli (PQ37), the mutagenicity and genotoxicity of the vegetables were evaluated. The two vegetables have elevated levels of heavy metals, PBDEs, PCBs, and hazardous PAHs. Compared to A. hybridus, T. triangulare was more contaminated. The amounts of organic constituents and heavy metals in the vegetables correlated favorably. The levels of the HQ, HI, and LCR were above the suggested guideline values, indicating a significant risk of both carcinogenic and non-carcinogenic consequences, particularly in children. The two vegetables were mutagenic even at 50 % concentration in the Ames test. This was corroborated with SOS-chromo test results showing that the two vegetables were indeed genotoxic. This study demonstrated the harmful effects of growing food crops close to dumpsites; therefore, sufficient measures should be implemented to stop farmers and individuals from utilizing dirt from dumps as fertilizer or from planting in soil that has been used as a dump in the past or present.