A bibliometric analysis of global research hotspots and progress on emerging environmental pollutants 6PPD and 6PPD-quinone from 2004 to 2024.

The emerging toxicants, N-(1,3-dimethylbutyl)-N'-phenyl-p-phenylenediamine quinone (6PPD-Q), resulting from environmental exposure to N-(1,3-dimethylbutyl)-N'-phenyl-p-phenylenediamine (6PPD), have gained considerable attention owing to their ubiquitous occurrence and high toxicity. We performed a scientometric analysis on this topical area of research over the past two decades, spanning from 2004 to April 2024. The overarching aim was to reveal potential future directions in this research area, exploring several key aspects. These included publication and citation growth trends, relevant subject fields, distribution of contribution by country, influential journals in the field, keyword co-occurrence network and cluster analysis, and identification of top authors. The information was collected from the Scopus database and processed using the VOS viewer software. We observed a notable increase in the number of publications over the past four years. With a share of 46.2% of publications, "Environmental Sciences" dominated as the primary scientific category. Among all journals, "Science of the Total Environment" was the most prolific, publishing 33 documents, accounting for 15.6% of the total records. China, representing 76 publications (36%), followed by the United States, with 40 (18.9%), stood out as the leading countries. The occurrence of keywords such as "Pollution exposure", "Mass spectrometry", and "toxicity" highlighted the importance of assessing the toxicological properties, analytical methods, and environmental implications of these emerging contaminants to mitigate their adverse effects and protect environmental and human health. Cai, Zongwei from Hong Kong Baptist University was highly productive in this field, publishing 11 papers. Based on the bibliometric analysis presented, it seems that the future direction of research on 6PPD and 6PPD-Q will shift towards strategies focused on their removal and treatment.

Trends and insights in animal and biomedical research: A 5-year scientometric analysis of orthodontic peer-reviewed journals.

BACKGROUND: Biomedical research plays a critical role in advancing orthodontic innovations by identifying new targets for therapeutic interventions and developing more effective, personalized orthodontic treatment. This study evaluates the major contributors and trends in animal-related orthodontic research over the past 5 years (2017-2023). METHODS: All animal-related studies published in the eight orthodontic journals listed in the 2022 Journal Citation Reports between January 2017 and June 2023 were retrieved from the Web of Science Core Collection. After examination, the following bibliometric data were extracted from each article: title, authors, affiliations, geographic origin, year of publication, journal name, and keywords. Multiple bibliometric software packages including Biblioshiny R-package software, Datawrapper, and Datasmith were used to analyze different bibliometric outcomes. RESULTS: A total of 3669 articles were screened from which 266 were selected and included in the analysis. The annual growth rate of production exhibited a decline of 11.18%. Most of the included studies focused on orthodontic tooth movement (32.3%), mainly utilizing rat models (50%). Although the United States accounted for the highest number of publications (n = 236), the trend in funded research showed a decreasing trajectory over time, with notably limited funding from the National Institutes of Health. CONCLUSION: This study reveals a declining trend in overall animal-related orthodontic research, highlighted by a significant decrease in National Institutes of Health funding over time. To address this gap, academic institutions and professional organizations should support initiatives fostering biomedical orthodontic research.

Digital finance development in China: A scientometric review.

The continuous integration of digital technology and finance has spurred the rapid development of the digital finance industry, making it a critical area of interest for scholars. This study combines quantitative research methods using Citespace software for scientometric analysis and qualitative research methods involving manual selection and content analysis of key literature to summarise the research status, hot topics, and frontiers in the field of digital finance in China. The research findings highlight several influential factors in the digital finance literature, such as regional and journal distribution, institutional and author collaboration, and highly cited literature. Currently, the four most important and cutting-edge research areas are digital currency, digital inclusive finance, fintech and blockchain technology. Furthermore, an analysis of the development trends in digital finance research is conducted and future research perspectives are suggested.

Infectious disease research in the Association of Southeast Asian Nations region: a scientometric analysis.

BACKGROUND: This study compared the research output of Association of Southeast Asian Nations (ASEAN) countries to understand research trends and clarify past, present, and future patterns using scientometric techniques. METHODS: This scientometric study systematically mined health and social science publications from the Web of Science and Scopus databases using keywords associated with infectious disease. The analysis included only English-language articles and review articles by authors from any ASEAN country. Publication, citation, and text co-occurrence network analyses were performed. R Studio and VOSviewer enabled data management, analysis, and visualization. RESULTS: Searches identified 12,511 articles published between 1925 and 2022, with a notable increase in research publications since 2003. The leading journals on infectious disease were associated with established publishing houses, including BMC, BMJ, and The Lancet. The most-cited articles were primarily global burden of disease studies, with 7,367 citations. Among ASEAN countries, Thailand, Malaysia, and Singapore had the most publications and collaborative efforts on the topic. Analysis of keyword co-occurrence revealed clusters related to global health, dengue, bacterial studies, non-dengue viral topics, and diagnostics. Most early studies examined diagnostics, gene and sequencing methodologies, and virology; later, the focus shifted toward herbal and alternative medicine. CONCLUSION: Recently, the research capacity of Southeast Asia has expanded dramatically, with substantial contributions from high-income countries. Intense cooperation between member states is essential, emphasizing the role of HICs in supporting their neighbors. Increased research efforts and collaboration must be dedicated to innovative approaches to combat persistent health conditions, along with emerging issues like climate change.

Chinese Medicine-Derived Salvianolic Acid B for Disease Therapy: A Scientometric Study.

Salvianolic acid B (SalB), among the most abundant bioactive polyphenolic compounds found in Salvia miltiorrhiza Bge., exerts therapeutic and protective effects against various diseases. Although some summaries of the activities of SalB exist, there is lack of a scientometric and in-depth review regarding disease therapy. In this review, scientometrics was employed to analyze the number of articles, publication trends, countries, institutions, keywords, and highly cited papers pertaining to SalB research. The scientometric findings showed that SalB exerts excellent protective effects on the heart, lungs, liver, bones, and brain, along with significant therapeutic effects against atherosclerosis (AS), Alzheimer's disease (AD), liver fibrosis, diabetes, heart/brain ischemia, and osteoporosis, by regulating signaling pathways and acting on specific molecular targets. Moreover, this review delves into in-depth insights and perspectives, such as the utilization of SalB in combination with other drugs, the validation of molecular mechanisms and targets, and the research and development of novel drug carriers and dosage forms. In conclusion, this review aimed to offer a comprehensive scientometric analysis and in-depth appraisal of SalB research, encompassing both present achievements and future prospects, thereby providing a valuable resource for the clinical application and therapeutic exploitation of SalB.

A study of poverty alleviation strategies for sustainable development: A scientometric analysis.

Purpose: The present study aims to investigate the current and future trends in poverty alleviation strategies for sustainable development, show the gaps and propose the way forward for future research. Methods: This research covers four decades from 1981 to 2023. We identified a corpus of 5,982 articles from the Scopus database using the bibliometric and scientometric methods. We excluded 653 to remain, with 5,329 fulfilling the conditions of non-duplicates, suitable authorship, and conform content. These documents include articles, reviews, journals, books and other publications in our study field. With the help of VOS viewer and R-Studio software, we have performed two significant tests: performance analysis and science mapping. Results: Despite the poverty alleviation strategies for sustainable development that emerged in 1981, it has experienced steady growth from 2000 onwards and has reached the pick in 2022 with 316 publications. The most prolific countries are China, the USA and the UK. At the same time, the most contributing authors are Liu Y, Wang Y, and Lily, both from China and Ravaillion, M from Australia. They have discussed more about poverty alleviation and poverty reduction. Furthermore, we realize that the household, remittance and land use have no connection with any item besides the government and IMF. Conclusion: We have underlined the countries and authors that contributed the most and revealed the challenges in poverty alleviation via thematic mapping. Therefore, we recommend that future researchers, while keeping an eye on Africa, livelihoods, gender inequality, and India, focus more on poverty alleviation, China, and sustainable development. Special attention also must focus on the household, remittance, land use, government, and IMF and find ways to improve their role in poverty alleviation strategies for sustainable development.

Emergent Patterns, Collaborative Networks and Thematic Evolution on Black Stain and Dental Caries: A Scientometric Study.

AIM: To conduct a scientometric analysis on black stains, and dental caries, with a focus on identifying emergent patterns, collaborative networks, and thematic evolution. MATERIALS AND METHODS: A retrospective, descriptive, observational study was conducted using a scientometric approach. The Scopus database was utilized for literature search, selecting articles published between 1976 and 2023. The literature search was carried out on February 8, 2024, using AND and OR Boolean operators which were adapted to the search strategy. Finally, SciVal used different scientometric indicators such as "Scholarly Output", "Views Count", "Field-Weighted Citation Impact" and the "Citation Count". RESULTS: A total of 13 documents from 10 different sources were analyzed, covering a period from 1976 to 2023. Despite an annual growth rate of 0%, each document has an average of 21.08 citations, indicating their relevance in the field. The documents have an average age of 12.9 years and contain 336 references. A total of 143 additional keywords and 26 author keywords were identified. The documents were written by 62 different authors, with an average of 5 coauthors per document and 30.77% international coauthorships. CONCLUSION: The results indicate a significant relevance of the documents in the field, a notable collaboration among authors, and a significant thematic evolution in the research topics. The mentioned institutions and sources produced documents with notable results, indicating a significant interest and impact in the field. CLINICAL SIGNIFICANCE: This study provides a detailed view of the trends and patterns in the research of dental caries and black stains. The findings can assist dental health professionals in better understanding the prevalence and impact of these conditions. Furthermore, it can guide future research and treatment strategies in this field. How to cite this article: Mayta-Tovalino F, Espinoza-Carhuancho F, Reyes-Carmona J, et al. Emergent Patterns, Collaborative Networks and Thematic Evolution on Black Stain and Dental Caries: A Scientometric Study. J Contemp Dent Pract 2024;25(4):326-330.

Emerging Themes and Research Frontiers in Suicide Prediction: A Scientometric Analysis.

Suicide remains a critical global health issue despite advancements in mental health treatment. The purpose of this analysis is to emphasize the development, patterns, and noteworthy outcomes of suicide prediction research. It also helps to uncover gaps and areas of under-researched topics within suicide prediction. A scientometric analysis was conducted using Biblioshiny and VOSviewer. To thoroughly assess the academic literature on suicide prediction, various scientometric methodologies such as trend analysis and citation analysis were employed. We utilized the temporal features of the Web of Science to analyze publication trends over time. Author affiliation data were used to investigate the geographic distribution of research. Cluster analysis was performed by grouping related keywords into clusters to identify overarching themes within the literature. A total of 1,703 articles from 828 different sources, spanning from 1942 to 2023, were collected for the analysis. Machine learning techniques might have a big influence on suicide-related event prediction, which would enhance attempts at suicide prevention and intervention. The conceptual understanding of suicide prediction is enhanced by scientometric analysis, which further uncovers the research gap and literature in this area. Suicide prediction research underscores that suicidal behavior is not caused by a single factor but is the result of a complex interplay of multiple factors. These factors may include biological, psychological, social, and environmental factors. Understanding and integrating these factors into predictive models is a theoretical advancement in the field. Unlike previous bibliometric studies in the field of suicide prediction that have typically focused on specific subtopics or data sources, our analysis offers a comprehensive mapping of the entire landscape. We encompass a wide range of suicide prediction literature, including research from medical, psychological, and social science domains, thus providing a holistic overview.

The past forty-three years of dental implantology literature. A global mapping and scientometric analysis.

PURPOSE: The aim of this research is to make a scientometric analysis of the dental implantology literature and to present the results in a more understandable way to the reader by visualizing them with maps. METHODS: The dental implantology literature was accessed through the Web of Science database. Scientometric data was obtained with Citespace 6.1 software, co-citation, clustering analysis, citation burst, and mapping analyzes were performed. Scimago Graphica software was used for additional visualizations. RESULTS: A total of 35,704 articles were included in the analysis. There were 88,616 authors, 72,333 institutes, 142 countries/regions, and 3,265 journals contributing to the dental implantology literature. The United States was first with 7,334 publications and 225,868 citations. The literature between 1980 and 2023 was divided into 19 different clusters, and the literature between 2000 and 2023 was divided into 16 different clusters. CONCLUSIONS: Key themes in the field include the use of autogenous bone, advancements in implant surface technology, and the use of platform switching and intraoral scanners. Emerging topics of interest include esthetic considerations in the treatment of the anterior region, stress distribution, the use of zirconia, and the impact of implant treatment on oral health-related quality of life. With similar scientometric analysis studies to be done in the future, the progress of the literature can be followed on the basis of evidence.

Scientometric review on multiple climate-related hazards indices.

As the spectre of climate change looms large, there is an increasing imperative to develop comprehensive risk assessment tools. The purpose of this work is to evaluate the evolution and current state of research on multi-hazard indices associated with climate-related hazards, highlighting their crucial role in effective risk assessment amidst the growing challenges of climate change. A notable gap in cross-regional comparative studies persists, presenting an opportunity for future research to enhance global understanding and foster universal resilience strategies. However, a significant surge in research output is apparent, following key global milestones related to climate change action. The research landscape is shown to be highly responsive to international policy developments, increasingly adopting interdisciplinary approaches that integrate physical, social, and technological dimensions. Findings reveal a robust emphasis on geospatial analysis and the development of various indices that transform abstract climate risks into actionable data, underscoring a trend towards localized, context-specific vulnerability assessments. Based on dataset systematically curated under the PRISMA guidelines, the review explores how prevailing research themes are reflected in influential journals and author networks, mapping out a dynamic and expanding academic community. Moreover, this work provides critical insights into the underlying literature by conducting a thematic analysis on the typology of studies, the focus on coastal areas, the inclusion of climate change scenarios, the geographical coverage, and the types of climate-related hazards. The practical implications of this review are profound, providing policymakers and practitioners with meaningful insights to enhance climate change mitigation and adaptation efforts through the application of index-based methodologies. By charting a course for future scholarly endeavours, this article aims to strengthen the scientific foundations supporting resilient and adaptive strategies for regions worldwide facing the multifaceted impacts of climate change.

Urgent needs for second life using and recycling design of wasted electric vehicles (EVs) lithium-ion battery: a scientometric analysis.

Currently, lithium-ion batteries are increasingly widely used and generate waste due to the rapid development of the EV industry. Meanwhile, how to reuse "second life" and recycle "extracting of valuable metals" of these wasted EVBs has been a hot research topic. The 4810 relevant articles from SCI and SSCI Scopus databases were obtained. Scientometric analysis about second life using and recycling methodologies of wasted EVBs was conducted by VOSviewer, Pajek, and Netdraw. According to analytical results, the research of second life using and recycling mythologies has been growing and the expected achievement will continue to increase. China, Germany, the USA, Italy, and the UK are the most active countries in this field. Tsinghua University in China, "Fraunhofer ISI, Karlsruhe" in Germany, and "Polytechnic di Torino" in Italy are the most productive single and collaborative institutions. The journals SAE technical papers and World Electric Vehicle Journal have the highest publication and citations than other journals. Chinese author "Li Y" has the highest number of 36 publications, and his papers were cited 589 times by other authors. By analyzing the co-occurrence and keywords, energy analysis, second life (stationary using, small industry), and treatment methods, (hydrometallurgy and pyrometallurgical, electrochemical, bio-metallurgical) were the hot research topics. The S-curve from the article indicates hydrometallurgical and bio-metallurgical methods are attached with great potential in the near future. Further, different treatment methodologies are observed especially advanced techniques in hydrometallurgical, and spent medium bioleaching techniques in bio-metallurgical are good, economically cheap, has low CO2 emission, environmentally friendly, and has high recovery rate. Finally, this research provides information on second life use and top recycling methodology opportunities for future research direction for researchers and decision-makers who are interested in this research.

Hypertension Research in Pakistan: A Scientometric Analysis of Two Decades (2003-2022).

Hypertension is a highly prevalent chronic disease that leads to a significant number of deaths and disabilities as a consequence of cardiovascular complications. However, there is insufficient information regarding research trends and performance assessments from South Asian countries, including Pakistan. In this review, we analyzed research data related to hypertension from Pakistan over the last 20 years (2003-2022). We used the Web of Science (WoS) database to retrieve research data related to hypertension from Pakistan, and then applied scientometric analysis using the "R-Bibliometrix" package. An extensive range of indicators was studied to determine the quality and quantity of these hypertension-related publications. A total of 4,008 research articles from 891 sources were extracted through WoS over the last 20 years (2003-2022). There was a continuous growth in the number of research articles, with relatively more increase observed from 2012, and maximum output in 2021. Among 16,855 authors contributing from 67 countries, three authors had >50 publications and five had >1,500 citations. The country's leading affiliation was the Aga Khan University which showed networking trends with international institutes while the other national universities restricted their institutional partnerships to the provincial or city level. The Higher Education Commission was the only local sponsoring institute among the top funding sources. Pakistan Journal of Medical Sciences was the leading and most consistent source, whereas hypertension, diabetes mellitus, and obesity were the most frequently used keywords. This review provides a comprehensive account of hypertension-related research productivity from Pakistan. Some characteristic trends were detected for top authors' contributions, impact, productivity, international collaborations, funding sources, and institutional affiliations. Particularly, the funding sources and collaboration patterns of corresponding authors along with their affiliated institutes showed striking results. These findings can be very helpful for the relevant stakeholders in the accurate interpretation of trends and performance of hypertension-related research work from the region.

Exploring trends and developments in cholesteatoma research: a bibliometric analysis.

PURPOSE: Examination of the scientific literature on cholesteatoma from past to present using bibliometric methods. METHODS: A total of 2353 articles on cholesteatoma between 1980 and 2023 were obtained from the Web of Science database and statistically analysed using bibliometric techniques. RESULTS: The journals with the highest number of contributions to the literature were Otology & Neurotology (n = 192), Acta Oto-Laryngologica (156) and Laryngoscope (149). The most impactful journals based on h-index and total citation (TC) counts were Laryngoscope (h:36, TC: 4241), Otology & Neurotology (29, 3141), and American Journal of Otology (26, 2071) respectively. The most prolific author was Kojima H. (n = 49). According to the findings of the Reference Publication Year Spectroscopy (RPYS) analysis, there has been a significant increase in academic interest in Cholesteatoma since its first description in 1959, particularly following the expansion of its definition in 1977. Subsequently, the trend of increased interest has risen rapidly in later years, with notable peaks in research intensity observed in 1989, 2006, and 2011. The highest academic trend occurred in 2006. In recent years, trending topics have included innovative approaches such as diagnostic and imaging methods particularly alongside technological developments, endoscopic surgery, recurrence and complications, prognosis and quality of life, artificial intelligence, and obliteration. CONCLUSION: In conclusion, the evolution of cholesteatoma and its research priorities reveal temporal shifts and emerging areas of interest over time. Primarily, diagnosis, treatment, and surgical approaches remain central. Additionally, research has expanded to encompass developments in surgical techniques, imaging modalities, cellular biology, pathology, and molecular mechanisms.

Global scholarly output on orthodontic temporary anchorage devices (TADs): A silver jublee scientometric analysis.

OBJECTIVES: This study aimed to analyze the global scholarly production of articles related to temporary anchorage devices (TADs) from 1998-2023 in peer-reviewed dental journals indexed in the Web of Science. MATERIALS AND METHODS: A database of TADs-related articles was created via a Web of Sciences structured search. The bibliometric characteristics of the studies, including the number of citations, publication year, journal title, journal impact factor (IF), authorship, contributing institutions and countries, thematic field, and study design, were extracted. Keyword co-occurrence network analyses and the correlation between the number of citations and the article age, journal IF, and journal quartile of each article were performed. RESULTS: The top 50 cited articles were published from 1999-2016, and the total number of citations ranged from 82-602, with 160.36 citations/paper on average. Most of the articles originated from Japan (n = 12), with the most remarkable contributions from Nihon and Okayama Universities, Japan (n = 5, each). The American Journal of Orthodontics and Dentofacial Orthopedics had the most cited articles, with 196.57 citations/paper on average. A significant positive correlation occurred between the number of citations and publication age (rho = 0.392, P = 0.005). CONCLUSION: Our scientometric analysis reported the characteristics of TADs-related articles published over 25 years. Most highly-cited articles were published between 2005 and 2008. The positive correlation between articles' publication date and the number of citations might impact the top 50 within the next 5-10 years.

A Bibliometric Analysis of Literature on the Impact of Diet on Oral Health.

The complex connection between oral health and dietary habits is fundamental to holistic well-being. Oral health is closely linked to dietary choices, both as a reflection and a factor in overall health. This bibliometric analysis investigates clinical trials published in the PubMed database spanning six decades to understand the landscape of research on the impact of diet on oral health. The analysis reveals a fluctuating yet generally increasing trend over the decades, with significant growth periods interspersed with occasional declines, culminating in a recent slight decrease in research output. With strong collaborative networks, Devizio and Proskin emerge as primary contributors. The University of Sydney has published the maximum number of clinical trials. Thematic clusters highlight diverse research facets, including physiological measurements, socio-economic influences, and biochemical aspects. The evolution in research priorities from experimental studies to longitudinal evaluations underscores the interdisciplinary nature of the field. The analysis of country-wise research output revealed that the United States, Germany, and Australia lead in scientific research output, with notable contributions to the global landscape. While larger countries like China and India are represented, their frequencies are relatively lower, suggesting potential areas for further exploration. Collaboration patterns vary between countries, influencing the global impact of their scientific output. Despite the limitations inherent in database selection, this study integrates bibliometric and thematic analyses to offer comprehensive insights into research trends and priorities.

Listening to the Past, Predicting the Future: A Bibliometric Exploration of Hearing Loss Publications Over Four Decades.

OBJECTIVES: This article aims to analyze the scientific literature on hearing loss (HL) in the field of Otorhinolaryngology published from the past to the present. METHODS: A comprehensive dataset comprising 8013 articles on HL, spanning from 1980 to 2023, was retrieved from the Web of Science database and analyzed using various statistical and bibliometric methods. RESULTS: The leading countries in productivity were the United States, Japan, and Germany. The top productive journals included the International Journal of Pediatric Otorhinolaryngology (n = 652), Otology & Neurotology (579), and Acta Oto-Laryngologica (512). The journals with the highest h-index on hearing loss were Hearing Research (h = 65), Ear and Hearing (60), and Laryngoscope (55). Factor analysis revealed that the HL literature consisted of four constructs: main topics, speech/sound, genetics, and pharmaceutical therapies. Sudden sensorineural HL, sensorineural HL, cochlear implant, unilateral, noise-induced and conductive HL, pediatric and age-related HL, tinnitus, auditory brainstem response, audiometry, and prognoses for hearing health were the most researched topics from past to present. In recent years, the trending topics are genomic analysis, gene mutations, whole-exome sequencing, genetic sequencing technique, the use of machine learning in HL, and the effect of COVID-19 on hearing health. CONCLUSION: The bibliometric analysis results clearly indicate significant progress in the field of hearing loss over the past 40 years. The 8013 articles published between 1980 and 2023 encompass a wide range of research in this area. These analyses can assist in identifying priority areas and focal points for future research. LEVEL OF EVIDENCE: N/A Laryngoscope, 2024.

A scientometric analysis and visualisation of elderly suicide research from 1951 to 2022.

BACKGROUND: There are still many gaps in both national and international literature on elderly suicide. This study aimed to identify the most influential journals in elderly suicide, the countries and authors that contribute the most to the field, and the trends in the field. MATERIAL AND METHODS: Studies published on elderly suicide between 1951 and 2022 were retrieved utilising the Web of Science Core Collection. Co-authorship analysis of countries and authors, as well as co-occurrence analysis of keywords, were conducted using VOSviewer 1.6.18. RESULTS: There were 2864 articles retrieved, including 95 countries, 889 academic journals, 9162 authors and 4160 keywords. The number of publications in this field has significantly increased after the 2000s, and the United States is the most productive country (996). The most prolific author is Yeates Conwell, while the journal with the highest number of publications in this field is the International Journal of Geriatric Psychiatry. Other than 'suicide' and 'elderly', the most trending keywords are 'depression', 'primary care', 'treatment', 'antidepressant', 'loneliness', 'quality of life' and 'COVID-19'. CONCLUSION: There has been an increase in both the thematic diversity and quantity of studies on elderly suicide over time. However, these publications predominantly originate from socioeconomically affluent countries with relatively low suicide rates. While the increasing numbers of publications from developing countries in recent years are promising, there is a greater need for publications from countries with lower socioeconomic status for the prevention or intervention of elderly suicides.

A Bibliometric Analysis of Literature on the Impact of Rheumatoid Arthritis on Oral Health (1987-2024).

This bibliometric analysis investigates the research landscape concerning the impact of rheumatoid arthritis (RA) on oral health through a comprehensive literature review. The study includes all English-language articles retrieved from the PubMed database, focusing on the relationship between RA and various aspects of oral health without any filter. The analysis of 261 publications revealed fluctuations in publication patterns from 1987 to 2024, with notable surges and declines in research activity. Collaborative networks among authors and institutions were identified, highlighting key contributors and prolific institutions such as Karolinska Institutet. The themes prevalent in the research included demographics, oral microbiota, biomarkers, treatment outcomes, and molecular mechanisms. Trend topic and thematic evolution analyses elucidated shifts in research focus from traditional concerns to emerging areas such as oral microbiology and immunological mechanisms. Key findings underscored the need for more clinical trials to comprehend the impact of RA on oral health, enhanced interdisciplinary collaboration, exploration of emerging areas, and longitudinal studies. This analysis provides valuable insights into the evolving research landscape, informing future investigations and interventions to improve oral health outcomes in individuals with RA.

Antibody-drug conjugates in urothelial carcinoma: scientometric analysis and clinical trials analysis.

In 2020, bladder cancer, which commonly presents as urothelial carcinoma, became the 10th most common malignancy. For patients with metastatic urothelial carcinoma, the standard first-line treatment remains platinum-based chemotherapy, with immunotherapy serving as an alternative in cases of programmed death ligand 1 expression. However, treatment options become limited upon resistance to platinum and programmed death 1 or programmed death ligand 1 agents. Since the FDA's approval of Enfortumab Vedotin and Sacituzumab Govitecan, the therapeutic landscape has expanded, heralding a shift towards antibody-drug conjugates as potential first-line therapies. Our review employed a robust scientometric approach to assess 475 publications on antibody-drug conjugates in urothelial carcinoma, revealing a surge in related studies since 2018, predominantly led by U.S. institutions. Moreover, 89 clinical trials were examined, with 36 in Phase II and 13 in Phase III, exploring antibody-drug conjugates as both monotherapies and in combination with other agents. Promisingly, novel targets like HER-2 and EpCAM exhibit substantial therapeutic potential. These findings affirm the increasing significance of antibody-drug conjugates in urothelial carcinoma treatment, transitioning them from posterior-line to frontline therapies. Future research is poised to focus on new therapeutic targets, combination therapy optimization, treatment personalization, exploration of double antibody-coupled drugs, and strategies to overcome drug resistance.

Cellulose-based materials in environmental protection: A scientometric and visual analysis review.

As sustainable materials, cellulose-based materials have attracted significant attention in the field of environmental protection, resulting in the publication of numerous academic papers. However, there is a scarcity of literature that involving scientometric analysis within this specific domain. This review aims to address this gap and highlight recent research in this field by utilizing scientometric analysis and a historical review. As a result, 21 highly cited articles and 10 mostly productive journals were selected out. The scientometric analysis reveals that recent studies were objectively clustered into five interconnected main themes: extraction of cellulose from raw materials and its degradation, adsorption of pollutants using cellulose-based materials, cellulose-acetate-based membrane materials, nanocellulose-based materials, and other cellulose-based materials such as carboxymethyl cellulose and bacterial cellulose for environmental protection. Analyzing the distribution of author keywords and thoroughly examining relevant literature, the research focuses within these five themes were summarized. In the future, the development of eco-friendly and cost-effective methods for extracting and preparing cellulose and its derivatives, particularly nanocellulose-based materials, remains an enduring pursuit. Additionally, machine learning techniques holds promise for the advancement and application of cellulose-based materials. Furthermore, there is potential to expand the research and application scope of cellulose-based materials for environmental protection.