The power of (surreptitiously) mentioning your mentor's name: Subliminal priming of mentor's name modulates N170 responses to blurred faces.

Using the event-related potentials (ERPs) technique and subliminal priming paradigm, the present study examined the influence of mentioning a mentor's name on graduate students. Fifty-eight graduate students were subliminally primed by mentor and stranger names before making pressure judgments of a series of unrelated blurred facial photos with neutral emotion. The face-sensitive N170 components were analyzed according to the pressure judgment × name prime conditions. The results showed that relative to stranger names, subliminal priming of mentor's name could modulate students' N170 reactions during facial processing. Specifically, the mentor-name priming attenuated N170 amplitudes for high-pressure judgment trials on the right hemisphere but heightened the overall N170 responses on the left hemisphere. Behavioral results also showed that the mentor-name priming slowed students' reaction time during pressure judgments; in addition, students' attitudes towards mentors were correlated with N170 amplitudes on high-pressure judgment conditions. These findings provided neuroscientific evidence demonstrating the psychological significance of mentors to graduate students. Theoretical and practical implications were also discussed.

Reward History Modulates the Processing of Task-Irrelevant Emotional Faces in a Demanding Task.

The aim of the current study was to examine how reward-associated emotional facial distractors could capture attentional resources in a demanding visual task using event-related potentials (ERPs). In the learning phase, a high- or low-reward probability was paired with angry, happy, or neutral faces. Then, in the test phase, participants performed a face-irrelevant task with no reward at stake, in which they needed to discriminate the length of two lines presented in the center of the screen while faces that were taken from the learning phase were used as distractors presented in the periphery. The behavioral results revealed no effect of distractor emotional valence since the emotional information was task-irrelevant. The ERP results in the test phase revealed a significant main effect of distractor emotional valence for the parieto-occipital P200 (170-230 ms); the mean amplitudes in both the angry- and happy-face conditions were more positive than the neutral-face condition. Moreover, we found that the high-reward association enhanced both the N170 (140-180 ms) and EPN (260-330 ms) relative to the low-reward association condition. Finally, the N2pc (270-320 ms) also exhibited enhanced neural activity in the high-reward condition compared to the low-reward condition. The absence of emotional effects indicated that task-irrelevant emotional facial stimuli did not impact behavioral or neural responses in this highly demanding task. However, reward-associated information was processed when attention was directed elsewhere, suggesting that the processing of reward-associated information worked more in an automatic way, irrespective of the top-down task demand.

Far from the eyes, far from the heart: COVID-19 confinement dampened sensitivity to painful facial features.

In the last 2 years, governments of many countries imposed heavy social restrictions to contain the spread of the COVID-19 virus, with consequent increase of bad mood, distress, or depression for the people involved. Few studies investigated the impact of these restrictive measures on individual social proficiency, and specifically the processing of emotional facial information, leading to mixed results. The present research aimed at investigating systematically whether, and to which extent, social isolation influences the processing of facial expressions. To this end, we manipulated the social exclusion experimentally through the well-known Cyberball game (within-subject factor), and we exploited the occurrence of the lockdown for the Swiss COVID-19 first wave by recruiting participants before and after being restricted at home (grouping factor). We then tested whether either form of social segregation influenced the processing of pain, disgust, or neutral expressions, across multiple tasks probing access to different components of affective facial responses (state-specific, shared across states). We found that the lockdown (but not game-induced exclusion) affected negatively the processing of pain-specific information, without influencing other components of the affective facial response related to disgust or broad unpleasantness. In addition, participants recruited after the confinement reported lower scores in empathy questionnaires. These results suggest that social isolation affected negatively individual sensitivity to other people's affect and, with specific reference to the processing of facial expressions, the processing of pain-diagnostic information.

Associations of negative affective biases and depressive symptoms in a community-based sample.

BACKGROUND: Major depressive disorder (MDD) was previously associated with negative affective biases. Evidence from larger population-based studies, however, is lacking, including whether biases normalise with remission. We investigated associations between affective bias measures and depressive symptom severity across a large community-based sample, followed by examining differences between remitted individuals and controls. METHODS: Participants from Generation Scotland (N = 1109) completed the: (i) Bristol Emotion Recognition Task (BERT), (ii) Face Affective Go/No-go (FAGN), and (iii) Cambridge Gambling Task (CGT). Individuals were classified as MDD-current (n = 43), MDD-remitted (n = 282), or controls (n = 784). Analyses included using affective bias summary measures (primary analyses), followed by detailed emotion/condition analyses of BERT and FAGN (secondary analyses). RESULTS: For summary measures, the only significant finding was an association between greater symptoms and lower risk adjustment for CGT across the sample (individuals with greater symptoms were less likely to bet more, despite increasingly favourable conditions). This was no longer significant when controlling for non-affective cognition. No differences were found for remitted-MDD v. controls. Detailed analysis of BERT and FAGN indicated subtle negative biases across multiple measures of affective cognition with increasing symptom severity, that were independent of non-effective cognition [e.g. greater tendency to rate faces as angry (BERT), and lower accuracy for happy/neutral conditions (FAGN)]. Results for remitted-MDD were inconsistent. CONCLUSIONS: This suggests the presence of subtle negative affective biases at the level of emotion/condition in association with depressive symptoms across the sample, over and above those accounted for by non-affective cognition, with no evidence for affective biases in remitted individuals.

The Effects of Separate Facial Areas on Emotion Recognition in Different Adult Age Groups: A Laboratory and a Naturalistic Study.

The identification of facial expressions is critical for social interaction. The ability to recognize facial emotional expressions declines with age. These age effects have been associated with differential age-related looking patterns. The present research project set out to systematically test the role of specific facial areas for emotion recognition across the adult lifespan. Study 1 investigated the impact of displaying only separate facial areas versus the full face on emotion recognition in 62 younger (20-24 years) and 65 middle-aged adults (40-65 years). Study 2 examined if wearing face masks differentially compromises younger (18-33 years, N = 71) versus middle-aged to older adults' (51-83 years, N = 73) ability to identify different emotional expressions. Results of Study 1 suggested no general decrease in emotion recognition across the lifespan; instead, age-related performance seems to depend on the specific emotion and presented face area. Similarly, Study 2 observed only deficits in the identification of angry, fearful, and neutral expressions in older adults, but no age-related differences with regards to happy, sad, and disgusted expressions. Overall, face masks reduced participants' emotion recognition; however, there were no differential age effects. Results are discussed in light of current models of age-related changes in emotion recognition.

Short-term effects of nicotine gum on facial detection in healthy nonsmokers: a pilot randomized controlled trial.

Objective: The main purpose of this study was to investigate short-term effects of nicotine gum on facial detection. Methods: Fourteen participants (mean age = 26.8 years, SD = 2.5 years; eight males) were enrolled in this pilot randomized controlled trial of nicotine gum administration (placebo, 2-mg and 4-mg doses). The participants were instructed to detect the location of a face when it was presented in a face/nonface pair on the screen. A repeated multivariate analysis of variance was conducted to analyze the results for reaction time and discrimination index. Demographics were used to explore significant association on facial detection. Bayesian analyses were also carried out considering maximum robustness to avoid bias. Results: The results indicated that the 2-mg dose resulted in faster reaction time and better discrimination than the 4-mg dose (p < 0.001). The 4-mg dose resulted in slower reaction time and lower discrimination index compared to both placebo (p < 0.01) and 2-mg doses (p < 0.001). Demographic data were not related to the outcomes. Conclusions: The results indicate that nicotine improved facial detection, but only at low doses (i.e., 2-mg), following a U-shaped curve. We trust future studies will continue to advance this research field, and if further work supports these preliminary findings, nicotine can act as therapeutic target in populations such as those with low vision.

Facing recovery: Emotional bias in working memory, rumination, relapse, and recurrence of major depression; an experimental paradigm conducted five years after first episode of major depression.

Identifying vulnerability factors for relapse of depression is essential in planning preventive interventions. Emotional face processing in major depression (MDD) shows promise as a potential cognitive marker for depression. The current study investigates how working memory (WM) load in face processing relates to rumination and new episodes of MDD in a novel explorative paradigm. It was expected that history of MDD is associated with reduction of the ability to process sad stimuli in high WM load conditions and reduction of the ability to process happy stimuli in low WM conditions. It was further predicted that these relations are associated with rumination and risk for relapse. The experiment was included as a cross sectional part in a follow-up study of a population that previously experienced first episode (FE) depression. The FE (N = 23) and a healthy control group (N = 22) completed a WM face processing task. In the task, three happy or sad faces were presented, processed in either a high or low WM taxing manner, followed by a target stimulus consisting of one of the previous pictures. Response time and accuracy were dependent variables. Rumination and number of relapses or recurrences were measured. The FE group recalled the placement of significantly fewer happy faces in the low WM load condition, and significantly fewer sad faces in the high WM load condition compared to controls. Significantly different scores between groups predicted trait rumination. Poor accuracy in the sad high WM load condition correlated with high degree of rumination. Relapse or recurrence was predicted by rumination. The present study supports an emotional WM deficit in remitted MDD. This suggests that deficits in manipulation of sad faces could represent a trait bias related to rumination and depression.

The Animal in Me: Enhancing Emotion Recognition in Adolescents with Autism Using Animal Filters.

People with autism are often characterized as having difficulties with theory of mind abilities such as emotion recognition. However, rather than being a pervasive deficit of 'mindblindness,' a number of studies suggests these difficulties vary by context, and when people with autism mindread non-human agents, such as animals or cartoons, these abilities improve. To replicate this effect, 15 adolescents with both autism and intellectual disability participated in a test of facial emotion recognition, with both human and animal faces. Participants performed significantly better on the animal version of the assessment compared to the human version, and human rather than animal scores were the strongest predictor of symptom severity. These results were shown to be primarily driven by improvement in recognition of the emotions happiness and anger in animal rather than human faces. Implications with regards to social motivation and theory of mind interventions are discussed.

Self-Regulation of the Fusiform Face Area in Autism Spectrum: A Feasibility Study With Real-Time fMRI Neurofeedback.

One of the most important and early impairments in autism spectrum disorder (ASD) is the abnormal visual processing of human faces. This deficit has been associated with hypoactivation of the fusiform face area (FFA), one of the main hubs of the face-processing network. Neurofeedback based on real-time fMRI (rtfMRI-NF) is a technique that allows the self-regulation of circumscribed brain regions, leading to specific neural modulation and behavioral changes. The aim of the present study was to train participants with ASD to achieve up-regulation of the FFA using rtfMRI-NF, to investigate the neural effects of FFA up-regulation in ASD. For this purpose, three groups of volunteers with normal I.Q. and fluent language were recruited to participate in a rtfMRI-NF protocol of eight training runs in 2 days. Five subjects with ASD participated as part of the experimental group and received contingent feedback to up-regulate bilateral FFA. Two control groups, each one with three participants with typical development (TD), underwent the same protocol: one group with contingent feedback and the other with sham feedback. Whole-brain and functional connectivity analysis using each fusiform gyrus as independent seeds were carried out. The results show that individuals with TD and ASD can achieve FFA up-regulation with contingent feedback. RtfMRI-NF in ASD produced more numerous and stronger short-range connections among brain areas of the ventral visual stream and an absence of the long-range connections to insula and inferior frontal gyrus, as observed in TD subjects. Recruitment of inferior frontal gyrus was observed in both groups during FAA up-regulation. However, insula and caudate nucleus were only recruited in subjects with TD. These results could be explained from a neurodevelopment perspective as a lack of the normal specialization of visual processing areas, and a compensatory mechanism to process visual information of faces. RtfMRI-NF emerges as a potential tool to study visual processing network in ASD, and to explore its clinical potential.

Ethnic effects when facing children: An ERP study.

Abundant research has highlighted a disadvantage experienced by children of ethnic minority groups in, for example, educational and health care settings. In order to understand implicit attitudes that contribute to ethnic disparities, underlying neural correlates have been widely studied. However, this has been limited to the context of adults. Using a sample of nulliparous Caucasian females (N = 46), the current study is the first to examine how early attentional and facial perceptual processing stages, assessed with event-related brain potentials (ERPs), differentiate for stimuli of young ingroup (of the same ethnicity) or outgroup (of a different ethnicity) children. Additionally, we assessed how a differentiation in ERPs may relate to subsequent adult responsiveness to children by measuring both cuteness ratings and motivation to view child faces. Similar to previous findings for adult facial stimuli, we found significant differences in attentional (N200) and facial perceptual (N170) processing when adults were faced with children of different ethnicities. Furthermore, increased differentiation in attentional processing (N200) for ingroup and outgroup children was associated with reduced cuteness ratings of outgroup children. Importantly however, participants showed no overall preference for ingroup child faces, as motivation to view child faces was even greater towards outgroup child faces. In addition, increased self-reported motivation for parental care was related to enhanced cuteness appraisals of outgroup child faces. Taken together, these findings reveal how early social categorization processes may lead to biased behavior when interacting with children of ethnic minorities.

Unconscious Processing of Facial Expressions in Individuals with Internet Gaming Disorder.

Internet Gaming Disorder (IGD) is characterized by impairments in social communication and the avoidance of social contact. Facial expression processing is the basis of social communication. However, few studies have investigated how individuals with IGD process facial expressions, and whether they have deficits in emotional facial processing remains unclear. The aim of the present study was to explore these two issues by investigating the time course of emotional facial processing in individuals with IGD. A backward masking task was used to investigate the differences between individuals with IGD and normal controls (NC) in the processing of subliminally presented facial expressions (sad, happy, and neutral) with event-related potentials (ERPs). The behavioral results showed that individuals with IGD are slower than NC in response to both sad and neutral expressions in the sad-neutral context. The ERP results showed that individuals with IGD exhibit decreased amplitudes in ERP component N170 (an index of early face processing) in response to neutral expressions compared to happy expressions in the happy-neutral expressions context, which might be due to their expectancies for positive emotional content. The NC, on the other hand, exhibited comparable N170 amplitudes in response to both happy and neutral expressions in the happy-neutral expressions context, as well as sad and neutral expressions in the sad-neutral expressions context. Both individuals with IGD and NC showed comparable ERP amplitudes during the processing of sad expressions and neutral expressions. The present study revealed that individuals with IGD have different unconscious neutral facial processing patterns compared with normal individuals and suggested that individuals with IGD may expect more positive emotion in the happy-neutral expressions context. HIGHLIGHTS: • The present study investigated whether the unconscious processing of facial expressions is influenced by excessive online gaming. A validated backward masking paradigm was used to investigate whether individuals with Internet Gaming Disorder (IGD) and normal controls (NC) exhibit different patterns in facial expression processing.• The results demonstrated that individuals with IGD respond differently to facial expressions compared with NC on a preattentive level. Behaviorally, individuals with IGD are slower than NC in response to both sad and neutral expressions in the sad-neutral context. The ERP results further showed (1) decreased amplitudes in the N170 component (an index of early face processing) in individuals with IGD when they process neutral expressions compared with happy expressions in the happy-neutral expressions context, whereas the NC exhibited comparable N170 amplitudes in response to these two expressions; (2) both the IGD and NC group demonstrated similar N170 amplitudes in response to sad and neutral faces in the sad-neutral expressions context.• The decreased amplitudes of N170 to neutral faces than happy faces in individuals with IGD might due to their less expectancies for neutral content in the happy-neutral expressions context, while individuals with IGD may have no different expectancies for neutral and sad faces in the sad-neutral expressions context.

Increased local connectivity of brain functional networks during facial processing in schizophrenia: evidence from EEG data.

Schizophrenia is often considered to be a disconnection syndrome. The abnormal interactions between large-scale functional brain networks result in cognitive and perceptual deficits. The present study investigated event-related functional connectivity networks to compare facial processing in individuals with and without schizophrenia. Faces and tables were presented to participants, and event-related phase synchrony, represented by the phase lag index (PLI), was calculated. In addition, cortical oscillatory dynamics may be useful for understanding the neural mechanisms underlying the disparate cognitive and functional impairments in schizophrenic patients. Therefore, the dynamic graph theoretical networks related to facial processing were compared between individuals with and without schizophrenia. Our results showed that event-related phase synchrony was significantly reduced in distributed networks, and normalized clustering coefficients were significantly increased in schizophrenic patients relative to those of the controls. The present data suggest that schizophrenic patients have specific alterations, indicated by increased local connectivity in gamma oscillations during facial processing.

Modulation of the N170 with Classical Conditioning: The Use of Emotional Imagery and Acoustic Startle in Healthy and Depressed Participants.

Recent studies have suggested that classical conditioning may be capable of modulating early sensory processing in the human brain, and that there may be differences in the magnitude of the conditioned changes for individuals with major depressive disorder. The effect of conditioning on the N170 event-related potential was investigated using neutral faces as conditioned stimuli (CS+) and emotional imagery and acoustic startle as unconditioned stimuli (UCS). In the first experiment, electroencephalogram was recorded from 24 undergraduate students (M = 21.07 years, SD = 3.38 years) under the following conditions: (i) CS+/aversive imagery, (ii) CS+/aversive imagery and acoustic startle, (iii) CS+/acoustic startle, and (iv) CS+/pleasant imagery. The amplitude of the N170 was enhanced following conditioning with aversive imagery as well as acoustic startle. In the second experiment, 26 healthy control participants were tested (17 females and 9 males, age M = 25.97 years, SD = 9.42) together with 18 depressed participants (13 females and 5 males, age M = 23.26 years, SD = 4.01) and three conditions were used: CS+/aversive imagery, CS+/pleasant imagery, and CS-. N170 amplitude at P7 was increased for the CS+/aversive condition in comparison to CS- in the conditioning blocks versus baseline. No differences between depressed and healthy participants were found. Across both experiments, evaluative conditioning was absent. It was concluded that aversive UCS are capable of modulating early sensory processing of faces, although further research is also warranted in regards to positive UCS.

What's in a line? Verbal, facial, and emotional influences on the line bisection task.

In Bryden and MacRae's [(1988). Dichotic laterality effects obtained with emotional words. Neuropsychiatry, Neuropsychology, and Behavioral Neurology, 1(3), 171-176] dichotic listening task, attending to verbal (left hemisphere) or emotional (right hemisphere) auditory stimuli can result in opposite patterns of behaviour. We examined whether performance on the line bisection task might also be influenced in opposite ways by left- and right-lateralized functions. The line bisection task is a simple and effective measure of visuospatial bias. Pseudoneglect, a leftward bias, is typically found on this task, and appears to result from right hemisphere dominance for spatial processing. We investigated how emotion, verbal, and facial processing impacted line bisection performance, while also examining the influence of hand-use. Line type (face, word, and solid), valence (positive, negative, and neutral), and hand-use (left, right, and both) were manipulated. Results indicated that face and word lines decreased and increased the extent of pseudoneglect, respectively, and that valence accentuated these results. These results were in the opposite direction from our predictions. Hand-use had little influence. We discuss the impact that visual scanning, and local and global processing, may have had on line bisection performance. Until future research clarifies how lateralized functions affect line bisections, we suggest caution in adapting the line bisection task as a general measure of relative hemispheric activation.

The temporal unfolding of face processing in social anxiety disorder--a MEG study.

The current study is the first to use magnetoencephalography (MEG) to examine how individuals with social anxiety disorder (SAD) process emotional facial expressions (EFEs). We expected that, compared to healthy controls (HCs), participants with SAD will show an early (<200 ms post-stimulus) over-activation in the insula and the fusiform gyrus (FG, associated with the N170/M170 component), and later (>200 ms post-stimulus) over-activation in the dorsolateral prefrontal cortex (DLPFC). Individuals with SAD (n = 12) and healthy controls (HCs, n = 12) were presented with photographs of facial displays during MEG recording. As compared to the HC group, the SAD group showed a reduced M170 (right FG under-activation around 130-200 ms); early reduced activation in the right insula, and lower insular sensitivity to the type of EFE displayed. In addition, the SAD group showed a late over-activation in the right DLPFC. This unique EFE processing pattern in SAD suggests an early under-activation of cortical areas, possibly related to reduced emphasis on high spatial frequency information and greater early emphasis on low spatial frequency information. The late DLPFC over-activation in the SAD group may correlate to failures of cognitive control in this disorder. The importance of a temporal perspective for the understanding of facial processing in psychopathology is underlined.

Task difficulty and response complexity modulate affective priming by emotional facial expressions.

In this study we used an affective priming task to address the issue of whether the processing of emotional facial expressions occurs automatically independent of attention or attentional resources. Participants had to attend to the emotion expression of the prime face, or to a nonemotional feature of the prime face, the glasses. When participants attended to glasses (emotion unattended), they had to report whether the face wore glasses or not (the glasses easy condition) or whether the glasses were rounded or squared (the shape difficult condition). Affective priming, measured on valence decisions on target words, was mainly defined as interference from incongruent rather than facilitation from congruent trials. Significant priming effects were observed just in the emotion and glasses tasks but not in the shape task. When the key-response mapping increased in complexity, taxing working memory load, affective priming effects were reduced equally for the three types of tasks. Thus, attentional load and working memory load affected additively to the observed reduction in affective priming. These results cast some doubts on the automaticity of processing emotional facial expressions.

Is it a face of a woman or a man? Visual mismatch negativity is sensitive to gender category.

The present study investigated whether gender information for human faces was represented by the predictive mechanism indexed by the visual mismatch negativity (vMMN) event-related brain potential (ERP). While participants performed a continuous size-change-detection task, random sequences of cropped faces were presented in the background, in an oddball setting: either various female faces were presented infrequently among various male faces, or vice versa. In Experiment 1 the inter-stimulus-interval (ISI) was 400 ms, while in Experiment 2 the ISI was 2250 ms. The ISI difference had only a small effect on the P1 component, however the subsequent negativity (N1/N170) was larger and more widely distributed at longer ISI, showing different aspects of stimulus processing. As deviant-minus-standard ERP difference, a parieto-occipital negativity (vMMN) emerged in the 200-500 ms latency range (~350 ms peak latency in both experiments). We argue that regularity of gender on the photographs is automatically registered, and the violation of the gender category is reflected by the vMMN. In conclusion the results can be interpreted as evidence for the automatic activity of a predictive brain mechanism, in case of an ecologically valid category.