Evolutionary sequential genetic search technique-based cancer classification using fuzzy rough nearest neighbour classifier.

Cancer is one of the deadly diseases of human life. The patient may likely to survive if the disease is diagnosed in its early stages. In this Letter, the authors propose a genetic search fuzzy rough (GSFR) feature selection algorithm, which is hybridised using the evolutionary sequential genetic search technique and fuzzy rough set to select features. The genetic operator's selection, crossover and mutation are applied to generate the subset of features from dataset. The generated subset is subjected to the evaluation with the modified dependency function of the fuzzy rough set using positive and boundary regions, which act as a fitness function. The generation and evaluation of the subset of features continue until the best subset is arrived at to develop the classification model. Selected features are applied to the different classifiers, from the classifiers fuzzy-rough nearest neighbour (FRNN) classifier, which outperforms in terms of classification accuracy and computation time. Hence, the FRNN is applied for performance analysis of existing feature selection algorithms against the proposed GSFR feature selection algorithm. The result generated from the proposed GSFR feature selection algorithm proved to be precise when compared to other feature selection algorithms.

Gene expression feature selection for prostate cancer diagnosis using a two-phase heuristic-deterministic search strategy.

Here, a two-phase search strategy is proposed to identify the biomarkers in gene expression data set for the prostate cancer diagnosis. A statistical filtering method is initially employed to remove the noisiest data. In the first phase of the search strategy, a multi-objective optimisation based on the binary particle swarm optimisation algorithm tuned by a chaotic method is proposed to select the optimal subset of genes with the minimum number of genes and the maximum classification accuracy. Finally, in the second phase of the search strategy, the cache-based modification of the sequential forward floating selection algorithm is used to find the most discriminant genes from the optimal subset of genes selected in the first phase. The results of applying the proposed algorithm on the available challenging prostate cancer data set demonstrate that the proposed algorithm can perfectly identify the informative genes such that the classification accuracy, sensitivity, and specificity of 100% are achieved with only nine biomarkers.