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1.
Vet Dermatol ; 33(6): 568-571, 2022 Dec.
Article in English | MEDLINE | ID: mdl-36052581

ABSTRACT

Follicular cysts and infundibular keratinizing acanthomas are common benign cutaneous lesions in dogs. Current treatment options include surgical excision under general anaesthesia, cryotherapy, carbon dioxide laser and retinoids, each with potential disadvantages. We describe a conscious, minimally invasive, surgical excision procedure with high success rate and no complications in five dogs.


Les kystes folliculaires et les acanthomes kératinisant infundibulaires sont des lésions cutanées bénignes fréquentes chez le chien. Les options de traitement actuelles comprennent l'exérèse chirurgicale sous anesthésie générale, la cryothérapie, le laser au dioxyde de carbone et les rétinoïdes, chacun présentant des inconvénients potentiels. Nous décrivons une procédure d'exérèse chirurgicale consciente, peu invasive, avec un taux de réussite élevé et aucune complication chez cinq chiens.


Los quistes foliculares y los acantomas queratinizantes infundibulares son lesiones cutáneas benignas comunes en perros. Las opciones de tratamiento actuales incluyen la escisión quirúrgica bajo anestesia general, crioterapia, láser de dióxido de carbono y retinoides, cada uno con posibles desventajas. Describimos un procedimiento de escisión quirúrgica consciente, mínimamente invasivo, con una alta tasa de éxito y sin complicaciones en cinco perros.


Cistos foliculares e acantomas infundibulares queratinizantes são lesões cutâneas benignas em cães. As opções terapêuticas existentes atualmente são excisão cirúrgica sob anestesia geral, crioterapia, laser de dióxido de carbono e retinoides, cada um com desvantagens potenciais. Nós descrevemos aqui um procedimento de excisão cirúrgica minimamente invasivo, consciente, com um grande potencial de sucesso e sem complicações em cinco cães.


Subject(s)
Acanthoma , Dog Diseases , Follicular Cyst , Minimally Invasive Surgical Procedures , Skin Neoplasms , Animals , Dogs , Acanthoma/pathology , Acanthoma/surgery , Acanthoma/veterinary , Cryotherapy/veterinary , Dog Diseases/surgery , Dog Diseases/pathology , Follicular Cyst/surgery , Follicular Cyst/veterinary , Follicular Cyst/pathology , Skin Neoplasms/surgery , Skin Neoplasms/veterinary , Skin Neoplasms/pathology , Minimally Invasive Surgical Procedures/veterinary
2.
J Vet Dent ; 34(4): 241-247, 2017 12.
Article in English | MEDLINE | ID: mdl-28978273

ABSTRACT

Canine acanthomatous ameloblastoma (CAA) has been reported to be the most common odontogenic tumor in dogs. This retrospective study evaluated 263 dogs with histopathologically confirmed CAA. Within this data set, CAA presents most commonly in the rostral mandible in adult large breed dogs, with golden retriever dogs being overrepresented. Patients with appropriate follow-up after curative intent surgery were evaluated to assess the effect of histopathological margin on local tumor recurrence. No local recurrence was noted in any patient. This study raises questions about what the recommended surgical margin should be for treatment of CAA. It also serves as a stimulus for discussion as to whether further treatment for CAA is required when inadequate surgical margins are obtained, or if medical surveillance would be an appropriate management recommendation. Prospective studies are necessary to answer these questions.


Subject(s)
Ameloblastoma/veterinary , Dog Diseases/surgery , Margins of Excision , Acanthoma/diagnosis , Acanthoma/pathology , Acanthoma/surgery , Acanthoma/veterinary , Ameloblastoma/diagnosis , Ameloblastoma/pathology , Ameloblastoma/surgery , Animals , Dog Diseases/diagnosis , Dog Diseases/pathology , Dogs , Female , Jaw Neoplasms/diagnosis , Jaw Neoplasms/pathology , Jaw Neoplasms/surgery , Jaw Neoplasms/veterinary , Male , Mandible/pathology , Odontogenic Tumors/diagnosis , Odontogenic Tumors/pathology , Odontogenic Tumors/surgery , Odontogenic Tumors/veterinary , Recurrence , Retrospective Studies
3.
Acta Vet Hung ; 59(2): 225-36, 2011 Jun.
Article in English | MEDLINE | ID: mdl-21665576

ABSTRACT

Uterine adenoacanthoma, a subtype of primary endometrial adenocarcinoma, was found in a tissue specimen removed during ovariohysterectomy from an 8-year-old German Shepherd dog. Multifocal, benign squamous metaplastic islands were identified in the parenchyma of the malignant endometrial tumour. The tumour was highly infiltrative but did not metastasise to other organs. Detailed immunohistochemical analyses were carried out in order to characterise the immunophenotype of the tumour.


Subject(s)
Acanthoma/veterinary , Dog Diseases/pathology , Endometrial Neoplasms/veterinary , Acanthoma/pathology , Acanthoma/surgery , Animals , Dog Diseases/surgery , Dogs , Endometrial Neoplasms/pathology , Endometrial Neoplasms/surgery , Female
4.
Jpn J Vet Res ; 58(3-4): 165-9, 2010 Nov.
Article in English | MEDLINE | ID: mdl-21180256

ABSTRACT

A cutaneous melanocytoma-acanthoma was diagnosed in a 7-year-old intact female mixed breed dog. Grossly, this tumor was a solitary and darkly pigmented nodule located in the face. Histologically, the lesions consisted of melanocytic and epithelial tumor cells. The melanocytic component consisted predominantly of large round-to-polygonal and heavily pigmented melanocytic cells arranged in nests and clusters. These melanocytes were positive for S-100 and vimentin. The epithelial component was composed of multiple small horn cysts with concentric keratin within the cyst lumina and was positive for cytokeratin. Atypism was not observed in both components. Since this tumor has previously been reported in only two dogs, this report adds to the data that will help determing predilections of age, breed, sex and site.


Subject(s)
Acanthoma/veterinary , Dog Diseases/pathology , Melanocytes/pathology , Skin Neoplasms/veterinary , Acanthoma/pathology , Animals , Cell Division , Diagnosis, Differential , Dogs , Female , Keratins/analysis , Skin Neoplasms/pathology , Vimentin/analysis
6.
Vet Dermatol ; 19(5): 271-9, 2008 Oct.
Article in English | MEDLINE | ID: mdl-18803621

ABSTRACT

Cell stress and death are linked in the neoplastic process, and heat shock proteins appear to play an important role by inhibiting apoptotic pathways. The apoptotic rates in 9 canine infundibular keratinizing acanthomas (IKAs) and 17 canine squamous cell carcinomas (SCCs) were correlated with the immunohistochemical expression of caspase-3 and the antiapoptotic heat shock proteins Hsp27, 72 and 73. Apoptosis was evaluated using the terminal deoxynucleotidyl transferase biotin-dUTP nick end labelling (TUNEL) method. The absence of a correlation between the TUNEL index and active-caspase-3 expression, a paucity of active-caspase-3-positive cells and Hsp72 over-expression were considered to be indicative of inhibition of apoptosis, and suggestive that inhibition of cell death plays a key role in oncogenesis and tumour growth of some canine skin neoplasms.


Subject(s)
Acanthoma/veterinary , Apoptosis/physiology , Carcinoma, Squamous Cell/veterinary , Dog Diseases/metabolism , Heat-Shock Proteins/metabolism , Acanthoma/pathology , Animals , Apoptosis/genetics , Carcinoma, Squamous Cell/pathology , Dogs , Gene Expression Regulation , Heat-Shock Proteins/genetics , Immunohistochemistry/veterinary , In Situ Nick-End Labeling
8.
Vet Surg ; 34(3): 214-22, 2005.
Article in English | MEDLINE | ID: mdl-16115077

ABSTRACT

OBJECTIVE: To determine the clinical outcome and factors affecting cutaneous or mucosal flaps in dogs treated with radiation therapy (RT). STUDY DESIGN: Longitudinal clinical study. ANIMALS: Twenty-six client-owned dogs. METHODS: Dogs entered in the study had a flapping procedure and RT as part of their treatment. The sequence of flapping and RT included: (1) planned preoperative RT, (2) postoperative RT, and (3) flapping as a salvage procedure for management of complications or local tumor recurrence after RT. Flap complications were defined as necrosis, local infection, dehiscence, and ulceration. The risk and severity of flap complication were analyzed independently. RESULTS: Twenty (77%) dogs had a complication; 6 dogs required an additional flapping procedure; and 4 dogs had an unresolved complication. Flapping procedures performed to correct a complication, or failure of RT, had a significantly greater risk for complication; however, postoperative RT decreased the severity of complication. A dose per fraction of 4 Gy compared with 3 Gy was prognostic for increased severity of complications, whereas the head and neck location was prognostic for decreased severity of complication. CONCLUSIONS: Although morbidity was substantial, cutaneous or mucosal flaps were used successfully in an RT field in 85% of the dogs. Flaps that were part of the planned therapy as opposed to those used to correct a complication or failure of RT had a better clinical outcome. CLINICAL RELEVANCE: Cutaneous or mucosal flaps can be part of the treatment of dogs with tumor when adjuvant or neoadjuvant RT is to be used.


Subject(s)
Dog Diseases/radiotherapy , Dog Diseases/surgery , Skin Neoplasms/veterinary , Surgical Flaps/veterinary , Acanthoma/veterinary , Animals , Carcinoma, Squamous Cell/veterinary , Combined Modality Therapy , Dogs , Female , Head , Longitudinal Studies , Male , Mast-Cell Sarcoma/veterinary , Melanoma/veterinary , Neck , Osteosarcoma/veterinary , Postoperative Complications , Radiotherapy, Adjuvant/veterinary , Sarcoma/veterinary , Skin Neoplasms/radiotherapy , Skin Neoplasms/surgery , Treatment Outcome
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