ABSTRACT
La acrodermatitis enteropática (AE) es una genodermatosis autosómica recesiva causada por la mutación del gen responsable de codificar a la proteína transportadora de Zinc (Zn) SLC39A4. A pesar de ser una rara enfermedad es de fácil manejo y gran relevancia clínica. Se caracteriza por la siguiente tríada: dermatitis acral y periorificial, diarrea y alopecia. Comunicamos un caso de presentación atípica en una lactante de 6 meses de edad con lesiones periorificiales y ampollas acrales que resolvió rápidamente con la terapia suplementaria con Zinc (AU)
Enteropathic acrodermatitis is an autosomal recessive genodermatosis caused by the mutation of the gene responsible for encoding the Zinc transporter protein SLC39A4. Despite being a rare disease, it is easy to manage and of great clinical relevance. It is characterized by the following triad: acral and periorificial dermatitis, diarrhea and alopecia. We report a case of atypical presentation in an almost 6-month-old infant with periorificial lesions and acral blisters that quickly resolved with supplemental Zinc therapy (AU)
Subject(s)
Humans , Female , Infant , Zinc/deficiency , Acrodermatitis/diagnosis , Gastrointestinal Diseases/diagnosis , Acrodermatitis/drug therapy , Zinc Sulfate/therapeutic use , Gastrointestinal Diseases/drug therapyABSTRACT
Acroangiodermatitis is an angioproliferative disease usually related to chronic venous insufficiency, and it is considered a clinical and histological simulator of Kaposi's sarcoma (KS). Immunohistochemistry is the suitable method to differentiate between these two entities. It reveals the following immunostaining profile: immunopositivity with anti-CD34 antibody is restricted to the vascular endothelium in acroangiodermatitis, and diffuse in the KS (endothelial cells and perivascular spindle cells); immunopositivity with anti-HHV-8 only in KS cases. We report the case of an HIV seropositive patient without apparent vascular disease, who presented violaceous and brownish erythematous lesions on the feet, and whose histopathology and immunohistochemistry indicated the diagnosis of acroangiodermatitis.
Subject(s)
Acrodermatitis/pathology , HIV Seropositivity/pathology , Hepatitis C/pathology , Sarcoma, Kaposi/pathology , Syphilis/pathology , Acrodermatitis/drug therapy , Adult , Coinfection/pathology , Diagnosis, Differential , Humans , Immunohistochemistry , Male , Skin/pathologyABSTRACT
Acroangiodermatitis is an angioproliferative disease usually related to chronic venous insufficiency, and it is considered a clinical and histological simulator of Kaposi's sarcoma (KS). Immunohistochemistry is the suitable method to differentiate between these two entities. It reveals the following immunostaining profile: immunopositivity with anti-CD34 antibody is restricted to the vascular endothelium in acroangiodermatitis, and diffuse in the KS (endothelial cells and perivascular spindle cells); immunopositivity with anti-HHV-8 only in KS cases. We report the case of an HIV seropositive patient without apparent vascular disease, who presented violaceous and brownish erythematous lesions on the feet, and whose histopathology and immunohistochemistry indicated the diagnosis of acroangiodermatitis.
Subject(s)
Adult , Humans , Male , Acrodermatitis/pathology , HIV Seropositivity/pathology , Hepatitis C/pathology , Sarcoma, Kaposi/pathology , Syphilis/pathology , Acrodermatitis/drug therapy , Coinfection/pathology , Diagnosis, Differential , Immunohistochemistry , Skin/pathologyABSTRACT
Acrodermatitis enteropathica is an uncommon disease caused by hereditary or acquired zinc deficiency. It is characterized by a triad of alopecia, diarrhea and acraland periorificial dermatitis. It is treated with Zinc supplementation. We report a31-year-old indigent and drug addict female with a cutaneous-mucous syndromecharacteristic of acrodermatitis enteropathica. She had a positive clinical evolutionafter Zinc supplementation.
Subject(s)
Adult , Female , Humans , Acrodermatitis/pathology , Dermis/pathology , Zinc/deficiency , Acrodermatitis/diagnosis , Acrodermatitis/drug therapy , Biopsy , Diagnosis, Differential , Zinc/metabolism , Zinc/therapeutic useABSTRACT
Acrodermatitis enteropathica is an uncommon disease caused by hereditary or acquired zinc deficiency. It is characterized by a triad of alopecia, diarrhea and acral and periorificial dermatitis. It is treated with Zinc supplementation. We report a 31-year-old indigent and drug addict female with a cutaneous-mucous syndrome characteristic of acrodermatitis enteropathica. She had a positive clinical evolution after Zinc supplementation.
Subject(s)
Acrodermatitis/pathology , Dermis/pathology , Zinc/deficiency , Acrodermatitis/diagnosis , Acrodermatitis/drug therapy , Adult , Biopsy , Diagnosis, Differential , Female , Humans , Zinc/metabolism , Zinc/therapeutic useABSTRACT
Acrodermatitis Continua of Hallopeau is a rare, chronic, recurrent disorder classified as a form of pustular psoriasis, and most cases affect one or two digits. It tends to be resistant to both topical and systemic treatments for psoriasis. We present an infant with Acrodermatitis Continua of Hallopeau affecting nineteen nails, with an excellent response to the combination of thalidomide and ultraviolet B phototherapy.
Subject(s)
Acrodermatitis/drug therapy , Acrodermatitis/radiotherapy , Immunosuppressive Agents/administration & dosage , Thalidomide/administration & dosage , Ultraviolet Therapy , Child, Preschool , Combined Modality Therapy , Foot Dermatoses/drug therapy , Foot Dermatoses/radiotherapy , Hand Dermatoses/drug therapy , Hand Dermatoses/radiotherapy , Humans , Infant , Male , Psoriasis/drug therapy , Psoriasis/radiotherapyABSTRACT
Acrodermatitis enteropathica (AE) is a rare hereditary disorder caused by impaired absorption of zinc from the gastrointestinal tract. It is characterized by acral and periorificial dermatitis, alopecia, and diarrhea. Symptoms usually begin on weaning from breast or formula feeding. We report a full-term, 21-month-old boy with typical skin lesions and decreased plasma zinc level (12 micro g/dl). The patient was given zinc sulfate 40 mg/day and at the end of 1 month his condition had improved significantly. After reviewing the literature we emphasize the important role of zinc in human metabolism and the difference between AE and acquired zinc deficiencies.
Subject(s)
Acrodermatitis/genetics , Malabsorption Syndromes/genetics , Zinc/deficiency , Acrodermatitis/drug therapy , Acrodermatitis/etiology , Dietary Supplements , Humans , Infant , Malabsorption Syndromes/complications , Malabsorption Syndromes/drug therapy , Male , Treatment Outcome , Wound Healing/drug effects , Wound Healing/genetics , Zinc/therapeutic useABSTRACT
Acrodermatitis continua of Hallopeau (ACH) is a rare type of localized pustular psoriasis. We report the case of a 65-year-old alcoholic woman who had severe inflammatory ACH for 10 years. Initial therapy with sulfasalazine was unsuccessful. The patient was then treated with oral tetracycline and topical betamethasone valerate with occlusive dressing. Her condition improved dramatically after one week.
Subject(s)
Acrodermatitis/complications , Acrodermatitis/drug therapy , Anti-Bacterial Agents/therapeutic use , Anti-Inflammatory Agents/therapeutic use , Betamethasone Valerate/therapeutic use , Psoriasis/complications , Psoriasis/drug therapy , Tetracycline/therapeutic use , Administration, Oral , Administration, Topical , Aged , Drug Therapy, Combination , Female , Glucocorticoids , HumansABSTRACT
La acrodermatitis enteropática es una enfermedad, autosómica recesiva poco frecuente, que se presenta en los primeros meses de vida. Se comunican dos pacientes que presentaron alopecia, dermatitis acral, alteraciones digestivas, además de irritabilidad e infecciones recurrentes. Los estudios de laboratorio confirman niveles bajos de zinc y de fosfatasa alcalina. La terapia sustitutiva con sulfato de zinc produjo una rápida mejoría
Subject(s)
Humans , Male , Female , Infant , Acrodermatitis/diagnosis , Infant Nutrition Disorders/complications , Infant Nutrition Disorders/drug therapy , Zinc/deficiency , Acrodermatitis/drug therapy , Acrodermatitis/etiology , Diagnosis, Differential , Zinc/blood , Zinc/therapeutic useABSTRACT
La acrodermatitis enteropática es una enfermedad, autosómica recesiva poco frecuente, que se presenta en los primeros meses de vida. Se comunican dos pacientes que presentaron alopecia, dermatitis acral, alteraciones digestivas, además de irritabilidad e infecciones recurrentes. Los estudios de laboratorio confirman niveles bajos de zinc y de fosfatasa alcalina. La terapia sustitutiva con sulfato de zinc produjo una rápida mejoría (AU)
Subject(s)
Humans , Male , Female , Infant , Acrodermatitis/diagnosis , Zinc/deficiency , Infant Nutrition Disorders/complications , Infant Nutrition Disorders/drug therapy , Zinc/blood , Zinc/therapeutic use , Diagnosis, Differential , Acrodermatitis/etiology , Acrodermatitis/drug therapyABSTRACT
Se describen los hallazgos clínicos y de laboratorio en un niño de 26/12 años de edad con acrodermatitis enteropática y la respuesta favorable a la terapia con cinc oral. Las manifestaciones clínicas remitieron rápidamente y después de un año de tratamiento se encuentra libre de síntomas y con incremento considerable del peso y la talla
Subject(s)
Child, Preschool , Humans , Male , Acrodermatitis/blood , Zinc/deficiency , Acrodermatitis/diagnosis , Acrodermatitis/drug therapy , Deficiency Diseases/etiology , Zinc/therapeutic useABSTRACT
The clinical course and intestinal absorption studies of a female infant who developed diarrhea after cessation of breast feeding, mood changes, and intermittently had mild perioral and perianal rashes are described. She showed a partial response to a pancreatic enzyme preparation which was attributed to its content of a zinc-binding ligand, picolinic acid. Complete recovery occurred on pharmacologic doses of zinc. Exacerbation occurred twice upon withdrawal of the oral zinc medication. The zinc concentrations of plasma and intestinal mucosa were normal.
Subject(s)
Acrodermatitis/drug therapy , Enzyme Therapy , Picolinic Acids/therapeutic use , Acrodermatitis/complications , Diarrhea, Infantile/complications , Diarrhea, Infantile/drug therapy , Female , Humans , Infant , Infant Food , Ligands , Pancreas/enzymology , Zinc/blood , Zinc/therapeutic useABSTRACT
Acrodermatitis chronica atrophicans (ACA) is a puzzling, chronic, antibiotic-responsive condition that is rather common in western Europe, bur rarely seen in native Americans.