ABSTRACT
A boy in his mid-teens presented with progressively increasing bleeding from the right eye and nostril intermittently over a period of 6 weeks. A complete ophthalmic examination revealed nothing significant. His otorhinological examination and haematological investigations were within normal limits. The patient came a month later with frank bleeding from the right eye. Ophthalmic examination revealed hyperaemia and maceration of the right lower palpebral conjunctiva. A histopathological examination of conjunctival scrapings from the site showed abnormal dilated blood vessels suggestive of a vascular malformation. Digital subtraction angiography confirmed the presence of a conjunctival micro arteriovenous malformation supplied by the external carotid and ophthalmic artery branches. He underwent successful transarterial Onyx embolisation resulting in complete resolution of the haemolacria.
Subject(s)
Conjunctiva , Embolization, Therapeutic , Humans , Male , Embolization, Therapeutic/methods , Conjunctiva/blood supply , Eye Hemorrhage/therapy , Eye Hemorrhage/etiology , Angiography, Digital Subtraction , Arteriovenous Malformations/therapy , Arteriovenous Malformations/complications , Arteriovenous Malformations/diagnostic imaging , Adolescent , Ophthalmic Artery/diagnostic imaging , Ophthalmic Artery/abnormalities , Vascular Malformations/therapy , Vascular Malformations/complications , Vascular Malformations/diagnosis , Polyvinyls/therapeutic use , Conjunctival Diseases/therapy , Treatment Outcome , Hemobilia/therapy , Hemobilia/etiologyABSTRACT
BACKGROUND: Currently, the treatment outcomes for complex congenital arteriovenous malformations (AVMs) remain unsatisfactory. This article reports on the utilization of an abdominal aortic stent graft, in conjunction with embolization techniques, for managing acute heart failure triggered by complex congenital arteriovenous malformations in the lower limb. CASE PRESENTATION: We present a case involving a patient with congenital AVMs in the lower limb, who had suffered from prolonged swelling in the left lower limb and recently developed symptoms of heart failure. At the age of 67, the patient was definitively diagnosed with a complex congenital AVMs in the lower limb. This article delves into the practical experiences and limitations encountered in employing an abdominal aortic stent graft, coupled with embolization, to address acute heart failure caused by complex congenital AVMs in the lower limb. CONCLUSIONS: Our article presents the initial report on the challenges and limitations encountered in treating acute heart failure triggered by complex congenital AVMs in the lower limb, utilizing a combination of abdominal aortic stent graft placement and embolization techniques.
Subject(s)
Arteriovenous Malformations , Embolization, Therapeutic , Endovascular Procedures , Heart Failure , Lower Extremity , Stents , Humans , Embolization, Therapeutic/instrumentation , Treatment Outcome , Arteriovenous Malformations/therapy , Arteriovenous Malformations/diagnostic imaging , Lower Extremity/blood supply , Endovascular Procedures/instrumentation , Heart Failure/therapy , Heart Failure/diagnosis , Heart Failure/physiopathology , Heart Failure/etiology , Aged , Blood Vessel Prosthesis Implantation/instrumentation , Male , Blood Vessel Prosthesis , FemaleABSTRACT
Intraosseous occurrence of a spinal AVM is anecdotal, with only four such cases reported previously. This is the first report of a spinal intraosseous AVM in the cervical vertebrae. A 44-year-old male patient presented with a 2-month history of progressive quadriparesis and bladder dysfunction. Magnetic resonance imaging showed multiple flow voids within the C4 and C5 vertebral bodies, and an extradural component causing cord compression. CT showed extensive bony destruction at both levels. The diagnosis of an intraosseous AVM was confirmed with spinal angiography. The AVM was noted to be fed by branches from the ascending cervical arteries and the vertebral artery. The nidus was draining into the vertebral venous plexus and thence into the jugular vein through the marginal sinus. The patient underwent partial embolization of the AVM. Surgical resection was attempted but found to be unfeasible due to torrential bleeding. A 360-degree stabilization along with decompressive laminectomies was performed, resulting in clinical improvement and disease stabilization at one year follow-up. The case and its management dilemmas are discussed in light of a brief literature review.
Subject(s)
Arteriovenous Malformations , Cervical Vertebrae , Embolization, Therapeutic , Humans , Male , Adult , Cervical Vertebrae/surgery , Cervical Vertebrae/diagnostic imaging , Arteriovenous Malformations/diagnostic imaging , Arteriovenous Malformations/surgery , Arteriovenous Malformations/therapy , Embolization, Therapeutic/methods , Vertebral Artery/diagnostic imaging , Vertebral Artery/surgery , Vertebral Artery/abnormalities , Spinal Cord Compression/surgery , Spinal Cord Compression/etiology , Spinal Cord Compression/diagnostic imaging , Treatment Outcome , Magnetic Resonance Imaging , Laminectomy/methods , Decompression, Surgical/methodsABSTRACT
BACKGROUND: Pulmonary arteriovenous malformations are a relatively uncommon medical condition, affecting roughly 1 in every 2500 individuals. Of those suffering from pulmonary arteriovenous malformations, 80% have an underlying genetic condition: hereditary hemorrhagic telangiectasia. CASE PRESENTATION: We present the case of a 20-year-old Pakistani male with a history of persistent slower-onset frontal headaches that increased in severity within the course of the day. His hemoglobin was 18 g/dl, indicating polycythemia, for which he had undergone seven venesections in a month previously. His physical examination was unremarkable. His computed tomography scan depicted multiple dilated tortuous vessels with branching linear opacities in the right lower lobe of the lungs. The multiple feeding arteries were supplied by the right main pulmonary artery, and the large draining veins led to the right inferior pulmonary vein. This was identified as a diffuse pulmonary arteriovenous malformation. He was recommended for a right pulmonary artery angiogram. It showed multiple tortuous vessels with a nidus and large draining veins-features of a diffuse arteriovenous malformation in the right lower lobe of the lung consistent with the computed tomography scan. Embolization of two of these vessels feeding the arteriovenous malformation was conducted, using Amplatzer Vascular plug 2, whereas multiple pushable coils (five coils) were used for embolizing the third feeding vessel. This achieved 70-80% successful embolization of right pulmonary AVM; however, some residual flow was still seen in the arteriovenous malformation given the complexity of the lesion. Immediately after, his oxygen saturation improved from 78% to 96%. CONCLUSION: Diffuse pulmonary arteriovenous malformations, as seen in this patient, are rare, accounting for less than 5% of total pulmonary arteriovenous malformations diagnosed. The patient presented with a complaint of progressive frontal headaches, which can be attributed to low oxygen saturation or the presence of a cerebral arteriovenous malformation. There was no history of hereditary hemorrhagic telangiectasia in the patient's family. Furthermore, although most patients with hereditary hemorrhagic telangiectasia and hence pulmonary arteriovenous malformation have complaints of iron-deficiency anemia, our patient in contrast was suffering from polycythemia. This can be explained as a compensatory mechanism in hypoxemic conditions. Moreover, the patient had no complaint of hemoptysis or epistaxis, giving a varied presentation in comparison with a typical pulmonary arteriovenous malformation.
Subject(s)
Arteriovenous Malformations , Embolization, Therapeutic , Headache , Polycythemia , Pulmonary Artery , Pulmonary Veins , Humans , Male , Polycythemia/complications , Pulmonary Veins/abnormalities , Pulmonary Veins/diagnostic imaging , Pulmonary Artery/abnormalities , Pulmonary Artery/diagnostic imaging , Young Adult , Arteriovenous Malformations/complications , Arteriovenous Malformations/diagnostic imaging , Headache/etiology , Tomography, X-Ray Computed , Treatment Outcome , Arteriovenous FistulaABSTRACT
KRAS gain-of-function mutations are frequently observed in sporadic arteriovenous malformations. The mechanisms underlying the progression of such KRAS-driven malformations are still incompletely understood, and no treatments for the condition are approved. Here, we show the effectiveness of sotorasib, a specific KRAS G12C inhibitor, in reducing the volume of vascular malformations and improving survival in two mouse models carrying a mosaic Kras G12C mutation. We then administered sotorasib to two adult patients with severe KRAS G12C-related arteriovenous malformations. Both patients had rapid reductions in symptoms and arteriovenous malformation size. Targeting KRAS G12C appears to be a promising therapeutic approach for patients with KRAS G12C-related vascular malformations. (Funded by the European Research Council and others.).
Subject(s)
Arteriovenous Malformations , Proto-Oncogene Proteins p21(ras) , Animals , Female , Humans , Male , Mice , Middle Aged , Arteriovenous Malformations/diagnosis , Arteriovenous Malformations/diagnostic imaging , Arteriovenous Malformations/drug therapy , Arteriovenous Malformations/genetics , Disease Models, Animal , Gain of Function Mutation , Mutation , Piperazines/therapeutic use , Proto-Oncogene Proteins p21(ras)/genetics , Pyridines/therapeutic use , Pyrimidines , Cardiovascular Agents/therapeutic use , Young AdultABSTRACT
Arteriovenous malformation (AVM) is an abnormal connection of vasculature resulting in capillary bed bypassing and leading to neurological deterioration and high risk of bleeding. Intramedullary AVMs in the cervical spinal cord are rare and require precise diagnostics and treatment. We present a clinical case of recurrent AVMs in a 28-year-old Caucasian female with sudden and severe neck pain and variable neurological symptoms along with current diagnostic and treatment modalities. Conservative treatment was partially effective. MRI and DSA confirmed AVMs at C4 level with subsequent several endovascular treatment sessions at the age of 15 and 24 with mild neurological improvement. Afterwards the patient underwent rehabilitation with minor neurological improvement. This case highlights the clinical progression and treatment of AVMs along with showcasing current pathophysiology, classification, and imaging.
Subject(s)
Arteriovenous Malformations , Humans , Female , Adult , Arteriovenous Malformations/complications , Arteriovenous Malformations/diagnostic imaging , Magnetic Resonance Imaging , Cervical Vertebrae/diagnostic imaging , Cervical Vertebrae/blood supply , Cervical Cord/diagnostic imaging , Spinal Cord/blood supply , Spinal Cord/diagnostic imagingABSTRACT
Pulmonary arteriovenous malformations (PAVMs) occur in 30% to 50% of patients with hereditary hemorrhagic telangiectasia. Clinical presentations vary from asymptomatic disease to complications resulting from the right to left shunting of blood through the PAVM such as paradoxical stroke, brain abscesses, hypoxemia, and cardiac failure. Radiology plays an important role both in the diagnosis and treatment of PAVM. Based on different clinical scenarios, the appropriate imaging study has been reviewed and is presented in this document. The American College of Radiology Appropriateness Criteria are evidence-based guidelines for specific clinical conditions that are reviewed annually by a multidisciplinary expert panel. The guideline development and revision process support the systematic analysis of the medical literature from peer reviewed journals. Established methodology principles such as Grading of Recommendations Assessment, Development, and Evaluation or GRADE are adapted to evaluate the evidence. The RAND/UCLA Appropriateness Method User Manual provides the methodology to determine the appropriateness of imaging and treatment procedures for specific clinical scenarios. In those instances where peer reviewed literature is lacking or equivocal, experts may be the primary evidentiary source available to formulate a recommendation.
Subject(s)
Evidence-Based Medicine , Pulmonary Artery , Pulmonary Veins , Societies, Medical , Humans , United States , Pulmonary Artery/diagnostic imaging , Pulmonary Artery/abnormalities , Pulmonary Veins/diagnostic imaging , Pulmonary Veins/abnormalities , Arteriovenous Malformations/diagnostic imaging , Arteriovenous Fistula/diagnostic imagingABSTRACT
PURPOSE: To evaluate the angiographic recanalization rate of patients who underwent embolization juxta-proximal to the sac with AMPLATZER Vascular Plug type IV (AVP IV) for a simple pulmonary arteriovenous malformation (PAVM). MATERIAL AND METHODS: Ten patients (7 females and 3 males; median age, 47 years [range 28-83 years]) with 19 simple-type PAVMs who underwent embolization using an AVP IV between May 2015 and November 2021 were included in this retrospective study. The median feeding artery diameter on computed tomography was 4.0 mm (range 3-5.9 mm), and the median ratio of AVP IV size to feeding artery diameter on computed tomography was 1.5 (range 1.3-2.1). Technical success was defined by AVP IV placement at the junction between the pulmonary artery and the sac, or the pulmonary artery within 1 cm from the junction and beyond the last normal branch. The primary endpoint was the PAVM recanalization rate in selective or segmental pulmonary angiography performed 1 year post-embolization. RESULTS: The technical success rate of embolization juxta-proximal to the sac for simple-type PAVMs was 100%. None of the 19 lesions showed recanalization in pulmonary angiography performed 1 year after embolization. One patient experienced hemoptysis and pneumonia. CONCLUSION: Embolization of simple-type PAVMs' feeding vessel using AVP IV is safe and effective, with a high technical success rate and no recanalization on pulmonary angiography performed at 1 year post-embolization.
Subject(s)
Arteriovenous Malformations , Embolization, Therapeutic , Pulmonary Artery , Pulmonary Veins , Humans , Female , Male , Middle Aged , Adult , Aged , Pulmonary Artery/abnormalities , Pulmonary Artery/diagnostic imaging , Retrospective Studies , Embolization, Therapeutic/methods , Aged, 80 and over , Pulmonary Veins/abnormalities , Pulmonary Veins/diagnostic imaging , Arteriovenous Malformations/therapy , Arteriovenous Malformations/diagnostic imaging , Treatment Outcome , Angiography , Tomography, X-Ray Computed/methods , Septal Occluder Device , Computed Tomography Angiography/methodsSubject(s)
Arteriovenous Malformations , Dyspnea , Epistaxis , Humans , Arteriovenous Malformations/complications , Arteriovenous Malformations/diagnostic imaging , Arteriovenous Malformations/diagnosis , Dyspnea/etiology , Dyspnea/diagnosis , Epistaxis/etiology , Epistaxis/diagnosis , Telangiectasis/complications , Telangiectasis/diagnosis , Tomography, X-Ray ComputedABSTRACT
PURPOSE: To evaluate the correlation between pulmonary hypertension (PH) and recurrence of pulmonary arteriovenous malformation (PAVM) after embolization. MATERIALS AND METHODS: With institutional review board (IRB) approval, the records of 377 patients with PAVMs evaluated at a single hereditary hemorrhagic telangiectasia (HHT) center of excellence between January 1, 2013, and September 10, 2023, were retrospectively reviewed. PAVMs embolized during this time period were evaluated for recurrence. Patients and PAVMs not treated during this time period were excluded. Growth of previously untreated PAVMs was not considered recurrence. Patients without chest computed tomography (CT) follow-up were excluded. General demographics, HHT status as defined by genetic testing or Curacao criteria, presence of PH, history of smoking, anemia, and hepatic arteriovenous malformations (AVMs) were documented. Odds ratio (OR) was calculated and stratified analysis was performed to assay the correlation between PAVM recurrence, PH, and possible confounders. RESULTS: A total of 151 patients with PAVMs were treated during the study period, including 438 PAVMs, for which follow-up was available. This included 106 patients with definite, 31 with doubtful, and 14 with possible HHT. The presence of PH was significantly associated with PAVM recurrence both by patient (OR, 8.13; 95% CI, 3.50-19.67) and by lesion (OR, 4.07; 95% CI, 2.14-7.91). Multivariate analysis demonstrated that this correlation was independent of several variables including HHT status, smoking history, presence of hepatic AVMs, and anemia. CONCLUSIONS: There is a high correlation between PH and PAVM recurrence, suspected to be due to high pulmonary artery pressures causing recanalization. PH may suggest the need for shorter surveillance intervals.
Subject(s)
Arteriovenous Malformations , Embolization, Therapeutic , Hypertension, Pulmonary , Pulmonary Artery , Pulmonary Veins , Recurrence , Humans , Female , Male , Pulmonary Artery/abnormalities , Pulmonary Artery/diagnostic imaging , Pulmonary Artery/physiopathology , Retrospective Studies , Embolization, Therapeutic/adverse effects , Middle Aged , Hypertension, Pulmonary/etiology , Hypertension, Pulmonary/diagnostic imaging , Hypertension, Pulmonary/physiopathology , Hypertension, Pulmonary/therapy , Treatment Outcome , Pulmonary Veins/abnormalities , Pulmonary Veins/diagnostic imaging , Pulmonary Veins/physiopathology , Adult , Arteriovenous Malformations/therapy , Arteriovenous Malformations/diagnostic imaging , Arteriovenous Malformations/complications , Risk Factors , Time Factors , Aged , Telangiectasia, Hereditary Hemorrhagic/complications , Telangiectasia, Hereditary Hemorrhagic/diagnostic imaging , Telangiectasia, Hereditary Hemorrhagic/therapy , Young Adult , Arterial PressureSubject(s)
Arteriovenous Malformations , Embolization, Therapeutic , Enbucrilate , Pulmonary Artery , Pulmonary Veins , Humans , Enbucrilate/therapeutic use , Embolization, Therapeutic/methods , Pulmonary Artery/diagnostic imaging , Pulmonary Artery/abnormalities , Pulmonary Veins/abnormalities , Pulmonary Veins/diagnostic imaging , Arteriovenous Malformations/therapy , Arteriovenous Malformations/diagnostic imaging , Endovascular Procedures/methods , Treatment OutcomeABSTRACT
Hereditary Hemorrhagic Telangiectasia (HHT), commonly known as Osler-Weber-Rendu disease, is an autosomal dominant multisystemic vascular disease associated with approximately 70% of cases of pulmonary arteriovenous malformations (PAVMs). Prenatal cases of PAVMs typically present with pulmonary vein dilatation on ultrasonography. This study presents a prenatal diagnosis of PAVMs with enlarged right pulmonary vein, cardiomegaly, cystic-appearing areas in the right lung and subsequent confirmation of Osler-Weber-Rendu syndrome using autopsy and whole exom sequencing.
Subject(s)
Arteriovenous Malformations , Pulmonary Artery , Pulmonary Veins , Telangiectasia, Hereditary Hemorrhagic , Ultrasonography, Prenatal , Humans , Telangiectasia, Hereditary Hemorrhagic/diagnostic imaging , Telangiectasia, Hereditary Hemorrhagic/complications , Female , Ultrasonography, Prenatal/methods , Pulmonary Veins/abnormalities , Pulmonary Veins/diagnostic imaging , Pregnancy , Adult , Pulmonary Artery/diagnostic imaging , Pulmonary Artery/abnormalities , Arteriovenous Malformations/diagnostic imaging , Infant, Newborn , Arteriovenous FistulaABSTRACT
Paradoxical embolism due to an isolated pulmonary arteriovenous malformation (PAVM) is a rare cause of ischemic stroke. PAVMs are abnormal high-flow connections between pulmonary arteries and veins, diverting deoxygenated blood into the systemic circulation and they represent a less common source of paradoxical embolisms, especially in young individuals. Endovascular embolization is the preferred treatment for clinically significant PAVMs. We present the case of a 34-year-old woman with a left thalamic ischemic stroke. Severe contrast passage was detected in cerebral arteries through transcranial Doppler. Intracardiac ultrasound did not reveal a patent foramen ovale, prompting further investigation with pulmonary CT angiography, confirming the presence of PAVM. The patient underwent successful endovascular treatment. It is essential to consider PAVM in the etiological diagnosis of ischemic stroke, especially in young patients with signs of abnormal right-to-left communication. Periodic follow-up imaging is recommended to assess potential recurrence or changes in PAVM, emphasizing the importance of appropriate management of these malformations.
La embolia paradojal debido a una malformación arteriovenosa pulmonar (MAVP) aislada es una causa infrecuente de accidente cerebrovascular (ACV) isquémico. Las MAVP son conductos anómalos de alta circulación entre arterias y venas pulmonares, desviando sangre desoxigenada hacia la circulación sistémica y representan una fuente menos común de embolias paradojales, especialmente en personas jóvenes. La embolización endovascular es el tratamiento preferido para MAVP clínicamente significativas. Presentamos el caso de una mujer de 34 años con ACV isquémico talámico izquierdo. Se detectó pasaje de burbujas "en cortina" en arterias cerebrales mediante Doppler transcraneal. En ecografía intracardíaca no se encontró foramen oval permeable, motivo por el cual se avanzó con realización de angiotomografía pulmonar, la cual confirmó la presencia de MAVP. La paciente recibió tratamiento endovascular exitoso. Es esencial considerar la MAVP en el diagnóstico etiológico del ACV isquémico, especialmente en pacientes jóvenes con signos de comunicación anormal de derecha a izquierda. Se recomienda un seguimiento periódico mediante imágenes para evaluar la posible recurrencia o cambios en la MAVP, resaltando la importancia del manejo adecuado de estas malformaciones.
Subject(s)
Arteriovenous Malformations , Embolism, Paradoxical , Ischemic Stroke , Pulmonary Artery , Pulmonary Artery/abnormalities , Pulmonary Veins , Pulmonary Veins/abnormalities , Humans , Adult , Female , Embolism, Paradoxical/diagnostic imaging , Embolism, Paradoxical/etiology , Ischemic Stroke/etiology , Ischemic Stroke/diagnostic imaging , Pulmonary Artery/diagnostic imaging , Pulmonary Veins/diagnostic imaging , Arteriovenous Malformations/complications , Arteriovenous Malformations/diagnostic imaging , Computed Tomography Angiography , Arteriovenous Fistula/diagnostic imaging , Arteriovenous Fistula/complications , Embolization, Therapeutic/methodsABSTRACT
Arteriovenous malformations of the head and neck are rare and inborn errors of vascular morphogenesis. They pose therapeutic challenges owing to their bleeding tendency and a high chance of recurrence. Treatment modalities include digital subtraction angiography with embolisation as a primary treatment or can be done preoperatively followed by surgical excision. We present a case of recurrent arteriovenous malformation of the postauricular region in an adolescent male who was taken up for upfront surgical excision with the help of a tumescent solution, thereby eliminating the need for embolisation and drastically reduced intraoperative blood loss.
Subject(s)
Arteriovenous Malformations , Humans , Male , Arteriovenous Malformations/diagnostic imaging , Arteriovenous Malformations/therapy , Arteriovenous Malformations/surgery , Adolescent , Recurrence , Angiography, Digital Subtraction , Blood Loss, Surgical/prevention & control , Embolization, Therapeutic/methods , Treatment OutcomeABSTRACT
BACKGROUND AND PURPOSE: The prognosis of untreated spinal arteriovenous malformations (SAVMs) is poor. Embolization plays an important role in the management of intramedullary SAVMs. Delayed aggravation due to spinal venous thrombosis following successful embolization has been reported; however, perioperative management strategies to prevent thrombosis have not been explored. We present our single-center experience of SAVM embolization and perioperative management, including anticoagulation. MATERIAL AND METHODS: We retrospectively evaluated 18 patients with SAVMs who underwent transarterial embolization. Perioperative anticoagulation therapy was administered to selected patients. We compared the characteristics of the patients, including perioperative management procedures, between those with and without postoperative worsening following embolization. RESULTS: Acute postoperative worsening within 1 week occurred in 4 (22.2%) patients. Of these, immediate worsening was observed in one patient as a procedure-related complication. Delayed worsening after 24â¯h was observed in 3 patients, caused by delayed venous thrombosis with severe back pain. Rescue anticoagulation for delayed worsening improved symptoms in two patients. A comparison between patients with and without acute postoperative worsening revealed significant differences in age (median 46.5 vs. 26.5 years, pâ¯= 0.009) and the presence of postoperative back pain (75.0% vs. 0%, pâ¯= 0.005); however, there was no significant difference in use of selective anticoagulation (pâ¯= 0.274). CONCLUSION: The results of this study suggest that SAVM embolization can cause acute worsening due to postoperative venous thrombosis with severe back pain, which may be reversed by anticoagulation therapy. Back pain is an important finding that suggests venous thrombosis, and anticoagulation should be urgently administered.
Subject(s)
Anticoagulants , Embolization, Therapeutic , Venous Thrombosis , Humans , Embolization, Therapeutic/methods , Female , Male , Adult , Middle Aged , Retrospective Studies , Venous Thrombosis/diagnostic imaging , Venous Thrombosis/etiology , Anticoagulants/therapeutic use , Treatment Outcome , Back Pain/etiology , Perioperative Care/methods , Young Adult , Spinal Cord/blood supply , Spinal Cord/diagnostic imaging , Adolescent , Arteriovenous Malformations/therapy , Arteriovenous Malformations/diagnostic imaging , Arteriovenous Malformations/complications , Postoperative Complications/etiology , Postoperative Complications/prevention & controlABSTRACT
PURPOSE: To investigate the safety and efficacy of microballoon-occluded transcatheter embolization using n-butyl-2-cyanoacrylate (NBCA) in patients with a single pulmonary arteriovenous malformation (PAVM). METHODS: From November 2017 to November 2020, this retrospective study included 38 previously untreated patients with a single PAVM who underwent microballoon-occluded transcatheter embolization using NBCA. All 38 patients had follow-up that included simple chest radiography and contrast-enhanced chest computed tomography (CT). RESULTS: A microballoon was successfully placed in a feeding artery of the PAVM to control the delivery of the NBCA cast in all 38 patients, with complete embolization of sacs and the feeding artery achieved in all cases. The mean diameters of the feeding artery, sac, and draining vein were 3.9 ± 0.9 mm, 7.5 ± 2.6 mm, and 4.6 ± 1.3 mm, respectively. A fixed 1:2 NBCA/Lipiodol ratio was used, and the mean amount of embolic mixture per patient was 1.4 mL (range 0.6-2.2 mL). There were no complications related to microballoon adhesion and non-target embolization of the systemic circulation. Follow-up CT in all 38 patients with a mean delay of 34.5 ± 8.8 months (range 20.7-56.5 months) showed no continued perfusion of the PAVM. CONCLUSION: In our hands, microballoon-occluded n-butyl-2-cyanoacrylate embolization seemed to be safe and appeared to be clinically effective in patients with simple and complex types of single PAVM. Therefore, the present technique has the potential to become a standard treatment for a single PAVM.
Subject(s)
Arteriovenous Malformations , Embolization, Therapeutic , Enbucrilate , Pulmonary Artery , Pulmonary Veins , Humans , Male , Female , Enbucrilate/therapeutic use , Enbucrilate/administration & dosage , Retrospective Studies , Embolization, Therapeutic/methods , Adult , Pulmonary Artery/diagnostic imaging , Pulmonary Artery/abnormalities , Middle Aged , Pulmonary Veins/abnormalities , Pulmonary Veins/diagnostic imaging , Arteriovenous Malformations/therapy , Arteriovenous Malformations/diagnostic imaging , Treatment Outcome , Young Adult , Adolescent , Aged , Tomography, X-Ray ComputedABSTRACT
PURPOSE: To assess the different adjunctive catheter techniques required to achieve complete occlusion of renal arteriovenous malformations (rAVMs) of different angioarchitectural types. MATERIALS AND METHODS: Overall, data on 18 patients with rAVM (Type 1, n = 7; Type 2, n = 2; Type 3, n = 9; mean age, 53.8 years) who underwent 25 procedures between 2011 and 2022 were reviewed. The clinical presentations, endovascular techniques, arteriovenous malformation (AVM) occlusion rate, adverse events (including the incidence of renal infarction), and clinical symptoms and outcomes (including recurrence/increase of AVM) were analyzed according to the Cho-Do angioarchitectural classification. Posttreatment renal infarction was classified as no infarction, small infarction (<12.5%), medium infarction (12.5%-25%), and large infarction (>25%) using contrast-enhanced computed tomography or magnetic resonance imaging. RESULTS: Hematuria and heart failure were presenting symptoms in 10 and 2 patients, respectively. The embolic materials used were as follows: Type 1 rAVM, coils alone or with n-butyl-2-cyanoacrylate (nBCA); Type 2 rAVM, nBCA alone or with coils; and Type 3 rAVMs, nBCA alone. Fourteen patients underwent adjunctive catheter techniques, including flow control with a balloon catheter and multiple microcatheter placement, alone or in combination. Immediate postprocedural angiography revealed complete occlusion in 15 patients (83%) and marked regression of rAVM in 3 (17%). Small asymptomatic renal infarctions were observed in 6 patients with Type 3 rAVMs without any decrease in renal function. No major adverse events were observed. All symptomatic patients experienced symptom resolution. Recurrence/increase of rAVM was not observed during the mean 32-month follow-up period (range, 2-120 months). CONCLUSIONS: Transarterial embolization using adjunctive catheter techniques according to angioarchitectural types can be an effective treatment for rAVMs.