1.
Headache
; 55(9): 1249-55, 2015 Oct.
Article
in English
| MEDLINE
| ID: mdl-26368117
ABSTRACT
In this retrospective, Dr. Lars Edvinsson recounts early steps and milestones in our understanding of the neuropeptide calcitonin gene-related peptide (CGRP) in the trigeminovascular system and its role in migraine. The discovery of the presence and function of CGRP and other neuropeptides in the cerebral vasculature and its sensory innervation is described. He relates the seminal finding that CGRP is uniquely released during migraine and the journey to develop blockers of CGRP effects. Now, over 30 years since its discovery, CGRP has become the target for a number of promising novel treatments for migraine patients.
Subject(s)
Calcitonin Gene-Related Peptide/history , Calcitonin Gene-Related Peptide/physiology , Migraine Disorders/history , Migraine Disorders/physiopathology , Neurology/history , Animals , History, 20th Century , History, 21st Century , Humans , Retrospective Studies
2.
Biochem Biophys Res Commun
; 425(3): 548-55, 2012 Aug 31.
Article
in English
| MEDLINE
| ID: mdl-22925672