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1.
Jt Dis Relat Surg ; 35(2): 448-454, 2024 Feb 13.
Article in English | MEDLINE | ID: mdl-38727128

ABSTRACT

Several surgical procedures are used to treat dynamic pronation position of the forearm and flexion deformity of the wrist in cerebral palsy. Postoperative results of pronator teres rerouting were explored, while specially designed postoperative physiotherapy and its outcomes were limited. Herein, we present a case in whom the outcomes of electromyographic biofeedback (EMG-BF) training were assessed after pronator teres rerouting and brachioradialis tendon to extensor carpi radialis brevis tendon transfer combined with derotation osteotomy. The peak value increased, while the resting value decreased for the muscles after the intervention. Range of motion, hand function, manual ability, functional independence, and quality of life levels were improved. In conclusion, EMG biofeedback training may have a positive effect on neuromuscular control of pronator teres and brachioradialis. Free use of the upper extremity and improved manual ability positively affect the activity and quality of life of the patients.


Subject(s)
Cerebral Palsy , Muscle, Skeletal , Range of Motion, Articular , Tendon Transfer , Humans , Tendon Transfer/methods , Cerebral Palsy/surgery , Cerebral Palsy/rehabilitation , Cerebral Palsy/physiopathology , Muscle, Skeletal/surgery , Muscle, Skeletal/physiopathology , Male , Forearm/surgery , Electromyography , Quality of Life , Treatment Outcome , Biofeedback, Psychology/methods , Osteotomy/methods , Pronation/physiology , Recovery of Function/physiology
2.
Neurosurg Rev ; 47(1): 142, 2024 Apr 08.
Article in English | MEDLINE | ID: mdl-38587684

ABSTRACT

Cervical perivascular sympathectomy (CPVS) can improve communication disorders in children with cerebral palsy (CP); however, there are no research reports on the factors affecting surgical efficacy. This study aimed to establish a nomogram for poor prognosis after CPVS. We collected data from 313 CP patients who underwent CPVS at the Neurosurgery Cerebral Palsy Center of the Second Affiliated Hospital of Xinjiang Medical University from January 2019 to January 2023. Among them, 70% (n = 216) formed the training cohort and 30% (n = 97) the validation cohort. The general data and laboratory examination data of both groups were analyzed. In training cohort, 82 (37.96%) showed improved postoperative communication function. Logistic analysis identified motor function, serum alkaline phosphatase, serum albumin, and prothrombin activity as the prognostic factors. Using these four factors, a prediction model was constructed with an area under the curve (AUC) of 0.807 (95% confidence interval [CI], 0.743-0.870), indicating its ability to predict adverse outcomes after CPVS. The validation cohort results showed an AUC of 0.76 (95% CI, 0.650-0.869). The consistency curve and Hosmer-Lemeshow test (χ2 = 10.988 and p = 0.202, respectively) demonstrated good consistency between the model-predicted incidence and the actual incidence of poor prognosis. Motor function, serum alkaline phosphatase, serum albumin, and prothrombin activity are independent risk factors associated with the prognosis of communication disorders after CPVS. The combined prediction model has a good clinical prediction effect and has promising potential to be used for early prediction of prognosis of CPVS.


Subject(s)
Cerebral Palsy , Communication Disorders , Child , Humans , Alkaline Phosphatase , Cerebral Palsy/complications , Cerebral Palsy/surgery , Prothrombin , Sympathectomy , Serum Albumin
3.
PLoS One ; 19(4): e0301230, 2024.
Article in English | MEDLINE | ID: mdl-38593122

ABSTRACT

BACKGROUND: Instrumented gait analysis (IGA) has been around for a long time but has never been shown to be useful for improving patient outcomes. In this study we demonstrate the potential utility of IGA by showing that machine learning models are better able to estimate treatment outcomes when they include both IGA and clinical (CLI) features compared to when they include CLI features alone. DESIGN: We carried out a retrospective analysis of data from ambulatory children diagnosed with cerebral palsy who were seen at least twice at our gait analysis center. Individuals underwent a variety of treatments (including no treatment) between sequential gait analyses. We fit Bayesian Additive Regression Tree (BART) models that estimated outcomes for mean stance foot progression to demonstrate the approach. We built two models: one using CLI features only, and one using CLI and IGA features. We then compared the models' performance in detail. We performed similar, but less detailed, analyses for a number of other outcomes. All results were based on independent test data from a 70%/30% training/testing split. RESULTS: The IGA model was more accurate than the CLI model for mean stance-phase foot progression outcomes (RMSEIGA = 11∘, RMSECLI = 13∘) and explained more than 1.5 × as much of the variance (R2IGA = .45, R2CLI = .28). The IGA model outperformed the CLI model for every level of treatment complexity, as measured by number of simultaneous surgeries. The IGA model also exhibited superior performance for estimating outcomes of mean stance-phase knee flexion, mean stance-phase ankle dorsiflexion, maximum swing-phase knee flexion, gait deviation index (GDI), and dimensionless speed. INTERPRETATION: The results show that IGA has the potential to be useful in the treatment planning process for ambulatory children diagnosed with cerebral palsy. We propose that the results of machine learning outcome estimators-including estimates of uncertainty-become the primary IGA tool utilized in the clinical process, complementing the standard medical practice of conducting a through patient history and physical exam, eliciting patient goals, reviewing relevant imaging data, and so on.


Subject(s)
Cerebral Palsy , Gait Disorders, Neurologic , Child , Humans , Gait Analysis , Retrospective Studies , Cerebral Palsy/surgery , Bayes Theorem , Gait , Range of Motion, Articular , Immunoglobulin A , Biomechanical Phenomena , Gait Disorders, Neurologic/therapy
4.
JBJS Case Connect ; 14(2)2024 Apr 01.
Article in English | MEDLINE | ID: mdl-38669444

ABSTRACT

CASE: A 13-year-old adolescent boy with hemiplegic cerebral palsy suffering from fixed knee flexion deformity of 10° despite extensive conservative treatment. Owing to a posterior tibial slope (PTS) of 16°, anterior hemiepiphysiodesis was applied to the proximal tibia. The 2 screws were removed after 9 months. Final follow-up at 16 months showed complete knee extension and a PTS of 4°. CONCLUSION: The presented technique is a good alternative in knee flexion deformity with an increased PTS and has surprisingly not been described in the literature. This might be worth considering for other pathologies such as pediatric anterior cruciate ligament injury with an increased PTS.


Subject(s)
Bone Screws , Knee Joint , Tibia , Humans , Male , Adolescent , Tibia/surgery , Knee Joint/surgery , Knee Joint/diagnostic imaging , Cerebral Palsy/complications , Cerebral Palsy/surgery , Contracture/surgery , Contracture/etiology , Epiphyses/surgery
5.
Gait Posture ; 110: 53-58, 2024 May.
Article in English | MEDLINE | ID: mdl-38492261

ABSTRACT

BACKGROUND: Crouch gait, or flexed knee gait, represents a common gait pattern in patients with spastic bilateral cerebral palsy (CP). Distal femoral extension and/or shortening osteotomy (DFEO/DFSO) and patellar tendon advancement (PTA) can be considered as viable options when knee flexion contractures are involved. Better outcomes have been reported after a combination of both, independently of the presence of knee extensor lag. In this study, we evaluated the clinical and kinematic outcomes of these procedures. PATIENTS AND METHODS: We reviewed a cohort of 52 limbs (28 patients) who were treated for crouch gait by DFEO/DFSO alone (group 1, n = 15) or DFEO/DFSO + PTA (group 2, n = 37) as a part of single event multilevel surgery (SEMLS). The mean age at surgery was 14 years, and the mean follow-up time was 18 months. The physical examination data and three-dimensional standardized gait analysis were collected and analyzed before the surgery and postoperatively. RESULTS: Overall knee range of motion improved in all limbs. The knee flexion decreased significantly in both groups at initial, mid, and terminal stance. Hip flexion significantly decreased in mid-stance for limbs in group 2. Both clinical and gait parameters were most improved in limbs who underwent DFEO/DFSO + PTA. Increased pelvic tilt was observed in both groups after surgery. CONCLUSION: Although DFEO/DFSO alone was successful in correcting knee flexion contractures, PTA has helped to improve knee extensor lag and knee extension during gait. LEVEL OF EVIDENCE: Therapeutic level IV.


Subject(s)
Cerebral Palsy , Femur , Gait Disorders, Neurologic , Knee Joint , Osteotomy , Patellar Ligament , Range of Motion, Articular , Humans , Cerebral Palsy/surgery , Cerebral Palsy/complications , Cerebral Palsy/physiopathology , Osteotomy/methods , Male , Female , Adolescent , Range of Motion, Articular/physiology , Femur/surgery , Gait Disorders, Neurologic/surgery , Gait Disorders, Neurologic/etiology , Gait Disorders, Neurologic/physiopathology , Patellar Ligament/surgery , Child , Knee Joint/physiopathology , Knee Joint/surgery , Biomechanical Phenomena , Young Adult , Treatment Outcome , Retrospective Studies , Gait/physiology , Contracture/surgery , Contracture/physiopathology
6.
Pediatr Cardiol ; 45(5): 1079-1088, 2024 Jun.
Article in English | MEDLINE | ID: mdl-38512487

ABSTRACT

To address the research hypothesis that the Alberta Infant Motor Scale (AIMS) completed following complex cardiac surgery (CCS) is a useful outcomes measure this study determined: (1) AIMS scores at age 8 months after CCS; (2) predictive validity of AIMS at 8 months for Bayley Scales of Infant and Toddler Development-III Gross Motor-scaled scores (GMSS) and diagnosis of cerebral palsy (CP) at 21 months; and (3) predictive demographic and surgical variables of AIMS scores. A prospective cohort study of 250/271 (92.3%) surviving children from Northern Alberta (born 2009-2020) who had CCS at age < 6 months determined AIMS scores at age mean (SD) 8.6 (2.4) and the GMSS at 21.9 (3.8) months. Gross motor delay was defined as AIMS < 5th percentile and GMSS as < 4 (-2SD). Predictions using multiple logistic regressions were expressed as Odds Ratios (OR) and 95% Confidence Interval (CI). Of children, 100/250 (40%) had AIMS < 5th predicting GMSS < 4 (n = 43); sensitivity, specificity, positive, and negative predictive values were 88%, 71%, 40%, and 97%. Hospitalization days were independently associated with AIMS < 5th, OR 1.02 (95% CI 1.007, 1.032; p = 0.005). Excluding hospital days, ventilation days independently predicted AIMS < 5th, OR 1.08 (95% CI 1.038, 1.125, p < 0.001. Gross motor delay determine by AIMS scores of < 5th percentile occurred in 40% of survivors with good prediction of continued delay. Delay determined by AIMS was predicted by longer hospitalization and ventilation; further investigations about the causes are required. AIMS results provide opportunity for early motor intervention.


Subject(s)
Cardiac Surgical Procedures , Heart Defects, Congenital , Motor Skills , Humans , Infant , Male , Female , Cardiac Surgical Procedures/adverse effects , Prospective Studies , Alberta , Heart Defects, Congenital/surgery , Cerebral Palsy/surgery , Child Development , Outcome Assessment, Health Care , Infant, Newborn , Developmental Disabilities/diagnosis
7.
Acta Neurochir (Wien) ; 166(1): 157, 2024 Mar 28.
Article in English | MEDLINE | ID: mdl-38546890

ABSTRACT

Spasticity is a prevalent symptom of upper motor neuron syndrome, becoming debilitating when hindering voluntary movement and motor function and causing contractures and pain. Functional neurosurgery plays a crucial role in treating severe spasticity. Despite extensive literature on SDR for lower limb spasticity, there is a scarcity of papers regarding the procedure in the cervical region to alleviate upper limb spasticity. This case report details a cervical dorsal rhizotomy (CDR) performed for upper limb spasticity, resulting in significant improvement in spasticity with sustained outcomes and low complication rates. Neuroablative procedures like CDR become an option to treat spasticity.


Subject(s)
Cerebral Palsy , Rhizotomy , Humans , Rhizotomy/adverse effects , Treatment Outcome , Muscle Spasticity/etiology , Muscle Spasticity/surgery , Neurosurgical Procedures/adverse effects , Upper Extremity/surgery , Cerebral Palsy/surgery
8.
Int Orthop ; 48(6): 1657-1665, 2024 Jun.
Article in English | MEDLINE | ID: mdl-38483563

ABSTRACT

PURPOSE: As progressive hip dislocation causes pain in children with spastic cerebral palsy (CP) and spasticity needs surgical correction, we aimed to describe clinical and radiographic outcomes in CP patients with painful hip deformity treated with the Castle salvage procedure. METHODS: We included all patients operated in the same hospital between 1989 and 2017 with painful spastic hips and femoral head deformity making joint reconstruction unfeasible. We collected clinical and functional data from medical records and evaluated radiographies to classify cases for femoral head shape and migration, type of deformity, spinal deformity, and heterotopic ossification. We investigated quality of life one year after surgery. RESULTS: We analyzed 41 patients (70 hips) with complete medical records. All had severe function compromise GMFCS V (Gross Motor Function Classification System) and heterotopic ossifications, all but one had scoliosis, and most had undergone other surgeries before Castle procedure. Patients were followed up for 77.1 months (mean) after surgery. The mean initial migration index was 73%. Seven patients had complications, being three patients minor (two femur and one tibial fracture) and four majors (patients requiring surgical revision). Quality of life was considered improved by most of the carers (35 children; 85.3%) as level 4/5 according to CPCHILD instrument. No child was able to stand or walk, but moving in and out of bed, of vehicles, and to a chair, remaining seated, or visiting public places was "very easy." CONCLUSION: We considered most patients (37 patients-90%, 66 hips-94%) as having satisfactory outcomes because they had no or minor complications, absence of pain, free mobility of the lower limbs and were able to sit in a wheelchair.


Subject(s)
Cerebral Palsy , Hip Dislocation , Muscle Spasticity , Quality of Life , Humans , Cerebral Palsy/complications , Cerebral Palsy/surgery , Male , Female , Child , Cross-Sectional Studies , Hip Dislocation/surgery , Adolescent , Treatment Outcome , Muscle Spasticity/surgery , Muscle Spasticity/etiology , Child, Preschool , Casts, Surgical
9.
J Biomech ; 164: 111968, 2024 Feb.
Article in English | MEDLINE | ID: mdl-38325195

ABSTRACT

Selective dorsal rhizotomy (SDR) is commonly used to permanently reduce spasticity in children with cerebral palsy (CP). However, studies have yielded varying results regarding muscle strength and activity after SDR. Some studies indicate weakness or no changes, while a recent study using NMSK simulations demonstrates improvements in muscle forces during walking. These findings suggest that SDR may alleviate spasticity, reducing dynamic muscle constraints and enhancing muscle force without altering muscle activity during walking in children with CP. In this study, we combined NMSK simulations with physical examinations to assess children with CP who underwent SDR, comparing them to well-matched peers who did not undergo the procedure. Each group (SDR and No-SDR) included 81 children, with pre- and post-SDR assessments. Both groups were well-matched in terms of demographics, clinical characteristics, and gait parameters. The results of the physical examination indicate that SDR significantly reduces spasticity without impacting muscle strength. Furthermore, our findings show no significant differences in gait deviation index improvements and walking speed between the two groups. Additionally, there were no statistically significant changes in muscle activity during walking before and after SDR for both groups. NMSK results demonstrate a significant increase in muscle force in the semimembranosus and calf muscles during walking, compared to children with CP who received other clinical treatments. Our findings confirm that although SDR does not significantly impact muscle strength compared to other treatments, it creates a more favorable dynamic environment for suboptimal muscle force production, which is essential for walking.


Subject(s)
Cerebral Palsy , Rhizotomy , Child , Humans , Rhizotomy/methods , Walking , Gait/physiology , Muscle, Skeletal , Mechanical Phenomena , Muscle Spasticity , Cerebral Palsy/surgery , Treatment Outcome
10.
Acta Neurochir (Wien) ; 166(1): 108, 2024 Feb 26.
Article in English | MEDLINE | ID: mdl-38409557

ABSTRACT

OBJECTIVE: This study aimed to evaluate the potential alleviation of quadriceps spasticity in children diagnosed with spastic cerebral palsy (CP) following selective dorsal rhizotomy (SDR). METHODS: A retrospective study was conducted on children suffering from spastic CP who underwent SDR at the Department of Neurosurgery, Shanghai Children's Hospital, from July 2018 to September 2020. Inclusion criteria comprised children exhibiting quadriceps spasticity exceeding modified Ashworth Scale grade 2. Muscle tone and motor function were assessed before the operation, at short-term follow-up and at the last follow-up after SDR. Additionally, intraoperative neurophysiological monitoring data were reviewed. RESULTS: The study comprised 20 eligible cases, where, prior to surgery, 35 quadriceps muscles exhibited spasticity exceeding modified Ashworth Scale grade 2. Following short-term and mid-term follow-up, specifically an average duration of 11 ± 2 days and 1511 ± 210 days after SDR, it was observed that muscle tension in adductors, hamstrings, gastrocnemius, and soleus decreased significantly. This reduction was accompanied by a decrease in quadriceps muscle tone in 24 out of 35 muscles (68.6%). Furthermore, the study found that intraoperative electrophysiological parameters can predict postoperative spasticity relief in the quadriceps. The triggered electromyographic (EMG) output of the transected sensory root/rootlets after single-pulse stimulation revealed that the higher the EMG amplitudes in quadriceps, the greater the likelihood of postoperative decrease in quadriceps muscle tension. CONCLUSIONS: SDR demonstrates the potential to reduce muscle spasticity in lower extremities in children diagnosed with CP, including a notable impact on quadriceps spasticity even they are not targeted in SDR. The utilization of intraoperative neurophysiological monitoring data enhances the predictability of quadriceps spasticity reduction following SDR.


Subject(s)
Cerebral Palsy , Rhizotomy , Child , Humans , Muscle Spasticity/etiology , Muscle Spasticity/surgery , Quadriceps Muscle/surgery , Retrospective Studies , Cerebral Palsy/complications , Cerebral Palsy/surgery , China , Treatment Outcome
12.
J Clin Neurophysiol ; 41(2): 134-137, 2024 Feb 01.
Article in English | MEDLINE | ID: mdl-38306221

ABSTRACT

SUMMARY: The majority of cases of dorsal rhizotomy surgeries in children are done to improve the spasticity associated with cerebral palsy, and more recent techniques are selective in nature and referred to as selective dorsal rhizotomy (SDR). The techniques applied to selective dorsal rhizotomy surgery has changed since it was first described and continues to undergo modifications. Approaches to surgery and monitoring vary slightly among centers. This article provides a review of the rationale, variety of surgical approaches, and intraoperative neurophysiologic monitoring methods used along with discussion of the risks, complications and outcomes in these surgeries.


Subject(s)
Cerebral Palsy , Intraoperative Neurophysiological Monitoring , Child , Humans , Rhizotomy/adverse effects , Rhizotomy/methods , Muscle Spasticity/complications , Muscle Spasticity/surgery , Cerebral Palsy/complications , Cerebral Palsy/surgery , Intraoperative Neurophysiological Monitoring/adverse effects , Treatment Outcome
13.
Childs Nerv Syst ; 40(5): 1461-1469, 2024 May.
Article in English | MEDLINE | ID: mdl-38252157

ABSTRACT

PURPOSE: It is known that cerebral palsy (CP) children's caregivers suffer from burden, depression, and stress, impairing their quality of life (QoL). The more severe the CP, the more burden the caregiver has. Psychosocial support, education, therapies, and financial support are inversely related to the level of stress of the caregiver. Most parents of CP patients submitted to selective dorsal rhizotomy (SDR) report improvement not just on spasticity, but also in the functional role of the children, what can impact on caregiver's QoL. Our objective was to evaluate the burden of CP children's caregivers with and without previous SDR. METHODS: Spastic CP children caregivers were divided into two groups: those who take care of children without previous SDR (control group) and those that children were previously submitted to SDR (surgical group). The burden index was compared between groups using Burden Interview Questionnaire (BIQ). For statistical analysis, we used SPSS. RESULTS: The control group had enrolled 31 participants and the surgical group 36. The mean GMFCS level on the control and surgical groups was 3.94 ± 1.26 and 3.74 ± 1.12 (p = 0.61), respectively. The surgical group caregivers presented less burden related to the feeling that they should be doing more to their child (p = 0.003) and if they could do a better job in caring (p = 0.032), compared to controls. The total BIQ index was not significantly different between groups (surgical 32.14 ± 12.34 vs. control 36.77 ± 12.77; p = 0.87). Low economic status had a weak correlation to a higher BIQ index (R2 = 0.24). After age-matching, there was a significative higher BIQ index in the control group (p = 0.008). CONCLUSION: Caregivers of spastic CP children who were previously submitted to SDR presented less burden related to feeling of the amount of given care than those without previous surgery. The impression that they could do a better job with their kids was higher in the control group. The severity of CP and low economic status were related to more burden in both groups. After pairing groups by age, the control group had a significative higher BIQ index compared to the SDR group. CLINICAL TRIAL REGISTRATION: Trial registration number: CAAE 73407317.6.0000.0068 (Ethical and Research Committee of University of Sao Paulo, Sao Paulo, Brazil, approved on 08/06/2021). All the subjects were freely given an informed consent to participate in the study that was obtained from all participants. Non-consented ones were excluded from the study.


Subject(s)
Cerebral Palsy , Rhizotomy , Child , Humans , Caregivers , Cerebral Palsy/surgery , Quality of Life , Treatment Outcome , Muscle Spasticity/surgery , Brazil
14.
Gait Posture ; 109: 109-114, 2024 Mar.
Article in English | MEDLINE | ID: mdl-38295485

ABSTRACT

BACKGROUND: Studies have shown good reliability for gait analysis interpretation among surgeons from the same institution. However, reliability among surgeons from different institutions remains to be determined. RESEARCH QUESTION: Is gait analysis interpretation by surgeons from different institutions as reliable as it is for surgeons from the same institution? METHODS: Gait analysis data for 67 patients with cerebral palsy (CP) were reviewed prospectively by two orthopedic surgeons from different institutions in the same state, each with > 10 years' experience interpreting gait analysis data. The surgeons identified gait problems and made treatment recommendations for each patient using a rating form. Percent agreement between raters was calculated for each problem and treatment, and compared to expected agreement based on chance using Cohen's kappa. RESULTS: For problem identification, the greatest agreement was seen for equinus (85% agreement), calcaneus (88%), in-toeing (89%), and out-toeing (90%). Agreement for the remaining problems ranged between 66-78%. Percent agreement was significantly higher than expected due to chance for all issues (p ≤ 0.01) with modest kappa values ranging from 0.12 to 0.51. Agreement between surgeons for treatment recommendations was highest for triceps surae lengthening (89% agreement), tibial derotation osteotomy (90%), and foot osteotomy (87%). Agreement for the remaining treatments ranged between 72-78%. Percent agreement for all treatments was significantly higher than the expected values (p ≤ 0.002) with modest kappa values ranging from 0.22 to 0.52. SIGNIFICANCE: Previous research established that computerized gait analysis data interpretation is reliable for surgeons within a single institution. The current study demonstrates that gait analysis interpretation can also be reliable among surgeons from different institutions. Future research should examine reliability among physicians from more institutions to confirm these results.


Subject(s)
Cerebral Palsy , Foot Deformities , Gait Disorders, Neurologic , Humans , Gait Analysis/methods , Cerebral Palsy/complications , Cerebral Palsy/surgery , Reproducibility of Results , Gait Disorders, Neurologic/diagnosis , Gait Disorders, Neurologic/etiology , Gait Disorders, Neurologic/surgery , Gait
16.
Childs Nerv Syst ; 40(2): 487-494, 2024 Feb.
Article in English | MEDLINE | ID: mdl-37676296

ABSTRACT

PURPOSE: We aim to determine whether preoperatively initiated gabapentin for pain control impacts the percentage of rootlets cut during monitored, limited laminectomy selective dorsal rhizotomy (SDR) procedure. METHODS: This retrospective cohort study includes participants with cerebral palsy who had SDR for treatment of spasticity between 2010 and 2019 at a single-institution tertiary care center. One-level laminectomy SDR aimed to evaluate the cauda equina roots from levels L2-S1 with EMG monitoring. Gabapentin titration began 3 weeks prior to SDR. Data was analyzed using simple linear regression. Thirty-one individuals met inclusion criteria. Mean age was 7 years, 4 months. Eighteen participants (58%) identified as male, 12 (39%) female, and one (3%) non-binary. Thirty (97%) had bilateral CP. Sixteen (52%) were GMFCS II, four (13%) GMFCS III, five (16%) GMFCS IV, and six (19%) GMFCS V. RESULTS: Mean percentage of rootlets transected was 50.75% (SD 6.00, range 36.36-60.87). There was no relationship between the dose of gabapentin at time of SDR and percentage of rootlets cut with a linear regression slope of - 0.090 and an R2 of 0.012 (P = 0.56). CONCLUSION: Results indicate that preoperative initiation of gabapentin did not impact the percentage of rootlets transected. Thus, gabapentin can be initiated prior to SDR at moderate dosages without impacting SDR surgical outcomes.


Subject(s)
Cerebral Palsy , Rhizotomy , Humans , Male , Female , Child , Rhizotomy/methods , Gabapentin , Retrospective Studies , Spinal Nerve Roots/surgery , Cerebral Palsy/surgery , Muscle Spasticity/surgery , Pain , Treatment Outcome
17.
Childs Nerv Syst ; 40(1): 171-180, 2024 Jan.
Article in English | MEDLINE | ID: mdl-37439914

ABSTRACT

PURPOSE: Assess the effects of selective dorsal rhizotomy (SDR) on motor function and quality of life in children with a Gross Motor Function Classification System (GMFCS) level of IV or V (non-ambulatory). METHODS: This is a prospective, observational study in three tertiary neurosurgery units in England, UK, performing SDR on children aged 3-18 with spastic diplegic cerebral palsy, and a GMFCS level of IV or V, between 2012 and 2019. The primary outcome measure was the change in the 66-item Gross Motor Function Measure (GMFM-66) from baseline to 24 months after SDR, using a linear mixed effects model. Secondary outcomes included spasticity, bladder function, quality of life, and pain scores. RESULTS: Between 2012 and 2019, 144 children who satisfied these inclusion criteria underwent SDR. The mean age was 8.2 years. Fifty-two percent were female. Mean GMFM-66 score was available in 77 patients (53.5%) and in 39 patients (27.1%) at 24 months after SDR. The mean increase between baseline and 24 months post-SDR was 2.4 units (95% CI 1.7-3.1, p < 0.001, annual change 1.2 units). Of the 67 patients with a GMFM-66 measurement available, a documented increase in gross motor function was seen in 77.6% (n = 52). Of 101 patients with spasticity data available, mean Ashworth scale decreased after surgery (2.74 to 0.30). Of patients' pain scores, 60.7% (n = 34) improved, and 96.4% (n = 56) of patients' pain scores remained the same or improved. Bladder function improved in 30.9% of patients. CONCLUSIONS: SDR improved gross motor function and reduced pain in most patients at 24 months after surgery, although the improvement is less pronounced than in children with GMFCS levels II and III. SDR should be considered in non-ambulant patients.


Subject(s)
Cerebral Palsy , Child , Humans , Female , Male , Cerebral Palsy/complications , Cerebral Palsy/surgery , Rhizotomy , Prospective Studies , Quality of Life , Treatment Outcome , Muscle Spasticity/etiology , Muscle Spasticity/surgery , Pain
18.
J Pediatr Orthop ; 44(2): 76-81, 2024 Feb 01.
Article in English | MEDLINE | ID: mdl-37970741

ABSTRACT

BACKGROUND: Anterior distal femoral hemiepiphysiodesis (ADFH) is a surgical treatment choice to correct flexed knee gait and fixed knee flexion deformities in children with cerebral palsy who are skeletally immature. Increased anterior pelvic tilt has been reported after surgeries that correct knee flexion deformities, including hamstring lengthening (HSL) and distal femoral extension osteotomies, but anterior pelvic tilt has not been studied after ADFH. We hypothesized that anterior pelvic tilt would increase after ADFH, especially when combined with HSL, and it would correlate with the change in minimum knee flexion in stance and dynamic hamstring lengths. METHODS: Thirty-four eligible participants (age: 13.0, SD: 2.0) were included. Change in mean pelvic tilt across the gait cycle was compared as a function of clinical and gait parameters using linear mixed models. The relationship of change in pelvic tilt to change in other variables was examined using Pearson correlation. RESULTS: Overall, anterior pelvic tilt increased significantly after ADFH by 4.4 degrees ( P = 0.02). Further, the analysis revealed anterior pelvic tilt only increased significantly in the group that had concurrent HSL (11.1 degrees, P < 0.001). Overall, minimum knee flexion significantly decreased (increase in knee extension) in stance (-19.1 degrees, P < 0.001) and there was an increase in maximum normalized dynamic hamstring lengths (0.03, P < 0.001). The anterior pelvic tilt increased significantly in Gross Motor Function Classification System levels III to IV (5.9 degrees, P = 0.02) but did not change significantly in Gross Motor Function Classification System I to II (2.5 degrees, P = 0.37). Change in pelvic tilt was correlated with change in maximum dynamic hamstring lengths ( r = 0.87, P < 0.0001) and change in minimum knee flexion in stance ( r = -0.71, P < 0.0001). CONCLUSIONS: Anterior distal hemiepiphysiodesis without concurrent HSL for flexion knee deformities does not result in increased anterior pelvic tilt. Surgeons should consider anterior distal hemiepiphysiodesis in patients with cerebral palsy and flexed knee gait, who preoperatively have long dynamically modeled hamstrings, are skeletally immature, and when maintenance of pelvic tilt is desired. LEVEL OF EVIDENCE: Level III-retrospective comparative study.


Subject(s)
Cerebral Palsy , Contracture , Gait Disorders, Neurologic , Child , Humans , Adolescent , Retrospective Studies , Cerebral Palsy/surgery , Knee Joint/surgery , Knee , Gait , Contracture/surgery , Range of Motion, Articular , Biomechanical Phenomena , Treatment Outcome
19.
Hand Surg Rehabil ; 43(1): 101623, 2024 Feb.
Article in English | MEDLINE | ID: mdl-38000449

ABSTRACT

OBJECTIVES: To evaluate the functional impact of individualised multisite neuro-orthopedic upper-limb surgery in children with unilateral cerebral palsy, and to assess patient satisfaction. PATIENTS AND METHODS: This retrospective study evaluated the impact of surgery on unilateral functional capacity on the Melbourne Assessment (MA2) and Box and Blocks test, on bimanual performance on the Assisting Hand Assessment, and on achievement of individualised goals. Satisfaction was assessed on a Likert scale between 6 and 14 months after surgery. RESULTS: Twenty-three children were included (mean age, 13.2 ± 3 years). They underwent neuro-orthopedic surgery as part of their care pathway, with botulinum toxin, splints and functional training. After surgery, there was a significant 11.7-point improvement in the MA2 dexterity domain (p = 0.003) and 10.6 points in the MA2 range of motion domain (p = 0.005). Satisfaction was high in 81% of patients. CONCLUSION: Neuro-orthopedic upper-limb surgery included in a global care pathway in children with unilateral cerebral palsy improved unilateral upper-limb function and patient satisfaction. The present cohort should be expanded to further explore the impact of surgery on bimanual performance, focusing on more homogeneous functional levels and surgical procedures.


Subject(s)
Cerebral Palsy , Child , Humans , Adolescent , Cerebral Palsy/surgery , Retrospective Studies , Treatment Outcome , Upper Extremity/surgery , Personal Satisfaction
20.
J Hand Surg Eur Vol ; 49(3): 390-395, 2024 Mar.
Article in English | MEDLINE | ID: mdl-37917831

ABSTRACT

Tendon transfers in cerebral palsy are commonly described as a method to improve function in the upper limb. The field can be considered by some to be more of an art than science due to the unique challenges involved, which include poor volitional control and spasticity. Surgical outcomes can be uncertain and, in certain circumstances, worsened. This presentation looks at the rationale behind tendon transfers for patients with cerebral palsy and the application of this rationale (science vs. art) to a philosophy of treatment.


Subject(s)
Cerebral Palsy , Humans , Cerebral Palsy/complications , Cerebral Palsy/surgery , Tendon Transfer/methods , Upper Extremity , Muscle Spasticity/surgery
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