ABSTRACT
The signs of lower cranial nerve palsies are rare and are often caused by tumors. A 49-year-old woman was admitted to our hospital with progressive right-sided atrophy of the tongue, sternocleidomastoid and trapezius, dysarthria, and dysphagia for 3 years. Brain magnetic resonance imaging revealed a circular lesion adjacent to the lower cranial nerves. Cerebral angiography confirmed that the lesion was an unruptured aneurysm in the C1 segment of the right internal carotid artery. After endovascular treatment, the symptoms of this patient had partially improved.
Subject(s)
Aneurysm , Carotid Artery Diseases , Cranial Nerve Diseases , Intracranial Aneurysm , Female , Humans , Middle Aged , Carotid Artery, Internal/diagnostic imaging , Carotid Artery, Internal/surgery , Carotid Artery, Internal/pathology , Cranial Nerve Diseases/diagnostic imaging , Cranial Nerve Diseases/etiology , Cranial Nerve Diseases/pathology , Aneurysm/complications , Carotid Artery Diseases/complications , Carotid Artery Diseases/diagnostic imaging , Carotid Artery Diseases/surgery , Magnetic Resonance Imaging/adverse effects , Intracranial Aneurysm/complications , Intracranial Aneurysm/diagnostic imaging , Intracranial Aneurysm/surgeryABSTRACT
BACKGROUND: Several case series of patients with Tolosa-Hunt syndrome have been described in the literature; however, few studies have focused on the cerebrospinal fluid (CSF) characteristics. This study aimed to analyse the CSF characteristics of patients with Tolosa-Hunt syndrome. METHODS: Fifty-five patients who fulfilled the 3rd Edition of the International Classification of Headache Disorders diagnostic criteria for Tolosa-Hunt syndrome were included in this study. We retrospectively analysed data on CSF parameters, imaging findings, and clinical characteristics of these patients. RESULTS: Oligoclonal bands (OBs) were detected in the CSF of 13 (13/44, 29.5%) patients. The sex ratio was balanced. The mean age at onset of Tolosa-Hunt syndrome was 46.9 ± 10.23 (range 22-72) years. Eight (8/13, 61.5%) patients had multiple cranial nerve palsies. Lesions limited to the cavernous sinus were found on magnetic resonance imaging in 7 (7/13, 53.8%) patients. OBs were significantly detected more frequently in patients whose samples were evaluated less than 30 days after the onset of this diseases (p = 0.026); however, there were no significant differences in the protein level (p = 0.360) and IgG synthesis rate (p = 0.614). CONCLUSIONS: The detection of OBs in the CSF of patients with Tolosa-Hunt syndrome was not rare. It would be interesting to follow-up patients with OBs to determine whether they eventually developed an otherwise more specific inflammatory diagnosis.
Subject(s)
Cavernous Sinus , Cranial Nerve Diseases , Tolosa-Hunt Syndrome , Adult , Aged , Cavernous Sinus/pathology , Cranial Nerve Diseases/pathology , Humans , Magnetic Resonance Imaging , Middle Aged , Retrospective Studies , Tolosa-Hunt Syndrome/diagnosis , Tolosa-Hunt Syndrome/pathology , Young AdultABSTRACT
OBJECTIVE: We report disease remission and recovery of fifth and seventh nerve paresis in a case of primary mucosal melanoma of the middle ear and petrous temporal bone. PATIENT: A 74-year-old man developed sudden, profound, right sided sensorineural hearing loss, disequilibrium, otalgia, and cranial nerve V and VII dysfunction. Imaging demonstrated an unresectable, osteolytic lesion involving the middle ear and anterior petrous apex. Melanoma was diagnosed via in-office biopsy; whole-body metabolic imaging revealed no other primary site. INTERVENTION: Multidisciplinary management included radiation therapy (30âGy, 10 fractions) followed by induction (five cycles, q2w) and maintenance nivolumab (six cycles, q3w). MAIN OUTCOME MEASURE: Complete metabolic response of primary site and metastases on imaging, recovery of cranial neuropathies. RESULTS: Following palliative radiation therapy and induction nivolumab, cranial neuropathies resolved. With maintenance-dose nivolumab, primary site and metastases exhibited a complete response. Therapy was stopped at 16âmonths post-diagnosis. Complete remission was maintained until 22âmonths after diagnosis. The patient developed a solitary cerebral metastasis which was refractory to radiosurgery and biopsy confirmed melanoma. He expired 2âyears, 8âmonths post-diagnosis. CONCLUSIONS: Mucosal melanoma of the middle ear and petrous temporal bone is exceedingly rare. Management is individualized and surgery is undertaken when possible. Key observations in this case are the complete metabolic response and reversal of cranial nerve neuropathies following radiation and anti-programed cell death receptor ligand 1 therapy. Non-surgical treatment is worthy of study as initial management for similar lesions.
Subject(s)
Cranial Nerve Diseases , Melanoma , Aged , Cranial Nerve Diseases/drug therapy , Cranial Nerve Diseases/etiology , Cranial Nerve Diseases/pathology , Cranial Nerves/pathology , Ear, Middle/pathology , Humans , Male , Nivolumab/therapeutic use , Paresis , Petrous Bone/surgeryABSTRACT
Multiple sclerosis (MS) is an inflammatory neurodegenerative disorder manifesting as gradual or progressive loss of neurological functions. Most patients present with relapsing-remitting disease courses. Extensive research over recent decades has expounded our insights into the presentations and diagnostic features of MS. Groups of genetic diseases, CADASIL and leukodystrophies, for example, have been frequently misdiagnosed with MS due to some overlapping clinical and radiological features. The delayed identification of these diseases in late adulthood can lead to severe neurological complications. Herein we discuss genetic diseases that have the potential to mimic multiple sclerosis, with highlights on clinical identification and practicing pearls that may aid physicians in recognizing MS-mimics with genetic background in clinical settings.
Subject(s)
Genetic Diseases, Inborn/diagnosis , Genetic Diseases, Inborn/pathology , Multiple Sclerosis/diagnosis , Multiple Sclerosis/pathology , Nervous System Diseases/diagnosis , Nervous System Diseases/pathology , Brain Diseases/diagnosis , Brain Diseases/pathology , Cranial Nerve Diseases/diagnosis , Cranial Nerve Diseases/pathology , Delayed Diagnosis , Diagnosis, Differential , Diagnostic Errors , Genetic Diseases, Inborn/genetics , Humans , Magnetic Resonance ImagingABSTRACT
BACKGROUND: Cranial nerve (CN) palsy due to cancer involvement has been considered as an unfavorable prognostic factor for patients with nasopharyngeal carcinoma (NPC). We assessed the role of IMRT based treatment on the recovery of CN palsy and investigated the prognostic value of complete recovery of CN palsy. METHODS: A total of 115 NPC patients with cancer-related CN palsy were included in the study. We referred CTCAE version 5.0 to evaluate the grade of CN palsy. RESULTS: All patients with grade 1 CN palsy recovered completely during the 2 years of follow-up after definite treatment. Most grade 2 palsy could change gradually to grade 1 palsy or complete recovery during 2 years of follow-up. Patients with more than 2 symptoms of CN palsy had poor 3-year disease-free survival (DFS) than these with 1 or 2 symptoms (60.3% vs. 84.9%, HR 0.25, 95% CI 0.07-0.89, P = 0.001). There were no significant differences for PFS, OS, DMFS and LRFS between patients with complete recovery and non-complete recovery from CN palsy after receiving IMRT based comprehensive treatment. CONCLUSIONS: IMRT based comprehensive treatment could effectively promote the recovery of tumor-related CN palsy for NPC patient. More than 2 symptoms of CN palsy was a poor prognostic factor for DFS of NPC patients. The prognostic role of complete recovery of CN palsy was not identified in our study.
Subject(s)
Cranial Nerve Diseases/radiotherapy , Nasopharyngeal Carcinoma/radiotherapy , Radiotherapy Planning, Computer-Assisted/methods , Radiotherapy, Intensity-Modulated/methods , Recovery of Function , Adolescent , Adult , Aged , Aged, 80 and over , Cranial Nerve Diseases/complications , Cranial Nerve Diseases/pathology , Female , Humans , Male , Middle Aged , Nasopharyngeal Carcinoma/complications , Nasopharyngeal Carcinoma/pathology , Prognosis , Radiotherapy Dosage , Retrospective Studies , Survival Rate , Young AdultABSTRACT
The complete features of the neurological complications of coronavirus disease 2019 (COVID-19) still need to be elucidated, including associated cranial nerve involvement. In the present study we describe cranial nerve lesions seen in magnetic resonance imaging (MRI) of six cases of confirmed COVID-19, involving the olfactory bulb, optic nerve, abducens nerve, and facial nerve. Cranial nerve involvement was associated with COVID-19, but whether by direct viral invasion or autoimmunity needs to be clarified. The development of neurological symptoms after initial respiratory symptoms and the absence of the virus in the cerebrospinal fluid (CSF) suggest the possibility of autoimmunity.
Subject(s)
Abducens Nerve/diagnostic imaging , COVID-19/diagnostic imaging , Cranial Nerve Diseases/diagnostic imaging , Facial Nerve/diagnostic imaging , Olfactory Bulb/diagnostic imaging , Optic Nerve/diagnostic imaging , Abducens Nerve/immunology , Abducens Nerve/pathology , Abducens Nerve/virology , Adult , Aged , Autoimmunity , COVID-19/immunology , COVID-19/pathology , COVID-19/virology , Cranial Nerve Diseases/immunology , Cranial Nerve Diseases/pathology , Cranial Nerve Diseases/virology , Facial Nerve/immunology , Facial Nerve/pathology , Facial Nerve/virology , Female , Humans , Magnetic Resonance Imaging , Male , Neuroimaging , Olfactory Bulb/immunology , Olfactory Bulb/pathology , Olfactory Bulb/virology , Optic Nerve/immunology , Optic Nerve/pathology , Optic Nerve/virology , SARS-CoV-2/pathogenicityABSTRACT
Multiple cranial neuropathies have been reported in nasopharyngeal carcinoma. Nasopharyngeal carcinoma is an uncommon cause of multiple cranial nerve palsies. However, it is difficult to diagnose at the early stage; furthermore, it can be easily misdiagnosed as inflammation, pituitary tumor, etc. A 38-year-old female patient had an ipsilateral 3rd, 5th, 6th, and 7th cranial nerves injury in this study. She was successively misdiagnosed with nonspecific inflammation and pituitary tumor. More than 1 year later, she was diagnosed with invasive nasopharyngeal carcinoma.
Subject(s)
Cranial Nerve Diseases , Nasopharyngeal Neoplasms , Pituitary Neoplasms , Adult , Cranial Nerve Diseases/diagnosis , Cranial Nerve Diseases/etiology , Cranial Nerve Diseases/pathology , Diagnostic Errors , Female , Humans , Nasopharyngeal Carcinoma/complications , Nasopharyngeal Carcinoma/diagnosis , Nasopharyngeal Neoplasms/pathology , Pituitary Neoplasms/complications , Pituitary Neoplasms/diagnosisABSTRACT
The neurological disorders caused by Varicella Zoster Virus (VZV) in the absence of skin rash are a challenge to the clinician. The presentation varies from acute to subacute to chronic. Reactivation of VZV usually produces zoster (shingles), meningitis or meningoencephalitis, cerebellitis, isolated or multiple cranial nerve palsies (polyneuritis cranialis), myelitis, and vasculopathy. In our case, we report a 41-year-old female presented with right oculomotor, vestibulocochlear and facial neuropathies occurred 1 year before admission and making the diagnosis. There were no skin or mucosa lesions. Magnetic Resonance Imaging revealed multiple subcortical infractions in the right temporal and occipital lobes which consist with silent vasculopathy. The diagnosis was confirmed by the existence of anti-VZV IgG in cerebrospinal fluid (CSF).
Subject(s)
Brain/pathology , Cranial Nerve Diseases/virology , Exanthema/virology , Neuritis/virology , Adult , Brain/virology , Cranial Nerve Diseases/diagnosis , Cranial Nerve Diseases/pathology , Exanthema/diagnosis , Female , Herpes Zoster/virology , Humans , Magnetic Resonance Imaging/methods , Myelitis/diagnosis , Myelitis/virology , Nervous System Diseases , Neuritis/diagnosis , Neuritis/pathologyABSTRACT
Objectives: Cranial neuropathies (CNs) can be due to a wide spectrum of causes, and the differential diagnosis is particularly challenging in patients with positive history of hematological malignancies, when neoplastic meningitis (NM) must be excluded.Patients and Methods: We retrospectively selected a series of twelve haematological patients with isolated cranial neuropathies (ICNs) or multiple cranial neuropathies (MCNs). among 71 patients that developed neurologic symptoms during different stages of the cancer, between 1 January, 2010 and 31 December, 2017. Brain and cauda equina magnetic resonance imaging (MRI) with gadolinium, cerebrospinal fluid (CSF) analysis, including flow cytometry for cell immunophenotyping and microbiological exams were performed in all patients.Results: Patients developed signs and symptoms of involvement of isolated (n = 11) or multiple (n = 1) cranial nerves, at different stages of the primary disease, and, in 5 of these cases in complete remission after hematopoietic stem cell transplantation. Among the 5 cases that eventually were diagnosed as having NM, cerebrospinal fluid was positive for neoplastic cells in 3, and MRI gadolinium-enhancement was present in 3. The other episodes were attributed to heterogeneous pathologies that were unrelated to meningeal infiltration by neoplastic cells.Conclusions: Our observations confirm that NM in haematological malignancies can yield insidious isolated signs of cranial nerves. Only a multidisciplinary approach allows prompt recognition of these conditions through a challenging process of differential diagnosis, and proper therapies.
Subject(s)
Cranial Nerve Diseases/diagnosis , Cranial Nerve Diseases/etiology , Leukemia/complications , Leukemia/diagnosis , Lymphoma/complications , Lymphoma/diagnosis , Meningeal Carcinomatosis/diagnosis , Adult , Brain/diagnostic imaging , Cauda Equina/diagnostic imaging , Cranial Nerve Diseases/cerebrospinal fluid , Cranial Nerve Diseases/pathology , Diagnosis, Differential , Female , Hematopoietic Stem Cell Transplantation , Humans , Leukemia/cerebrospinal fluid , Leukemia/pathology , Lymphoma/cerebrospinal fluid , Lymphoma/pathology , Magnetic Resonance Imaging , Male , Meningeal Carcinomatosis/cerebrospinal fluid , Meningeal Carcinomatosis/etiology , Meningeal Carcinomatosis/pathology , Middle Aged , Remission Induction , Retrospective StudiesABSTRACT
Good's syndrome is a primary immunodeficiency phenocopy characterized for thymoma and immunodeficiency. The most frequent clinical presentation is recurrent or opportunistic infections, hematological alterations, and chronic diarrhea. We treated a 66-year-old man who consulted for 5 days of headache and diplopia with right sixth cranial nerve palsy at examination. Patient reported chronic diarrhea and prolonged febrile syndrome accompanied by weight loss of 23 kg in the last year. Exhaustive evaluation revealed Herpes simplex virus (HSV) type 2 meningitis, eosinophilic colitis, and type A thymoma. Severe antibody deficiency (hypogammaglobulinemia) associated with thymoma confirmed the diagnosis of Good's syndrome.
Subject(s)
Agammaglobulinemia/pathology , Colitis/pathology , Cranial Nerve Diseases/pathology , Herpes Simplex/pathology , Herpesvirus 2, Human/pathogenicity , Meningitis, Viral/pathology , Neoplasms, Glandular and Epithelial/pathology , Thymus Neoplasms/pathology , Agammaglobulinemia/diagnosis , Agammaglobulinemia/immunology , Agammaglobulinemia/virology , Aged , Colitis/diagnosis , Colitis/immunology , Colitis/virology , Cranial Nerve Diseases/diagnosis , Cranial Nerve Diseases/immunology , Cranial Nerve Diseases/virology , Diplopia/diagnosis , Diplopia/immunology , Diplopia/pathology , Diplopia/virology , Eosinophilia/diagnosis , Eosinophilia/immunology , Eosinophilia/pathology , Eosinophilia/virology , Headache/diagnosis , Headache/immunology , Headache/pathology , Headache/virology , Herpes Simplex/diagnosis , Herpes Simplex/immunology , Herpes Simplex/virology , Herpesvirus 2, Human/growth & development , Herpesvirus 2, Human/immunology , Humans , Lymphocyte Count , Male , Meningitis, Viral/diagnosis , Meningitis, Viral/immunology , Meningitis, Viral/virology , Neoplasms, Glandular and Epithelial/diagnosis , Neoplasms, Glandular and Epithelial/immunology , Neoplasms, Glandular and Epithelial/virology , Thymus Neoplasms/diagnosis , Thymus Neoplasms/immunology , Thymus Neoplasms/virologyABSTRACT
This review provides a symptom-driven approach to neuroimaging of disease processes affecting the cranial nerves. In addition to describing characteristic imaging appearances of a disease, the authors emphasize exceptions to the rules and neuroimaging pearls. The focus is on adult neurology although some important pediatric conditions are included. On reviewing this material, the reader should be able to (1) differentiate intra- and extra-axial causes of cranial nerve dysfunction and (2) appropriately use neuroimaging to investigate abnormalities of cranial nerve function.
Subject(s)
Cranial Nerve Diseases/diagnostic imaging , Cranial Nerve Diseases/pathology , Cranial Nerves/diagnostic imaging , Cranial Nerves/pathology , Neuroimaging/methods , Humans , Magnetic Resonance Imaging/methodsABSTRACT
A 58-year-old man with a history of rheumatoid arthritis and stage IV diffuse large B-cell lymphoma, in complete remission with no evidence of residual disease on positron emission tomography/CT after completing six cycles of rituximab, cyclophosphamide, doxorubicin, vincristine and prednisone chemotherapy, presented with acute onset of dysphagia to solids and liquids. On further evaluation, his dysphagia was attributed to a vagus nerve palsy, and later during his admission, he developed rapidly progressing left facial and vestibulocochlear nerve palsies. Imaging studies displayed pathological enhancement of bilateral seventh and eighth cranial nerves, concerning for leptomeningeal recurrence of lymphoma. Cerebrospinal fluid analysis and flow cytometry were confirmatory, revealing markedly atypical monotypic CD19 positive B cells.
Subject(s)
Cranial Nerve Diseases/pathology , Lymphoma, Large B-Cell, Diffuse/pathology , Meningeal Neoplasms/pathology , Neoplasm Recurrence, Local/pathology , Antineoplastic Combined Chemotherapy Protocols , Cranial Nerve Diseases/drug therapy , Cranial Nerve Diseases/radiotherapy , Diagnosis, Differential , Facial Nerve Diseases/etiology , Humans , Lymphoma, Large B-Cell, Diffuse/drug therapy , Lymphoma, Large B-Cell, Diffuse/radiotherapy , Male , Meningeal Neoplasms/drug therapy , Meningeal Neoplasms/radiotherapy , Middle Aged , Neoplasm Recurrence, Local/drug therapy , Neoplasm Recurrence, Local/radiotherapy , Vestibulocochlear Nerve Diseases/etiologyABSTRACT
We present two cases of women who suffered from neurotrophic keratopathy (one of them had undergone penetrating keratoplasty) which had led to corneal thinning. Tachosil® was used as an adjuvant treatment after topical medication by itself failed in both cases. To our knowledge, there are no reported cases of the use of Tachosil® in corneal grafts.
Subject(s)
Corneal Perforation/prevention & control , Corneal Ulcer/therapy , Cranial Nerve Diseases/therapy , Fibrinogen/therapeutic use , Ophthalmic Nerve/pathology , Surgical Sponges , Thrombin/therapeutic use , Aged , Aged, 80 and over , Corneal Ulcer/pathology , Cranial Nerve Diseases/pathology , Drug Combinations , Female , Humans , Keratoplasty, PenetratingABSTRACT
Vernet syndrome, often referred to as jugular foramen syndrome, is a rare clinical entity characterised by a set of signs and symptoms caused by dysfunction of IX, X and XI cranial nerves. Although paraganglioma of the head and neck is the most frequent aetiology, it may also be caused by meningioma, VIII cranial nerve schwannoma, pontocerebellar cistern metastases, head and neck trauma, infections and very rarely by cholesteatoma which extends to the petrous apex. The authors describe a case of a patient with a jugulotympanic paraganglioma in which evolution ends up in Vernet syndrome. The patient preferred a 'wait and scan' strategy. With the lack of data available to develop an unequivocal algorithm for paraganglioma management, we always consider not only age but also comorbidities, prior treatment and progression of the lesion. Each case has to be addressed individually and treatment should be discussed in detail with every patient.
Subject(s)
Cranial Nerve Diseases/pathology , Paraganglioma/pathology , Tympanic Membrane/pathology , Aged , Conservative Treatment , Cranial Nerve Diseases/diagnosis , Female , Foramen Magnum/pathology , Humans , Jugular Veins/pathology , Syndrome , Tinnitus/etiology , Vocal Cord Paralysis/etiologyABSTRACT
Objectives: To investigate longitudinally corneal sub-basal nerve plexus (SNP) by means of in vivo confocal microscopy (IVCM) in the contralateral eye (CE) of patients with unilateral neurotrophic keratitis (NK) secondary to central nervous system (CNS) diseases who underwent different treatments. Methods: Ten patients with NK and 10 matched controls were included. In 7 NK patients, conservative treatment maintained unchanged the clinical picture over the 1-year follow-up (Group 1), while NK progressed in 3 patients who underwent direct corneal neurotization (Group 2). IVCM scans of SNP of NK patients were acquired in CE at baseline (V0) ad after 1-year follow-up (V1). All images were analyzed with the automated software "ACCMetrics" and compared with controls. The following IVCM corneal nerve parameters were calculated at V0 and V1 with ACCMetrics: fiber density (CNFD), branch density (CNBD), fiber length (CNFL), total branch density (CTBD), fiber area (CNFA), fiber width (CNFW), and fractal dimension (CNFrD). Results: At V0, significantly lower mean values of CNFD and CNBD, and higher values of CNFW were detected in CE of NK patients compared to controls (respectively, 16.9 ± 8.7 vs 25.0 ± 8.3 n/mm2, P= .029; 19.3 ± 13.8 vs 33.8 ± 18.9 n/mm2, P= .023; 0.022 ± 0.002 vs 0.020 ± 0.001 mm/mm2, P< .001). From V0 to V1, all IVCM metrics of CE remained unchanged in Group 1, while they improved in Group 2. Conclusions: Contralateral eye of patients with unilateral NK secondary to CNS disease showed lower CNFD and CNBD and higher CNFW compared to controls. Unlike conservative treatment, direct corneal neurotization was able to improve SNP metrics also in CE.
Subject(s)
Cornea/innervation , Cranial Nerve Diseases/pathology , Keratitis/pathology , Ophthalmic Nerve/pathology , Adult , Aged , Cranial Nerve Diseases/diagnostic imaging , Cranial Nerve Diseases/surgery , Female , Humans , Keratitis/diagnostic imaging , Keratitis/surgery , Longitudinal Studies , Male , Microscopy, Confocal , Middle Aged , Nerve Fibers/pathology , Nerve Transfer , Ophthalmic Nerve/diagnostic imaging , Prospective Studies , Slit Lamp MicroscopyABSTRACT
BACKGROUND/AIMS: The composition of the extracellular matrix (ECM) in the central nervous system (CNS) has several features that make it unique. For instance, it is remarkable for the presence of proteoglycans such as versican, brevican, and neurocan, some of which have been identified as substrates of different members of the ADAMTS family of secreted metalloproteases. Previous studies have associated ADAMTSs with the repair of the CNS, including recovery following degradation of glial scar tissue and the stimulation of axonal growth after brain injury. However, the involvement of ADAMTSs in diseases of the CNS is complex and not understood fully, and a current challenge is unraveling the precise roles of these metalloproteases in the brain. METHODS: ADAMTS12 and neurocan gene expression was examined by quantitative PCR. Western blot analysis was employed to detect ADAMTS12 and neurocan protein expression in cell lines, and immunostaining techniques were used to detect neurocan in mouse brain tissues. Neurocan cleavage using recombinant ADAMTS1, ADAMTS4, ADAMTS5, and ADAMTS12 metalloproteases was evaluated by western blotting. Cell adhesion and migration were assessed using uncoated culture dishes or dishes coated with Matrigel or ECM components. RESULTS: We identified neurocan as a novel component of brain ECM that can be cleaved by ADAMTS12. In addition, we showed that neurocan cleavage by ADAMTS12 altered the adhesive properties of the human neuroglioma H4 cell line. Moreover, immunohistochemical analysis of Adamts12-deficient mice revealed the significant accumulation of neurocan in the brain of neonatal mice. CONCLUSION: Overall, our results suggest that ADAMTS12 could be involved in the repair of the CNS through its ability to degrade neurocan. Moreover, it can be inferred that alterations in neurocan degradation processes could be associated with the pathogenesis of neurological disorders.
Subject(s)
ADAMTS Proteins/biosynthesis , ADAMTS Proteins/metabolism , Chondroitin Sulfate Proteoglycans/metabolism , Cranial Nerve Diseases/metabolism , Lectins, C-Type/metabolism , Nerve Tissue Proteins/metabolism , Proteoglycans/metabolism , Proteolysis , ADAMTS Proteins/genetics , Animals , Cell Adhesion , Cell Line, Tumor , Cell Movement , Chondroitin Sulfate Proteoglycans/genetics , Cranial Nerve Diseases/genetics , Cranial Nerve Diseases/pathology , Gene Expression Regulation , Humans , Lectins, C-Type/genetics , Mice , Nerve Tissue Proteins/genetics , Neurocan , Proteoglycans/geneticsABSTRACT
Upper cervical osteomyelitis is rare. Its presenting features are fever and neck pain, but rarely it can involve lower nerves. MRI is the main imaging modality, but it is difficult to interpret due to the unique anatomy of C1 and C2 vertebra and complex intervertebral joint. We describe a case of a 67-year-old woman, who presented with the complaint of loss of voice, neck pain and fever for 5 days. Despite repeated imaging of neck, the diagnosis was not reached. As the patient's condition continued to deteriorate, clinical signs of bilateral 10th and 12th cranial nerve paralysis appeared and lead to a focused workup for base of skull pathology. Discussion with the radiologist helped guide the imaging protocol, which leads to the correct diagnosis being made. Treatment was tailored by blood cultures and available images. Temporary immobilisation with a cervical collar and a total of 12 weeks of antibiotics lead to complete remission.