ABSTRACT
Benign tumors of the eye and eyelid are common in children and adults, and they rarely undergo malignant transformation. Their workup and management have evolved over the years with increasing advancements in surgical and laser therapies. This contribution focuses on describing the following benign eye and eyelid tumors and their diagnostic and treatment approaches: congenital and acquired melanocytic nevi; nevus of Ota (Hori nevus); conjunctival papilloma; seborrheic keratosis; epidermoid cyst; dermoid cyst; milium; xanthelasma; hemangioma (cherry angioma and pyogenic granuloma); neurofibroma; neurilemmoma (schwannoma); and fibroepithelial polyp. Surgical removal is the primary treatment approach for many of these benign tumors. With advancements in laser technologies, there are now several laser types that can be used in the treatment of these benign eye and eyelid tumors. Other treatment modalities include cryosurgery, electrosurgery, and topical or intralesional medications. We hope this review will provide a reference to dermatologists and ophthalmologists in their approach to evaluation and management of benign eye and eyelid tumors.
Subject(s)
Eyelid Neoplasms , Humans , Eyelid Neoplasms/therapy , Eye Neoplasms/therapy , Eye Neoplasms/diagnosis , Dermoid Cyst/therapy , Neurofibroma/therapy , Neurofibroma/surgery , Hemangioma/therapy , Epidermal Cyst/therapy , Epidermal Cyst/diagnosis , Epidermal Cyst/surgery , Nevus, Pigmented/therapy , Keratosis, Seborrheic/therapy , Keratosis, Seborrheic/diagnosis , Neurilemmoma/therapy , Laser Therapy , Xanthomatosis/therapyABSTRACT
BACKGROUND: Dermoids are common benign head and neck cysts in children containing a variety of different skin elements. Current standard treatment is surgical removal that sometimes requires extensive dissection to ensure complete resection and often leaves unwanted facial scarring. A minimally invasive treatment alternative should offer a similar rate of success with a decrease in operative complexity, recovery time and postoperative scarring. OBJECTIVE: To assess the outcomes of our minimally invasive percutaneous treatment of head and neck dermoids, we reviewed our 9-year interventional radiology (IR) department experience. MATERIALS AND METHODS: The medical records, imaging and procedural details were reviewed from a cohort of pediatric patients with dermoids treated in our IR department from January 2009 through February 2018. Patients in the study underwent ultrasound (US)-guided cyst puncture, 3% Sotradecol (sodium tetradecyl sulfate [STS]) emulsification of the thick cyst contents allowing complete drainage, and radiofrequency coblation of the cyst wall. RESULTS: In this retrospective study, we report on 22 dermoids in 21 patients. The average patient age was 3 years. Twenty-one of the 22 dermoids were successfully treated for an overall success rate of 95%. Four intraosseous dermoids were successfully treated using computed tomography (CT) guidance instead of, or in addition to, US. Average follow-up time was 22 months. CONCLUSION: The combination of percutaneous cyst drainage using STS as an emulsifying agent followed by radiofrequency coblation is a safe, effective, minimally invasive treatment for pediatric patients with head and neck dermoids.
Subject(s)
Head and Neck Neoplasms/therapy , Radiofrequency Ablation/methods , Adolescent , Child , Child, Preschool , Dermoid Cyst/therapy , Drainage/methods , Female , Humans , Infant , Male , Minimally Invasive Surgical Procedures , Retrospective StudiesABSTRACT
Tubo-ovarian abscesses (TOAs) are inflammatory masses involving the fallopian tube, ovary and occasionally other adjacent pelvic organs. A 32-year-old woman with no significant medical history presented with a chief complaint of lower abdominal pain. Initial CT of the abdomen was suggestive of a colon abscess; however, a repeat CT suggested a TOA. The left ovary was densely adherent to the left pelvic sidewall and the rectosigmoid colon. The content of the ovary was consistent with a dermoid and suspected of superinfection. Pathological examination of the tissue revealed normal ovarian cortical tissue, hair cells, melanin, and epidermal and neural tissue, as well as evidence of a foreign object resembling vegetable matter. The vegetable fibre found in this patient's biopsy was of an unclear aetiology, but probably indicates a perforation of the bowel. Any cause of bowel perforation adjacent to the adnexa can lead to TOA, therefore providing a rational speculation for this case.
Subject(s)
Abdominal Pain/etiology , Abscess/diagnostic imaging , Anti-Bacterial Agents/therapeutic use , Dermoid Cyst/pathology , Fallopian Tube Diseases/diagnostic imaging , Ovarian Diseases/diagnostic imaging , Superinfection/pathology , Abdominal Pain/diagnostic imaging , Abdominal Pain/pathology , Abscess/pathology , Abscess/therapy , Adult , Ampicillin/therapeutic use , Dermoid Cyst/diagnostic imaging , Dermoid Cyst/therapy , Doxycycline/therapeutic use , Fallopian Tube Diseases/pathology , Fallopian Tube Diseases/therapy , Female , Humans , Intestinal Perforation/pathology , Laparoscopy , Ovarian Diseases/pathology , Ovarian Diseases/therapy , Ovariectomy , Ovary/pathology , Sulbactam/therapeutic use , Superinfection/drug therapy , Tomography, X-Ray Computed , Treatment OutcomeABSTRACT
OBJECTIVE: Mature cystic teratomas, also referred to as dermoid cysts, are one of the commonly occurring ovarian germ cell tumors. Malignant transformation of a germ cell tumor occurs approximately 1-2% of the time. Treatment options vary by stage and are not well outlined in the literature. Here we report a case of a perimenopausal female who presented with increasing abdominal girth and an elevated CA-125. Final pathology revealed an invasive squamous cell carcinoma, moderately to poorly differentiated, multifocal, arising in a cyst on the left ovary, possibly a teratoma. At the time of diagnosis, the patient was FIGO stage IA. The decision was made against adjuvant treatment. Squamous cell carcinoma arising in a mature cystic teratoma of the ovary is rare. Treatment options are not well outlined in the literature, especially for disease less than stage II. Further research is needed to better inform the clinician on management recommendations.
Subject(s)
Carcinoma, Squamous Cell , Dermoid Cyst , Ovarian Neoplasms , Teratoma , Carcinoma, Squamous Cell/therapy , Dermoid Cyst/therapy , Female , Humans , Ovarian Neoplasms/therapy , Teratoma/therapyABSTRACT
Soft-tissue sarcomas are uncommon and heterogeneous tumors of mesenchymal origin. A soft-tissue mass that is increasing in size, greater than 5 cm, or located under deep fascia are criteria for suspicion of sarcoma. Diagnosis, treatment, and management should preferably be performed by a multidisciplinary team in reference centers. MRI and lung CT scan are mandatory for local and distant assessment. A biopsy indicating histological type and grade is needed previous to the treatment. Wide surgical resection with tumor-free tissue margin is the primary treatment for localized disease. Radiotherapy is indicated in large, deep, high-grade tumors, or after marginal resection not likely of being improved with reexcision. Neoadjuvant and adjuvant chemotherapy improve survival in selected cases, usually in high-grade sarcomas of the extremities. In the case of metastatic disease, patients with exclusive lung metastasis could be considered for surgery. First-line treatment with anthracyclines (or in combination with ifosfamide) is the treatment of choice. New drugs have shown activity in second-line therapy and in specific histological subtypes (AU)
No disponible
Subject(s)
Humans , Male , Female , Sarcoma/diagnosis , Sarcoma/therapy , Decision Making/physiology , Image-Guided Biopsy/instrumentation , Image-Guided Biopsy/methods , Dermoid Cyst/complications , Dermoid Cyst/therapy , Societies, Medical/standards , Molecular Biology/methods , Neoplasm Staging/classification , Neoplasm Staging , Neoadjuvant Therapy/methods , Radiotherapy, Adjuvant , Retroperitoneal Neoplasms/classification , Retroperitoneal Neoplasms/complications , Retroperitoneal Neoplasms/therapyABSTRACT
In contrast to more common nasal and cervical lesions, the frontotemporal pit is a rarely encountered lesion that is often associated with a dermoid and may track intracranially. Due to delays in diagnosis, the propensity to spread intracranially, and the risk of infection, awareness of these lesions and appropriate diagnosis and management are important. The authors present 2 cases of frontotemporal pits from a single institution. Epidemiology, presentation, and management recommendations are discussed.
Subject(s)
Dermoid Cyst/diagnostic imaging , Dermoid Cyst/therapy , Skull Neoplasms/diagnostic imaging , Skull Neoplasms/therapy , Child, Preschool , Dermoid Cyst/pathology , Female , Frontal Bone/abnormalities , Frontal Bone/diagnostic imaging , Frontal Bone/surgery , Humans , Male , Skull Neoplasms/pathology , Temporal Bone/abnormalities , Temporal Bone/diagnostic imaging , Temporal Bone/surgeryABSTRACT
BACKGROUND: Dermoid cysts are rare intracranial lesions that can occasionally rupture into intraventricular and subarachnoid spaces and can present with a myriad of symptoms. The surgical intervention in such cases is demanding, because the disseminated contents are spread widely in intraventricular and subarachnoid space. CASE DESCRIPTION: A 22-year-old female patient who presented with history of seizures was diagnosed as having a left parasellar ruptured dermoid. Because there were no features of increased intracranial pressure, conservative management was considered with antiepileptic administration. At 11 years of follow-up, the patient continues to do well on 2 antiepileptics with repeat imaging showing no change in size of lesion. CONCLUSIONS: Surgical intervention may not be essential in all patients with ruptured intracranial dermoids. In a few selected patients who do not manifest increased intracranial pressure and show no change in the size of the lesion on sequential radiologic follow-up, conservative management may be attempted, especially when the ruptured intracranial dermoid is located at eloquent areas and with wide dissemination of contents.
Subject(s)
Brain Neoplasms/complications , Brain Neoplasms/therapy , Dermoid Cyst/complications , Dermoid Cyst/therapy , Epilepsy/drug therapy , Epilepsy/etiology , Anticonvulsants/therapeutic use , Brain Neoplasms/diagnosis , Dermoid Cyst/diagnosis , Female , Follow-Up Studies , Humans , Longitudinal Studies , Neurosurgical Procedures , Rupture, Spontaneous/diagnosis , Rupture, Spontaneous/surgery , Treatment Outcome , Young AdultABSTRACT
Congenital median dermoid is an uncommon disease. Surgery is the main curative treatment. To review a clinical case and to summarise the characteristics and treatment experience of this disease, referring to the related literature, it is expected that we can provide more clinical thought and therapeutic method for congenital median dermoid fistula of nasal dorsum.
Subject(s)
Dermoid Cyst/congenital , Fistula/congenital , Nose Neoplasms/congenital , Nose/pathology , Dermoid Cyst/therapy , Fistula/therapy , Humans , Nose Neoplasms/therapyABSTRACT
Dermoid cysts in the floor of the mouth with tongue fistula are unusual lesions. This study reported a case of dermoid cyst in the floor of the mouth with tongue fistula, analyzed the causes of such formation, and discussed the appropriate diagnosis and treatment methods by reviewing relevant literature.
Subject(s)
Dermoid Cyst/diagnosis , Dermoid Cyst/therapy , Fistula , Mouth Neoplasms/diagnosis , Mouth Neoplasms/therapy , Dermoid Cyst/complications , Fistula/complications , Humans , Mouth Floor , Mouth Neoplasms/complications , TongueABSTRACT
PURPOSE: We retrospectively studied the efficacy and safety of different surgical approaches to treating pediatric limbal dermoids with regard to intra and postoperative complications. METHODS: The data of 12 consecutive patients (14 eyes), who underwent monocentric surgery of a limbal demoid in the past 9 years, were retrospectively analyzed for intra and postoperative complications. Group one consists of eleven eyes: seven eyes with a bare-sclera deep lamellar excision of the dermoid and four eyes with an additional amniotic membrane transplantation subsequent to excision. Group two consists of three eyes: two eyes treated with Mitomycin C 0.02% over 2 min following the excision, and one eye treated with Mitomycin C and amniotic membrane transplantation after removal of the dermoid. Follow-up ranged from 2 to 53 months (median 17 months). RESULTS: Intraoperative complications did not occur in any of the patients. Postoperatively, all patients showed corneal reepithelialization within a week. Limbal stem cell deficiency with a pseudopterygium developed in four eyes, one treated with bare-sclera excision and the others with amniotic membrane transplantation. One pseudopterygium had to be removed surgically because of visual acuity deterioration. Not a single eye treated with Mitomycin C developed a pseudopterygium. CONCLUSIONS: The transplantation of amniotic membrane following removal of a limbal dermoid cannot prevent the occurrence of a pseudopterygium. However, the use of Mitomycin C seems to have a protective effect.
Subject(s)
Alkylating Agents/administration & dosage , Corneal Diseases/therapy , Dermoid Cyst/therapy , Eye Neoplasms/therapy , Limbus Corneae/pathology , Mitomycin/administration & dosage , Ophthalmologic Surgical Procedures , Amnion/transplantation , Child , Child, Preschool , Combined Modality Therapy , Corneal Diseases/drug therapy , Corneal Diseases/pathology , Corneal Diseases/surgery , Dermoid Cyst/drug therapy , Dermoid Cyst/pathology , Dermoid Cyst/surgery , Eye Neoplasms/drug therapy , Eye Neoplasms/pathology , Eye Neoplasms/surgery , Female , Humans , Intraoperative Complications , Male , Microscopy, Acoustic , Postoperative Complications , Retrospective Studies , Treatment Outcome , Visual Acuity/physiologyABSTRACT
PURPOSE: To report nonsurgical treatment of periorbital dermoid cysts with foam sclerotherapy using sodium tetradecyl sulfate (STS). METHODS: Single-center, retrospective, interventional case series. Clinical records of all patients diagnosed to have congenital orbital dermoid cyst and treated with STS foam sclerotherapy between 2012 and 2013 were reviewed. The ectodermal contents of the dermoid cyst were aspirated through a stab incision with 18G needle, followed by saline lavage. Intraluminal foam sclerotherapy was then performed using STS (30 mg/ml) in a proportion of 10% of the total aspirate volume. Retrospective data analysis included demographic profile, clinicoradiologic findings, and treatment outcomes of foam sclerotherapy. RESULTS: Four patients were treated in the given period. Average age at presentation was 20.2 years. All cysts were reported to be congenital in nature, and the location was medial angular in 2 cases, lateral angular in 1 case, and lateral orbitotemporal in 1 case. The average aspirate of the pultaceous cyst content was 3.75 ml (range, 2-5 ml). Of the 4 patients, 2 dermoid cysts resolved completely within 8 weeks. Two cysts showed partial response and required a second foam sclerotherapy to achieve complete resolution. At an average follow up of 13.25 months (range, 11-16 months), complete cyst resolution was noted. No sclerotherapy-related complications were observed. CONCLUSIONS: Foam sclerotherapy is successful in obliterating periorbital dermoid cysts and provides a minimally invasive nonsurgical approach to achieve an aesthetic result.
Subject(s)
Dermoid Cyst/therapy , Orbital Neoplasms/therapy , Sclerosing Solutions/therapeutic use , Sclerotherapy/methods , Sodium Tetradecyl Sulfate/therapeutic use , Adolescent , Adult , Dermoid Cyst/diagnostic imaging , Female , Humans , Male , Orbital Neoplasms/diagnostic imaging , Retrospective Studies , Tomography, X-Ray Computed , Young AdultABSTRACT
OBJECTIVES: This report is intended to bring out the association of recurrent postauricular abscess in children with various underlying congenital anomalies. MATERIALS AND METHODS: A retrospective study was done in tertiary care setting from the year August 2005 to February 2012 using the medical record department database to retrieve the patient details. During this study period, a total of 215 children with an age range of 1-14 years were treated at the hospital with postauricular abscess. We analysed the data using appropriate statistical tests for parametric and nonparametric data and setting the p value at 0.05 for significance. For testing the association between the recurrence of abscess and the presence of underlying congenital anomalies, Fischer's t test was used. RESULTS: A total of 215 patients were studied, of which 41 patients presented with recurrence. 26 of the 41 patients (63.4%) had recurrent postauricular abscess with associated congenital anomalies. Among the 26 patients, in 16 patients (62%), the recurrent abscesses were due to postauricular sinuses. Other less common causes were infected post auricular dermoid cyst, first branchial cysts, collaural fistula and congenital aural atresia. There was a statistically significant association of the recurrence of abscess with presence of underlying congenital anomalies. CONCLUSION: Paediatric recurrent postauricular abscesses are rare in the post antibiotic era. Their presence should alert a treating physician of an underlying congenital anomaly.
Subject(s)
Abscess/diagnosis , Abscess/etiology , Branchial Region/abnormalities , Branchioma/complications , Dermoid Cyst/complications , Staphylococcal Infections/diagnosis , Abscess/therapy , Adolescent , Branchioma/diagnosis , Branchioma/therapy , Child , Child, Preschool , Dermoid Cyst/diagnosis , Dermoid Cyst/therapy , Female , Humans , Infant , Male , Recurrence , Retrospective Studies , Risk Factors , Staphylococcal Infections/etiology , Staphylococcal Infections/therapyABSTRACT
PURPOSE: The aim was to describe the demographic and clinical data of 116 consecutive cases of ocular dermoids. METHODS: This was a retrospective case series and a review of clinical records of all the patients diagnosed with ocular dermoids. Both demographic and clinical data were recorded. Statistical analysis was performed with SPSS v. 18. Descriptive statistics are reported. RESULTS: The study included 116 consecutive patients with diagnosis consistent with ocular dermoids: corneal 18% (21), dermolipomas 38% (44), and orbital 44% (51). Sixty-five percent (71) were female, and 46% (54) were detected at birth. Secondary manifestations: amblyopia was present in 14% (3), and strabismus was detected in 6.8% (8). The Goldenhar syndrome was the most frequent syndromic entity in 7.5% (12) of the patients. Surgical resection was required on 49% (25) of orbital dermoids, 24% (5) of corneal dermoids, and 13% (6) of dermolipomas. CONCLUSIONS: Orbital dermoids were the most frequent variety, followed by conjunctival and corneal. In contrast to other reports, corneal dermoids were significantly more prevalent in women. Goldenhar syndrome was the most frequent syndromatic entity.
Subject(s)
Dermoid Cyst/epidemiology , Eye Neoplasms/epidemiology , Adolescent , Adult , Aged , Aged, 80 and over , Child , Child, Preschool , Dermoid Cyst/therapy , Eye Neoplasms/therapy , Female , Humans , Incidence , Infant , Male , Mexico/epidemiology , Middle Aged , Retrospective Studies , Sex Distribution , Young AdultABSTRACT
BACKGROUND: Mature cystic teratomas (MCTs) are the most common ovarian neoplastic lesions found in adolescents. MCTs are usually asymptomatic and are often discovered incidentally on exam or imaging. The recurrence rate of MCTs following cystectomy is 3-4% and incidence of malignant transformation is estimated to be 0.17-2%. Given the accuracy with which MCTs can be diagnosed preoperatively studies suggest that these lesions can be treated surgically using laparoscopic techniques. The management of MCTs in the adolescent population poses unique challenges given the potential impact on sexual development and fertility. CASE: A 17-year-old female was found to have bilateral adnexal masses consistent in appearance with MCTs on computed tomography after a motor vehicle accident. She underwent exploratory laparotomy with pathology confirming the presence of bilateral ovarian MCTs. Three years later she returned to the office with occasional abdominopelvic pain. Ultrasound revealed bilateral complex cysts suggestive of recurrent MCTs. She was expectantly managed with serial ultrasounds and after 24 months, slow but visible growth of the MCTs was confirmed. The patient is now 22 years old and asymptomatic. What is the most appropriate management? SUMMARY AND CONCLUSION: The risks of expectant management in women like the one presented are small. This suggests that although the traditional treatment for MCTs is laparoscopic ovarian cystectomy, in children and adolescents with MCTs we should consider close follow-up without intervention to preserve ovarian function and future fertility.
Subject(s)
Dermoid Cyst/therapy , Ovarian Neoplasms/therapy , Watchful Waiting , Adolescent , Dermoid Cyst/diagnosis , Female , Humans , Ovarian Neoplasms/diagnosis , Young AdultABSTRACT
Facial nerve paralysis in children may occur as a complication of infections, trauma, or rarely from benign or malignant tumors of the facial nerve. We present the first reported case of a dermoid tumor in the facial nerve causing facial paralysis in a child. Case report at a tertiary Children's Hospital. A 9-month-old was referred to our institution for evaluation of persistent, complete right sided facial paralysis three months after receiving a diagnosis of Bell's palsy. A workup at our institution including MRI and CT revealed marked widening of the facial canal in the mastoid segment consistent with facial nerve schwannoma or hemangioma. Surgical exploration via mastoidectomy and facial nerve decompression revealed keratinous material containing hair that had fully eroded the facial nerve, disrupting it completely. The entire tumor was removed along with the involved segment of facial nerve, and the missing facial nerve segment was cable grafted. Histological examination of the tumor confirmed a ruptured dermoid cyst in the facial nerve. Facial nerve tumors are rare causes of facial paralysis in children, accounting for fewer than 10% of cases of facial paralysis in the pediatric population. Dermoid cyst can occur throughout the head and neck region in children, but a dermoid tumor in the facial nerve has not been described in the literature prior to this report. This represents a new and uncommon diagnostic entity in the evaluation of facial nerve paralysis in children. Appropriate imaging studies and pathology slides will be reviewed.
Subject(s)
Cranial Nerve Neoplasms/diagnosis , Dermoid Cyst/diagnosis , Facial Nerve Diseases/diagnosis , Cranial Nerve Neoplasms/etiology , Cranial Nerve Neoplasms/therapy , Dermoid Cyst/etiology , Dermoid Cyst/therapy , Facial Nerve Diseases/etiology , Facial Nerve Diseases/therapy , Humans , Infant , MaleABSTRACT
OBJECTIVE: Squamous cell carcinoma (SCC) is the most common type of malignant transformation in mature cystic teratoma (MCT) of the ovary. The SCC is difficult to preoperatively diagnose. We conducted a retrospective study to seek the possible risk/prognostic factors and treatments for SCC arising from MCT of the ovary. METHODS: Using an institutional database, we identified 3 women treated for SCC arising from an MCT of the ovary at the Kaohsiung Veteran General Hospital. A retrospective chart review was conducted, with information obtained from radiographs, operative reports, pathology reports, and radiation oncology records. RESULTS: A total of 1551 cases of MCT were diagnosed at Kaohsiung Veteran General Hospital from 1990 to 2009, of which, malignant teratoma SCC type was noted in 3 cases (0.19%). The median age of the subjects was 39 years. Abdominal fullness was the most common symptom (3/3 cases). The mean diameter of the ovarian tumor was 17.3 cm, ranging from 16 to 18 cm. All 3 patients received simple right salpingo-oophorectomy or debulking surgery. Two of the patients reached stage IIIC and died. CONCLUSIONS: : With our review as basis, we recommend being cautious of the following risk factors: patient age, tumor size, ultrasound characteristics, sonar tumor vessel wave form, computed tomography, and levels of SCC and CA125 tumor markers. We suggest that patients have regular ovarian ultrasound examination. Based on our literature review, stage IA patients who undergo standardized operational procedures do well without adjuvant treatment, but such patients must be confirmed accurately with complete surgical staging to be in stage IA before undergoing conservative management. The optimal approach to the management of patients with advanced stage and recurrent disease is unclear. Surgical cytoreduction with proper staging, adjuvant therapy with platinum-based or paclitaxel-based chemotherapy, and concurrent whole pelvic radiation have been recommended as possible methods of treatment.
Subject(s)
Carcinoma, Squamous Cell/pathology , Dermoid Cyst/pathology , Ovarian Neoplasms/pathology , Teratoma/pathology , Adult , Carcinoma, Squamous Cell/therapy , Combined Modality Therapy , Dermoid Cyst/therapy , Female , Humans , Middle Aged , Ovarian Neoplasms/therapy , Prognosis , Retrospective Studies , Teratoma/therapyABSTRACT
Primary rectal teratomas are rare and only few cases have been reported in the literature worldwide. These usually occur in females. These are usually cystic but very rarely solid variants may occur. We present a case of a solid intra-rectal dermoid arising primarily in rectum from postero-lateral wall. Excision biopsy was done per rectally. Histology revealed the presence of squamous epithelium, fat cells, hair follicles, cartilaginous material and columnar lining of glandular structures suggestive of mature teratoma. It is usually benign but may become malignant, therefore complete resection is advised.
Subject(s)
Dermoid Cyst/diagnosis , Dermoid Cyst/therapy , Rectal Neoplasms/diagnosis , Rectal Neoplasms/therapy , Adult , Female , HumansABSTRACT
This study reports 3 unusual cases of malignant transformation in mature cystic teratoma of the ovary (dermoid cyst), namely carcinosarcoma, atypical choroid plexus papilloma, and papillary thyroid carcinoma, the last case involving both ovaries and with peritoneal dissemination. Adequate sampling is essential in such ovarian tumors to establish their teratomatous origin and avoid an erroneous diagnosis of primary ovarian or metastatic tumors. The authors present the clinicopathological findings in these 3 cases with a review of literature.