Subject(s)
Conjunctivitis/chemically induced , Cough/chemically induced , Dermatitis, Allergic Contact/etiology , Dermatitis, Occupational/etiology , Dicyclohexylcarbodiimide/adverse effects , Headache/chemically induced , Indicators and Reagents/adverse effects , Accidents, Occupational , Adult , Female , Humans , Pruritus/chemically inducedSubject(s)
Allergens/adverse effects , Dermatitis, Allergic Contact/diagnosis , Dermatitis, Occupational/diagnosis , Dicyclohexylcarbodiimide/adverse effects , Adult , Dermatitis, Allergic Contact/etiology , Dermatitis, Allergic Contact/pathology , Dermatitis, Occupational/etiology , Dermatitis, Occupational/pathology , Diagnosis, Differential , Facial Dermatoses/chemically induced , Facial Dermatoses/diagnosis , Facial Dermatoses/pathology , Female , Hand Dermatoses/chemically induced , Hand Dermatoses/diagnosis , Hand Dermatoses/pathology , Humans , Male , Neck/pathology , Occupations , Patch Tests , Wrist/pathologyABSTRACT
Dicyclohexylcarbodiimide is a commonly used coupling agent found in protein synthesis. It is a potent allergic sensitizer found especially in the emerging industries involved in recombinant DNA synthesis. Chemists who work in research and development of this industry are especially at risk of development of contact dermatitis, unless they are careful and avoid skin contact. This report describes two chemists with allergic contact dermatitis from repeated contact with this compound in their work as research and development chemists. An appropriate concentration for patch testing is suggested.
Subject(s)
Carbodiimides/adverse effects , Dermatitis, Contact/etiology , Dermatitis, Occupational/chemically induced , Dicyclohexylcarbodiimide/adverse effects , Adult , Humans , Male , Patch Tests , Protective Clothing , Proteins/chemical synthesisABSTRACT
We report a case of a female laboratory worker in the chemical industry who acquired contact allergy to dicyclohexylcarbodiimide and N-hydroxyphthalimide. Both substances are used in the chemical synthesis of peptides. So far there have only been a few reports concerning contact allergy to these substances.
Subject(s)
Carbodiimides/adverse effects , Dermatitis, Contact/etiology , Dermatitis, Occupational/chemically induced , Dicyclohexylcarbodiimide/adverse effects , Phthalimides/adverse effects , Adult , Female , Humans , Patch TestsABSTRACT
Allergic contact dermatitis occurring in a 25 years old female biochemist was found to be due to occupational handling of dicyclohexylcarbodiimide (DCC). This was confirmed by patch testing. Though DCC is widely used in peptide chemistry as completing reagent, only a few publications report occupational allergic contact dermatitis.
