Adherence to the EAT-Lancet Diet and Risk of Stroke and Stroke Subtypes: A Cohort Study.

BACKGROUND AND PURPOSE: We investigated the association between adherence to the EAT-Lancet diet, a sustainable and mostly plant-based diet, and risk of stroke and subtypes of stroke in a Danish population. For comparison, we also investigated the Alternate Healthy Eating Index-2010 (AHEI). METHODS: We used the Danish Diet, Cancer and Health cohort (n=55 016) including adults aged 50 to 64 years at baseline (1993-1997). A food frequency questionnaire was used to assess dietary intake and group participants according to adherence to the diets. Stroke cases were identified using a national registry and subsequently validated by review of medical records (n=2253). Cox proportional hazards models were used to estimate hazard ratios and 95% CIs for associations with the EAT-Lancet diet or the AHEI and risk of stroke and stroke subtypes. RESULTS: Adherence to the EAT-Lancet diet was associated with a lower risk of stroke, although not statistically significant (highest versus lowest adherence: hazard ratio, 0.91 [95% CI, 0.76-1.09]). A lower risk was observed for AHEI (0.75 [95% CI, 0.64-0.87]). For stroke subtypes, we found that adherence to the EAT-Lancet diet was associated with a lower risk of subarachnoid hemorrhage (0.30 [95% CI, 0.12-0.73]), and the AHEI was associated with a lower risk of ischemic stroke (0.76 [95% CI, 0.64-0.90]) and intracerebral hemorrhage (0.58 [95% CI, 0.36-0.93]). CONCLUSIONS: Adherence to the EAT-Lancet diet in midlife was associated with a lower risk of subarachnoid stroke, and the AHEI was associated with a lower risk of total stroke, mainly ischemic stroke and intracerebral hemorrhage.

Bending the curve of terrestrial biodiversity needs an integrated strategy.

Increased efforts are required to prevent further losses to terrestrial biodiversity and the ecosystem services that it  provides1,2. Ambitious targets have been proposed, such as reversing the declining trends in biodiversity3; however, just feeding the growing human population will make this a challenge4. Here we use an ensemble of land-use and biodiversity models to assess whether-and how-humanity can reverse the declines in terrestrial biodiversity caused by habitat conversion, which is a major threat to biodiversity5. We show that immediate efforts, consistent with the broader sustainability agenda but of unprecedented ambition and coordination, could enable the provision of food for the growing human population while reversing the global terrestrial biodiversity trends caused by habitat conversion. If we decide to increase the extent of land under conservation management, restore degraded land and generalize landscape-level conservation planning, biodiversity trends from habitat conversion could become positive by the mid-twenty-first century on average across models (confidence interval, 2042-2061), but this was not the case for all models. Food prices could increase and, on average across models, almost half (confidence interval, 34-50%) of the future biodiversity losses could not be avoided. However, additionally tackling the drivers of land-use change could avoid conflict with affordable food provision and reduces the environmental effects of the food-provision system. Through further sustainable intensification and trade, reduced food waste and more plant-based human diets, more than two thirds of future biodiversity losses are avoided and the biodiversity trends from habitat conversion are reversed by 2050 for almost all of the models. Although limiting further loss will remain challenging in several biodiversity-rich regions, and other threats-such as climate change-must be addressed to truly reverse the declines in biodiversity, our results show that ambitious conservation efforts and food system transformation are central to an effective post-2020 biodiversity strategy.

Vegetarianismo entre ingressantes de uma universidade pública no sul do Brasil, 2018 / Vegetarianismo entre estudiantes de primer año en una universidad pública del sur de Brasil, 2018 / Vegetarianism among first-year students at a public university in Southern Brazil, 2018

Objetivo: Analisar a prevalência de vegetarianismo e fatores associados em estudantes de uma universidade pública no sul do Brasil. Métodos: Estudo transversal realizado em 2017-2018, incluindo ingressantes universitários. Questionário foi aplicado para avaliar o tipo de dieta (onívora ou vegetariana). Regressão logística foi utilizada para estimar razões de odds (RO) e intervalos de confiança de 95% (IC95%). Resultados: De 2.706 indivíduos elegíveis, 1.841 fizeram parte da amostra. O tipo de dieta predominante foi a onívora (93,6%), seguida por ovolactovegetariana (5,4%), vegetariana estrita (0,7%), ovovegetariana (0,2%) e lactovegetariana (0,1%). Mulheres (RO=0,58 - IC95% 0,38;0,89), ingressantes que referiram uso prejudicial de álcool (RO=2,02 - IC95% 1,34;3,04) e matriculados na área de Linguística, Letras e Artes - comparados aos matriculados em Ciências Sociais Aplicadas e Humanas (RO=2,59 - IC95% 1,42;4,71) - tiveram maior chance de serem vegetarianos. Conclusão: A dieta vegetariana associou-se ao sexo feminino, uso de álcool e ingresso em cursos de linguística, letras e artes.

Objetivos: Identificar la prevalencia del vegetarianismo y factores asociados entre estudiantes de una universidad pública en el sur del Brasil. Métodos: Estudio transversal realizado entre 2017-2018, incluyendo a estudiantes de primer año de una universidad pública. Se aplicó el cuestionario para evaluar el tipo de dieta (omnívora o vegetariana). Se utilizó la regresión logística para verificar factores asociados (demográficos, socioeconómicos, curso, comportamientos relacionados con la salud y estado nutricional) e intervalos de confianza de 95% (IC95%). Resultados: De 2,706 individuos elegibles, 1,841 hicieron parte de la muestra. El tipo de dieta predominante fue omnívora (93.6%), seguida de ovolactovegetariana (5.4%), vegetariana estricta (0.7%), ovo vegetariana (0.2%) y lactovegetariana (0.1%). Mujeres (RO=0,58 - IC95% 0,38;0,89), estudiantes que relataron uso perjudicial de alcohol (RO=2.02 - IC95% 1.34;3.04) e inscritos en Lingüística, Letras y Artes fueron más propensos a ser vegetarianos comparados con los inscritos en Ciencias Sociales Aplicadas y Humanas (RO=2,59 - IC95% 1,42;4,71). Conclusión: la dieta vegetariana se asoció al sexo femenino, consumo de alcohol y al ingreso a cursos de Lingüística, Letras y Artes.

Objective: To identify vegetarianism prevalence and associated factors among students at a public university in Southern Brazil. Methods: This was a cross-sectional study carried out in 2017-2018 with first-year university students. A questionnaire was administered to assess diet type (omnivorous or vegetarian). Logistic regression was used to estimate odds ratios (OR) and 95% confidence intervals (95%CI). Results: Of 2,706 eligible individuals, 1,841 formed part of the sample. The predominant type of diet was omnivorous (93.6%), followed by lacto-ovo vegetarian (5.4%), strict vegetarian (0.7%), ovo vegetarian (0.2%) and lacto vegetarian (0.1%). Females (OR=0.58 - 95%CI 0.38;0.89), students reporting harmful use of alcohol (OR=2.02 - 95%CI 1.34;3.04) and students enrolled in Linguistics, Modern Languages and Arts courses - compared to those enrolled in Applied Social Sciences and Humanities courses (OR=2.59 - 95%CI 1.42;4.71) - were more likely to be vegetarians. Conclusion: Vegetarian diet was associated with the female sex, alcohol use, and taking linguistics, modern language and arts courses.

La dieta vegetariana en niños y preadolescentes / Vegetarian diet in children and pre-adolescents

Basándonos en una consulta de una niña que desea realizar una dieta vegetariana se realizó una búsqueda bibliográfica para identificar evidencia sobre el impacto de este tipo de dieta en la salud. La evidencia actual indica que la dieta vegetariana es una opción saludable que no produciría un impacto negativo en el crecimiento y desarrollo de los niños, si bien existiría la posibilidad de déficit de micronutrientes. (AU)

Based on a consultation of a girl who wishes to make a vegetarian diet, a literature search was conducted to identify evidence on the impact of this type of diet on health. Current evidence indicates that the vegetarian diet is a healthy option that would not have a negative impact on the growth and development of children, although there is a possibility of micronutrient deficits. (AU)

Future prospects for dissecting inter-individual variability in the absorption, distribution and elimination of plant bioactives of relevance for cardiometabolic endpoints.

PURPOSE: The health-promoting potential of food-derived plant bioactive compounds is evident but not always consistent across studies. Large inter-individual variability may originate from differences in digestion, absorption, distribution, metabolism and excretion (ADME). ADME can be modulated by age, sex, dietary habits, microbiome composition, genetic variation, drug exposure and many other factors. Within the recent COST Action POSITIVe, large-scale literature surveys were undertaken to identify the reasons and extent of inter-individual variability in ADME of selected plant bioactive compounds of importance to cardiometabolic health. The aim of the present review is to summarize the findings and suggest a framework for future studies designed to investigate the etiology of inter-individual variability in plant bioactive ADME and bioefficacy. RESULTS: Few studies have reported individual data on the ADME of bioactive compounds and on determinants such as age, diet, lifestyle, health status and medication, thereby limiting a mechanistic understanding of the main drivers of variation in ADME processes observed across individuals. Metabolomics represent crucial techniques to decipher inter-individual variability and to stratify individuals according to metabotypes reflecting the intrinsic capacity to absorb and metabolize bioactive compounds. CONCLUSION: A methodological framework was developed to decipher how the contribution from genetic variants or microbiome variants to ADME of bioactive compounds can be predicted. Future study design should include (1) a larger number of study participants, (2) individual and full profiling of all possible determinants of internal exposure, (3) the presentation of individual ADME data and (4) incorporation of omics platforms, such as genomics, microbiomics and metabolomics in ADME and efficacy studies.

Factors influencing the cardiometabolic response to (poly)phenols and phytosterols: a review of the COST Action POSITIVe activities.

PURPOSE: Evidence exists regarding the beneficial effects of diets rich in plant-based foods regarding the prevention of cardiometabolic diseases. These plant-based foods are an exclusive and abundant source of a variety of biologically active phytochemicals, including polyphenols, carotenoids, glucosinolates and phytosterols, with known health-promoting effects through a wide range of biological activities, such as improvements in endothelial function, platelet function, blood pressure, blood lipid profile and insulin sensitivity. We know that an individual's physical/genetic makeup may influence their response to a dietary intervention, and thereby may influence the benefit/risk associated with consumption of a particular dietary constituent. This inter-individual variation in responsiveness has also been described for dietary plant bioactives but has not been explored in depth. To address this issue, the European scientific experts involved in the COST Action POSITIVe systematically analyzed data from published studies to assess the inter-individual variation in selected clinical biomarkers associated with cardiometabolic risk, in response to the consumption of plant-based bioactives (poly)phenols and phytosterols. The present review summarizes the main findings resulting from the meta-analyses already completed. RESULTS: Meta-analyses of randomized controlled trials conducted within POSITIVe suggest that age, sex, ethnicity, pathophysiological status and medication may be responsible for the heterogeneity in the biological responsiveness to (poly)phenol and phytosterol consumption and could lead to inconclusive results in some clinical trials aiming to demonstrate the health effects of specific dietary bioactive compounds. However, the contribution of these factors is not yet demonstrated consistently across all polyphenolic groups and cardiometabolic outcomes, partly due to the heterogeneity in trial designs, low granularity of data reporting, variety of food vectors and target populations, suggesting the need to implement more stringent reporting practices in the future studies. Studies investigating the effects of genetic background or gut microbiome on variability were limited and should be considered in future studies. CONCLUSION: Understanding why some bioactive plant compounds work effectively in some individuals but not, or less, in others is crucial for a full consideration of these compounds in future strategies of personalized nutrition for a better prevention of cardiometabolic disease. However, there is also still a need for the development of a substantial evidence-base to develop health strategies, food products or lifestyle solutions that embrace this variability.

Improving the reporting quality of intervention trials addressing the inter-individual variability in response to the consumption of plant bioactives: quality index and recommendations.

PURPOSE: The quality of the study design and data reporting in human trials dealing with the inter-individual variability in response to the consumption of plant bioactives is, in general, low. There is a lack of recommendations supporting the scientific community on this topic. This study aimed at developing a quality index to assist the assessment of the reporting quality of intervention trials addressing the inter-individual variability in response to plant bioactive consumption. Recommendations for better designing and reporting studies were discussed. METHODS: The selection of the parameters used for the development of the quality index was carried out in agreement with the scientific community through a survey. Parameters were defined, grouped into categories, and scored for different quality levels. The applicability of the scoring system was tested in terms of consistency and effort, and its validity was assessed by comparison with a simultaneous evaluation by experts' criteria. RESULTS: The "POSITIVe quality index" included 11 reporting criteria grouped into four categories (Statistics, Reporting, Data presentation, and Individual data availability). It was supported by detailed definitions and guidance for their scoring. The quality index score was tested, and the index demonstrated to be valid, reliable, and responsive. CONCLUSIONS: The evaluation of the reporting quality of studies addressing inter-individual variability in response to plant bioactives highlighted the aspects requiring major improvements. Specific tools and recommendations favoring a complete and transparent reporting on inter-individual variability have been provided to support the scientific community on this field.

¿Son las dietas vegetarianas nutricionalmente adecuadas? Una revisión de la evidencia científica / Are vegetarian diets nutritionally adequate? A revision of the scientific evidence

El seguimiento de dietas vegetarianas está en auge y, aunque estas se han relacionado con algunos beneficios para la salud, la baja biodisponibilidad de determinados micronutrientes en los alimentos vegetales puede resultar en riesgo de déficit nutricional, por lo que se hace necesaria una adecuada planificación de dichas dietas. En este sentido, se ha evidenciado el déficit de vitamina B12 en vegetarianos y está consensuada la necesidad de ingerir complementos de esta vitamina. La deficiencia de vitamina D puede ser más frecuente que en omnívoros, particularmente durante el invierno, cuando la síntesis cutánea es mínima. La baja biodisponibilidad del hierro, el zinc y el selenio en los alimentos vegetales puede afectar también al estado nutricional de vegetarianos. Además, las dietas vegetarianas suelen ser deficitarias en ácidos grasos poliinsaturados de la serie omega-3, eicosapentaenoico (EPA) y docosahexaenoico (DHA). Por otro lado, estas dietas sí parecen aportar cantidades adecuadas de otras vitaminas, como el ácido ascórbico, el ácido fólico y las vitaminas liposolubles A y E. En esta revisión se presentan las características de la ingesta de macro- y micronutrientes procedentes de las dietas vegetarianas y la relación dieta-salud. Se exponen, además, datos sobre el estado nutricional de adultos que consumen dichas dietas, proponiendo recomendaciones nutricionales primordiales para prevenir deficiencias. Finalmente, se presenta la posible aplicación clínica de intervenciones controladas con dietas vegetarianas

Vegetarian diets are booming and, although these diets have been linked to some health benefits, the low bioavailability of some micronutrients in plant foods may result in risk of nutritional deficiencies, which makes necessary adequate planning of these diets. In this regard, vitamin B12 deficiency in vegetarians has been evidenced and there is a consensus on the need of supplementation of this vitamin. Vitamin D deficiency may be more frequent than in omnivores, particularly during the winter, when skin synthesis is minimal. The low bioavailability of iron, zinc and selenium in vegetables can also affect nutritional status of vegetarians. Furthermore, vegetarian diets are usually deficient in polyunsaturated fatty acids of the omega-3 family, eicosapentaenoic (EPA) and docosahexaenoic (DHA) acids. On the other hand, these diets appear to provide adequate quantities of other vitamins, such as ascorbic acid, folic acid and the fat-soluble vitamins A and E. In this review, the characteristics of the intake of macro- and micronutrients of vegetarian diets and the diet and health relationships are presented. In addition, data on nutritional status of this population are also shown and suggestions on nutritional recommendations to prevent deficiencies are given. Finally, the possible clinical application of controlled interventions with vegetarian diets is presented

Association between nutrient patterns and serum lipids in Chinese adult women: A cross-sectional study.

AIM: To investigate the association between patterns of nutrient intake and serum lipids in Chinese women aged 18-80 years. METHODS: In the present study, cross-sectional data were analysed from 2886 female participants aged 18-80 years from the China Health and Nutrition Survey wave 2009. Nutrient patterns were identified using factor analysis combined with cluster analysis based on the data of nutrient intake for three consecutive days. Multivariate linear regression models were used to estimate the association of nutrient patterns with serum lipids. RESULTS: Four nutrient patterns were identified in Chinese adult women, which were the plant-based pattern, carbohydrate and animal fat pattern, plant fat and sodium pattern, and the animal-based pattern. Participants following different patterns varied significantly in sociodemographic characteristics, lifestyle behaviours and food consumption. Compared with the plant-based pattern, the carbohydrate and animal fat pattern was positively associated with low-density lipoprotein cholesterol (ß = 4.57, 95% CI: 0.29-8.85, P = 0.036) and total cholesterol (ß = 4.89, 95% CI: 0.34-9.44, P = 0.035). The corresponding rises for the animal-based pattern were 4.91 (95% CI: 0.99-8.82, P = 0.014) and 4.98 (95% CI: 0.82-9.15, P = 0.019), respectively. CONCLUSIONS: Nutrient patterns with a high intake of animal fat and a low intake dietary fibre and with high intakes of animal fat, animal protein and cholesterol may increase the serum cholesterol in Chinese women.

Past, present and future: The strength of plant-based dairy substitutes based on gluten-free raw materials.

Plant-based foods are gaining popularity and the market is developing fast. This trend is based on several factors, like the change of lifestyle, interest in alternative diets, and the increasing awareness about sustainable production of food and especially proteins. Plant-based dairy substitutes can serve as an option to traditional food products, meeting many of these interests. However, the market is in its infancy and needs to progress. Trends show, that the market will change from being focused on mainly soya, almond and rice-based products, due to their unsustainable farming, and nutritional concerns, like genetic modification and low protein content. The market is likely to shift towards alternative plants to meet consumers' needs and desire for healthy, flavourful and intriguing products. In this regard, the aspect of allergy-free, like gluten-free products gain in importance. Research studies are approaching the nutritional quality of plant-based dairy substitutes, such as improving the protein quality and glycaemic properties. Furthermore, the application of these products or plant proteins as functional ingredients or substitutes for cow's milk in dairy products like cheese and yoghurt are disseminated. However, there is still a need for much more diversified studies in order to overcome stability, textural, nutritional and sensory problems.

La Impossible Burger. La revolución de los alimentos en la UE / La Impossible Burger. La revolució dels aliments en la UE / The Impossible Burger. The food revolution in the EU

La difícil situación que atraviesa el planeta a causa, entre otros, del modelo agroalimentario actual, ha provocado que el sistema alimentario se convierta en uno de los grandes desafíos del siglo XXI y a la vez, en una nueva oportunidad económica. Empresas como Impossible Foods lideran una revolución tecnológica alimentaria. Su primer producto, la Impossible Burger, comercializado ya en los EEUU, es el objeto de esta tesina. Esta «Hamburguesa de plantas» pretende reemplazar a la hamburguesa de ternera convencional, proporcionando una experiencia sensorial idéntica o mejorada. Pero su ingrediente estrella, la heme, el cual marca la diferencia con el resto de hamburguesas vegetarianas, es la pieza clave que determinará el futuro comercial de este producto en Europa

La difícil situació del planeta a causa, entre altres factors, del model agroalimentari actual, ha provocat que el sistema alimentari es converteixi en un dels grans desafiaments del segle XXI i, alhora, en una nova oportunitat econòmica. Empreses com ara Impossible Foods lideren una revolució tecnològica alimentària. El seu primer producte, la Impossible Burger, comercialitzat ja als EUA, és l'objecte d'aquesta tesina. Aquesta «Hamburguesa de plantes» pretén substituir l'hamburguesa de vedella convencional, proporcionant una experiència sensorial idèntica o fins i tot millor. Però el seu ingredient estrella, la heme, que és el que marca la diferència amb la resta d'hamburgueses vegetarianes, és la peça clau que determinarà el futur comercial d'aquest producte a Europa

The difficult situation that the planet goes through due to the current agrifood model, among others, has caused the food system becomes one of the great challenges of the 21st century and nowadays, in a new economic opportunity. Companies like Impossible Foods lead a food technological revolution. Its first product, the Impossible Burger, already marketed in the United States, is the subject of this thesis. This «Burger of plants» aims to replace conventional beef burger, providing an identical or enhanced sensory experience. But its star ingredient, heme, which marks the difference with the rest of vegetarian burgers, is the key element which will determine the commercial prospects of this product in Europe

A New Approach to Assess Lifetime Dietary Patterns Finds Lower Consumption of Animal Foods with Aging in a Longitudinal Analysis of a Health-Oriented Adventist Population.

Life-course diet patterns may impact risk of disease, but little is known about dietary trends with aging. In a retrospective longitudinal analysis we estimated lifetime intake of animal products and adherence to vegetarian dietary patterns among 51,082 Adventist Health Study-2 (AHS-2) subjects using data from a reliable life-course dietary (meats, dairy, eggs) questionnaire. Results showed a marked tendency to consume fewer animal products (in total) in older years and to reduce consumption of meat, poultry and fish, but not eggs or dairy. Among the 29% of elderly subjects who during their lifetime kept the same dietary pattern (LTS) were: LTS-vegans (1.1%), LTS-lacto-ovo vegetarians (31.2%), LTS-pesco vegetarians (0.49%), LTS-semi vegetarians (3.7%), and LTS-non-vegetarians (63.5%). Among the 71% of switchers were "Converters" (59.7%) who moved towards and "Reverters" (9.1%) who moved away from vegetarian diets, and Multiverters (31.2%), who had moved in both directions. LTS-non-vegetarians, and also reverters, were more overweight and showed a less healthy lifestyle than others. We conclude that the dietary patterns are dynamic with strong trends to reduce animal foods and to adopt more vegetarian patterns with aging. The disease experience of subjects with different lifetime dietary patterns can be compared.

Vegan-vegetarian low-protein supplemented diets in pregnant CKD patients: fifteen years of experience.

BACKGROUND: Pregnancy in women with advanced CKD becoming increasingly common. However, experience with low-protein diets in CKD patients in pregnancy is still limited. Aim of this study is to review the results obtained over the last 15 years with moderately restricted low-protein diets in pregnant CKD women (combining: CKD stages 3-5, proteinuria: nephrotic at any time, or > =1 g/24 at start or referral; nephrotic in previous pregnancy). CKD patients on unrestricted diets were employed for comparison. STUDY PERIOD: January, 2000 to September, 2015: 36 on-diet pregnancies (31 singleton deliveries, 3 twin deliveries, 1 pregnancy termination, 1 miscarriage); 47 controls (42 singleton deliveries, 5 miscarriages). The diet is basically vegan; since occasional milk and yoghurt are allowed, we defined it vegan-vegetarian; protein intake (0.6-0.8 g/Kg/day), keto-acid supplementation, protein-unrestricted meals (1-3/week) are prescribed according to CKD stage and nutritional status. Statistical analysis was performed as implemented on SPSS. RESULTS: Patients and controls were similar (p: ns) at baseline with regard to age (33 vs 33.5), referral week (7 vs 9), kidney function (CKD 3-5: 48.4 % vs 64.3 %); prevalence of hypertension (51.6 % vs 40.5 %) and proteinuria >3 g/24 h (16.1 % vs 12.2 %). There were more diabetic nephropathies in on-diet patients (on diet: 31.0 % vs controls 5.3 %; p 0.007 (Fisher)) while lupus nephropathies were non-significantly higher in controls (on diet: 10.3 % vs controls 23.7 %; p 0.28 (Fisher)). The incidence of preterm delivery was similar (<37 weeks: on-diet singletons 77.4 %; controls: 71.4 %). The incidence of other adverse pregnancy related outcomes was non-significantly lower in on-diet patients (early preterm delivery: on diet: 32.3 % vs controls 35.7 %; birth-weight = <1.500 g: on diet: 9.7 % vs controls 23.8 %). None of the singletons in the on-diet series died, while two perinatal deaths occurred among the controls (p = 0.505). The incidence of small for gestational age (SGA <10th centile) and/or extremely preterm babies (<28th week) was significantly lower in singletons from on-diet mothers than in controls (on diet: 12.9 % vs controls: 33.3 %; p: 0.04 (Fisher)). CONCLUSION: Moderate protein restriction in the context of a vegan-vegetarian supplemented diet is confirmed as a safe option in the management of pregnant CKD patients.

What is new about diet in hepatic encephalopathy.

There is a relationship between hepatic encephalopathy (HE) protein malnutrition and muscle wasting. Muscle may play an alternative role in ammonia detoxification. Molecular mechanisms responsible for muscle depletion are under investigation. Specific nutrients may interact to reverse the molecular pathways involved in muscle wasting at an early stage. Training exercises have also been proposed to improve skeletal muscle mass. However, these data refer to small groups of patients. The amelioration of muscle mass may potentially help to prevent HE. The pathogenesis of HE is associated with modifications of the gut microbiota and diet is emerging to play a relevant role in the modulation of the gut milieu. Vegetarian and fibre-rich diets have been shown to induce beneficial changes on gut microbiota in healthy people, with reduction of Bacteroides spp., Enterobacteriaceae, and Clostridium cluster XIVa bacteria. By way of contrast, it has been suggested that a high-fat or protein diet may increase Firmicutes and reduce Bacteroidetes phylum. Milk-lysozyme and milk-oligosaccharides have also been proposed to induce a "healthy" microbiota. At present, no studies have been published describing the modification of the gut microbiota in cirrhotic patients with HE as a response to specific diets. New research is needed to evaluate the potentiality of foods in the modulation of gut microbiota in liver disease and HE.