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1.
Philos Trans R Soc Lond B Biol Sci ; 376(1831): 20200229, 2021 08 16.
Article in English | MEDLINE | ID: mdl-34176328

ABSTRACT

Animal-borne tags (biologgers) have now become extremely sophisticated, recording data from multiple sensors at high frequencies for long periods and, as such, have become a powerful tool for behavioural ecologists and physiologists studying wild animals. But the design and implementation of these tags is not trivial because engineers have to maximize performance and ability to function under onerous conditions while minimizing tag mass and volume (footprint) to maximize the wellbeing of the animal carriers. We present some of the major issues faced by tag engineers and show how tag designers must accept compromises while maintaining systems that can answer the questions being posed. We also argue that basic understanding of engineering issues in tag design by biologists will help feedback to engineers to better tag construction but also reduce the likelihood that tag-deploying biologists will misunderstand their own results. Finally, we suggest that proper consideration of conventional technology together with new approaches will lead to further step changes in our understanding of wild-animal biology using smart tags. This article is part of the theme issue 'Measuring physiology in free-living animals (Part II)'.


Subject(s)
Physiology/instrumentation , Vertebrates/physiology , Animals , Animals, Wild/physiology , Engineering/instrumentation , Technology/instrumentation
2.
Philos Trans R Soc Lond B Biol Sci ; 376(1830): 20200217, 2021 08 02.
Article in English | MEDLINE | ID: mdl-34121460

ABSTRACT

The latest technologies associated with implantable physiological monitoring devices can record multiple channels of data (including: heart rates and rhythms, activity, temperature, impedance and posture), and coupled with powerful software applications, have provided novel insights into the physiology of animals in the wild. This perspective details past challenges and lessons learned from the uses and developments of implanted biologgers designed for human clinical application in our research on free-ranging American black bears (Ursus americanus). In addition, we reference other research by colleagues and collaborators who have leveraged these devices in their work, including: brown bears (Ursus arctos), grey wolves (Canis lupus), moose (Alces alces), maned wolves (Chrysocyon brachyurus) and southern elephant seals (Mirounga leonina). We also discuss the potentials for applications of such devices across a range of other species. To date, the devices described have been used in fifteen different wild species, with publications pending in many instances. We have focused our physiological research on the analyses of heart rates and rhythms and thus special attention will be paid to this topic. We then discuss some major expected step changes such as improvements in sensing algorithms, data storage, and the incorporation of next-generation short-range wireless telemetry. The latter provides new avenues for data transfer, and when combined with cloud-based computing, it not only provides means for big data storage but also the ability to readily leverage high-performance computing platforms using artificial intelligence and machine learning algorithms. These advances will dramatically increase both data quantity and quality and will facilitate the development of automated recognition of extreme physiological events or key behaviours of interest in a broad array of environments, thus further aiding wildlife monitoring and management. This article is part of the theme issue 'Measuring physiology in free-living animals (Part I)'.


Subject(s)
Caniformia/physiology , Engineering/instrumentation , Heart Function Tests/veterinary , Physiology/instrumentation , Animals , Heart Function Tests/instrumentation , Monitoring, Ambulatory/instrumentation , Monitoring, Ambulatory/veterinary
3.
Nat Mater ; 20(8): 1149-1155, 2021 08.
Article in English | MEDLINE | ID: mdl-33875849

ABSTRACT

Leveraging the motion and force of individual molecular motors in a controlled manner to perform macroscopic tasks can provide substantial benefits to many applications, including robotics. Nonetheless, although millimetre-scale movement has been demonstrated with synthetic and biological molecular motors, their efficient integration into engineered systems that perform macroscopic tasks remains challenging. Here, we describe an active network capable of macroscopic actuation that is hierarchically assembled from an engineered kinesin, a biomolecular motor, and microtubules, resembling the contractile units in muscles. These contracting materials can be formed in desired areas using patterned ultraviolet illumination, allowing their incorporation into mechanically engineered systems, being also compatible with printing technologies. Due to the designed filamentous assembly of kinesins, the generated forces reach the micronewton range, enabling actuation of millimetre-scale mechanical components. These properties may be useful for the fabrication of soft robotic systems with advanced functionalities.


Subject(s)
Engineering/instrumentation , Kinesins/metabolism , Printing, Three-Dimensional , Microtubules/metabolism , Robotics
4.
PLoS One ; 15(3): e0229825, 2020.
Article in English | MEDLINE | ID: mdl-32142534

ABSTRACT

Organizations that develop or operate complex engineering systems are plagued by systems engineering failures like schedule overruns, budget exceedances, and project cancellations. Unfortunately, there is not much actionable guidance on why these failures happen or how to prevent them. Our approach contains two novel aspects. First, we argue that system accidents and other failures in systems engineering are manifestations of similar underlying problems. Therefore, we can leverage the literature on accident causation and the many publicly available accident investigation reports to better understand how and why failures in systems engineering occur, and to identify ways of preventing them. Second, to address the lack of concrete guidance on identifying and preventing incipient failures, we provide specific examples of each type of failure cause and of the recommendations for preventing these causes. We analyzed a set of 30 accidents and 33 project failures, spanning a range of industries, and found 23 different failure causes, most of which appear in both accidents and other project failures, suggesting that accidents and project failures do happen in similar was. We also identified 16 different recommended remedial actions. We link these causes and recommendations in a cause-recommendation network, and associate over 900 specific examples of how these causes manifested in failures, and over 600 specific examples of the associated recommended remedial actions, with each cause or recommendation.


Subject(s)
Accident Prevention , Accidents, Occupational/prevention & control , Data Analysis , Engineering/instrumentation , Industry/instrumentation , Root Cause Analysis/methods , Datasets as Topic , Humans
6.
PLoS One ; 14(1): e0211312, 2019.
Article in English | MEDLINE | ID: mdl-30682145

ABSTRACT

A geotextile mattress with sloping curtain is a newly proposed countermeasure against river and estuarine scour. In previous laboratory experiments, a geotextile mattress with sloping curtain was capable of protecting the bed downstream from scour and stimulating sediment deposition on both sides. However, the seepage scour under its geotextile mattress is inadequately researched at present. In this study, the Geotextile Mattress with Sloping Plate (GMSP) is proposed based on the simplification of the geotextile mattress with sloping curtain with the construction feasibility considered. A series of experiments was conducted to investigate the pressure distribution around the GMSP and the averaged seepage hydraulic gradient beneath its mattress. The results indicate remarkable pressure difference on two sides of the GMSP. The minimum bed pressure appears about 1.3 times the plate height downstream to the GMSP. The averaged seepage hydraulic gradient beneath the mattress increases with the sloping angle increasing from 35° to 60° in general. The averaged hydraulic gradient also ascends as the relative plate height increases, but reduces as the opening ratio increases at opening ratios greater than 0.143. The safety boundary for the averaged hydraulic gradient under the geotextile mattress of the GMSP could get much smaller than the critical hydraulic gradient of piping and can easily be overwhelmed. This phenomenon can mainly be attributed to the discontinuous contact between the mattress and the seabed. A suggestion for the parametric design of the GMSP is to extend the width of the mattress to reduce the risk of seepage failure.


Subject(s)
Engineering/instrumentation , China , Engineering/methods , Equipment Design , Hydrodynamics , Materials Testing , Rivers
7.
Transl Behav Med ; 9(4): 810-818, 2019 07 16.
Article in English | MEDLINE | ID: mdl-30099555

ABSTRACT

Within the behavioral field, a plethora of conceptual frameworks and tools have been developed to improve transition from efficacy to effectiveness trials; however, they are limited in their ability to support new, iterative intervention design decision-making methodologies beyond traditional randomized controlled trial design. Emerging theories suggest that researchers should employ engineering based user-centered design (UCD) methods to support more iterative intervention design decision-making in the behavioral field. We present, an adaptation of a UCD tool used in the engineering field-the Quality Function Deployment "House of Quality" correlation matrix, to support iterative intervention design decision-making and documentation for multicomponent behavioral interventions and factorial trial designs. We provide a detailed description of the adapted tool-"House of Quality for Behavioral Science", and a step-by-step use-case scenario to demonstrate the early identification of intervention flaws and prioritization of requirements. Four intervention design flaws were identified via the tool application. Completion of the relationship correlation matrix increased requirement ranking variance for the researcher (σ2 = 0.47 to 7.19) and participant (σ2 = 0.56 to 3.89) perspective. Requirement prioritization (ranking) was facilitated by factoring in the strength of the correlation between each perspective and corresponding importance. A correlational matrix tool such as the "House of Quality for Behavioral Science" may provide a structured, UCD approach that balances researcher and participant needs and identifies design flaws for pragmatic behavioral intervention design. This tool may support iterative design decision-making for multicomponent and factorial trial designs.


Subject(s)
Behavior Therapy/instrumentation , Behavioral Sciences/instrumentation , Decision Making/physiology , Behavior Therapy/methods , Engineering/instrumentation , Humans , Implementation Science , Pragmatic Clinical Trials as Topic/methods , Quality Control , Randomized Controlled Trials as Topic , Research Design , Translational Research, Biomedical/instrumentation
8.
PLoS One ; 13(6): e0198677, 2018.
Article in English | MEDLINE | ID: mdl-29944661

ABSTRACT

In order to solve the problem of Meshing Efficiency of spur-face gear sliding friction, a method for calculating the Meshing Efficiency of Spur-Face gear is proposed based on Elastohydrodynamic lubrication (EHL) theory. Through the Tooth Contact Analysis (TCA) and Loaded Tooth Contact Analysis technique (LTCA) method, the meshing process of the Spur-Face gear was simulated. The calculation model of Sliding friction coefficient was established by using non Newtonian quasi steady thermal Elastohydrodynamic lubrication (TEHL) theory, and the calculation model of Meshing Efficiency of Spur-Face gear was established. The influence of input torque and rotational speed on Meshing Efficiency is analyzed. The results show that Sliding friction coefficient is an important factor affecting the Meshing Efficiency of gears. Sliding friction coefficient is not the same at different positions of the tooth surface. Sliding friction coefficient is affected by input speed and input torque. This method provides a theoretical basis for further optimization calculation of Spur-Face gear.


Subject(s)
Engineering/methods , Friction , Algorithms , Computer Simulation , Elasticity , Engineering/instrumentation , Humans , Hydrodynamics , Lubrication , Models, Chemical
9.
PLoS One ; 12(2): e0171037, 2017.
Article in English | MEDLINE | ID: mdl-28182692

ABSTRACT

This paper proposed a method to update the on-line health reference baseline of the On-Board Engine Model (OBEM) to maintain the effectiveness of an in-flight aircraft sensor Fault Detection and Isolation (FDI) system, in which a Hybrid Kalman Filter (HKF) was incorporated. Generated from a rapid in-flight engine degradation, a large health condition mismatch between the engine and the OBEM can corrupt the performance of the FDI. Therefore, it is necessary to update the OBEM online when a rapid degradation occurs, but the FDI system will lose estimation accuracy if the estimation and update are running simultaneously. To solve this problem, the health reference baseline for a nonlinear OBEM was updated using the proposed channel controller method. Simulations based on the turbojet engine Linear-Parameter Varying (LPV) model demonstrated the effectiveness of the proposed FDI system in the presence of substantial degradation, and the channel controller can ensure that the update process finishes without interference from a single sensor fault.


Subject(s)
Aircraft/standards , Engineering/instrumentation , Engineering/methods , Internet/instrumentation
10.
Lab Chip ; 16(21): 4063-4081, 2016 10 18.
Article in English | MEDLINE | ID: mdl-27605305

ABSTRACT

More than 90% of cancer-related deaths can be attributed to the occurrence of metastatic diseases. Recent studies have highlighted the importance of the multicellular, biochemical and biophysical stimuli from the tumor microenvironment during carcinogenesis, treatment failure, and metastasis. Therefore, there is a need for experimental platforms that are able to recapitulate the complex pathophysiological features of the metastatic microenvironment. Recent advancements in biomaterials, microfluidics, and tissue engineering have led to the development of living multicellular microculture systems, which are maintained in controllable microenvironments and function with organ level complexity. The applications of these "on-chip" technologies for detection, separation, characterization and three dimensional (3D) propagation of cancer cells have been extensively reviewed in previous works. In this contribution, we focus on integrative microengineered platforms that allow the study of multiple aspects of the metastatic microenvironment, including the physicochemical cues from the tumor associated stroma, the heterocellular interactions that drive trans-endothelial migration and angiogenesis, the environmental stresses that metastatic cancer cells encounter during migration, and the physicochemical gradients that direct cell motility and invasion. We discuss the application of these systems as in vitro assays to elucidate fundamental mechanisms of cancer metastasis, as well as their use as human relevant platforms for drug screening in biomimetic microenvironments. We then conclude with our commentaries on current progress and future perspectives of microengineered systems for fundamental and translational cancer research.


Subject(s)
Engineering/instrumentation , Lab-On-A-Chip Devices , Microtechnology/instrumentation , Neoplasms/pathology , Tumor Microenvironment , Animals , Humans , Neoplasm Metastasis
11.
Water Res ; 93: 205-213, 2016 Apr 15.
Article in English | MEDLINE | ID: mdl-26905799

ABSTRACT

Reducing the energy consumption of membrane bioreactors (MBRs) is highly important for their wider application in wastewater treatment engineering. Of particular significance is reducing aeration in aerobic tanks to reduce the overall energy consumption. This study proposed an in situ ammonia-N-based feedback control strategy for aeration in aerobic tanks; this was tested via model simulation and through a large-scale (50,000 m(3)/d) engineering application. A full-scale MBR model was developed based on the activated sludge model (ASM) and was calibrated to the actual MBR. The aeration control strategy took the form of a two-step cascaded proportion-integration (PI) feedback algorithm. Algorithmic parameters were optimized via model simulation. The strategy achieved real-time adjustment of aeration amounts based on feedback from effluent quality (i.e., ammonia-N). The effectiveness of the strategy was evaluated through both the model platform and the full-scale engineering application. In the former, the aeration flow rate was reduced by 15-20%. In the engineering application, the aeration flow rate was reduced by 20%, and overall specific energy consumption correspondingly reduced by 4% to 0.45 kWh/m(3)-effluent, using the present practice of regulating the angle of guide vanes of fixed-frequency blowers. Potential energy savings are expected to be higher for MBRs with variable-frequency blowers. This study indicated that the ammonia-N-based aeration control strategy holds promise for application in full-scale MBRs.


Subject(s)
Bioreactors , Membranes, Artificial , Waste Disposal, Fluid/methods , Water Purification/methods , Air , Algorithms , Ammonia/chemistry , Ammonia/metabolism , Computer Simulation , Engineering/instrumentation , Engineering/methods , Models, Theoretical , Oxygen/metabolism , Waste Disposal, Fluid/instrumentation , Water Purification/instrumentation
12.
Sensors (Basel) ; 16(1)2016 Jan 20.
Article in English | MEDLINE | ID: mdl-26805833

ABSTRACT

To realize site-specific and variable-rate application of agricultural pesticides, accurately metering and controlling the chemical injection rate is necessary. This study presents a prototype of a direct nozzle injection system (DNIS) by which chemical concentration transport lag was greatly reduced. In this system, a rapid-reacting solenoid valve (RRV) was utilized for injecting chemicals, driven by a pulse-width modulation (PWM) signal at 100 Hz, so with varying pulse width the chemical injection rate could be adjusted. Meanwhile, a closed-loop control strategy, proportional-integral-derivative (PID) method, was applied for metering and stabilizing the chemical injection rate. In order to measure chemical flow rates and input them into the controller as a feedback in real-time, a thermodynamic flowmeter that was independent of chemical viscosity was used. Laboratory tests were conducted to assess the performance of DNIS and PID control strategy. Due to the nonlinear input-output characteristics of the RRV, a two-phase PID control process obtained better effects as compared with single PID control strategy. Test results also indicated that the set-point chemical flow rate could be achieved within less than 4 s, and the output stability was improved compared to the case without control strategy.


Subject(s)
Agriculture/instrumentation , Agriculture/methods , Agrochemicals , Engineering/instrumentation , Pesticides , Equipment Design , Thermodynamics , Viscosity
13.
PLoS One ; 10(11): e0143300, 2015.
Article in English | MEDLINE | ID: mdl-26588840

ABSTRACT

The effects of exposed pipe encasements on the local variation of hydrodynamic and sediment conditions in a river channel are examined. Laboratory experiments are performed to assess the response of water level, flow regime and bed deformation to several representative types of concrete encasements. The experimental conditions considered are: three types of exposed pipe encasements exposed on the bed, including trapezoidal shape, circular-arc shape and polygonal shape, and three sets of discharges, including annual discharge, once-in-3-year flood, and once-in-50-year flood. Our experiments show that: (1) the amount of backwater definitely depends on the encasement geometric shape and the background discharge; (2) smaller discharges generally tend to induce local scour of river bed downstream of the encasement, and the order of sensitivity of bed deformation to the encasement geometric shape is trapezoidal > circular-arc > polygonal; (3) comparatively speaking, the polygonal encasement may be considered as a suitable protective structure for pipelines across alluvial rivers, with relatively modest effects on the local hydrodynamic conditions and bed stabilization.


Subject(s)
Engineering/instrumentation , Floods , Hydrodynamics , Models, Statistical , Water Movements , Construction Materials , Geologic Sediments , Humans , Rivers
14.
PLoS One ; 9(8): e103937, 2014.
Article in English | MEDLINE | ID: mdl-25111800

ABSTRACT

For reliability testing an Energy Expansion Tree (EET) and a companion Energy Function Model (EFM) are proposed and described in this paper. Different from conventional approaches, the EET provides a more comprehensive and objective way to systematically identify external energy factors affecting reliability. The EFM introduces energy loss into a traditional Function Model to identify internal energy sources affecting reliability. The combination creates a sound way to enumerate the energies to which a system may be exposed during its lifetime. We input these energies into planning an accelerated life test, a Multi Environment Over Stress Test. The test objective is to discover weak links and interactions among the system and the energies to which it is exposed, and design them out. As an example, the methods are applied to the pipe in subsea pipeline. However, they can be widely used in other civil engineering industries as well. The proposed method is compared with current methods.


Subject(s)
Engineering/methods , Engineering/instrumentation , Equipment Failure , Models, Theoretical , Reproducibility of Results , Risk Factors , Stress, Mechanical , Time Factors
15.
Sensors (Basel) ; 14(8): 13556-91, 2014 Jul 25.
Article in English | MEDLINE | ID: mdl-25068865

ABSTRACT

Digital Musical Instruments (DMIs) are musical instruments typically composed of a control surface where user interaction is measured by sensors whose values are mapped to sound synthesis algorithms. These instruments have gained interest among skilled musicians and performers in the last decades leading to artistic practices including musical performance, interactive installations and dance. The creation of DMIs typically involves several areas, among them: arts, design and engineering. The balance between these areas is an essential task in DMI design so that the resulting instruments are aesthetically appealing, robust, and allow responsive, accurate and repeatable sensing. In this paper, we review the use of sensors in the DMI community as manifested in the proceedings of the International Conference on New Interfaces for Musical Expression (NIME 2009-2013). Focusing on the sensor technologies and signal conditioning techniques used by the NIME community. Although it has been claimed that specifications for artistic tools are harder than those for military applications, this study raises a paradox showing that in most of the cases, DMIs are based on a few basic sensors types and unsophisticated engineering solutions, not taking advantage of more advanced sensing, instrumentation and signal processing techniques that could dramatically improve their response. We aim to raise awareness of limitations of any engineering solution and to assert the benefits of advanced electronics instrumentation design in DMIs. For this, we propose the use of specialized sensors such as strain gages, advanced conditioning circuits and signal processing tools such as sensor fusion. We believe that careful electronic instrumentation design may lead to more responsive instruments.


Subject(s)
Electrical Equipment and Supplies , Engineering/instrumentation , Humans , Music
16.
Sensors (Basel) ; 14(8): 13661-78, 2014 Jul 29.
Article in English | MEDLINE | ID: mdl-25076218

ABSTRACT

In order to improve the accuracy and reliability of micro-electro mechanical systems (MEMS) navigation systems, an orthogonal rotation method-based nine-gyro redundant MEMS configuration is presented. By analyzing the accuracy and reliability characteristics of an inertial navigation system (INS), criteria for redundant configuration design are introduced. Then the orthogonal rotation configuration is formed through a two-rotation of a set of orthogonal inertial sensors around a space vector. A feasible installation method is given for the real engineering realization of this proposed configuration. The performances of the novel configuration and another six configurations are comprehensively compared and analyzed. Simulation and experimentation are also conducted, and the results show that the orthogonal rotation configuration has the best reliability, accuracy and fault detection and isolation (FDI) performance when the number of gyros is nine.


Subject(s)
Geographic Information Systems/instrumentation , Micro-Electrical-Mechanical Systems/instrumentation , Algorithms , Engineering/instrumentation , Equipment Design/instrumentation , Reproducibility of Results , Rotation , Systems Integration
18.
Nat Commun ; 5: 3435, 2014 Mar 19.
Article in English | MEDLINE | ID: mdl-24647049

ABSTRACT

Controlling thermal transport has become relevant in recent years. Traditionally, this control has been achieved by tuning the scattering of phonons by including various types of scattering centres in the material (nanoparticles, impurities, etc). Here we take another approach and demonstrate that one can also use coherent band structure effects to control phonon thermal conductance, with the help of periodically nanostructured phononic crystals. We perform the experiments at low temperatures below 1 K, which not only leads to negligible bulk phonon scattering, but also increases the wavelength of the dominant thermal phonons by more than two orders of magnitude compared to room temperature. Thus, phononic crystals with lattice constants ≥1 µm are shown to strongly reduce the thermal conduction. The observed effect is in quantitative agreement with the theoretical calculation presented, which accurately determined the ballistic thermal conductance in a phononic crystal device.


Subject(s)
Models, Chemical , Models, Molecular , Nanoparticles/chemistry , Phonons , Thermal Conductivity , Algorithms , Computer Simulation , Engineering/instrumentation , Engineering/methods , Nanotechnology/instrumentation , Nanotechnology/methods , Temperature
19.
Anal Chem ; 86(3): 1837-44, 2014 Feb 04.
Article in English | MEDLINE | ID: mdl-24417182

ABSTRACT

In this study, we report about the structural engineering and optical optimization of nanoporous anodic alumina rugate filters (NAA-RFs) for real-time and label-free biosensing applications. Structurally engineered NAA-RFs are combined with reflection spectroscopy (RfS) in order to develop a biosensing system based on the position shift of the characteristic peak in the reflection spectrum of NAA-RFs (Δλpeak). This system is optimized and assessed by measuring shifts in the characteristic peak position produced by small changes in the effective medium (i.e., refractive index). To this end, NAA-RFs are filled with different solutions of d-glucose, and the Δλpeak is measured in real time by RfS. These results are validated by a theoretical model (i.e., the Looyenga-Landau-Lifshitz model), demonstrating that the control over the nanoporous structure makes it possible to optimize optical signals in RfS for sensing purposes. The linear range of these optical sensors ranges from 0.01 to 1.00 M, with a low detection limit of 0.01 M of d-glucose (i.e., 1.80 ppm), a sensitivity of 4.93 nm M(-1) (i.e., 164 nm per refractive index units), and a linearity of 0.998. This proof-of-concept study demonstrates that the proposed system combining NAA-RFs with RfS has outstanding capabilities to develop ultrasensitive, portable, and cost-competitive optical sensors.


Subject(s)
Aluminum Oxide/chemistry , Biosensing Techniques/instrumentation , Engineering/instrumentation , Filtration/instrumentation , Nanotechnology/instrumentation , Optical Phenomena , Biosensing Techniques/economics , Cost-Benefit Analysis , Electrodes , Porosity , Time Factors
20.
Assist Technol ; 26(4): 196-201, 2014.
Article in English | MEDLINE | ID: mdl-25771604

ABSTRACT

An engineering drawing provides manufacturing information to a machine operator. An operator plans and executes machining operations based on this information. A visually impaired (VI) operator does not have direct access to the drawings. Drawing information is provided to them verbally or by using sample parts. Both methods have limitations that affect the quality of output. Use of engineering drawings is a standard practice for every industry; this hampers employment of a VI operator. Accessible engineering drawings are required to increase both independence, as well as, employability of VI operators. Today, Computer Aided Design (CAD) software is used for making engineering drawings, which are saved in CAD files. Required information is extracted from the CAD files and converted into Braille or voice. The authors of this article propose a method to make engineering drawings information directly accessible to a VI operator.


Subject(s)
Computer-Aided Design/instrumentation , Engineering/instrumentation , Occupational Health , Self-Help Devices , Software , Visually Impaired Persons , Humans
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