Determination of threshold values and heavy metal pollution assessment of soils in an industrial area in Ghana.

Industrial activities have the potential to pollute soils with a wide variety of heavy metals (HMs). In Ghana, however, assessment of HM pollution of soils in industrial areas remains limited. Accordingly, HM soil pollution in one of the industrial areas in Accra, Ghana was assessed. Soil samples were taken and analysed for HMs, including Fe, Zr, Zn, Ti, Sr, Rb, Mn, Pb, Cu, and Co, using X-Ray Fluorescence (XRF). HM geochemical threshold values (GTVs) were determined to establish soil HM pollution levels and identify areas needing remediation. Furthermore, risk assessments were conducted to evaluate the potential ecological and human health risks associated with these metals. The mean concentrations of Fe, Zn, Rb, Sr, Zr, Ti, Mn, Co, Cu, and Pb in the soils were: 27133.83, 147.72, 16.30, 95.95, 307.11, 4663.66, 289.85, 418.54, 44.97, and 112.88 mg/kg, respectively. Generally, the concentrations of HMs decreased with depth, although some lower layers exhibited elevated HM levels. Soil pollution levels were categorized as low for Fe, Rb, Zr, Ti, Mn, Co, and Cu; moderate for Sr and Zn; and considerable for Pb. Notably, the northwestern part of the study area displayed a considerable to very high degree of HM contamination. While HMs in the soils posed low ecological risk, the human health risk assessment indicated potential health effects from Co, particularly in children. The presence of HMs in the soils was noted to originate from both natural geological phenomena and human activities, including industrial operations, agricultural practices, landfill activities, and vehicular emissions.

Associations between plasma metabolites and heavy metal exposure in residents of environmentally polluted areas.

Heavy metals are commonly released into the environment through industrial processes such as mining and refining. The rapid industrialization that occurred in South Korea during the 1960s and 1970s contributed significantly to the economy of the country; however, the associated mining and refining led to considerable environmental pollution, and although mining is now in decline in South Korea, the detrimental effects on residents inhabiting the surrounding areas remain. The bioaccumulation of toxic heavy metals leads to metabolic alterations in human homeostasis, with disruptions in this balance leading to various health issues. This study used metabolomics to explore metabolomic alterations in the plasma samples of residents living in mining and refining areas. The results showed significant increases in metabolites involved in glycolysis and the surrounding metabolic pathways, such as glucose-6-phosphate, phosphoenolpyruvate, lactate, and inosine monophosphate, in those inhabiting polluted areas. An investigation of the associations between metabolites and blood clinical parameters through meet-in-the-middle analysis indicated that female residents were more affected by heavy metal exposure, resulting in more metabolomic alterations. For women, inhabiting the abandoned mine area, metabolites in the glycolysis and pentose phosphate pathways, such as ribose-5-phosphate and 3-phosphoglycerate, have shown a negative correlation with albumin and calcium. Finally, Mendelian randomization(MR) was used to determine the causal effects of these heavy metal exposure-related metabolites on heavy metal exposure-related clinical parameters. Metabolite biomarkers could provide insights into altered metabolic pathways related to exposure to toxic heavy metals and improve our understanding of the molecular mechanisms underlying the health effects of toxic heavy metal exposure.

Sustainable struggling: decoding microplastic released from bioplastics-a critical review.

This comprehensive review delves into the complex issue of plastic pollution, focusing on the emergence of biodegradable plastics (BDPs) as a potential alternative to traditional plastics. While BDPs seem promising, recent findings reveal that a large number of BDPs do not fully degrade in certain natural conditions, and they often break down into microplastics (MPs) even faster than conventional plastics. Surprisingly, research suggests that biodegradable microplastics (BDMPs) could have more significant and long-lasting effects than petroleum-based MPs in certain environments. Thus, it is crucial to carefully assess the ecological consequences of BDPs before widely adopting them commercially. This review thoroughly examines the formation of MPs from prominent BDPs, their impacts on the environment, and adsorption capacities. Additionally, it explores how BDMPs affect different species, such as plants and animals within a particular ecosystem. Overall, these discussions highlight potential ecological threats posed by BDMPs and emphasize the need for further scientific investigation before considering BDPs as a perfect solution to plastic pollution.

Environmental pollution and human health risk due to tailings storage facilities in China.

Tailings storage facilities (TSFs) represent an anthropogenic source of pollution, resulting in potential risks to both environmental integrity and human health. To date, the environmental and human health risks from TSFs in China have been under-researched. This study attempts to address this gap by developing, and geo-statistically analyzing two comprehensive databases. The first database (I) focuses on failed TSFs; we supply the statistics of environmental damages from 143 TSF failure incidents. Notably, approximately 75 % of the failure incidents involved tailings flows released into water bodies, resulting in a significant exacerbation of environmental pollution. To better inform ecological and human health risks, we present another database (II) for 147 non-failed TSFs to investigate the soil heavy metal contamination, considering 8 heavy metals. The findings reveal that (i) Cd, Pb, and Hg are the prominent pollutants across the non-failed TSF sites in China; (ii) lead­zinc and tungsten mine tailings storage sites exhibit the most severe pollution; (iii) Pb, Cd, and Ni present noteworthy non-carcinogenic risks to human health; (iv) >85 % of TSF sites pose carcinogenic risks associated with arsenic; and (v) health risks resulting from dermal absorption surpass ingestion for the majority of heavy metals, with the exception of Pb, where ingestion presents a more pronounced route of exposure. Our study presents a comprehensive evaluation of environmental and human health risks due to TSFs, highlighting the necessity for risk assessment of >14,000 existing TSFs in China.

Designing a circular carbon and plastics economy for a sustainable future.

The linear production and consumption of plastics today is unsustainable. It creates large amounts of unnecessary and mismanaged waste, pollution and carbon dioxide emissions, undermining global climate targets and the Sustainable Development Goals. This Perspective provides an integrated technological, economic and legal view on how to deliver a circular carbon and plastics economy that minimizes carbon dioxide emissions. Different pathways that maximize recirculation of carbon (dioxide) between plastics waste and feedstocks are outlined, including mechanical, chemical and biological recycling, and those involving the use of biomass and carbon dioxide. Four future scenarios are described, only one of which achieves sufficient greenhouse gas savings in line with global climate targets. Such a bold system change requires 50% reduction in future plastic demand, complete phase-out of fossil-derived plastics, 95% recycling rates of retrievable plastics and use of renewable energy. It is hard to overstate the challenge of achieving this goal. We therefore present a roadmap outlining the scale and timing of the economic and legal interventions that could possibly support this. Assessing the service lifespan and recoverability of plastic products, along with considerations of sufficiency and smart design, can moreover provide design principles to guide future manufacturing, use and disposal of plastics.

Metal mixture exposure and the risk for immunoglobulin A nephropathy: Evidence from weighted quantile sum regression.

Immunoglobulin A nephropathy (IgAN) is the most common type of glomerulonephritis in adults worldwide. Environmental metal exposure has been reported to be involved in the pathogenic mechanisms of kidney diseases, yet no further epidemiological study has been conducted to assess the effects of metal mixture exposure on IgAN risk. In this study, we conducted a matched case‒control design with three controls for each patient to investigate the association between metal mixture exposure and IgAN risk. A total of 160 IgAN patients and 480 healthy controls were matched for age and sex. Plasma levels of arsenic, lead, chromium, manganese, cobalt, copper, zinc, and vanadium were measured using inductively coupled plasma mass spectrometry. We used a conditional logistic regression model to assess the association between individual metals and IgAN risk, and a weighted quantile sum (WQS) regression model to analyze the effects of metal mixtures on IgAN risk. Restricted cubic splines were used to evaluate overall associations between plasma metal concentrations and estimated glomerular filtration rate (eGFR) levels. We observed that except for Cu, all the metals analyzed were nonlinearly associated with decreased eGFR, and higher concentrations of arsenic and lead were associated with elevated IgAN risk in both single-metal [3.29 (1.94, 5.57), 6.10 (3.39, 11.0), respectively] and multiple-metal [3.04 (1.66, 5.57), 4.70 (2.47, 8.97), respectively] models. Elevated manganese [1.76 (1.09, 2.83)] levels were associated with increased IgAN risk in the single-metal model. Copper was inversely related to IgAN risk in both single-metal [0.392 (0.238, 0.645)] and multiple-metal [0.357 (0.200, 0.638)] models. The WQS indices in both positive [2.04 (1.68, 2.47)] and negative [0.717 (0.603, 0.852)] directions were associated with IgAN risk. Lead, arsenic, and vanadium contributed significant weights (0.594, 0.195, and 0.191, respectively) in the positive direction; copper, cobalt, and chromium carried significant weights (0.538, 0.253, and 0.209, respectively). In conclusion, metal exposure was related to IgAN risk. Lead, arsenic, and copper were all significantly weighted factors of IgAN development, which may require further investigation.

A case study of environmental pollution by pathogenic bacteria and metal(oid)s at Soran Landfill Site, Erbil, Iraqi Kurdistan Region.

Environmental pollution is a serious issue all around the world, especially when it is caused by metal(oid)s and pathogenic microorganisms. This study reports here for the first time on the contamination of soil and water with metal(oid)s and pathogenic bacteria directly resulting from the Soran Landfill Site. Soran landfill is a level 2 solid waste disposal site that lacks leachate collection infrastructure. The site is potentially an environmental and public hazard caused by metal(oid)s content and significantly dangerous pathogenic microorganisms through leachate release into the soil and nearby river. This study reports on the levels of the metal(oid)s content of As, Cd, Co, Cr, Cu, Mn, Mo, Pb, Zn, and Ni obtained by inductively coupled plasma mass spectrometer in soil, leachate stream mud, and leachate samples. Five pollution indices are used to assess potential environmental risks. According to the indices, Cd and Pb contamination is significant, whereas As, Cu, Mn, Mo, and Zn pollution is moderate. A total of 32 isolates of bacteria were defined from soil, leachate stream mud, and liquid leachate samples: 18, 9, and 5, respectively. Moreover, 16 s rRNA analysis suggested that the isolates belong to three enteric bacterial phyla of Proteobacteria, Actinobacteria, and Firmicutes. The closest GenBank matches of 16S rDNA sequences indicated the presence of the genera: Pseudomonas, Bacillus, Lysinibacillus, Exiguobacterium, Trichococcus, Providencia, Enterococcus, Macrococcus, Serratia, Salinicoccus, Proteus, Rhodococcus, Brevibacterium, Shigella, Micrococcus, Morganella, Corynebacterium, Escherichia, and Acinetobacter. The identity percentage was mostly between 95%-100%. The results of this study show the levels of microbiological and geochemical contamination of soils, surface and potentially ground water with harmful microorganisms and toxic metal(oid)s originating specifically from Soran landfill leachate which subsequently incorporated into the surrounding environment, creating thus a considerable health and environmental risk.

Spatial and temporal distribution characteristics of typical pollution loads based on SWAT model across Tuojiang River watershed located in Sichuan Province, Southwest of China.

Tuojiang River watershed is an economically developed and densely populated area in Sichuan Province (southwest of China), which is also an important tributary of the Yangtze River. Nitrogen (N) and phosphorus (P) are the main pollutants affecting water quality, but there is still lack of study on the spatial and temporal distribution characteristics of these two pollutants. In this study, the typical non-point source pollution loads in the Tuojiang River watershed are simulated by Soil and Water Assessment Tool (SWAT) model, and the spatial autocorrelation method is used to reveal the spatial and temporal distribution characteristics of the pollution loads from the annual average and water periods. Combined with redundancy analysis (RDA) and geographically weighted regression (GWR) analysis, the main driving factors affecting the typical non-point source pollution loads in the Tuojiang River watershed are discussed from the global and local perspectives. The results show that (1) from different water periods, the pollution loads of total nitrogen (TN) and total phosphorus (TP) in three water periods show obviously different, is the highest in the abundant water period, with 323.4 kg/ha and 47.9 kg/ha, followed by the normal water period, with 95.7 kg/ha and 14.1 kg/ha, and the lowest in the dry water period, with 28.4 kg/ha and 4.2 kg/ha. The annual average value of TN pollution load is higher than that of TP, with 447.5 kg/ha and 66.1 kg/ha, respectively; (2) the TN and TP pollution loads are stable on the whole, and the overall level in the middle reaches is higher. The pollution loads of Shifang City and Mianzhu City are higher in all three water periods. (3) Elevation and slope are two main driving factors affecting the TN and TP pollution loads in the Tuojiang River watershed. Therefore, the visualization and quantification of temporal and spatial distribution characteristics of typical non-point source pollution loads in the Tuojiang River watershed are helpful to provide the basis for scientific prevention and control of pollution in the Tuojiang River watershed and are of great significance to promote the sustainable, coordinated, and healthy development of water environment and economy in the watershed.

Health risk assessment and bioaccumulation of potentially toxic metals from water, soil, and forages near coal mines of district Chakwal, Punjab, Pakistan.

Water, forages, and soil contamination with potentially toxic metals (PTMs) through anthropogenic activities has become a significant environmental concern. It is crucial to find out the level of PTMs in water, soil, and forages near industrial areas. The PTMs enter the body of living organisms through these sources and have become a potential risk for humans and animals. Therefore, the present study aims at the health risk assessment of PTMs and their accumulation in soil, water, and forages of three tehsils (Kallar Kahar, Choa Saidan Shah, and Chakwal) in district Chakwal. Samples of wastewater, soil, and forages were collected from various sites of district Chakwal. PTMs detected in the present study were cadmium (Cd), chromium (Cr), lead (Pb), zinc (Zn), cobalt (Co), copper (Cu), and nickel (Ni), and their levels were measured through atomic absorption spectrophotometer (AAs GF95 graphite furnace auto sampler). Pollution load index (PLI), bio concentration factor (BCF), soil enrichment factors (EF), daily intake value (DIM), and health risk index (HRI) in sheep, cow, and buffalo were also analyzed. The results revealed that the mean concentration (mg/L) of Cd (0.72-0.91 mg/L), Cr (1.84-2.23 mg/L), Pb (0.95-3.22 mg/L), Co (0.74-2.93 mg/L), Cu (0.84-1.96 mg/L), and Ni (1.39-4.39 mg/L) in wastewater samples was higher than permissible limits set by WHO, NEQS, WWF, USEPA, and Pakistan in all three tehsils of district Chakwal. Similarly, in soil samples, concentrations of Cd (1.21-1.95 mg/kg), Cr (38.1-56.4 mg/kg), and Ni (28.3-55.9 mg/kg) were higher than their respective threshold values. The mean concentration of PTMs in forage samples (Parthenium hysterophorus, Mentha spicata, Justicia adhatoda, Calotropis procera, Xanthium strumarium, Amaranthaceae sp.) showed that maximum values of Cd (5.35-7.55 mg/kg), Cr (5.47-7.51 mg/kg), Pb (30-36 mg/kg), and Ni (12.6-57.5 mg/kg) were beyond their safe limit set for forages. PLI, BCF, and EF were > 1.0 for almost all the PTMs. The DIM and HRI for sheep were less than < 1.0 but for cows and buffalo were > 1.0. The current study showed that soil, water, and forages near coal mines area are contaminated with PTMs which enter the food chain and pose significant harm to humans and animals. In order to prevent their dangerous concentration in the food chain, regular assessment of PTMs present in soil, forages, irrigating water, and food is recommended.

Polybrominated diphenyl ethers in type 2 diabetes mellitus cases and controls: Repeated measurements prior to and after diagnosis.

BACKGROUND: Previous studies have reported associations between certain persistent organic pollutants (POPs) and type 2 diabetes mellitus (T2DM). Polybrominated diphenyl ethers (PBDEs) are a class of POPs that are found in increasing concentrations in humans. Although obesity is a known risk factor for T2DM and PBDEs are fat-soluble, very few studies have investigated associations between PBDEs and T2DM. No longitudinal studies have assessed associations between repeated measurements of PBDE and T2DM in the same individuals and compared time trends of PBDEs in T2DM cases and controls. OBJECTIVES: To investigate associations between pre- and post-diagnostic measurements of PBDEs and T2DM and to compare time trends of PBDEs in T2DM cases and controls. METHODS: Questionnaire data and serum samples from participants in the Tromsø Study were used to conduct a longitudinal nested case-control study among 116 T2DM cases and 139 controls. All included study participants had three pre-diagnostic blood samples (collected before T2DM diagnosis in cases), and up to two post-diagnostic samples after T2DM diagnosis. We used logistic regression models to investigate pre- and post-diagnostic associations between PBDEs and T2DM, and linear mixed-effect models to assess time trends of PBDEs in T2DM cases and controls. RESULTS: We observed no substantial pre- or post-diagnostic associations between any of the PBDEs and T2DM, except for BDE-154 at one of the post-diagnostic time-points (OR = 1.65, 95% CI: 1.00, 2.71). The overall time trends of PBDE concentrations were similar for cases and controls. DISCUSSION: The study did not support PBDEs increasing the odds of T2DM, prior to or after T2DM diagnosis. T2DM status did not influence the time trends of PBDE concentrations.

Evaluating the Influences of Health Expenditure, Energy Consumption, and Environmental Pollution on Life Expectancy in Asia.

This study examines the effects of health expenditure, energy consumption, CO2 emissions, population size, and income on health outcomes in 46 Asian nations between 1997 and 2019. Cross-sectional dependence (CSD) and slope heterogeneity (SH) tests are utilized due to the close linkages between Asian nations as a result of commerce, tourism, religion, and international agreements. The research uses unit root and cointegration tests of the second generation after validating CSD and SH issues. Due to the results of the CSD and SH tests, it is clear that conventional methods of estimation are inappropriate, so a new panel method, the inter autoregressive distributive lag (CS-ARDL) model, is used instead. In addition to CS-ARDL, the study's results were checked with a common correlated effects mean group (CCEMG) method and an augmented mean group (AMG) method. According to the CS-ARDL study, higher rates of energy use and healthcare spending lead to better health outcomes for Asian countries over the long run. CO2 emissions are shown to be harmful to human health, according to the study. The influence of a population's size on health outcomes is shown to be negative in the CS-ARDL and CCEMG, but favorable in the AMG. Only the AMG coefficient is significant. In most instances, the results of the AMG and CCEMG corroborate the results of the CS-ARDL. Among all the factors influencing life expectancy in Asian countries, healthcare spending is the most influential. Hence, to improve health outcomes, Asian countries need to take the required actions to boost health spending, energy consumption, and long-term economic growth. To achieve the best possible health outcomes, Asian countries should also reduce their CO2 emissions.

Do human capital and governance thresholds matter for the environmental impact of FDI? The evidence from MENA countries.

This paper studies whether foreign direct investment (FDI)-CO2 emissions relationship may change depending on the data-driven estimated threshold levels for the country characteristics (CC) including human capital and governance in a sample of 13 Middle East and North Africa (MENA) economies during the 1996-2019 period. Our results strongly suggest that endogenously estimated CC thresholds matter for the impact of FDI on CO2 emissions. The pollution haven hypothesis, which maintains that FDI is associated with higher levels of pollution, appears to be valid for economies with weak CC. In addition to this, the pollution halo argument suggesting FDI lowers the emissions appears to be hold in countries with strong CC. The results in this study may indicate that policies aiming to improve human capital and governance may be expected not only to increase the economic benefits of FDI in terms of growth but also mitigate the negative environmental impacts of FDI in the MENA region.

Spatio-temporal interaction heterogeneity and driving factors of carbon emissions from the construction industry in China.

Global warming caused by carbon emissions has become a major issue that countries need to address. As the largest carbon emitter globally, the construction industry is one of the major contributors to carbon emissions in China. It is of significance for carbon reduction to study carbon emission from construction industry. Based on various methods, this study explored the spatio-temporal characteristics of carbon emissions and the driving factors of construction industry. This study found, in 2007, 2010, and 2012, carbon emissions from the construction industry exhibited an increasing trend, and the indirect carbon emissions accounted for approximately 77% of the total carbon emissions overall; in addition, the regional gaps in carbon emissions are widening. The space centers of gravity of direct, indirect, and total carbon emissions showed similar rotations in the counterclockwise direction and gradually shifted to the northeast direction. Carbon emissions from the construction industry were predominantly influenced by the total population, number of employees in construction industry, labor productivity in construction industry, added value of the construction industry, energy consumption in construction industry in 2007, evolution to the mutual influence of the total population, labor productivity in construction industry, and energy consumption in construction industry in 2012. The finds can make references for the regional sustainable development.

Contamination characteristics of heavy metals in a small-scale tanning area of southern China and their source analysis.

Tanning industry has been identified as a significant source of heavy metals; however, heavy metals contamination in farmland soil due to small-scale tanning activities remains unstudied. Here, samples from topsoil, profile soil, water and sediments in the vicinity of a small-scale tanning area in Nanning, Guangxi Zhuang Autonomous Region, southern China, were collected to explore the contamination characteristics and source apportionment of Cd, Cr, Hg, As, Cu, Pb, Ni and Zn. The results show that the farmland soil was mainly contaminated by Cr and its content was 33.40-3830.00 mg kg-1. The highest level of Cr, Cd and Hg was above their thresholds, while the average contents of Cd, Cr, Pb and Hg exceeded the corresponding background levels. Moreover, enrichment of Cr in soil profiles and stream sediments were also observed, whose concentrations varied from 11.50 to 2590.00 mg kg-1 and 738.00 to 11,200.00 mg kg-1, respectively. Concentrations of Cr in top soils and soil profiles from farmland surrounding the stream were significantly higher than those from other areas, and the soils surrounding the stream were moderately to heavily polluted. The multivariate statistical analysis indicated that the heavy metals originated from traffic (Cu, Ni, Zn, Hg, and Pb), agriculture (Cr and Cd) and nature (As). Source apportionment with PMF model results showed that the relative contribution rates of heavy metals by traffic, tanning, agriculture, other industrial activities and natural sources were 16.00%, 18.88%, 20.88%, 22.04% and 22.20%, respectively. These findings indicate that small-scale tanning activities could also lead to heavy metal accumulation in the surrounding environment, which requires decision-makers to pay more attention and to develop effective remediation procedures.

The Impact of Environmental Pollution and Economic Growth on Public Health: Evidence From China.

A comprehensive understanding of the impact of economic growth and environmental pollution on public health is crucial to the sustainable development of public health. In this paper, an individual fixed effect model is used to analyze the impact of environmental pollution and economic growth on public health, based on the panel data of 30 provinces in China from 2007 to 2018. The research finds that: First, the health status of China's four regions is not only affected by economic growth and environmental pollution, but also affected by the per capita disposable income and urbanization rate. Second, there is a long-term balanced relationship between China's economic growth, environmental pollution and public health. Third, environmental pollution harms children's health and significantly increases the perinatal mortality, while economic growth helps to reduce the perinatal mortality. Fourth, environmental pollution plays a regulatory role between economic growth and public health. Fifth, there are significant regional differences in the impact of environmental pollution and economic growth on public health. Among them, the degree of harm caused by sulfur dioxide emissions on mortality in northeastern China is significantly higher than that of the eastern China, eastern China is higher than that of the western China, and western China is higher than that of the central China. Finally, in order to reduce the adverse consequences of environmental pollution on public health in the process of economic development, this study puts forward relevant policy suggestions.

Environmental Pollution to Blame for Depressive Disorder?

Public concern has emerged about the effects of endocrine-disrupting compounds (EDCs) on neuropsychiatric disorders. Preclinical evidence suggests that exposure to EDCs is associated with the development of major depressive disorder (MDD) and could result in neural degeneration. The interaction of EDCs with hormonal receptors is the best-described mechanism of their biological activity. However, the dysregulation of the hypothalamic-pituitary-gonadal adrenal axis has been reported and linked to neurological disorders. At a worldwide level and in Mexico, the incidence of MDD has recently been increasing. Of note, in Mexico, there are no clinical associations on blood levels of EDCs and the incidence of the MDD. Methodology: Thus, we quantified for the first time the serum levels of parent compounds of two bisphenols and four phthalates in patients with MDD. The levels of di-ethyl-hexyl-phthalate (DEHP), butyl-benzyl-phthalate (BBP), di-n-butyl phthalate (DBP), and di-ethyl-phthalate (DEP), bisphenol A (BPA), and bisphenol S (BPS) in men and women with or without MDD were determined with a gas chromatograph-mass spectrometer. Results/conclusion: We found significant differences between concentrations of BBP between controls and patients with MDD. Interestingly, the serum levels of this compound have a dysmorphic behavior, being much higher in women (~500 ng/mL) than in men (≤10 ng/mL). We did not observe significant changes in the serum concentrations of the other phthalates or bisphenols tested, neither when comparing healthy and sick subjects nor when they were compared by gender. The results point out that BBP has a critical impact on the etiology of MDD disorder in Mexican patients, specifically in women.

Exposure study on susceptible people - SPES: An integrative biomonitoring approach.

BACKGROUND: The evaluation of environmental exposure risk requires a global analysis of pollution phenomena, including biological effects and potentially correlated clinical outcomes in susceptible populations. Although human biomonitoring plays a fundamental role in assessing the degree of contamination, it is not effective alone in identifying a direct link between exposure, biomolecular effects and outcomes on target organisms. While toxicogenomics and epidemiology are mainly focused on the investigation of molecular reactions and clinical outcomes, the monitoring of environmental matrices works independently to characterize the territorial distribution of toxic compounds, without proving any correlated health risk for residents. OBJECTIVES: We propose a new biomonitoring model based on a whole systemic analytical evaluation of environmental context. The paradigm of the method consists of identifying the sources of pollution, the migration pathways of those pollutants and their effects on target organisms. By means of this innovative, holistic epidemiological approach, we included healthy human subjects in a cohort to identify potential risks of exposure and predict possible correlated clinical outcomes. 4205 residents of the Campania region were enrolled in the "SPES" biomonitoring study, which especially focused on the areas dubbed "Land of Fires" in the recent decades. DISCUSSION: The analysis of environmental exposure risk suffers the lack of data integration from various science fields, and this comes down to a limited point of view and a limited knowledge of phenomena. In implementing our model, we first constructed an analytical picture of the Real-world situation. We next conducted a comparative risk assessment, in order to identify possible correlations between pollution and health within a holistic view. CONCLUSION: This type of research activities aims to support the implementation of public health interventions and to become a reference model in the evaluation of the risk of exposure to environmental pollutants.

Retrospect and Outlook of Research on Regional Haze Pollution in China: A Systematic Literature Review.

Regional haze pollution, a severe atmospheric environmental problem, has profoundly harmful effects on the ecological environment, public health and the quality of economic development, and has accordingly attracted considerable attention from policymakers, researchers and the public. This article comprises a systematic literature review of the existing research on the theoretical mechanism, empirical analysis and institutional arrangement of regional haze pollution. As a result, it is found that various studies from multiple disciplines have touched upon the relevance of haze issues, including theoretical and experimental research on its formation, evolution and mechanisms from the perspective of the natural sciences, as well as empirical analysis and policy research on governance strategies, effects and mechanisms from the perspective of the social sciences, yet a systematic review and critical assessment synthesizing the above research is urgently needed. Future directions and research prospects are highlighted, showing that it is necessary to supplement and improve the theory and practice concerning the identification, measurement and assessment of haze pollution, as well as regional controlling strategies and policy implementation assessments. In short, in this review, we have aimed to help integrate the theoretical and empirical consensus in multidisciplinary fields, thereby promoting the accurate analysis, fine management and the development of precise policies in regards to regional haze pollution.

Trace elements distribution in tropical tree rings through high-resolution imaging using LA-ICP-MS analysis.

BACKGROUND: The distribution of trace elements in tree rings although poorly known may be useful to better understand environmental changes, pollution trends, long-term droughts, forest dieback processes, and biology of trees. METHOD: Laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) is used for imaging micronutrients and potentially toxic elements distribution, allowing the investigation of trace elements at high spatial resolution within the tree rings. To ensure a more efficient determination of micronutrients and potentially toxic elements, LA-ICP-MS instrumental conditions were optimized and carbon, a major element in wood, is used as an internal standard during analysis to correct for random fluctuations. RESULTS: Spatial distributions maps of Ba, Cu, Fe, Mn, Ni, and Pb in growth layers of six tropical tree species were built-up using the LA-iMageS software, namely: Amburana cearensis (Fabaceae), Cedrela fissilis (Meliaceae), Hymenaea courbaril (Fabaceae), Maclura tinctoria (Moraceae), Parapiptadenia zehntneri (Fabaceae), Peltogyne paniculata (Fabaceae). A correlation between the trace element composition and different cell types (parenchyma, fiber, and vessel) was distinctly observed. It was observed a general pattern of Ba, Cu, Ni, Mn, and Pb accumulation mainly in the axial parenchyma and vessels. But the elemental composition of xylem cells is strongly species dependent. The multivariate analysis also points to a distinct accumulation of minerals between heartwood and sapwood in the same species. CONCLUSIONS: Imaging both essential and deleterious element distributions in the tree rings may improve visualization and can effectively contribute to understanding the lifetime metabolism of trees and evaluating the effects of environmental changes related to climatic seasonality, pollution, and future paleoclimate reconstructions.