Emerging from tabloid scandal: Dr. U.K. Mayo's Vegetable Vapor extends nitrous oxide's anesthetic duration.

Urial K. Mayo (1816-1900) was a successful Boston dentist who was plagued by personal scandal. In 1883 he patented extending the duration of nitrous-oxide anesthesia with an alcoholic tincture of hops and poppies.

Howard Wilcox Haggard and the Institutionalization of Modern Alcohol Studies.

OBJECTIVE: This biographical sketch and accompanying bibliography provide a new look at Howard Wilcox Haggard, M.D., Ph.D., whose career highlights the consolidation of alcohol studies as a field in twentieth-century America. METHOD: The article relies in large part on the works of Haggard assembled for the bibliography project, supplemented by published and unpublished documents and records from collections at Rutgers University. RESULTS: Haggard began his career in respiratory physiology, influenced by his work on chemical weapons for the Army during the First World War. As his reputation grew, he moved into anesthesiology and supplemented his research with textbooks and popular science bestsellers. Haggard moved into the burgeoning field of alcohol studies after the repeal of National Prohibition and, in 1940, became the inaugural editor and president of the corporation of the Quarterly Journal of Studies on Alcohol, now the Journal of Studies on Alcohol and Drugs. Under the aegis of the Yale Laboratory for Applied Physiology, he also assembled and oversaw what would become the Center of Alcohol Studies. Haggard died in 1959, his legacy established as a central figure in the 20th-century transformation of alcohol studies in the United States. CONCLUSIONS: A prolific researcher with a talent for tapping into the public zeitgeist, Haggard helped provide the institutional infrastructure, academic credibility, and broad audience that made the renaissance of alcohol studies in post-Prohibition America possible.

Medicinal brandy.

This paper describes the use of brandy and other forms of alcohol in the latter part of the 19th and early 20th centuries. Its prime use was as a cardiac stimulant as it seemed to increase the cardiac output and blood pressure. However it was also recognised as a depressant and was used as a sedative. Reconciling these two actions caused difficulties. In addition it was used as a food for invalids.

Assumptions in the European Union biofuels policy: frictions with experiences in Germany, Brazil and Mozambique.

The biofuel project is an agro-industrial development and politically contested policy process where governments increasingly become global actors. European Union (EU) biofuels policy rests upon arguments about societal benefits of three main kinds - namely, environmental protection (especially greenhouse gas savings), energy security and rural development, especially in the global South. Each argument involves optimistic assumptions about what the putative benefits mean and how they can be fulfilled. After examining those assumptions, we compare them with experiences in three countries - Germany, Brazil and Mozambique - which have various links to each other and to the EU through biofuels. In those case studies, there are fundamental contradictions between EU policy assumptions and practices in the real world, involving frictional encounters among biofuel promoters as well as with people adversely affected. Such contradictions may intensify with the future rise of biofuels and so warrant systematic attention.

Power is sweet: sugarcane in the global ethanol assemblage.

New alliances between Brazil and the US for ethanol production, transport, and trade are revitalising and expanding the centuries -old sugarcane plantation system in the Americas. In this paper I adopt the concept of global assemblages, building on the work of Aihwa Ong, Stephen Collier, and Saskia Sassen, to draw the contours of an "ethanol assemblage," which includes states, corporations, growers, technologies, urban consumers, and rural communities and landscapes. Though important to conceptualise agrofuels as a global phenomenon, it is also necessary to recognise the distinct regional patterns that cohere around various aspects of this polymorphous industry. Therefore, I focus on alliances around sugarcane ethanol, paying particular attention to the role of Miami as a global city serving as a gateway to information, investment, and commodities for the public/private and national/transnational entities that are engaged in the hemispheric project of ethanol promotion, production and distribution.

Fields of dreams: negotiating an ethanol agenda in the Midwest United States.

Corn ethanol production is central in the United States' agrofuels initiatives. In this paper I discuss corn ethanol production in Iowa, USA and examine several dynamics: farmers' positions in agrofuel supply chains; struggles around the construction and operation of agrofuel refineries; the politics of ethanol production and regulation; and the ecological consequences of increased corn production. I argue that current US agrofuels production and politics reinforce longstanding and unequal political economic relationships in industrial agriculture. I also argue that the politics of US agrofuels, focused on carbon accounting for greenhouse gas reduction and energy security, privilege urban and other actors' social and ecological interests over those of rural places of production.

Big Sugar in southern Africa: rural development and the perverted potential of sugar/ethanol exports.

This paper asks how investment in large-scale sugar cane production has contributed, and will contribute, to rural development in southern Africa. Taking a case study of the South African company Illovo in Zambia, the argument is made that the potential for greater tax revenue, domestic competition, access to resources and wealth distribution from sugar/ethanol production have all been perverted and with relatively little payoff in wage labour opportunities in return. If the benefits of agro-exports cannot be so easily assumed, then the prospective 'balance sheet' of biofuels needs to be re-examined. In this light, the paper advocates smaller-scale agrarian initiatives.

An unusual personalized cough mixture from the early twentieth century.

There is no way at this point to determine the financial or marketing impact of the personalized cough mixture upon the Randall Drug Store. Nor can there be an estimate of the influence that the likeness of Dr. Randall's daughter on the label might have had upon sales or use of the product. However, in an era of uncertainty and naiveté regarding health options in general and medicinal products in particular, it could be assumed that this photograph-adorned personalized cough mixture bottle would have been promoted in-store by Dr. Randall with confidence, and used with assurance by purchasers. This uniquely presented cough mixture was no doubt a point of pride for the pharmacist, as well as his lovely daughter.

Neurochemistry and epileptology.

This paper gives an account of the global evolution of (neuro-)chemistry in epileptology with an emphasis on the role of the International League Against Epilepsy (ILAE), which declared in its constitution a mission "to make the epilepsy-problem the object of special study and to make practical use of the results of such study." As Epilepsia is the scientific journal of the ILAE, the review emphasizes papers published in the journal.

Ethanol USA.

Environmental, social, economic, and food issues brought on by the rapidly expanding ethanol-from-corn industry in the United States are reviewed and discussed.

Liquor made quicker: alcohol as a synthetic reagent for molecules in anesthesia.

Ethanol was an early anesthetic, and chemists transformed it into better ones. Hypnotic/anesthetic/analgesic molecules prepared from ethanol include barbiturates, benzocaine, chloral hydrate, chloroform, diethyl ether, ethyl chloride, ethylene, etomidate, meperidine, paraldehyde, phenacetin, procaine, tribromoethanol, and urethane. Ethanol was sometimes mixed deliberately with the other anesthetics, and John Snow's inhaled amylene came from the "fusel oil" fraction of rotgut whisky.

The alcoholic lung disease: historical background and clinical features.

SUMMARY: The purpose of this review article is to prove the damage that alcohol causes to the respiratory system. We will make a brief review of alcohols history in the course of the centuries till nowadays. The problem of addiction to alcohol (alcoholism) will be examined for several countries. Alcohol's metabolism is another topic to be discussed parallel to its pharmacological action. In addition, alcohol's impact on the respiratory system varies from damaging the mucociliary system to the regulation of breathing and from the sleep apnea syndrome to diffusion disorders. "Alcoholic lung disease" constitutes a syndrome despite the fact that the damage of the lung due to concurrent smoking and drug use is often indistinguishable.