ABSTRACT
Biomphalaria glabrata, highly susceptible to Schistosoma mansoni, were seen to shed less and less cercariae along the time of infection. Histological examination kept a close correlation with this changing pattern of cercarial shedding, turning an initial picture of no-reaction (tolerance) gradually into one of hemocyte proliferation with formation of focal encapsulating lesions around disintegrating sporocysts and cercariae, a change that became disseminated toward the 142nd day post miracidial exposure. Findings were suggestive of a gradual installation of acquired immunity in snails infected with S. mansoni.
Subject(s)
Biomphalaria/ultrastructure , Schistosomiasis mansoni/physiopathology , Animals , Biomphalaria/parasitology , Digestive System/parasitology , Digestive System/pathology , Exocrine Glands/parasitology , Exocrine Glands/pathology , Kidney/parasitology , Kidney/pathology , Schistosoma mansoni/isolation & purification , Time FactorsABSTRACT
Biomphalaria glabrata, highly susceptible to Schistosoma mansoni, were seen to shed less and less cercariae along the time of infection. Histological examination kept a close correlation with this changing pattern of cercarial shedding, turning an initial picture of no-reaction (tolerance) gradually into one of hemocyte proliferation with formation of focal encapsulating lesions around disintegrating sporocysts and cercariae, a change that became disseminated toward the 142nd day post miracidial exposure. Findings were suggestive of a gradual installation of acquired immunity in snails infected with S. mansoni
Subject(s)
Animals , Biomphalaria/ultrastructure , Schistosomiasis mansoni/physiopathology , Biomphalaria/parasitology , Digestive System/parasitology , Digestive System/pathology , Exocrine Glands/parasitology , Exocrine Glands/pathology , Kidney/parasitology , Kidney/pathology , Schistosoma mansoni/isolation & purification , Time FactorsABSTRACT
A systematic study of the distribution of intracellular parasites in the organs and tissues of mice acutely infected (15 days) with the CL strain of Trypanosoma cruzi was performed. Almost all tissues and organs were parasitized with different intensities, including several epithelial cell types. In addition to striated, cardiac, and smooth muscles a very high parasitism of fat cells, pancreas, and genital adnexa was observed. A smaller number of parasites was found in all other structures studied except in highly vascularized structures such as in the penile corpora cavernosa, pulmonary and renal parenchyma, islets of Langerhans, hepatic sinusoids, and in atrial endothelium. This paper also shows, for the first time in the literature, the parasitism of milky spots, cornea epithelium, cornea stroma, retroorbital fibroblasts, seminal vesicles, and coagulative, Cowper's, urethral, preputial, sebaceous anal, and clitoris glands. The results indicated that CL strain is highly invasive, being able to infect cells derived from the three embryonic layers (ectoderm, mesoderm, and endoderm), suggesting that the paninfectivity may influence the outcome of immunological and pathological events.
Subject(s)
Chagas Disease/parasitology , Trypanosoma cruzi/physiology , Acute Disease , Adipose Tissue/parasitology , Adipose Tissue/pathology , Animals , Chagas Disease/pathology , Endocrine Glands/parasitology , Exocrine Glands/parasitology , Eye/parasitology , Female , Genitalia/parasitology , Male , Mice , Mice, Inbred BALB C , Muscles/parasitology , Pancreas/parasitology , Skin/parasitologyABSTRACT
The authors studied histopathologically the presence of amastigotes in the Weber's lingual salivary gland of mice infected with RC strain of Trypanosoma cruzi. Amastigotes were found in Weber's gland acini cells, excretory duct cells, intralobular connective tissue, muscle fibers and inside the acini lumen.
Subject(s)
Chagas Disease/parasitology , Salivary Glands, Minor/parasitology , Tongue/parasitology , Trypanosoma cruzi/isolation & purification , Animals , Exocrine Glands/parasitology , Male , Mice , MucusABSTRACT
Monogenetic insect trypanosomatids of the genera Crithidia, Leptomonas and Herpetomonas, multiplied as in axenic cultures, for many months, in the lumen of the scent glands of the opossum Didelphis marsupialis. Specific antibodies were detected in the serum of the animals but there was no evidence of invasion of their tissues by the parasites.
Subject(s)
Exocrine Glands/parasitology , Protozoan Infections/parasitology , Scent Glands/parasitology , Trypanosomatina/growth & development , Animals , Antibodies, Protozoan/analysis , Opossums , Trypanosomatina/immunologyABSTRACT
It has been found that species of the digenetic genus Trypanosoma as well as species of monogenetic trypanosomatids of insects can grow in the lumen of the scent glands of opossums reproducing the cycle they perform in the intestinal tract of their insect hosts. Based on these findings, speculations are made on the incompletely known cycles of many mammalian trypanosomes and on the evolution of the family Trypanosomatidae.