Subject(s)
Epstein-Barr Virus Infections/etiology , Immunosuppressive Agents/adverse effects , Lupus Erythematosus, Systemic/drug therapy , Lymphoproliferative Disorders/etiology , Skin Ulcer/etiology , Azathioprine/adverse effects , Conservative Treatment , Deprescriptions , Epstein-Barr Virus Infections/immunology , Facial Dermatoses/etiology , Facial Dermatoses/immunology , Female , Forehead , Humans , Lymphoproliferative Disorders/immunology , Methotrexate/adverse effects , Middle Aged , Skin Ulcer/immunologySubject(s)
Leprosy, Tuberculoid/diagnosis , Pregnancy Complications, Infectious/microbiology , Brazil/ethnology , Dapsone/therapeutic use , Delayed Diagnosis , Facial Dermatoses/diagnosis , Facial Dermatoses/drug therapy , Facial Dermatoses/immunology , Facial Dermatoses/microbiology , Female , Foot Dermatoses/diagnosis , Foot Dermatoses/drug therapy , Foot Dermatoses/immunology , Foot Dermatoses/microbiology , Hand Dermatoses/diagnosis , Hand Dermatoses/drug therapy , Hand Dermatoses/immunology , Hand Dermatoses/microbiology , Humans , Hypesthesia/etiology , Immunity, Cellular , Leprosy, Tuberculoid/drug therapy , Leprosy, Tuberculoid/immunology , Leprosy, Tuberculoid/microbiology , Occupational Exposure , Prednisone/therapeutic use , Pregnancy , Pregnancy Complications, Infectious/immunology , Rifampin/therapeutic use , SpainABSTRACT
Histoplasmosis is a fungal infection caused by the Histoplasma capsulatum. Mucosal manifestations are uncommon, but, when present, they are usually associated with pulmonary or chronic disseminated infection. The course of the disease is often related to the host immune response. The purpose of this article is to describe the clinical and microscopic findings of unusual involvement of nasal cartilage and septal destruction, and oral lesions of histoplasmosis in an immunosuppressed patient who presented an unusual form of the disease.
Subject(s)
Histoplasma/growth & development , Histoplasmosis/immunology , Immunocompromised Host/immunology , Kidney Transplantation/immunology , Nasal Septum/pathology , Adult , Antifungal Agents/therapeutic use , Facial Dermatoses/drug therapy , Facial Dermatoses/immunology , Facial Dermatoses/microbiology , Histocytochemistry , Histoplasmosis/drug therapy , Histoplasmosis/microbiology , Humans , Male , Nasal Mucosa/microbiology , Nasal Mucosa/pathology , Nasal Septum/microbiologyABSTRACT
Hereditary angioedema is an uncommon disorder mainly caused by defects of the gene for C1 inhibitor. These patients present recurrent edema episodes in the different regions of the body, including larynx edema in some cases. Low plasma levels of C1 inhibitor confirm the diagnosis. It is important to establish an early diagnosis and prompt treatment to this disorder due to its potential of fatal consequences and multiple alterations in the quality of life that have been associated with. The indicated treatment is substitutive therapy of C1 inhibitor concentrate. We present the case of a patient a 27 year-old female with a history of seven years of evolution, with daily periorbital, upper and lower extremities and labial edema episodes who was classified as C1 inhibitor deficiency type II. She began treatment with attenuated androgens in progressive increased doses with poor response, appearing torpid evolution without a favorable response. This case corresponds to a very atypical presentation of C1 inhibitor deficiency with daily symptoms, unlike the typical intermittent course of the classic disease.