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J Neurol Sci ; 64(2): 213-7, 1984 May.
Article in English | MEDLINE | ID: mdl-6379105

ABSTRACT

An immunohistological study of viral antigen (VA) in the brain was carried out in mice which had been infected with herpes simplex type 1 virus (HSV) in the skin of the face. In 77% of the mice with VA in the brain the olfactory system as well as the trigeminal system/brainstem was affected. The remaining 23% had VA in the trigeminal system/brainstem only. Eye swab cultures yielded HSV from all mice with VA in the olfactory system. The ease of access of virus infecting the face to the olfactory system shown in this model may have implications for human infections.


Subject(s)
Central Nervous System/microbiology , Encephalitis/etiology , Herpes Simplex , Olfactory Pathways/microbiology , Skin Diseases, Infectious/etiology , Trigeminal Nerve/microbiology , Animals , Facial Dermatoses/transmission , Female , Herpes Simplex/transmission , Histocytochemistry , Immunoenzyme Techniques , Male , Mice , Mice, Inbred BALB C , Neural Pathways/microbiology
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