ABSTRACT
Molluscum contagiosum is a common skin infection affecting different body areas, including the face. Previous data have shown cases of atypical lesions, notably on the face, and it was thought relevant to further examine differences between facial and non-facial lesions. All cases of children (0-18) diagnosed with molluscum contagiosum from 2013-2022 at the paediatric dermatology clinic of Soroka University Medical Center were retrospectively reviewed, and 615 children were included in the study. Facial lesions tended to be found in younger children (p = 0.018). Non-facial lesions were more erythematous (p < 0.001), itchier (p < 0.001), and showed similar patterns of ulceration (p = 0.078) and purulence (p = 0.779). The average lesion diameter was similar in patients with or without facial lesions (p = 1). Children with facial lesions were treated differently from patients without facial lesions (p < 0.001); however, there were no differences in treatment response. This research challenges assumptions concerning the severity of facial lesions, including eyelid lesions, by revealing that, overall, they exhibit less inflammation than non-facial lesions. Despite the potential for greater psychosocial burdens and impacts on self-esteem associated with lesions on the sensitive facial area, this study provides evidence that they are not inherently more worrisome and can be managed similarly to lesions found elsewhere in the body.
Subject(s)
Facial Dermatoses , Molluscum Contagiosum , Humans , Child , Child, Preschool , Female , Male , Retrospective Studies , Cross-Sectional Studies , Infant , Adolescent , Facial Dermatoses/virology , Infant, Newborn , Severity of Illness Index , Age FactorsABSTRACT
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Subject(s)
Cellulitis , Facial Dermatoses , Herpes Simplex , Wrestling , Humans , Male , Asian People , Cellulitis/drug therapy , Cellulitis/etiology , Cellulitis/virology , Republic of Korea , Sports , Herpesvirus 1, Human , Herpes Simplex/drug therapy , Herpes Simplex/etiology , Herpes Simplex/virology , Facial Dermatoses/drug therapy , Facial Dermatoses/etiology , Facial Dermatoses/virology , Acyclovir/therapeutic use , Antiviral Agents/therapeutic use , AdolescentSubject(s)
Camellia sinensis , Facial Dermatoses/drug therapy , Hair Diseases/drug therapy , Phytotherapy , Plant Preparations/therapeutic use , Adult , Extremities , Facial Dermatoses/virology , Female , Hair Diseases/virology , Hair Follicle/pathology , Humans , Immunocompromised Host , Ointments , Polyomavirus/isolation & purification , Polyomavirus Infections/complications , Polyomavirus Infections/drug therapySubject(s)
Facial Dermatoses/pathology , Facial Dermatoses/virology , Molluscum Contagiosum/pathology , Female , Forehead , Humans , Middle AgedSubject(s)
Facial Dermatoses/diagnosis , Hair Diseases/diagnosis , Immunosuppressive Agents/adverse effects , Kidney Transplantation/adverse effects , Polyomavirus Infections/diagnosis , Biopsy , Cidofovir/administration & dosage , Facial Dermatoses/drug therapy , Facial Dermatoses/immunology , Facial Dermatoses/virology , Female , Graft Rejection/immunology , Graft Rejection/prevention & control , Hair Diseases/drug therapy , Hair Diseases/immunology , Hair Diseases/virology , Hair Follicle/immunology , Hair Follicle/pathology , Hair Follicle/virology , Humans , Immunocompromised Host , Middle Aged , Polyomavirus/immunology , Polyomavirus/isolation & purification , Polyomavirus Infections/drug therapy , Polyomavirus Infections/immunology , Polyomavirus Infections/virology , Skin/immunology , Skin/pathology , Skin/virology , Skin Cream/administration & dosageSubject(s)
COVID-19/complications , Facial Dermatoses/virology , Foot Dermatoses/virology , Hand Dermatoses/virology , Purpura/virology , Skin Ulcer/virology , Adult , Aged , Aged, 80 and over , Ear , Female , Genitalia , Humans , Male , Middle Aged , Necrosis/virology , New York City , SARS-CoV-2 , Skin/pathology , Thrombophilia/virologySubject(s)
Facial Dermatoses/pathology , Facial Dermatoses/virology , Syphilis/diagnosis , Adult , Humans , Male , Syphilis/complicationsSubject(s)
Antiviral Agents/therapeutic use , Eyebrows/virology , Facial Dermatoses/therapy , Imiquimod/therapeutic use , Lasers, Solid-State/therapeutic use , Tattooing/adverse effects , Warts/therapy , Aged , Combined Modality Therapy , Cosmetic Techniques/adverse effects , Facial Dermatoses/virology , Female , Humans , Skin Cream , Warts/etiologyABSTRACT
BACKGROUND: Hydroa vacciniforme-like lymphoproliferative disorder (HVLPD) is a rare Epstein-Barr virus (EBV)-associated lymphoma that mainly affects children. OBJECTIVES: To examine the similarities and differences in the clinical pathological features, EBV infection status, and gene rearrangements in adults and children patients with HVLPD. METHODS: We compared the clinical manifestations, histopathology, immunophenotypical features, EBV infection status, and T-cell receptor gene rearrangements in the adult and children HVLPD groups. RESULTS: Clinical manifestations differed between children and adults groups. The children were characterized by blisters and severe facial swelling, whereas the adults were characterized by mild facial swelling and papules. Mosquito bite was significantly related to morbidity in the children group. Histologically, the number of mast cells in the adult group was greater than in the children group (P < 0.05). There were no significant differences in EBV infection status or TCR-γ gene rearrangements between 2 groups. CONCLUSIONS: There were differences in clinical pathology and prognosis between the 2 groups. A higher mast cell count and T-cell phenotype might be associated with a poor prognosis.
Subject(s)
Epstein-Barr Virus Infections/diagnosis , Facial Dermatoses/diagnosis , Gene Rearrangement, gamma-Chain T-Cell Antigen Receptor , Genes, T-Cell Receptor gamma , Herpesvirus 4, Human/isolation & purification , Hydroa Vacciniforme/diagnosis , Lymphoma/diagnosis , Skin , Adolescent , Adult , Age Factors , Child , Epstein-Barr Virus Infections/genetics , Epstein-Barr Virus Infections/immunology , Epstein-Barr Virus Infections/virology , Facial Dermatoses/genetics , Facial Dermatoses/immunology , Facial Dermatoses/virology , Female , Genetic Markers , Genetic Predisposition to Disease , Humans , Hydroa Vacciniforme/genetics , Hydroa Vacciniforme/immunology , Hydroa Vacciniforme/virology , Immunohistochemistry , Immunophenotyping/methods , In Situ Hybridization, Fluorescence , Lymphoma/genetics , Lymphoma/immunology , Lymphoma/virology , Male , Mast Cells/immunology , Mast Cells/pathology , Mast Cells/virology , Middle Aged , Phenotype , Polymerase Chain Reaction , Retrospective Studies , Risk Factors , Skin/immunology , Skin/pathology , Skin/virology , Young AdultABSTRACT
Warts are benign epithelial proliferations of the skin and mucous membranes caused by human papilloma viruses (HPVs). Plane warts are mainly caused by HPV-3 and HPV-10. There is no absolute effective single treatment, and multiple treatment modalities may be combined. One must take into consideration the probability of spontaneous regression, and so the therapeutic approach should not be too aggressive. We report a case of 11 years immunocompetent child presenting with recalcitrant multiple plane warts who was successfully treated with intralesional 2% zinc sulfate solution injection in one lesion after a failure of many other treatment modalities. Our case may represent a starting point for further studies to evaluate the best dose used for management and to avoid any side effects. Intralesional zinc sulfate injection could be a promising treatment option for plane warts.
Subject(s)
Facial Dermatoses/drug therapy , Papillomavirus Infections/drug therapy , Skin/drug effects , Warts/drug therapy , Zinc Sulfate/administration & dosage , Child , Facial Dermatoses/diagnosis , Facial Dermatoses/virology , Humans , Injections, Intralesional , Male , Papillomavirus Infections/diagnosis , Papillomavirus Infections/virology , Skin/pathology , Skin/virology , Treatment Outcome , Warts/diagnosis , Warts/virologySubject(s)
Cyclopropanes/administration & dosage , Facial Dermatoses/drug therapy , Immunologic Factors/administration & dosage , Immunotherapy/methods , Nail Diseases/drug therapy , Skin/drug effects , Warts/drug therapy , Adolescent , Adult , Child , Cyclopropanes/adverse effects , Drug Administration Schedule , Facial Dermatoses/diagnosis , Facial Dermatoses/immunology , Facial Dermatoses/virology , Female , Humans , Immunologic Factors/adverse effects , Immunotherapy/adverse effects , Male , Nail Diseases/diagnosis , Nail Diseases/immunology , Nail Diseases/virology , Remission Induction , Retrospective Studies , Skin/immunology , Skin/pathology , Skin/virology , Time Factors , Treatment Outcome , Warts/diagnosis , Warts/immunology , Warts/virology , Young AdultSubject(s)
Antimetabolites/therapeutic use , Facial Dermatoses/drug therapy , Fluorouracil/therapeutic use , HIV Infections/complications , Molluscum Contagiosum/complications , Molluscum Contagiosum/drug therapy , Antimetabolites/administration & dosage , Facial Dermatoses/complications , Facial Dermatoses/virology , Female , Fluorouracil/administration & dosage , Humans , Immunocompromised Host , Injections, Intralesional , Middle AgedABSTRACT
Trichodysplasia spinulosa is a rare disease that occurs in the setting of immunosuppression, associated with tolerogenic therapy used in allograft recipients or patients with hematologic malignancies. Clinically, it is characterized by a centrofacial cutaneous eruption of erythematous papules with a central keratinous spicule, often associated with variable degrees of alopecia. Histologic findings are characteristic, and electron microscopy reveals the presence of trichodysplasia spinulosa associated polyomavirus. We report a 47-year-old woman with idiopathic autoimmune pancytopenia refractory to diverse immunosuppressant regimens, with clinical and pathologic findings compatible with the disease, in whom complementary studies were required to exclude other differential diagnoses.
Subject(s)
Facial Dermatoses/pathology , Mucormycosis/pathology , Biopsy , Facial Dermatoses/surgery , Facial Dermatoses/virology , Female , Humans , Immunocompromised Host , Middle Aged , Mucormycosis/surgery , Mucormycosis/virology , Polyomavirus , Polyomavirus InfectionsABSTRACT
Trichodysplasia spinulosa is a rare disease that occurs in the setting of immunosuppression, associated with tolerogenic therapy used in allograft recipients or patients with hematologic malignancies. Clinically, it is characterized by a centrofacial cutaneous eruption of erythematous papules with a central keratinous spicule, often associated with variable degrees of alopecia. Histologic findings are characteristic, and electron microscopy reveals the presence of trichodysplasia spinulosa associated polyomavirus. We report a 47-year-old woman with idiopathic autoimmune pancytopenia refractory to diverse immunosuppressant regimens, with clinical and pathologic findings compatible with the disease, in whom complementary studies were required to exclude other differential diagnoses.
Subject(s)
Humans , Female , Middle Aged , Facial Dermatoses/pathology , Mucormycosis/pathology , Biopsy , Immunocompromised Host , Polyomavirus , Polyomavirus Infections , Facial Dermatoses/surgery , Facial Dermatoses/virology , Mucormycosis/surgery , Mucormycosis/virologyABSTRACT
Orf is a zoonotic infectious disease caused by parapoxvirus. Orf lesions are typically seen on the hand, but they have rarely been reported on the nose. Herein, the authors report a rare patient of an orf lesion on the nose of a 52-year-old man after the Muslim celebration of the feast of the sacrifice. The lesion spontaneously recovered 8 weeks after the initial appearance and showed no evidence of recurrence after 1 year of follow-up. Orf virus infections may occur more often after the celebration of the feast of the sacrifice in Muslim countries.