ABSTRACT
La hiperplasia epitelial focal (HEF) o enfermedad de Heck es una afección poco frecuente de la mucosa oral producida por la asociación entre el virus del papiloma humano (HPV) subtipos 13 y 32 y un factor genético predisponente. Se inicia a edades tempranas, afecta a ambos sexos por igual y tiene preferencia por la población indígena. Clínicamente se caracteriza por múltiples pápulas circunscriptas o nódulos en la cavidad oral (mucosa labial, yugal y lingual), asintomáticas, de evolución variable y malignización extraordinaria. Se comunican ocho casos que fueron vistos en la Sección Estomatología de la División Dermatología de nuestro hospital.
Subject(s)
Humans , Adult , Child , Focal Epithelial Hyperplasia/genetics , Focal Epithelial Hyperplasia/pathology , Focal Epithelial Hyperplasia/drug therapy , Lip/pathology , Mouth Mucosa/pathology , Papillomavirus InfectionsABSTRACT
Summary. Background. This report describes the case of a patient with focal epithelial hyperplasia (FEH), a rare but distinctive entity of viral aetiology with characteristic clinical and histopathological features. Case report. The condition is usually seen in children and adolescents of American Indian and Eskimo background. Surgical removal of papillomatous lesions is the treatment of choice, either for aesthetic reasons, or when the lesions interfere with function or are readily traumatized. Recurrence and the site of new lesions are unpredictable, and continued review of the patient is often necessary. The patient described here has been followed for 24 months without recurrences or changes in the aspect of the remaining lesions. Conclusion. This case highlights a possible genetic predilection for FEH, since the patient is a descent of a Brazilian Xavante Indian.
Subject(s)
Focal Epithelial Hyperplasia/diagnosis , Gingival Diseases/diagnosis , Indians, South American , Adolescent , Brazil , Female , Focal Epithelial Hyperplasia/genetics , Follow-Up Studies , Genetic Predisposition to Disease , Gingival Diseases/genetics , Humans , Indians, South American/genetics , RecurrenceABSTRACT
Os autores relatam um caso de hiperplasia epitelial focal em indivíduo de ascendência indígena e fazem revisäo da literatura pertinente