ABSTRACT
The authors studied ultrastructural characteristics of desmosomes from oral squamous cell carcinoma, reporting the cellular differentiation and size of the desmosomes. The length of the desmosome profiles was measured with a Zeiss KS-300. The desmosomes were grouped according to their size and the tumor histological grading. Statistical analysis indicated a significant correlation (p < .001) between the size of the desmosomes and the histological grading group of the malignancy. The comparison of the desmosome size among the tumor histological grading groups also showed significant difference (p < .001). A multiple comparisons test indicated homogeneity in the size of desmosomes within the histological grading groups: 100% in the well differentiated, 95.2% in the moderately differentiated, and 50% in the poorly differentiated group. The preliminary data strongly suggest that the homogeneity of length of the desmosome profiles may be exploited for diagnostic strategies.
Subject(s)
Carcinoma, Squamous Cell/pathology , Desmosomes/ultrastructure , Gingival Neoplasms/pathology , Lip Neoplasms/pathology , Tongue Neoplasms/pathology , Carcinoma, Squamous Cell/ultrastructure , Desmosomes/pathology , Gingival Neoplasms/ultrastructure , Humans , Lip Neoplasms/ultrastructure , Mouth Floor , Tongue Neoplasms/ultrastructureABSTRACT
Oral myofibroma is an uncommon, benign, solitary proliferation of myofibroblastic tissue. Few cases affecting maxillofacial region have been reported. We present a case of gingival myofibroma, diagnosed on clinical, histopathological, immunohistochemical, and ultrastructural basis.
Subject(s)
Gingival Neoplasms/pathology , Leiomyoma/pathology , Child , Diagnosis, Differential , Female , Gingival Neoplasms/chemistry , Gingival Neoplasms/ultrastructure , Humans , Immunohistochemistry , Leiomyoma/chemistry , Leiomyoma/ultrastructureABSTRACT
A case of epithelioid hemangioendothelioma that occurred in the mandible of a 4-years-old body is reported, and the tumor's ultrastructural features are examined. The presence of small atypical vascular lumina, rounded or fusiform endothelial cells packed with intermediate-sized microfilaments, Weibel-Palade bodies, a small amount of distended rough endoplasmic reticulum, pinocytotic vesicles, and a basal lamina are shown. The remarkable finding of large, apparently "free" spaces within the cells that exhibit vesicle formation and sections of protrusions similar to those found in endothelial cells is discussed