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1.
JAMA ; 331(16): 1357-1358, 2024 04 23.
Article in English | MEDLINE | ID: mdl-38568598

ABSTRACT

This Viewpoint discusses the concept of CARE (compassion, assistance, respect, and empathy) as a way physicians can practice the art of medicine in the current era of care that increasingly incorporates predictive analytics and artificial intelligence.


Subject(s)
Delivery of Health Care , Medicine , Patient-Centered Care , Physicians , Technology , Humans , Delivery of Health Care/methods , Education, Medical/methods , Education, Medical/standards , Empathy , Helping Behavior , Listening Effort , Medicine/methods , Patient-Centered Care/methods , Physician-Patient Relations , Physicians/psychology , Physicians/standards , Respect
2.
Proc Biol Sci ; 291(2021): 20232427, 2024 Apr 30.
Article in English | MEDLINE | ID: mdl-38628131

ABSTRACT

Cooperation may emerge from intrinsic factors such as social structure and extrinsic factors such as environmental conditions. Although these factors might reinforce or counteract each other, their interaction remains unexplored in animal populations. Studies on multilevel societies suggest a link between social structure, environmental conditions and individual investment in cooperative behaviours. These societies exhibit flexible social configurations, with stable groups that overlap and associate hierarchically. Structure can be seasonal, with upper-level units appearing only during specific seasons, and lower-level units persisting year-round. This offers an opportunity to investigate how cooperation relates to social structure and environmental conditions. Here, we study the seasonal multilevel society of superb fairy-wrens (Malurus cyaneus), observing individual responses to experimental playback of conspecific distress calls. Individuals engaged more in helping behaviour and less in aggressive/territorial song during the harsher non-breeding season compared to the breeding season. The increase in cooperation was greater for breeding group members than for members of the same community, the upper social unit, comprised of distinct breeding groups in association. Results suggest that the interaction between social structure and environmental conditions drives the seasonal switch in cooperation, supporting the hypothesis that multilevel societies can emerge to increase cooperation during harsh environmental conditions.


Subject(s)
Passeriformes , Songbirds , Humans , Animals , Songbirds/physiology , Cooperative Behavior , Territoriality , Helping Behavior
3.
J Exp Child Psychol ; 243: 105929, 2024 Jul.
Article in English | MEDLINE | ID: mdl-38663123

ABSTRACT

The current research provides a detailed longitudinal examination of instrumental helping, comforting, and sharing in early childhood. Preschoolers completed a series of prosocial behavior tasks when they were 2 years old (n = 200), 3 years old (n = 161), and 4 years old (n = 135). As expected, children's prosocial behaviors increased with age across all tasks. Yet children's prosocial behaviors were more nuanced than expected, with significant differences in scores between trials within each type of prosocial behavior. Cross-lagged panel modelling revealed that instrumental helping at 3 years predicted comforting when an experimenter was sad or cold at 4 years. Furthermore, children's comforting of a sad experimenter at 3 years predicted sharing their own toy with a sad experimenter at 4 years. These findings offer novel insights into the developmental trajectory of three types of prosocial behavior in early childhood.


Subject(s)
Child Behavior , Helping Behavior , Social Behavior , Humans , Child, Preschool , Male , Female , Longitudinal Studies , Child Behavior/psychology , Child Development , Age Factors
4.
Nat Hum Behav ; 8(4): 668-678, 2024 Apr.
Article in English | MEDLINE | ID: mdl-38379064

ABSTRACT

Trust and honesty are essential for human interactions. Philosophers since antiquity have long posited that they are causally linked. Evidence shows that honesty elicits trust from others, but little is known about the reverse: does trust lead to honesty? Here we experimentally investigated whether trusting young children to help can cause them to become more honest (total N = 328 across five studies; 168 boys; mean age, 5.94 years; s.d., 0.28 years). We observed kindergarten children's cheating behaviour after they had been entrusted by an adult to help her with a task. Children who were trusted cheated less than children who were not trusted. Our study provides clear evidence for the causal effect of trust on honesty and contributes to understanding how social factors influence morality. This finding also points to the potential of using adult trust as an effective method to promote honesty in children.


Subject(s)
Child Behavior , Deception , Morals , Trust , Humans , Trust/psychology , Female , Male , Child, Preschool , Child , Child Behavior/psychology , Helping Behavior
5.
Trends Cogn Sci ; 28(4): 281-283, 2024 Apr.
Article in English | MEDLINE | ID: mdl-38418366

ABSTRACT

In humans and other animals, individuals can actively respond to the specific needs of others. However, the neural circuits supporting helping behaviors are underspecified. In recent work, Zhang, Wu, and colleagues identified a new role for the anterior cingulate cortex (ACC) in the encoding and regulation of targeted helping behavior (allolicking) in mice.


Subject(s)
Brain , Helping Behavior , Humans , Mice , Animals , Brain/physiology , Gyrus Cinguli/physiology , Brain Mapping
6.
Am Nat ; 203(3): 393-410, 2024 Mar.
Article in English | MEDLINE | ID: mdl-38358814

ABSTRACT

AbstractIn cooperative breeding systems, inclusive fitness theory predicts that nonbreeding helpers more closely related to the breeders should be more willing to provide costly alloparental care and thus have more impact on breeder fitness. In the red-cockaded woodpecker (Dryobates borealis), most helpers are the breeders' earlier offspring, but helpers do vary within groups in both relatedness to the breeders (some even being unrelated) and sex, and it can be difficult to parse their separate impacts on breeder fitness. Moreover, most support for inclusive fitness theory has been positive associations between relatedness and behavior rather than actual fitness consequences. We used functional linear models to evaluate the per capita effects of helpers of different relatedness on eight breeder fitness components measured for up to 41 years at three sites. In support of inclusive fitness theory, helpers more related to the breeding pair made greater contributions to six fitness components. However, male helpers made equal contributions to increasing prefledging survival regardless of relatedness. These findings suggest that both inclusive fitness benefits and other direct benefits may underlie helping behaviors in the red-cockaded woodpecker. Our results also demonstrate the application of an underused statistical approach to disentangle a complex ecological phenomenon.


Subject(s)
Cooperative Behavior , Helping Behavior , Animals , Male , Birds , Reproduction
7.
Nature ; 626(7997): 136-144, 2024 Feb.
Article in English | MEDLINE | ID: mdl-38267578

ABSTRACT

Humans and animals exhibit various forms of prosocial helping behaviour towards others in need1-3. Although previous research has investigated how individuals may perceive others' states4,5, the neural mechanisms of how they respond to others' needs and goals with helping behaviour remain largely unknown. Here we show that mice engage in a form of helping behaviour towards other individuals experiencing physical pain and injury-they exhibit allolicking (social licking) behaviour specifically towards the injury site, which aids the recipients in coping with pain. Using microendoscopic imaging, we found that single-neuron and ensemble activity in the anterior cingulate cortex (ACC) encodes others' state of pain and that this representation is different from that of general stress in others. Furthermore, functional manipulations demonstrate a causal role of the ACC in bidirectionally controlling targeted allolicking. Notably, this behaviour is represented in a population code in the ACC that differs from that of general allogrooming, a distinct type of prosocial behaviour elicited by others' emotional stress. These findings advance our understanding of the neural coding and regulation of helping behaviour.


Subject(s)
Behavior, Animal , Empathy , Gyrus Cinguli , Helping Behavior , Pain , Social Behavior , Animals , Mice , Empathy/physiology , Gyrus Cinguli/cytology , Gyrus Cinguli/physiology , Behavior, Animal/physiology , Wounds and Injuries , Coping Skills , Stress, Psychological , Grooming
8.
J Stud Alcohol Drugs ; 85(3): 404-415, 2024 May.
Article in English | MEDLINE | ID: mdl-38270912

ABSTRACT

OBJECTIVE: Bystander intervention (BI) is a promising approach for promoting collective behavior change that has been applied to several domains, including sexual assault, bullying, and more recently, problematic alcohol use. Accurately measuring the strategies that bystanders use to reduce others' alcohol-related risk is an essential step toward improving bystanders' ability to reduce alcohol-related harm in their communities, but current measures of BI are not easily modifiable and applicable for alcohol-related BI. The current study aimed to develop a valid and reliable measure of the bystander construct most proximal to the reduction of risk: bystander strategies. METHOD: Young adults (N = 1,011) who reported being around someone who showed signs of alcohol intoxication in the past 3 months were recruited via Qualtrics Panels to participate in an online survey; a subsample (n = 345) completed a 2-week follow-up. Psychometric evaluation included exploratory and confirmatory factor analyses, item response theory analyses, convergent validity, and test-retest reliability. RESULTS: An initial set of 52 items was reduced to 17 items, representing two different factors. The first factor, Level 1, reflected strategies used during circumstances of acute risk. The second factor, Level 2, reflected strategies used to reduce risk for more longstanding problems with alcohol. Both factors demonstrated good model fit, strong internal consistency, evidence of convergent validity, and moderate test-retest reliability. CONCLUSIONS: This novel measure can contribute to the production of knowledge about the use and efficacy of peer-focused strategies and the value of BI training for alcohol use.


Subject(s)
Alcohol Drinking , Humans , Female , Male , Young Adult , Alcohol Drinking/psychology , Alcohol Drinking/epidemiology , Alcohol Drinking/prevention & control , Adolescent , Adult , Reproducibility of Results , Psychometrics/methods , Psychometrics/standards , Alcoholic Intoxication/psychology , Alcoholic Intoxication/prevention & control , Follow-Up Studies , Helping Behavior
9.
Pers Soc Psychol Bull ; 50(4): 645-656, 2024 Apr.
Article in English | MEDLINE | ID: mdl-36631739

ABSTRACT

Previous research found that experimentally reducing people's belief in free will affects social behaviors. However, more recent investigations could not replicate several findings in this literature. An explanation for the mixed findings is that free will beliefs are related to social behaviors on a correlational level, but experimental manipulations are not able to detect this relation. To test this interpretation, we conceptually replicated and extended a landmark study in the free will belief literature originally conducted by Baumeister et al. In five studies (total N = 1,467), we investigated whether belief in free will predicts helping behavior in comparison to other beliefs related to free will. Overall, our results support the original findings, as belief in free will correlated with helping behavior. However, the results also show that the best predictor of helping behavior is not belief in free will but belief in dualism. Theoretical implications are discussed.


Subject(s)
Helping Behavior , Personal Autonomy , Humans
10.
Death Stud ; 48(5): 522-532, 2024 May.
Article in English | MEDLINE | ID: mdl-37603417

ABSTRACT

This study explores the factors involved in the capacity of newly trained suicide prevention gatekeepers to engage in the identification and support of people at risk of suicide. In-depth telephone interviews were conducted with 18 gatekeepers from various settings who had participated in a larger quantitative study of the impact of gatekeeper training. Conventional content analysis was performed on the data collected. Participants said that gatekeeper training provided key information and legitimized their role. Previous experience with suicidal friends and family members motivated their involvement and helped them to engage with at-risk individuals. Support available from the setting, including attitudes toward suicide, resources for referrals and promotion of the gatekeeper activities, were instrumental in gatekeepers' ability to fulfill their role. Gatekeeper programs may benefit from adopting a comprehensive approach to gatekeeper helping behaviors by attending to their contextual influences, and the effects of gatekeepers' personal experiences.


Subject(s)
Suicide Prevention , Suicide , Humans , Helping Behavior , Suicidal Ideation , Family
11.
Psychogeriatrics ; 24(1): 117-126, 2024 Jan.
Article in English | MEDLINE | ID: mdl-37990417

ABSTRACT

BACKGROUND: Community members can play important roles in helping older adults in their community. This study aimed to clarify the actual situation of community members' helping behaviours towards older adults and examine the related factors. METHODS: This cross-sectional study was conducted using an online survey system with a sample of 1000 community members in the Tokyo metropolitan area selected using quota sampling. Participants were asked about their experiences with helping an older adult, involvement with older adults with dementia, knowledge of dementia and care resources in the community, and perceptions regarding the community. Content analysis was used to classify participants' freely answered responses about helping behaviours, with logistic regression analysis subsequently used to examine the related factors. RESULTS: Community members provided older adults with various types of spontaneous help, including help with walking (20.0%), accident care (16.8%), giving directions to a destination (11.6%), accompanying them to a destination (12.9%), and support in daily life (10.4%). In the multinominal logistic regression analysis, advanced helping behaviours were associated with having a family member with dementia, experiences involving people living with dementia, knowledge of dementia and community support centres, and a stronger sense of community integration (P < 0.05). The reasons for not being able to help included being physically unable to (42.5%), not feeling responsible (19.3%), not knowing how to help (17.4%), and hesitating to help (14.4%). CONCLUSION: The results suggest that providing learning opportunities for community members could further promote their helping behaviours for older adults. These could include interacting with older adults, especially those living with dementia; promoting a sense of community integration; or receiving training in helping actions. Such efforts could support the development of an effective community-based care system for older adults.


Subject(s)
Dementia , Helping Behavior , Humans , Aged , Cross-Sectional Studies , Family , Tokyo
12.
Evolution ; 78(4): 690-700, 2024 Mar 26.
Article in English | MEDLINE | ID: mdl-37948581

ABSTRACT

Cooperative breeding occurs when helpers provide alloparental care to the offspring of a breeding pair. One hypothesis of why helping occurs is that helpers gain valuable skills that may increase their own future reproductive success. However, research typically focuses on the effect of helping on short-term measures of reproductive success. Fewer studies have considered how helping affects long-term fitness measures. Here, we analyze how helping experience affects key breeding and fitness-related parameters in the Seychelles warbler (Acrocephalus sechellensis). Importantly, we control for females that have cobred (reproduced as a subordinate by laying an egg within a territory in which they are not a dominant breeder), as they already have experience with direct reproduction. Helping experience had no significant association with any of the metrics considered, except that helpers had an older age at first dominance. Accounting for helping experience, females that had cobred produced more adult offspring (≥1 year) after acquiring dominance and had a higher lifetime reproductive success (LRS) than females that had never cobred. Our results suggest that, in the Seychelles warbler, helping experience alone does not increase the fitness of helpers in any of the metrics considered, and highlights the importance of separating the effects of helping from cobreeding. Our findings also emphasize the importance of analyzing the effect of helping at various life-history stages, as higher short-term fitness may not translate to an overall increase in LRS.


Subject(s)
Passeriformes , Songbirds , Animals , Female , Songbirds/genetics , Reproduction , Life Cycle Stages , Cooperative Behavior , Helping Behavior
13.
J Interpers Violence ; 39(5-6): 1104-1131, 2024 Mar.
Article in English | MEDLINE | ID: mdl-37850670

ABSTRACT

Bystander intervention-when someone intervenes to help in situations that pose a risk for harm-is a promising strategy for sexual violence prevention. In the current study, a sample of U.S. Army male soldiers (N = 10; ages 18-24) who engaged in at-risk drinking completed a 90-min individual semi-structured interview to understand the ways in which soldiers intervene to address risk for sexual violence. Two independent raters coded soldier responses using thematic analysis and identified eight main themes: (a) recognizing risk for sexual violence; (b) labeling situations as problematic and taking responsibility; (c) facilitators of intervention; (d) barriers to intervention; (e) intervention strategies; (f) reactions and consequences to intervention; (g) alcohol's influence on intervention; and (h) using bystander intervention to shift cultural norms. As soldiers reported noticing more extreme risks for violence, prevention interventions may help service members identify situations earlier in the continuum of harm. Soldiers anticipated intervening in a way that was physical and aggressive, which could facilitate physical altercation and result in collateral misconduct. Results from the present study reveal ways that bystander intervention programs for civilians can be tailored to address the unique individual, situational, and contextual factors relevant to the military. These findings also highlight the importance of teaching soldiers indirect and nonaggressive strategies for intervention.


Subject(s)
Military Personnel , Sex Offenses , Humans , Male , Young Adult , Helping Behavior , Sex Offenses/prevention & control , Sexual Behavior , Violence/prevention & control , Universities
14.
Work ; 77(2): 601-614, 2024.
Article in English | MEDLINE | ID: mdl-37718830

ABSTRACT

BACKGROUND: Mutual help among members is critical to the accomplishment of complex tasks in an organization. Helping behaviors are infectious, and employees learn to imitate their coworkers' helping behaviors through observation. However, whether coworker helping triggers imitation learning depends on observers' motivational attributions for coworker helping behaviors to some extent. OBJECTIVE: Based on attribution theory and approach-avoidance framework, this research explored the approach and avoidance-oriented emotional and behavioral consequences of observers' prosocial and impression management motivational attributions of coworker helping behavior. METHODS: An experimental study with 178 participants and a field study with 259 employees was conducted. RESULTS: The results revealed that observers attribute coworkers' helpfulness to prosocial motivation, which elicited observers' approach-oriented emotions (i.e., positive empathy) and behaviors (i.e., helping behavior) and reduced coworker exclusion, while impression-management motivation elicited observers' avoidance-oriented emotions (i.e., disgust) and behaviors (i.e., coworker exclusion) and reduced helping behavior. CONCLUSION: The results suggest that prosocial motivational attributions and impression management motivational attributions are key factors in determining whether observers have approach- or avoidance-oriented emotions and behaviors toward coworker helping. Accordingly, individual employees and managers should focus on employees' motivation to help others in order to promote mutual support and harmony in the workplace.


Subject(s)
Helping Behavior , Motivation , Humans , Emotions , Empathy , Attitude
15.
Suicide Life Threat Behav ; 54(1): 108-121, 2024 Feb.
Article in English | MEDLINE | ID: mdl-37987534

ABSTRACT

INTRODUCTION: Gatekeeper (GK) training is a suicide prevention strategy in which community members learn to identify individuals at risk of suicide and refer them for appropriate help. Despite its widespread use, few studies have investigated its effects, including changes in helping behaviors. AIMS: To assess the impact of GK training on participants' knowledge, recognition of the influence of attitudes, perceived self-efficacy, intention to help and helping behaviors, and to identify variables associated with GK behaviors. METHODS: Mixed linear effects and forward stepwise logistic regressions were used to analyze data from 159 participants receiving the Quebec Provincial GK Training program offered by five different suicide prevention centers using pretest, posttest and 6-month follow-up questionnaires. RESULTS: Participants' knowledge of the GK role and suicide prevention, intention to help, self-efficacy, knowledge of services, and recognition of the influence of attitudes significantly increased following training. Most changes decreased at follow-up but remained higher than at pretest. Lower levels of education and higher intention to help were significant predictors of engaging in helping behaviors in the first 6 months after receiving training. CONCLUSIONS: The Quebec GK training appears to be effective in preparing participants for their role but does not appear to significantly increase helping behaviors.


Subject(s)
Intention , Suicide Prevention , Humans , Helping Behavior , Self Efficacy , Quebec
16.
J Interpers Violence ; 39(7-8): 1704-1730, 2024 Apr.
Article in English | MEDLINE | ID: mdl-37924261

ABSTRACT

Sexual harassment is a problem that continues to confront mostly women in the American workforce. One of the primary ways to reduce its prevalence and impact is through bystander intervention. A bystander is familiar with the incident and ultimately decides whether to proactively intervene, do nothing, or actually cause further damage to the victim by siding with the perpetrator. While bystanders can become engaged both prior to and during a sexually harassing event, or at the primary and secondary levels of prevention, they can also be involved after the incident, or at the tertiary level of prevention. This present study addressed tertiary prevention in real-life sexual harassment cases drawn from the fashion industry, whereby female models-as independent contractors represented by agencies and with few labor rights-were the victims, powerful men in the business were the key perpetrators, and other actors were the bystanders. Using thematic analysis to understand 18 accounts of harassment, this research identified bystander support from personal associates and some modeling agencies as institutions in the form of emotional resources and action-oriented advocacy. However, other modeling agencies more commonly engaged in bystander opposition, whereby they silenced their models who complained of harassment or continued to send models to work with known perpetrators in the business. This study thus draws attention to the ways in which some bystanders can help, but others can cause further harm through their particular employment relationships with victims that promote worker precarity. Implications for practitioners and public policy reforms for this industry are discussed.


Subject(s)
Sexual Harassment , Male , Humans , Female , Sexual Harassment/psychology , Sexual Partners/psychology , Helping Behavior
17.
J Appl Psychol ; 109(4): 551-572, 2024 Apr.
Article in English | MEDLINE | ID: mdl-37971830

ABSTRACT

Taking a follower's perspective on leadership and contributing to the new research stream on behaviors conducive to its emergence, we examined how distinct types of instrumental (task focused) helping-autonomy- versus dependency-helping-affected recipients' support for their helpers' leadership. Based on the literature on employees' needs for autonomy and mastery, combined with the empowering nature of autonomy-helping, we reasoned that autonomy- (vs. dependency-) helping typically signals greater benevolence toward recipients, enhancing their support for their helpers' leadership. Our findings were generalized across various samples (of U.S. and Israeli employees), manipulations, and research settings: simulations (Studies 1 and 2b), workplace role-play scenario (Study 2a), and recollections of helping events in the workplace (Study 3). We found that autonomy- (vs. dependency-) helping increased recipients' support for their helpers' leadership by heightening perceptions of helpers' benevolence-based (rather than ability-based) trustworthiness (Studies 1 and 3). We also showed time pressure to be a boundary condition under which the advantage of autonomy-helping disappeared (Studies 2a and 2b)-with dependency-helping then inducing comparable levels of perceived benevolence and thus similar support for the helper's potential leadership. Overall, we shed light on the development of informal leadership by uncovering how recipients interpret and respond to the two help types. Practically, this analysis opens the door to new ways for aspiring managers to enhance support for their leadership from potential followers, available even to those unlikely to be appointed to formal leadership positions. (PsycInfo Database Record (c) 2024 APA, all rights reserved).


Subject(s)
Helping Behavior , Interpersonal Relations , Humans , Leadership , Hunting
18.
J Interpers Violence ; 39(1-2): 184-213, 2024 01.
Article in English | MEDLINE | ID: mdl-37655590

ABSTRACT

Limited qualitative research has been conducted to understand the experiences of victims of sexual harassment or assault (SHA) when a bystander intervenes. Even less research has focused on the consequences of bystander actions from the victim's perspective, particularly regarding the aggressor's subsequent behavior toward the victim and occurrence of verbal or physical harm to those involved. This qualitative study aimed to address these limitations with the following research questions: (a) what strategies did victims of SHA identify bystanders use when intervening? (b) what strategies were present when the aggressor's behavior was stopped, paused, or continued toward the victim? and (c) what strategies were present when verbal or physical harm occurred to someone involved? Adult women between the ages of 18 to 30 (N = 25, college student = 80%) were interviewed about one situation of bystander intervention during SHA since the age of 16 years. Findings suggest that victims identified direct, distance, distract, delegate, and proximity strategies by bystanders. Most participants reported that the aggressor's behavior stopped or paused following bystander action, and in these cases, at least one distance or direct strategy was reportedly used most frequently. Approximately, 24% and 8% of participants reported verbal or physical harm, respectively, to at least one party. Direct and distance strategies were most frequently mentioned in experiences of SHA that involved harm. When the aggressor's behavior continued (i.e., was not altered during the event) despite bystander actions, strategies most frequently reported included distract, delegate, and proximity. Together, results suggest that bystander intervention training programs and future research may be needed to understand under what contexts certain strategies successfully prevent or thwart SHA while maintaining emotional and physical safety for those involved.


Subject(s)
Crime Victims , Sex Offenses , Sexual Harassment , Adult , Humans , Female , Adolescent , Young Adult , Crime Victims/psychology , Sex Offenses/psychology , Helping Behavior , Students/psychology
19.
Sci Rep ; 13(1): 18320, 2023 10 26.
Article in English | MEDLINE | ID: mdl-37884594

ABSTRACT

Previous research has demonstrated a link between the administration of analgesic drugs and the reduction of empathy levels in humans. This apparent blunting effect of pain medication has been explained through shared neural mechanisms for the first-hand and the empathic experience of pain (simulation theory). Considering that analgesics are among the most consumed drugs in the world and the ability to empathize with others is fundamental to human social interactions, the aim of the present study was to investigate whether the typical day-to-day analgesic consumption rate in Austria and Germany is associated with a reduction in empathy and prosocial behavior. We therefore collected self-reports of analgesic consumption behavior as well as empathy for pain and prosocial behavior measures in an online survey (n = 940). Analyses revealed no significant association between the analgesic intake frequency and measures of empathy or prosocial behavior. However, liberal intake of analgesics (i.e. mind-set of "a pill is a quick solution") was linked to lower empathic concern and helping behavior, which may hint towards a negative effect in people who take pain medication for non-pain related issues or episodes of low pain. Nevertheless, further research is needed to investigate the effects of analgesic drugs in high frequency users.


Subject(s)
Altruism , Empathy , Humans , Social Behavior , Pain/drug therapy , Helping Behavior , Analgesics
20.
Curr Biol ; 33(20): 4330-4342.e5, 2023 10 23.
Article in English | MEDLINE | ID: mdl-37734375

ABSTRACT

Many species living in groups can perform prosocial behaviors via voluntarily helping others with or without benefits for themselves. To provide a better understanding of the neural basis of such prosocial behaviors, we adapted a preference lever-switching task in which mice can prevent harm to others by switching from using a lever that causes shocks to a conspecific one that does not. We found the harm avoidance behavior was mediated by self-experience and visual and social contact but not by gender or familiarity. By combining single-unit recordings and analysis of neural trajectory decoding, we demonstrated the dynamics of anterior cingulate cortex (ACC) neural activity changes synchronously with the harm avoidance performance of mice. In addition, ACC neurons projected to the mediodorsal thalamus (MDL) to modulate the harm avoidance behavior. Optogenetic activation of the ACC-MDL circuit during non-preferred lever pressing (nPLP) and inhibition of this circuit during preferred lever pressing (PLP) both resulted in the loss of harm avoidance ability. This study revealed the ACC-MDL circuit modulates prosocial behavior to avoid harm to conspecifics and may shed light on the treatment of neuropsychiatric disorders with dysfunction of prosocial behavior.


Subject(s)
Gyrus Cinguli , Helping Behavior , Mice , Animals , Gyrus Cinguli/physiology , Thalamus/physiology , Neurons/physiology
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