ABSTRACT
Management of febrile neutropenia (FN) is an integral part of supportive care for patients undergoing cancer treatment. The NCCN Guidelines for Hematopoietic Growth Factors provide suggestions for appropriate evaluation, risk determination, prophylaxis, and management of FN. These NCCN Guidelines are intended to guide clinicians in the appropriate use of growth factors for select patients undergoing treatment of nonmyeloid malignancies. These NCCN Guidelines Insights highlight important updates to the NCCN Guidelines regarding the incorporation of newly FDA-approved granulocyte-colony stimulating factor biosimilars for the prevention and treatment of FN.
Subject(s)
Biosimilar Pharmaceuticals/therapeutic use , Chemotherapy-Induced Febrile Neutropenia/drug therapy , Hematopoietic Cell Growth Factors/therapeutic use , Neoplasms/drug therapy , Practice Guidelines as Topic , Antineoplastic Combined Chemotherapy Protocols/adverse effects , Biosimilar Pharmaceuticals/economics , Biosimilar Pharmaceuticals/standards , Chemotherapy-Induced Febrile Neutropenia/etiology , Drug Approval , Drug Costs , Education, Medical, Continuing , Hematopoietic Cell Growth Factors/economics , Hematopoietic Cell Growth Factors/standards , Humans , Medical Oncology/education , Medical Oncology/standards , Neoplasms/blood , Oncologists/education , Organizations, Nonprofit/standards , Risk Factors , United States , United States Food and Drug Administration/legislation & jurisprudenceABSTRACT
Hematopoietic growth factors are cytokines that regulate the growth, development, and function of hematopoetic lineages. These hematopoietic growth factors have great potential for improving the quality of life and for reducing toxicity. This article reviews some of the most clinically relevant hematopoietic growth factors and what is known about their use in veterinary medicine. In particular, the following hematopoietic growth factors are discussed: erythropoietin, stem-cell factor, interleukin-3, interleukin-5, granulocyte-macrophage colony-stimulating factor, granulocyte colony-stimulating factor, and macrophage colony-stimulating factor.
