ABSTRACT
Recent approach in treatment and drug development suggested that the control of oxidative stress in malarial infected patients may be an added advantage. In this study, effect of methanolic leaf extract of Sphenocentrum jollyanum pier (S. jollyanum) on liver damage, markers of oxidative stress and alteration in lipid profile in P. berghei infected mice was assessed. Oxidative stress was induced by intravenously inoculation of mice with 1 × 107 sporozoites P. berghei. Treatment of parasitized mice with leaf extract of S. jollyanum had a significant (p<0.05) reductions in elevated levels of total protein, globulin, AST, ALT, ALP, GGT and total bilirubin, serum, kidney and liver malondialdehyde (MDA) concentrations, but caused a significant (p<0.05) increased in the activities of serum and liver catalase (CAT), superoxide dismutase (SOD) and glutathione (GSH) level when compared with parasitized non-treated group (PNT). The extract treated group also showed significant (p<0.05) improvement in the levels of HDLc, total cholesterol, LDL and reduction in triglyceride compared with parasitized non treated group. Our results revealed that the protective capacity and antioxidant activity of the extract is dose dependant. The findings suggest that antioxidant property of Sphenocentrum jollyanum leave extract might be an added advantage to it anti-malarial activity.
Subject(s)
Antioxidants/pharmacology , Malaria/drug therapy , Menispermaceae/chemistry , Plant Extracts/pharmacology , Animals , Antimalarials/pharmacology , Cholesterol/metabolism , Female , Hepatic Insufficiency/drug therapy , Hepatic Insufficiency/enzymology , Hepatic Insufficiency/metabolism , Hepatic Insufficiency/parasitology , Kidney/drug effects , Kidney/metabolism , Kidney/parasitology , Lipid Metabolism/drug effects , Liver/drug effects , Liver/enzymology , Liver/metabolism , Liver/parasitology , Malaria/metabolism , Malaria/parasitology , Malaria/pathology , Male , Mice , Oxidative Stress/drug effects , Plant Leaves/chemistry , Plasmodium berghei/drug effects , Random Allocation , Sporozoites/drug effectsABSTRACT
We report the case of a 79-year-old woman admitted for sepsis from a hepatic hydatid cyst with multiple disseminations diagnosed one month earlier who refused the surgical treatment. Her family history was irrelevant with regard to the circumstances leading to Taenia Echinococcus infestation, and given her poor health status and absence of previous medical documents no useful information was obtained from her medical history. The patient also presented chronic ischemic heart disease and anemia secondary to a bleeding duodenal ulcer, found at necropsy, which worsened the already unfavorable course by the acute hepatic and renal failure secondary to toxic and septic shock. Despite the complex treatment, death occurred 6 days later, following a second episode of upper digestive hemorrhage. Particular to this case is the absence in patient's history of the anaphylactic/allergic reactions suggestive of hepatic hydatid cyst dissemination.
