ABSTRACT
Abstract Acute pancreatitis is a rare condition in pregnancy, associated with a high mortality rate. Hypertriglyceridemia represents its second most common cause.We present the case of a 38-year-old woman in the 24th week of gestation with a history of hypertriglyceridemia and recurrent episodes of pancreatitis. She was admitted to our hospital with acute pancreatitis due to severe hypertriglyceridemia. She was stabilized and treated with fibrates. Despite her favorable clinical course, she developed a second episode of acute pancreatitis complicated by multi-organ dysfunction and pancreatic necrosis, requiring a necrosectomy. The pregnancy was ended by cesarean section, after which three plasmapheresis sessions were performed. She is currently asymptomatic with stable triglyceride levels. Acute pancreatitis due to hypertriglyceridemia represents a diagnostic and therapeutic challenge in pregnant women, associated with serious maternal and fetal complications. When primary hypertriglyceridemia is suspected, such as familial chylomicronemia syndrome, the most important objective is preventing the onset of pancreatitis.
Subject(s)
Humans , Female , Pregnancy , Adult , Pregnancy Complications/diagnosis , Prenatal Diagnosis , Pancreatitis, Acute Necrotizing/diagnosis , Hyperlipoproteinemia Type I/diagnosis , Pregnancy Complications/diagnostic imaging , APACHE , Pancreatitis, Acute Necrotizing/complications , Pancreatitis, Acute Necrotizing/diagnostic imaging , Diagnosis, Differential , Hyperlipoproteinemia Type I/complications , Hyperlipoproteinemia Type I/diagnostic imagingABSTRACT
Acute pancreatitis is a rare condition in pregnancy, associated with a high mortality rate. Hypertriglyceridemia represents its second most common cause. We present the case of a 38-year-old woman in the 24th week of gestation with a history of hypertriglyceridemia and recurrent episodes of pancreatitis. She was admitted to our hospital with acute pancreatitis due to severe hypertriglyceridemia. She was stabilized and treated with fibrates. Despite her favorable clinical course, she developed a second episode of acute pancreatitis complicated by multi-organ dysfunction and pancreatic necrosis, requiring a necrosectomy. The pregnancy was ended by cesarean section, after which three plasmapheresis sessions were performed. She is currently asymptomatic with stable triglyceride levels. Acute pancreatitis due to hypertriglyceridemia represents a diagnostic and therapeutic challenge in pregnant women, associated with serious maternal and fetal complications. When primary hypertriglyceridemia is suspected, such as familial chylomicronemia syndrome, the most important objective is preventing the onset of pancreatitis.
Subject(s)
Hyperlipoproteinemia Type I/diagnosis , Pancreatitis, Acute Necrotizing/diagnosis , Pregnancy Complications/diagnosis , Prenatal Diagnosis , APACHE , Adult , Diagnosis, Differential , Female , Humans , Hyperlipoproteinemia Type I/complications , Hyperlipoproteinemia Type I/diagnostic imaging , Pancreatitis, Acute Necrotizing/complications , Pancreatitis, Acute Necrotizing/diagnostic imaging , Pregnancy , Pregnancy Complications/diagnostic imagingABSTRACT
CASO CLÍNICO: Presentamos tres casos de pacientes con hiperquilomicronemia familiar y lipemia retinalis, y analizamos de forma comparada las características fundoscópicas de cada uno de ellos. DISCUSIÓN: El aspecto característico del fondo retiniano en color salmón-pálido corresponde con grados severos de lipemia retinalis. Los hallazgos relativos a la tonalidad del árbol vascular en segmentos distales constituyen probablemente el dato exploratorio que mejor orienta el diagnóstico oftalmológico en niveles inferiores de hipertrigliceridemia
CASES REPORT: Three cases are presented of patients with familial hyperchylomicronaemia and lipaemia retinalis, in whom an analysis is made of the fundoscopic characteristics of each of them. DISCUSSION: The typical appearance of the retinal fundus is pale salmon coloured and corresponds to levels of severe lipaemia retinalis. As regards the findings, the vascular tree tonality is probably the best exploratory evidence to help in the ophthalmological diagnosis
Subject(s)
Humans , Female , Young Adult , Adult , Middle Aged , Hyperlipoproteinemia Type I/diagnostic imaging , Ophthalmoscopy/methods , Hyperlipidemias/diagnostic imaging , Retinal Diseases/diagnostic imaging , Hyperlipoproteinemia Type I/pathology , Hyperlipidemias/pathology , Retinal Diseases/pathology , Fundus OculiSubject(s)
Fluorodeoxyglucose F18/pharmacokinetics , Heart/diagnostic imaging , Hyperlipoproteinemia Type I/diagnostic imaging , Hyperlipoproteinemia Type I/metabolism , Myocardium/metabolism , Female , Humans , Male , Middle Aged , Radionuclide Imaging , Radiopharmaceuticals/pharmacokinetics , Tissue Distribution , Young AdultABSTRACT
We present the imaging findings in an 8-week-old infant with LPL deficiency. Due to markedly increased lipoproteins in the serum, abnormal hypodensity and abnormal T1-weighted hyperintensity were identified in the dural venous sinuses and medullary veins.