Pharmacogenetic variability of tuberculosis biomarkers in native and mestizo Peruvian populations.

In Peru, 29 292 people were diagnosed with tuberculosis in 2022. Although tuberculosis treatments are effective, 3.4%-13% are associated with significant adverse drug reactions, with drug-induced liver injury (DILI) considered the most predominant. Among the first-line antituberculosis drugs, isoniazid is the main drug responsible for the appearance of DILI. In liver, isoniazid (INH) is metabolized by N-acetyltransferase-2 (NAT2) and cytochrome P450 2E1 (CYP2E1). Limited information exists on genetic risk factors associated with the presence of DILI to antituberculosis drugs in Latin America, and even less is known about these factors in the native and mestizo Peruvian population. The aim of this study was to determine the prevalence of NAT2 and CYP2E1 genotypes in native and mestizo population. An analytical cross-sectional analysis was performed using genetic data from mestizo population in Lima and native participants from south of Peru. NAT2 metabolizer was determined as fast, intermediate and slow, and CYP2E1 genotypes were classified as c1/c1, c1/c2 and c2/c2, from molecular tests and bioinformatic analyses. Of the 472 participants, 36 and 6 NAT2 haplotypes were identified in the mestizo and native population, respectively. In mestizo population, the most frequent NAT2*5B and NAT2*7B haplotypes were associated with DILI risk; while in natives, NAT2*5G and NAT2*13A haplotypes were associated with decreased risk of DILI. For CYP2E1, c1/c1 and c1/c2 genotypes are the most frequent in natives and mestizos, respectively. The linkage disequilibrium of NAT2 single nucleotide polymorphisms (SNPs) was estimated, detecting a block between all SNPs natives. In addition, a block between rs1801280 and rs1799929 for NAT2 was detected in mestizos. Despite the limitations of a secondary study, it was possible to report associations between NAT2 and CYP2E alleles with Peruvian native and mestizo by prevalence ratios. The results of this study will help the development of new therapeutic strategies for a Tuberculosis efficient control between populations.

Resolutividade no Subsistema de Atenção à Saúde Indígena no Brasil: revisão de escopo / Resolubility in the Indigenous Health Care Subsystem in Brazil: scope review / Resolución en el Subsistema de Atención de la Salud Indígena en Brasil: revisión del alcance

RESUMO: A resolutividade relaciona-se à capacidade de solução dos problemas de saúde nos serviços. Em 1999, o Subsistema de Atenção à Saúde Indígena foi integrado ao Sistema Único de Saúde no Brasil, passando a seguir os seus princípios e diretrizes. Este estudo teve por objetivo identificar e mapear os desafios ou problemas relacionados às práticas em saúde para a resolutividade no Subsistema de Saúde Indígena após a integração. Trata-se de uma revisão de escopo que utilizou seis bases de dados nacionais e internacionais. Os estudos elegíveis tiveram como critério base o mnemônico PCC (P: população indígena; C: desafios ou problemas para a resolutividade; C: subsistema de saúde indígena brasileiro). Foram encontrados 1.748 estudos e selecionados 33, com predomínio de estudos qualitativos. Os desafios ou problemas sensíveis para o processo da resolutividade foram encontrados nos aspectos que tangem à educação em saúde, à interculturalidade, ao acesso universal e aos recursos em gestão. O saber tradicional é pouco valorizado pelo sistema de saúde. A deficiência de recursos humanos e materiais, a falta de efetiva educação permanente e de capacitações para trabalhar no contexto intercultural produzem barreiras de acesso e comprometem a resolutividade nos serviços, aumentando assim as iniquidades em saúde.

ABSTRACT: Resolubility relates to the ability to solve health problems in services. In 1999, the Indigenous Health Care Subsystem was integrated into the Brazilian Unified Health System, following its principles and guidelines. The objective of this study was to identify and map the challenges or problems related to health practices for solving in the Indigenous Health Subsystem after integration. This is a scope review that used six national and international databases. Eligible studies were based on mnemonic PCC (P: indigenous population; C: challenges or problems for resolution; C: Brazilian indigenous health subsystem). A total of 1,748 studies were found and 33 were selected, with predominance of qualitative studies. The challenges or problems that are sensitive to the resolution process were found in the aspects that are related to health education, interculturality, universal access and management resources. Traditional knowledge is underrated by the health system. The deficiency of human and material resources, the lack of effective permanent education and capacitations to work in the intercultural context, produce barriers to access and compromise the resolubility in services, thus increasing the inequities in health.

RESUMEN: La resolución se refiere a la capacidad de resolver problemas de salud en los servicios. En 1999, el Subsistema de Atención de Salud Indígena se integró en el Sistema Único de Salud de Brasil, siguiendo sus principios y directrices. El objetivo de este estudio fue identificar y mapear los desafíos o problemas relacionados con las prácticas de salud para resolver en el Subsistema de Salud Indígena después de la integración. Esta es una revisión de alcance que utilizó seis bases de datos nacionales e internacionales. Los estudios elegibles se basaron en PCC mnemónicos (P: población indígena; C: desafíos o problemas para la resolución; C: subsistema de salud indígena brasileño). Se encontraron 1.748 estudios y se seleccionaron 33, con predominio de estudios cualitativos. Los desafíos o problemas que son sensibles al proceso de resolución se encontraron en los aspectos que están relacionados con la educación en salud, la interculturalidad, el acceso universal y los recursos de gestión. El conocimiento tradicional es subestimado por el sistema de salud. La deficiencia de recursos humanos y materiales, la falta de educación permanente efectiva y de capacitaciones para trabajar en el contexto intercultural, producen barreras para acceder y comprometer la solubilidad en los servicios, aumentando así las desigualdades en salud.

Receitas padronizadas da alimentação escolar indígena de Mato Grosso do Sul / Recettes normalisées de l'alimentation scolaire indigène du Mato Grosso do Sul

Diante das dificuldades em padronizar fichas técnicas de preparações culinárias por parte dos profissionais atuantes na alimentação escolar, o CECANE/UFMS se propôs em realizar a elaboração de um receituário padrão. Tal documento tem o objetivo de auxiliar no planejamento, organização e execução do preparo das refeições nas escolas, de modo que este receituário se constitua como um instrumento de auxílio para melhor execução do PNAE nas escolas indígenas. Acompanhando o cenário nacional, a população indígena de Mato Grosso do Sul vem sofrendo com a insegurança alimentar e nutricional devido à carência de ingestão de proteínas, vitaminas e minerais, ocasionada pela redução do consumo de alimentos in natura e pelo aumento da oferta e acesso a alimentos industrializados com alto teor de açúcares, gorduras e aditivos alimentares. Essa situação é causada pela mudança dos hábitos alimentares ocasionada pela influência da população não-indígena, pela diminuição das terras indígenas, mudanças climáticas e escassez de alimentos (CHAMORRO; COMBÈS, 2015). Nesse contexto, o suporte governamental manifesto por meio da implantação de programas sociais e políticas públicas de alimentação e nutrição são ferramentas de extrema importância para combate à fome, garantia do direito à alimentação adequada e saudável, assim como a manutenção das tradições indígenas (CHAMORRO; COMBÈS, 2015). Dentre as ferramentas governamentais existentes para promover a Segurança Alimentar e Nutricional (SAN) no âmbito escolar, o PNAE desponta como um programa federal bem consolidado que viabiliza recursos financeiros para a alimentação dos estudantes e para ações de Educação Alimentar e Nutricional (EAN) nas comunidades (BRASIL, 2020). Os ditos materiais desenvolvidos pelo CECANE/UFMS visam tratar de temas tais quais o acesso aos alimentos de forma igualitária, bem como apoiar o desenvolvimento sustentável por meio do incentivo à compra de diferentes gêneros alimentícios produzidos pela agricultura familiar e pelos empreendedores familiares rurais, principalmente aqueles das comunidades tradicionais indígenas e quilombolas. Como disposto na legislação em relação aos cardápios escolares, seu planejamento e execução devem ser feitos pelo Responsável Técnico (RT) do PNAE, priorizandose a utilização de alimentos in natura ou minimamente processados, respeitando as necessidades nutricionais das respectivas faixas etárias, os hábitos alimentares locais, e atendendo às especificidades culturais das comunidades tradicionais, além de defender a sustentabilidade, sazonalidade e diversidade agrícola da região (BRASIL, 2020).

Receitas culinárias indígenas Guarani-Kaiowá e Terena na escola / Indigenous culinary recipes Guarani-Kaiowá and Terena at school

Este e-book, desenvolvido pelo Centro Colaborador em Alimentação e Nutrição Escolar (Cecane) da Universidade Federal de Mato Grosso do Sul (UFMS), apresenta receitas da culinária indígena Terena e Guarani Kaiowá, com suas respectivas Fichas Técnicas de Preparação (FTP). As receitas foram obtidas a partir de visitas e conversas informais com indígenas das etnias Guarani Kaiowá e Terena, nas Terras Indígenas Caarapó (Caarapó-MS), Limão Verde (Aquidauana-MS) e Nioaque (Nioaque-MS) e podem ser utilizadas como opções de preparações nos cardápios da alimentação escolar indígena das respectivas etnias, desde que façam parte da cultura alimentar daquela aldeia ou Terra Indígena e tenham boa aceitabilidade pelos escolares. O e-book também pode ser utilizado por indivíduos da comunidade em geral, que tenham interesse na culinária Guarani Kaiowá e Terena. A partir das visitas realizadas, por meio de conversas informais com membros das comunidades indígenas, foram registradas preparações culinárias Guarani Kaiowá e Terena. Posteriormente, as receitas obtidas nas visitas foram reproduzidas no Laboratório de Técnica Dietética e Gastronomia da UFMS e padronizadas através de Fichas Técnicas de Preparação. As fichas técnicas são instrumentos essenciais no planejamento de cardápios e se caracterizam por conter todas as informações necessárias para o desenvolvimento de uma preparação culinária, como as quantidades dos ingredientes em gramas/mililitros e também em medidas caseiras, indicadores culinários como fator de correção, rendimento da preparação, além de custo e valor nutricional. A Resolução CD/FNDE nº 06/2020, que regulamenta o PNAE, exige a Ficha Técnica de Preparação para todas as preparações do cardápio da alimentação escolar. Assim, o presente e-book traz preparações da culinária indígena Guarani Kaiowá e Terena com suas respectivas Fichas Técnicas de Preparação. O presente e-book teve por objetivo elaborar Fichas Técnicas de Preparações de receitas culinárias das etnias Guarani Kaiowá e Terena para encorajar seu uso na alimentação escolar indígena e assim buscar o pleno cumprimento do Programa Nacional de Alimentação Escolar (PNAE), o qual fortalece as políticas públicas de Segurança Alimentar e Nutricional, e assume papel fundamental para a promoção da saúde dos povos indígenas. Embora ainda existam muitos desafios no campo da nutrição a serem enfrentados no Brasil, a implementação e inserção de políticas públicas torna mais justo o acesso à alimentação adequada e saudável, combatendo todas as formas de má nutrição no país, numa abordagem focada em minimizar a problemática em saúde associada à alimentação nas comunidades vulneráveis, principalmente dos povos indígenas.

CCR5Δ32 in Brazil: Impacts of a European Genetic Variant on a Highly Admixed Population.

The genetic background of Brazilians encompasses Amerindian, African, and European components as a result of the colonization of an already Amerindian inhabited region by Europeans, associated to a massive influx of Africans. Other migratory flows introduced into the Brazilian population genetic components from Asia and the Middle East. Currently, Brazil has a highly admixed population and, therefore, the study of genetic factors in the context of health or disease in Brazil is a challenging and remarkably interesting subject. This phenomenon is exemplified by the genetic variant CCR5Δ32, a 32 base-pair deletion in the CCR5 gene. CCR5Δ32 originated in Europe, but the time of origin as well as the selective pressures that allowed the maintenance of this variant and the establishment of its current frequencies in the different human populations is still a field of debates. Due to its origin, the CCR5Δ32 allele frequency is high in European-derived populations (~10%) and low in Asian and African native human populations. In Brazil, the CCR5Δ32 allele frequency is intermediate (4-6%) and varies on the Brazilian States, depending on the migratory history of each region. CCR5 is a protein that regulates the activity of several immune cells, also acting as the main HIV-1 co-receptor. The CCR5 expression is influenced by CCR5Δ32 genotypes. No CCR5 expression is observed in CCR5Δ32 homozygous individuals. Thus, the CCR5Δ32 has particular effects on different diseases. At the population level, the effect that CCR5Δ32 has on European populations may be different than that observed in highly admixed populations. Besides less evident due to its low frequency in admixed groups, the effect of the CCR5Δ32 variant may be affected by other genetic traits. Understanding the effects of CCR5Δ32 on Brazilians is essential to predict the potential use of pharmacological CCR5 modulators in Brazil. Therefore, this study reviews the impacts of the CCR5Δ32 on the Brazilian population, considering infectious diseases, inflammatory conditions, and cancer. Finally, this article provides a general discussion concerning the impacts of a European-derived variant, the CCR5Δ32, on a highly admixed population.

Sorcery and well-being: bodily transformation at Beckeranta.

This paper examines bodily transformation and well-being within the context of a millenarian movement that emerged during the 1840s in the area surrounding Mount Roraima at the periphery of Brazil, Guyana (British Guiana at the time), and Venezuela. The site of this movement was Beckeranta - meaning 'Land of the Whites' - where up to 400 Amerindians were reportedly killed in a quest that is described in its sole historical account as centred around a goal of bodily transformation into white people. In examining this movement, the paper engages with longstanding debates in medical anthropology concerning the body, as well as conversations among Amazonianists concerning the social formation of bodies, and examines sorcery and shamanism as practices that go 'beyond the body'. Notions of bodily transformation in Amazonia, which are often activated by strong emotions, facilitate conceptual expansions of the body in medical anthropology. The paper suggests that bodily transformations tied to sorcery and shamanism are in some contexts, such as at Beckeranta, associated with desires for well-being.Supplemental data for this article is available online at https://doi.org/10.1080/13648470.2020.1807726.

Revelations of ancient head shape: Cranial modification in the Cuzco region of Peru, Early Horizon to Inca Imperial Period.

OBJECTIVES: Cranial vault modification (CVM), the intentional reshaping of the head, indicated group affiliation in prehistoric Andean South America. This study aims to analyze CVM data from the Cuzco region of Peru to illuminate patterns of early migration and settlement along with the later impact of the Inca Empire (AD 1438-1532) on the ethnic landscape. MATERIALS AND METHODS: 419 individuals from 10 archaeological sites spanning over 2300 years were assessed for CVM using morphological analysis. RESULTS: CVM patterns show distinct temporal attributes: the tabular type of modification appeared first and dominated the early sample (900 BC-AD 600), followed by an influx of unmodified crania during the Middle Horizon (AD 600-1000). The annular type appeared later during the Late Intermediate Period (AD 1000-1438). In the subsequent period of Inca imperialism, modification rates were higher at sites in the Cuzco countryside than in Cuzco city sites. DISCUSSION: The study results, combined with archaeological and ethnohistoric data, reveal the sociopolitical transformations that occurred prior to and during the rise of the Inca Empire. The influx of unmodified crania during the Middle Horizon resulted at least partly from Wari occupation, while the appearance of the annular type during the LIP points to migration into the area, possibly from the Lake Titicaca region. In the Inca Imperial Period, Inca individuals at Cuzco city sites refrained from modification as a sign of their ethnic identity, while modification patterns in the Cuzco countryside likely reflect state-coerced resettlement of different ethnic groups.

Allelic frequencies with 23 autosomic STRS in the Aymara population of Peru.

Population data of the Aymara in the province of Puno were established for 23 autosomal STR markers. DNA was obtained from unrelated individuals (n = 190) who reside in three areas of the Floating Islands of Lake Titicaca, residents on the border with Bolivia and residents who are not from the border with Bolivia. The PENTA E marker presented the highest PD (0.9738), PIC (0.8793), and PM (0.7847) values. The combined PD was greater than 0.99999999 and the combined PE was 0.99999994. The largest distance, based on Fst values, was between the Aymara population and the Ashaninca population (0.04022), and the smallest distance was with the populations of Bolivia (0.00136) and Peru (0.00525).

The character of conflict: A bioarchaeological study of violence in the Nasca highlands of Peru during the Late Intermediate Period (950-1450 C.E.).

OBJECTIVES: This study uses osteological and radiocarbon datasets combined with formal quantitative analyses to test hypotheses concerning the character of conflict in the Nasca highlands during the Late Intermediate Period (LIP, 950-1450 C.E.). We develop and test osteological expectations regarding what patterns should be observed if violence was characterized by intragroup violence, ritual conflict, intermittent raiding, or internecine warfare. MATERIALS AND METHODS: Crania (n = 267) were examined for antemortem and perimortem, overkill, and critical trauma. All age groups and both sexes are represented in the sample. One hundred twenty-four crania were AMS dated, allowing a detailed analysis of diachronic patterns in violence among various demographic groups. RESULTS: Thirty-eight percent (102/267) of crania exhibit some form of cranial trauma, a significant increase from the preceding Middle Horizon era. There are distinct trauma frequencies within the three subphases of the LIP, but Phase III (1300-1450 C.E.) exhibits the highest frequencies of all trauma types. Males exhibit significantly more antemortem trauma than females, but both exhibit similar perimortem trauma rates. DISCUSSION: There was chronic, internecine warfare throughout the Late Intermediate Period with important variations in violence throughout the three temporal phases. Evidence for heterogeneity in violent mortality shows a pattern consistent with social substitutability, whereby any and all members of the Nasca highland population were appropriate targets for lethal and sublethal violence. We argue that by testing hypotheses regarding the targets and types of conflict we are better able to explain the causes and consequences of human conflict.

Covid-19 pandemic and the motivations for demanding health service in indigenous villages.

OBJECTIVE: To discuss the fundamental aspects in the establishment of preventive measures to tackle covid-19 among indigenous people in view of the motivations for seeking health care in villages of the Terra Indígena Buriti, Mato Grosso do Sul, Brazil. METHODS: Theoretical-reflective study based on assumptions of the National Health System and previous ethnographic research that enabled the identification of the motivations to seek health care in Buriti villages. RESULTS: Indigenous people seek health centers for health care programs assistance, treatment of cases they cannot resolve and to chat. Such motivations were the basis for discussing the indigenization process in the confrontation of the new coronavirus pandemic in indigenous lands. FINAL CONSIDERATIONS: The motivations for seeking health care show the physical and social vulnerability of the Terena ethnicity. The effectiveness of the social isolation measure in the villages depends on the dialogue with indigenous leaders, professional engagement and intersectoral actions.

"Hunting Otherwise" : Women's Hunting in Two Contemporary Forager-Horticulturalist Societies.

Although subsistence hunting is cross-culturally an activity led and practiced mostly by men, a rich body of literature shows that in many small-scale societies women also engage in hunting in varied and often inconspicuous ways. Using data collected among two contemporary forager-horticulturalist societies facing rapid change (the Tsimane' of Bolivia and the Baka of Cameroon), we compare the technological and social characteristics of hunting trips led by women and men and analyze the specific socioeconomic characteristics that facilitate or constrain women's engagement in hunting. Results from interviews on daily activities with 121 Tsimane' (63 women and 58 men) and 159 Baka (83 women and 76 men) show that Tsimane' and Baka women participate in subsistence hunting, albeit using different techniques and in different social contexts than men. We also found differences in the individual and household socioeconomic profiles of Tsimane' and Baka women who hunt and those who do not hunt. Moreover, the characteristics that differentiate hunter and non-hunter women vary from one society to the other, suggesting that gender roles in relation to hunting are fluid and likely to change, not only across societies, but also as societies change.

Coloniality and perspectivism in psychology: from damnation to ecosophical care relations.

Inspired by Amerindian peoples' philosophy, this article aims to problematise the modern philosophical anthropology that underlies psychology as a social practice, and to use the Amerindian perspectivist philosophy proposed by Viveiros de Castro as a critique of Western values. Thus, we approach some of coloniality's epistemological implications in the institution of subject-object and nature-culture separations that grounds psychology. On the one hand, there is a totalising unification, which operates alongside a transcendental subject that subjugates its object. Beginning from nature's homogeneity, the differentiation and hierarchy of each being depends on its representations or its soul, expressed as a people's culture or as an individual psychology. This spiritual-representational aspect is the very foundation of the colonialism and racism of damnation, and their purpose in perpetuating the miserable ways of life of those considered to be scum. On the other hand, in Amerindian cosmogony, humanity is a pronominal mode, a non-exclusive perspectivist position of mankind, built in each context of relations. It is based on this idea that we posit other bases and a new agenda for psychology as a social practice which can enable us to broaden our ways of living towards ecosophical care, as a way of resistance to coloniality.

New and old knowledge aimed at decolonising mental health: reflections and proposals from Chile.

Assuming that coloniality and its expression in hegemonic medicine and conventional psychiatry are present in most Latin American countries, this article explores unknown dimensions of decolonisation: the subjective, but social process of decolonisation of the being in hegemonic groups as the physicians. Although in Chile there are new models and state programmes that promote collective mental health and interculturality, they generally fail because they are trapped in the colonial system of power/knowledge and life/being. Grounded on the perspective of critical interculturality, we need to rethink mental health from the colonial difference to propose a new epistemology of power/knowledge and life/being based on indigenous concepts as well-being. Considering structural transformation as a key issue, through a case study of a lived intercultural experience, we point out that the activation of the decolonisation process requires not only new models of mental health but also a profound epistemic subjective transformation of physicians as colonised subjects.

Fine-scale genomic analyses of admixed individuals reveal unrecognized genetic ancestry components in Argentina.

Similarly to other populations across the Americas, Argentinean populations trace back their genetic ancestry into African, European and Native American ancestors, reflecting a complex demographic history with multiple migration and admixture events in pre- and post-colonial times. However, little is known about the sub-continental origins of these three main ancestries. We present new high-throughput genotyping data for 87 admixed individuals across Argentina. This data was combined to previously published data for admixed individuals in the region and then compared to different reference panels specifically built to perform population structure analyses at a sub-continental level. Concerning the Native American ancestry, we could identify four Native American components segregating in modern Argentinean populations. Three of them are also found in modern South American populations and are specifically represented in Central Andes, Central Chile/Patagonia, and Subtropical and Tropical Forests geographic areas. The fourth component might be specific to the Central Western region of Argentina, and it is not well represented in any genomic data from the literature. As for the European and African ancestries, we confirmed previous results about origins from Southern Europe, Western and Central Western Africa, and we provide evidences for the presence of Northern European and Eastern African ancestries.

[Reduction of HBV and HDV infection in two indigenousmpeoples of Peruvian Amazon after the vaccination against hepatitis B]. / Reducción en la infección por VHB y VHD en dos poblaciones indígenas de la Amazonia peruana después de la vacunación contra la hepatitis B.

OBJECTIVE: To determine the outcome of the vaccination against hepatitis, we determined the prevalence of hepatitis B virus (HBV) and hepatitis D virus (HDV) infections, eight years after introduction of the vaccination. MATERIALS AND METHODS: A cross-sectional study was performed in 2 944 participants of 67 Kandozi and Chapra indigenous peoples in April 2010. Serological screening for hepatitis B surface antigen (HBsAg), antibody anti-HBc IgM and IgG, antibody anti-HBs and anti-HDV were determined by ELISA tests. RESULTS: The prevalence rates of HBsAg, anti-HBc total, anti- HBs ≥10 mlUI/ml and anti-HDV were 2.3, 39.13, 50.95 and 2.11%, respectively. The prevalence rate of HBsAg in children <11 years was 0%. Among carriers of HBsAg, the prevalence rates of HDV and acute HBV infections were 2.11% (all were >14 years) and 11.94%, respectively. HBsAg and anti-HBc total were associated with individuals ≥10 years (p<0.001). CONCLUSIONS: These findings show the elimination of HBVmcarriers in children <11 years, eight years following introduction of the vaccination against HBV.

OBJETIVO: Conocer el resultado de la vacunación contra la hepatitis B en las comunidades hiperendémicas Kandozi y Chapra de la Amazonia Peruana a partir de la prevalencia de infecciones por los virus de la hepatitis B (VHB) y Delta (VHD), ocho años después de iniciada la vacunación. MATERIAL Y MÉTODOS: Se realizó un estudio transversal en 2 944 pobladores de 67 comunidades indígenas Kandozi y Chapra en abril de 2010. El tamizaje serológico para el antígeno de superficie del VHB (HBsAg), anticuerpos anti-HBc IgM e IgG, anticuerpos anti-HBs y anti-VHD se determinaron mediante pruebas de ELISA. RESULTADOS: Las tasas de prevalencia del HBsAg, anti-HBc IgG, anti-HBs ≥10 mlUI/ml y anti-VHD fueron 2.3, 39.13, 50.95 y 2.11%, respectivamente. La prevalencia del HBsAg en niños <11 años fue cero. Entre los portadores del HBsAg, las tasas de prevalencia de sobreinfeccion por el VHD e infección aguda por el VHB fueron 2.11% (todos fueron >14 años) y 11.94%, respectivamente. CONCLUSIONES: Estos hallazgos muestran la eliminación de portadores de VHB en niños <11 años, ocho años después de iniciada la vacunación contra el VHB.

Reducción en la infección por VHB y VHD en dos poblaciones indígenas de la Amazonia peruana después de la vacunación contra la hepatitis B / Reduction of HBV and HDV infection in two indigenous peoples of Peruvian Amazon after the vaccination against hepatitis B

Resumen: Objetivo: Conocer el resultado de la vacunación contra la hepatitis B en las comunidades hiperendémicas Kandozi y Chapra de la Amazonia Peruana a partir de la prevalencia de infecciones por los virus de la hepatitis B (VHB) y Delta (VHD), ocho años después de iniciada la vacunación. Material y métodos: Se realizó un estudio transversal en 2 944 pobladores de 67 comunidades indígenas Kandozi y Chapra en abril de 2010. El tamizaje serológico para el antígeno de superficie del VHB (HBsAg), anticuerpos anti-HBc IgM e IgG, anticuerpos anti-HBs y anti-VHD se determinaron mediante pruebas de ELISA. Resultados: Las tasas de prevalencia del HBsAg, anti-HBc IgG, anti-HBs ≥10 mlUI/ml y anti-VHD fueron 2.3, 39.13, 50.95 y 2.11%, respectivamente. La prevalencia del HBsAg en niños <11 años fue cero. Entre los portadores del HBsAg, las tasas de prevalencia de sobreinfeccion por el VHD e infección aguda por el VHB fueron 2.11% (todos fueron >14 años) y 11.94%, respectivamente. Conclusiones: Estos hallazgos muestran la eliminación de portadores de VHB en niños <11 años, ocho años después de iniciada la vacunación contra el VHB.

Abstract: Objective: To determine the outcome of the vaccination against hepatitis, we determined the prevalence of hepatitis B virus (HBV) and hepatitis D virus (HDV) infections, eight years after introduction of the vaccination. Materials and methods: A cross-sectional study was performed in 2 944 participants of 67 Kandozi and Chapra indigenous peoples in April 2010. Serological screening for hepatitis B surface antigen (HBsAg), antibody anti-HBc IgM and IgG, antibody anti-HBs and anti-HDV were determined by ELISA tests. Results: The prevalence rates of HBsAg, anti-HBc total, anti-HBs ≥10 mlUI/ml and anti-HDV were 2.3, 39.13, 50.95 and 2.11%, respectively. The prevalence rate of HBsAg in children <11 years was 0%. Among carriers of HBsAg, the prevalence rates of HDV and acute HBV infections were 2.11% (all were >14 years) and 11.94%, respectively. HBsAg and anti-HBc total were associated with individuals ≥10 years (p<0.001). Conclusions: These findings show the elimination of HBV carriers in children <11 years, eight years following introduction of the vaccination against HBV.

Endemic violence in a pre-Hispanic Andean community: A bioarchaeological study of cranial trauma from the Majes Valley, Peru.

OBJECTIVES: This study examines violence-related cranial trauma frequencies and wound characteristics in the pre-Hispanic cemetery of Uraca in the lower Majes Valley, Arequipa, Peru, dating to the pre- and early-Wari periods (200-750 CE). Cranial wounds are compared between status and sex-based subgroups to understand how violence shaped, and was shaped by, these aspects of identity, and to reconstruct the social contexts of violence carried out by and against Uracans. MATERIALS AND METHODS: Presence, location, and characteristics (lethality, penetration, and post-traumatic sequelae) of antemortem and perimortem cranial fractures are documented for 145 crania and compared between subgroups. Cranial wounds are mapped in ArcGIS and the locational distribution of injuries is compared between male and female crania. RESULTS: Middle adult males were disproportionately interred at Uraca, particularly in the elite Sector I. The Uraca mortuary population presents the highest rate of cranial trauma reported for pre-Hispanic Peru: 67% of adults present trauma, and among those, 61.1% present more than one cranial injury. Males exhibit significantly more cranial trauma than females and present a higher mean number of injuries per person. Elite males show the highest mean number of injuries per person, more antemortem injuries, and are the only ones with perimortem cranial trauma, bladed injuries, penetrating injuries, and post-traumatic sequelae. Both sexes were most frequently injured on the anterior of the cranium, while the proportion of posterior injuries was higher for females. DISCUSSION: The rate, intensity, and locational patterns of cranial trauma suggests the community was engaged in raids and/or war with enemy groups, some of which may have increased physical violence between community members. Engaging in violence was likely a prerequisite for burial in the elite sector and was bound up with the generation and maintenance of social status differences linked to male social life.

Violence against indigenous children and adolescents in Venezuela.

Research on violence in indigenous communities refers to traditional practices of competition for scarce goods and clashes with other populations over their territories. Violence against children is not described, and authors of some studies state a tradition of good treatment towards them. In our study we shows that the situation has changed and new forms of violence are affecting 725,000 inhabitants from 51 indigenous groups of Venezuela, especially those composed of children and adolescents. The method used was interviews with key informants and for secondary census, civil society data and journalists' reports. Results describe the existence of four types of violence: (a) structural violence, derived from the shortage of food and medicines that have caused deaths due to malnutrition and lack of medical attention, prostitution, girl trafficking and forced emigration; (b) violence of organized crime, which exercise control of illegal mining and affect the Yanomami and Pemón peoples, as workforce for the production of coca and drug trafficking with the Yupka people; and contraband of gasoline in the Wayúu people; (c) domestic violence due to cultural changes derived from new patterns of alcohol consumption or the use of physical punishment of children between Piaroa and Yekuana peoples; and (d) the illegal violence of the State for the imposition of mining with the Pemón people or the repression for the protests with the Warao and Inga peoples. In the article we show the great difference between the official discourse of protection of indigenous peoples and the realities of violence, criminal exploitation and violation of rights suffered by indigenous children and adolescents.

[Health promotion with indigenous women: the contribution of ethnography on self-care practices among the Munduruku people in the Amazonas State, Brazil]. / Promoção da saúde da mulher indígena: contribuição da etnografia das práticas de autoatenção entre os Munduruku do Estado do Amazonas, Brasil.

Longevity, health, and collective and individual well-being are among the socially shared expectations of the Munduruku people who live on the Kwatá-Laranjal Indian Reservation in Amazonas State, Brazil. Daily life in a cosmos full of beings is surrounded by dangers that threaten these expectations, and whose agencies can result in disease and death. Based on ethnography, through participant observation and narratives, we analyze the self-care practices dedicated to the construction of the Munduruku woman's body, valuing the perspectives and active role of "lay" persons in this process. These practices begin in pregnancy and extend throughout life in an ongoing process of construction of the body, maintenance of health, and acquisition of skills, marked by interaction between persons of different ages. The focus of Munduruku practices is not the body in the sense determined by the biomedical paradigm, but its participation as a person in social and cosmological relations, through experiences that link body, health, and environment. The Munduruku perspective on this process displays radical differences in relation to modern individualism and the biomedical notion of the body, excessively reductionist. An understanding of the indigenous perspective can help promote improvements in the quality of differentiated care, as recommended by the Brazilian National Healthcare Policy for Indigenous Peoples.

A longevidade, a saúde e o bem-estar coletivo e individual figuram entre as expectativas socialmente compartilhadas pelos Munduruku que habitam a Terra Indígena Kwatá-Laranjal, Amazonas, Brasil. A condução da vida diária, em um cosmo pleno de seres, é cercada de perigos que ameaçam essas expectativas, cujas agências podem resultar em doença e morte. A partir de etnografia, conduzida por meio da observação participante e narrativas, analisamos as práticas de autoatenção voltadas à construção do corpo da mulher Munduruku, valorizando a perspectiva e o papel ativo das pessoas "leigas" nesse processo. Essas práticas iniciam-se na gestação e estendem-se ao longo da vida, em um processo contínuo de construção do corpo, manutenção da saúde e aquisição de habilidades, marcado pela interação entre pessoas de diferentes idades. O foco das práticas de atenção Munduruku não é o corpo no sentido dado pelo paradigma biomédico, mas a participação deste, como pessoa, nas relações sociais e cosmológicas, por meio de experiências que articulam corpo, saúde e ambiente. A perspectiva Munduruku sobre esse processo apresenta diferenças radicais em relação ao individualismo moderno e à noção biomédica de corpo excessivamente reducionista. A compreensão da perspectiva indígena contribui para promover melhorias na qualidade da atenção diferenciada, conforme preconizado pela Política Nacional de Atenção à Saúde dos Povos Indígenas.

La longevidad, la salud y el bienestar colectivo e individual figuran entre las expectativas socialmente compartidas por los Munduruku, que habitan la Tierra Indígena Kwatá-Laranjal, en el Amazonas, Brasil. El quehacer de la vida diaria, en un cosmos lleno de seres, está rodeado de peligros que amenazan las expectativas mencionadas anteriormente, cuyas vicisitudes pueden resultar en enfermedad y muerte. A partir de la etnografía, realizada mediante observación participante y narraciones, analizamos las prácticas de autoatención, dirigidas a la construcción del cuerpo de la mujer Munduruku, valorando tanto la perspectiva, como el papel activo de las personas "no especialistas" en este proceso. Estas prácticas se inician en la gestación y se extienden a lo largo de la vida, en un proceso continuo de construcción del cuerpo, mantenimiento de la salud y adquisición de habilidades, marcado por la interacción entre personas de diferentes edades. El foco de las prácticas de atención Munduruku no es el cuerpo, tal y como lo entiende el paradigma biomédico, sino la participación de este, como persona, en las relaciones sociales y cosmológicas, mediante experiencias que articulan cuerpo, salud y ambiente. La perspectiva Munduruku sobre este proceso presenta diferencias radicales, respecto al individualismo moderno y la noción biomédica de cuerpo, excesivamente reduccionista. La comprensión de la perspectiva indígena contribuye a promover mejorías en la calidad de la atención diferenciada, conforme lo preconizado por la Política Nacional de Atención de la Salud de los Pueblos Indígenas.

The Proximate Causes of Waorani Warfare.

In response to recent work on the nature of human aggression, and to shed light on the proximate, as opposed to ultimate, causes of tribal warfare, we present a record of events leading to a fatal Waorani raid on a family from another tribe, followed by a detailed first-person observation of the behavior of the raiders as they prepared themselves for war, and upon their return. We contrast this attack with other Waorani aggressions and speculate on evidence regarding their hormonal underpinnings. On-the-ground ethnographic observations are examined in light of the neuroendocrinological literature. The evidence suggests a chain of causality in launching lethal violence, beginning with a perceived injury, culminating in a massacre, and terminating in rejoicing. Although no blood or saliva samples were taken at the time of this raid, the behaviors were consistent with a deliberate initiation of the hormonal cascade characterizing the "fight-or-flight" response, along with other hormonal changes. We conclude with observations on the stratified interrelationships of the cognitive, social, emotional, and neuroendocrinological causes of aggression leading to coalitional male homicide.