ABSTRACT
This study investigates the occurrence of aflatoxins in Ecuador. Early investigators proved the presence of aflatoxins in human and animal food, but the disturbing data lead to the formation of two research teams at Guayaquil University and the Agrarian University of Ecuador to investigate aflaxotins and other mycotoxins in food and their relationship to human health. Because the concept of mycotoxicosis as a result of the secondary metabolites produced by different species of moulds could cause different clinical patterns, the research team includes Aspergillus metabolites found in the urine of a patient with pulmonary aspergilloma. We considered that the body itself could create secondary metabolites. An ELISA method was used to detect mycotoxins with the specific reactive compounds using a company base assay. This allows the detection quantitative of such metabolites in 24 h collected urine. The patient was treated with itraconazole for nine months, after clinical, radiological and aflatoxins testing. We also investigated three other cases in children with a second level of malnutrition and only with vomitoxins results and in three investigated cases of otomycosis caused by Aspergillus niger only in one case traces of aflatoxins were found.
Subject(s)
Food Contamination , Mycotoxicosis/epidemiology , Mycotoxins/toxicity , Adult , Aflatoxins/toxicity , Aflatoxins/urine , Aspergillosis/complications , Aspergillosis/urine , Child , Child, Preschool , Ecuador/epidemiology , Female , Food Contamination/statistics & numerical data , Gastritis/complications , Humans , Lung Diseases, Fungal/complications , Lung Diseases, Fungal/microbiology , Lung Diseases, Fungal/urine , Male , Malnutrition/complications , Middle Aged , Mycotoxicosis/etiology , Mycotoxicosis/urine , Mycotoxins/analysis , Mycotoxins/pharmacokinetics , Otitis Media/complications , Otitis Media/microbiology , Rural Population , Trichothecenes/urine , Zearalenone/toxicity , Zearalenone/urineSubject(s)
Choroiditis/microbiology , Eye Infections, Fungal/etiology , Histoplasmosis/etiology , Immunocompetence , Acute Disease , Antibodies, Fungal/analysis , Antifungal Agents/therapeutic use , Antigens, Fungal/urine , Child, Preschool , Choroiditis/drug therapy , Choroiditis/urine , Eye Infections, Fungal/drug therapy , Eye Infections, Fungal/urine , Fluconazole/therapeutic use , Fundus Oculi , Histoplasma/immunology , Histoplasmosis/drug therapy , Histoplasmosis/urine , Humans , Lung Diseases, Fungal/drug therapy , Lung Diseases, Fungal/etiology , Lung Diseases, Fungal/urine , Male , Nuclear Family , Visual AcuityABSTRACT
This paper reports a case of chronic necrotizing pulmonary aspergillosis in a patient without underlying disease. Aspergilluria was the starting point in the search for the origin of the pulmonary disease, later confirmed by an open lung biopsy.
Subject(s)
Aspergillosis/diagnosis , Lung Diseases, Fungal/diagnosis , Aspergillosis/urine , Biopsy , Brazil , Chronic Disease , Humans , Lung/surgery , Lung Diseases, Fungal/urine , Male , Middle Aged , Necrosis , Urine/microbiologyABSTRACT
A case of urinary crystalluria occurring in a patient during treatment with flucytosine (5-fluorocytosine) is presented. A reduction in the dosage of the 5-fluorocytosine resulted in a marked decrease in the excretion of urinary gravel which was shown to be a coprecipitate of 5-fluorocytosine and uric acid.